Swiss School of Archaeology in Greece
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Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model
No full textPrognostic Factors of Late-onset Hearing Loss in Infants With Congenital Cytomegalovirus and Normal Audiologic Assessment at Birth
No full textChildren with congenital cytomegalovirus (cCMV) can develop late-onset sensorineural hearing loss (LO-SNHL). In this study, we aim to assess the characteristics and predictors of LO-SNHL in infants with cCMV having normal hearing at the first neonatal assessment.
A retrospective study within the European Registry of Children with cCMV ( www.ccmvnet.org ) was performed. Included children had cCMV and a normal first audiological assessment by Auditory Brainstem Response (ABR). Late-onset hearing loss (LO-SNHL) is defined as the presence of sensorineural hearing loss after an initial normal hearing test. Hearing evaluation was performed at birth, at 6 months of age, and at least annually up to 6 years of age.
Seven hundred twenty-one children with normal audiological tests at birth were included, and 47/721 (6.5%) developed LO-SNHL. LO-SNHL was diagnosed at a range of 4-65 months of age [median (IQR) age: 34.3 (15.1-48.7) months]. Children with LO-SNHL had a higher proportion of abnormalities on physical examination at birth (45.7% vs. 20.8%; P < 0.001): petechiae (17.4% vs. 6.0%; P = 0.008), splenomegaly (8.7% vs. 2.3%; P = 0.031), hepatomegaly (13% vs. 2.9%; P = 0.001), microcephaly (15.2% vs. 4.5%; P = 0.005) and small for gestational age (21.7% vs. 8.3% P = 0.005). Children with LO-SNHL showed lower platelet count at birth [177500.0 (88750.0-261250.0)/μL vs. 243500.0 (173000.0-304000.0)/μL; P = 0.012], and higher blood viral load at birth [3.7 log (3.3-4.4) vs. 3.4 log (2.7-3.9) IU/mL; P = 0.013] and had more frequent white matter involvement (27.7% vs. 14.7%; P = 0.03) and ventriculomegaly (20.7% vs. 4.6%; P = 0.001) on birth magnetic resonance imaging. Overall, symptomatic children at birth showed a higher risk of developing LO-SNHL than asymptomatic children (32/317, 10.1%, vs. 15/404, 3.7%; P < 0.0001). