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The role of the adenylate kinase 5 gene in various diseases and cancer
No full textAdenylate kinases (AKs) are important enzymes involved in cellular energy metabolism. Among AKs, AK5 (adenylate kinase 5), a cytosolic protein, is emerging as a significant contributor to various diseases and cellular processes. This comprehensive review integrates findings from various research groups on AK5 since its discovery, shedding light on its multifaceted roles in nucleotide metabolism, energy regulation, and cellular differentiation. We investigate its implications in a spectrum of diseases, including autoimmune encephalitis, epilepsy, neurodegenerative disorders such as Alzheimer’s and Parkinson’s, diabetes, lower extremity arterial disease, celiac disease, and various cancers. Notably, AK5’s expression levels and methylation status have been associated with cancer progression and patient outcomes, indicating its potential as a prognostic indicator. Furthermore, AK5 is implicated in regulating cellular processes in breast cancer, gastric cancer, colorectal carcinoma, prostate cancer, and colon adenocarcinoma, suggesting its relevance across different cancer types. However, a limitation lies in the need for more robust clinical validation and a deeper understanding of AK5’s precise mechanisms in disease pathogenesis, despite its association with various pathophysiological conditions. Nonetheless, AK5 holds promise as a therapeutic target, with emerging evidence suggesting its potential in therapy development
Incorporación de materiales de cambio de fase
No full textEl mortero de cal se utiliza desde la antigüedad por sus propiedades mecánicas y durabilidad, lo que lo ha convertido en un material fundamental para la construcción de edificios históricos. Sin embargo, en las últimas décadas, su aplicación ha evolucionado. Hoy en día, no solo se utilizan en la restauración del patrimonio arquitectónico, sino también en proyectos que buscan sostenibilidad y eficiencia energética. Esta evolución ha abierto el camino a nuevas investigaciones, como la incorporación de materiales avanzados, como los materiales de cambio de fase (PCMs a partir de ahora por sus siglas en inglés), para mejorar su rendimiento térmico sin perder las características tradicionales del mortero
Editorial – The Dynamic Theodicy Model: Understanding God, Evil, and Evolution
No full textThe scientific papers published in a special edition of the journal “Scientia et Fides” are the result of an international scientific project titled “The Dynamic Theodicy Model: Understanding God, Evil, and Evolution.” The project leaders are Prof. Piotr Roszak (Nicolaus Copernicus University) and Prof. Saša Horvat (University of Rijeka), under the auspices of the University of Oxford and the John Templeton Foundation. Other members of the project team include Grzegorz Karwasz, Michał Oleksowicz, Tomasz Huzarek, and Jan Wółkowski
Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
No full textPurpose: Vitamin D deficiency has been associated with multiple chronic diseases, including metabolic disorders such as insulin resistance and type 2 diabetes (T2D). The aim of the study was to analyze the association between validated predicted serum vitamin D status and the risk of developing T2D in a large prospective cohort based on a Mediterranean population.
Methods: The SUN project is a prospective and dynamic Spanish cohort that gathers university graduates who have answered lifestyle questionnaires, including a validated Food Frequency Questionnaire. The association between predicted serum vitamin D and the risk of T2D was assessed through Cox regression models according to quartiles (Q) of predicted vitamin D at baseline. The models were adjusted for potential confounders and sensitivity analyses were performed to ensure the robustness of our findings.
Results: Our study included a total of 18,594 participants and after a total follow-up of 238,078 person-years (median follow-up of 13.5 years), 209 individuals were diagnosed with incident T2D. We found a significant inverse association between predicted levels of serum vitamin D and the risk of developing T2D, after adjusting for potential confounders and performing different sensitivity analyses (hazard ratio Q4 vs. Q1: 0.48, 95% CI 0.26-0.88; p for trend = 0.032).
Conclusion: The outcomes suggest that higher levels of vitamin D at baseline may be associated with a reduced risk of developing T2D
Green way of improving the thermal efficiency of mortars by the addition of biobased phase change materials
No full textThe thermal efficiency of air lime-based mortars was improved by directly integrating varying amounts (5 wt. %, 10 wt. %, and 20 wt. %) of a biobased Phase Change Material (PCM) into the fresh mortars. The composition of this PCM is vegetable oils and other organic wastes from the agri-food sector. To optimise the mortar formulation, different chemical additives and mineral admixtures were added. The mortar formulation was meticulously designed to produce rendering mortars that are easily workable, crack-free, and fully adherent for use in building envelopes. Positive outcomes in thermal efficiency tests have demonstrated the ability of these materials to store thermal latent energy, offering an environmentally friendly alternative to enhance the thermal comfort of building inhabitants
Alcohol drinking impacts on adiposity and steatotic liver disease: concurrent effects on metabolic pathways and cardiovascular risks
No full textPurpose of review: This integrative search aimed to provide a scoping overview of the relationships between the benefits and harms of alcohol drinking with cardiovascular events as associated to body fat mass and fatty liver diseases, as well as offering critical insights for precision nutrition research and personalized medicine implementation concerning cardiovascular risk management associated to ethanol consumption.
Recent findings: Frequent alcohol intake could contribute to a sustained rise in adiposity over time. Body fat distribution patterns (abdominal/gluteus-femoral) and intrahepatic accumulation of lipids have been linked to adverse cardiovascular clinical outcomes depending on ethanol intake. Therefore, there is a need to understand the complex interplay between alcohol consumption, adipose store distribution, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular events in adult individuals. The current narrative review deals with underconsidered and apparently conflicting benefits concerning the amount of alcohol intake, ranging from abstention to moderation, and highlights the requirements for additional robust methodological studies and trials to interpret undertrained and existing controversies. The conclusion of this review emphasizes the need of newer multifaceted clinical approaches for precision medicine implementation, considering epidemiological strategies and pathophysiological mechanistic. Newer investigations and trials should be derived and performed particularly focusing both on alcohol's objective consequences as putatively mediated by fat deposition, including associated roles in fatty liver disease as well as to differentiate the impact of different levels of alcohol consumption (absence or moderation) concerning cardiovascular risks and accompanying clinical manifestations. Indeed, the threshold for the safe consumption of alcoholic drinks remains to be fully elucidated
Persistence in Tax Revenues: Evidence from Some OECD Countries
No full textThis paper examines persistence in tax revenues in a set of 21 OECD countries
over the period 1965–2021 using long-range dependence techniques based on fractional integration. The results imply that there are only a few cases of mean reversion: one for total revenue (Switzerland); three for VAT (Belgium, Italy, and Spain),
and six for tax on income (Austria, Belgium, Finland, Spain, Sweden and USA).
The analysis is also carried out for infation in the same set of countries. Again the
I(1) hypothesis cannot be rejected in most cases, mean reversion only occurring in
Korea, Iceland, Norway and Sweden. However, stronger evidence of mean reversion is found for the diferences between the three original tax series and infation
compared to the tax series themselves, which points to the existence of a linkage
between taxation and infation, especially in the case of VAT and tax on incom
Química Farmacéutica I. Antibióticos. Parte 1, reacción 1: Síntesis del derivado enamina. Aislamiento
No full textTemas de la Asignatura Química Farmacéutica I de 3º de Farmacia