Swiss School of Archaeology in Greece
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Health-Related Expertise in the Digital Age: Reconfigurations and Redistributions
No full textSpecial Issue "Health-Related Expertise in the Digital Age: Reconfigurations and Redistributions", guest edited by Sandra Bärnreuther, Nolwenn Bühler and Giada Danesi
Coût de bluff ? Les Jeux Olympiques d’hiver face au déficit d’attractivité
No full textCe deuxième numéro spécial de Movement & Sport Sciences – Science & Motricité consacré aux Jeux Olympiques d’hiver est la conséquence d’un appel à contributions ayant rencontré un large écho. Cela témoigne de l’intérêt croissant de la communauté scientifique pour une thématique jusqu’ici peu investie. Il rassemble cinq articles issus de l’économie, de la sociologie et du management, qui explorent de manière complémentaire les ressorts du déficit d’attractivité des Jeux d’hiver. Les deux premières contributions économiques interrogent la dynamique de gigantisme et la rentabilité de l’événement, en croisant analyse des coûts d’infrastructure et évolution des recettes olympiques. Les articles suivants, venant de la sociologie et du management, examinent
l’acceptabilité sociale des candidatures, à partir de candidatures canadiennes, en mettant en lumière les effets du manque de transparence, les tensions liées aux priorités publiques et la difficile inclusion des communautés autochtones. Une dernière contribution propose une lecture longitudinale des méthodes d’évaluation économique mobilisées autour des Jeux, plaidant pour une meilleure prise en compte des coûts d’opportunité. L’ensemble offre un éclairage multidimensionnel sur les limites structurelles du modèle olympique hivernal, dans un contexte où les enjeux démocratiques et environnementaux pèsent de plus en plus dans le débat public
Bowstringing of the extensor digitorum: clinical and biomechanical results using an ankle extensor retinaculum graft.
No full textWe report a case of extensor digitorum bowstringing after complete rupture of the extensor retinaculum treated successfully with an ankle extensor retinaculum graft. Reconstruction of structure, form and mechanical properties of the extensor retinaculum is possible owing to the histological similarity of anatomical pulleys throughout the body.Level of evidence: V
Adaptive hip exoskeleton control using heart rate feedback reduces oxygen cost during ecological locomotion.
No full textDespite their potential, exoskeletons have not reached widespread adoption in daily life, partly due to the challenge of seamlessly adapting assistance across various tasks and environments. Task-specific designs, reliance on complex sensing and extensive data-driven training often limit the practicality of the existing control strategies. To address this challenge, we introduce an adaptive control strategy for hip exoskeletons, emphasizing minimal sensing and ease of implementation. Using only insole pressure and heart rate (HR) sensing, the controller modulates assistance across various locomotor tasks. We evaluated this strategy with twelve able-bodied participants in a real-world scenario including level walking, stairs, and inclines. The controller successfully adapted assistance timing and amplitude to different activities. This resulted in effort intensity reductions (measured by oxygen uptake) of up to 12.6% compared to walking with no exoskeleton, and up to 25.5% compared to walking with the exoskeleton in zero-torque mode. Cardiodynamic response of HR, although delayed, proved sufficient for adaptation in tasks lasting longer than around 45 s, and delay-induced limitations primarily affected brief bouts of abrupt change in intensity. However, we found discernible patterns in HR shortly after the onset of such changes that can be exploited to improve responsiveness. Our findings underscore the potential of HR as a promising measure of user effort intensity, encouraging future research to explore its integration into advanced adaptive algorithms
Bioethics knowledge, attitudes, and practices among healthcare professionals in Cameroon: a cross sectional analytical observational study of doctors and nurses in Cameroon's Southwest Region
No full textDupilumab for immune checkpoint inhibitors-induced pruritic dermatoses: A retrospective, multicentric study
No full textSeizure worsening in SCN1A-associated Dravet syndrome while on cenobamate: case series and literature review
No full textBackground New treatment approaches are needed to manage refractory disease courses of Dravet syndrome (DS). In recent years, several case reports of the successful use of cenobamate (CNB) in DS have been published. The present case series and systematic review aims to evaluate the potential efficacy of CNB as a treatment alternative in DS based on additional treated cases and to critically summarize current data. Methods Two cases, an adolescent and a young adult with treatment-resistant DS, who were treated with CNB are presented in detail. To identify all available studies on the use of CNB in DS, we conducted a systematic literature search covering the period from 2019 to June 2025. Results We present two new case reports on treatment with CNB in SCN1A-associated DS, both of which led to seizure worsening: case 1 describes a 17-year-old adolescent with status epilepticus and seizure exacerbation while on CNB and case 2 a 23-year-old woman with increase in myoclonus. In the literature, 13 additional cases could be identified. The overall analysis of 15 cases shows no response or seizure worsening in 53%, with significant age dependency: the median age of responders was 25 years, that of nonresponders 9 years (p = 0.01). Conclusion Based on the reported cases, there appears to be an age-dependent response to CNB in patients with DS. Following the initially published successful treatments in DS adults, reports of seizure worsening are increasing, particularly in younger patients. The use of sodium channel blockers in DS is considered contraindicated, and this appears particularly the case in the first two decades of life. CNB should only be considered in DS after careful risk-benefit assessment and, if at all, preferably in adults
Study Protocol for HeartMagic: A Prospective Observational Cohort Characterizing Subtypes of Heart Failure With Preserved Ejection Fraction
No full textHeart failure (HF) is a life-threatening syndrome with significant morbidity and mortality. Although evidence-based drug treatments have effectively reduced morbidity and mortality in HF with reduced ejection fraction (EF), few therapies have been demonstrated to improve outcomes in HF with preserved EF. This may be caused by the existence of several HF with preserved EF subtypes that each need different treatments. There is therefore an unmet need for a comprehensive approach to subtype patients with HF with preserved EF. This protocol details the approach employed in the HeartMagic (Heart Failure Studied With a Machine Learning, Genomics, and Imaging Combination) study to address this gap.
This prospective multicenter observational cohort study will include 500 consecutive patients with HF with preserved EF at 2 Swiss university hospitals, along with 50 age-matched patients with HF with reduced EF and 50 healthy controls. In addition to routine clinical workup, participants undergo genomic, transcriptomic, and metabolomic analyses, and the anatomy, composition, and function of the heart are quantified by comprehensive echocardiography and magnetic resonance imaging. Quantitative magnetic resonance imaging is also applied to characterize the kidney. The primary outcome is a composite of 1-year cardiovascular mortality or rehospitalization. Machine learning-based multimodal clustering will be employed to identify distinct HF with preserved EF subtypes. Statistical analysis will include group comparisons, survival analysis, and integrative multimodal clustering combining clinical, imaging, ECG, genomic, transcriptomic, and metabolomic data to identify and validate HF with preserved EF subtypes.
The integration of comprehensive magnetic resonance imaging with extensive genomic and metabolomic profiling in this study will result in an unprecedented panoramic view of HF with preserved EF and help distinguish functional subgroups, which may provide a basis for personalized therapies
Spatial analysis identifies DC niches as predictors of pembrolizumab therapy in head and neck squamous cell cancer.
No full textHead and neck squamous cell carcinoma (HNSCC) shows variable response to anti-programmed cell death protein 1 (PD-1) therapy, which can be partially explained by a combined positive score (CPS) of tumor and immune cell expression of programmed death-ligand 1 (PD-L1) within the local tumor microenvironment (TME). To better define TME immune determinants associated with treatment efficacy, we conduct a study of n = 48 HNSCC tumors from patients prior to pembrolizumab therapy. Our investigation combines a rapid bioorthogonal multiplex staining method with computational analysis of whole-slide imaging to capture the single-cell spatial heterogeneity and complexity of the TME. Analyzing 6,316 fields of view (FOVs), we provide comprehensive PD-L1 phenotyping and cell proximity assays across the entirety of tissue sections. While none of the PD-L1 metrics adequately predict response, we find that the spatial organization of CCR7 + dendritic cells (DCs) in niches better predicts overall patient survival than CPS alone. This study highlights the importance of understanding the spatial context of immune networks for immunotherapy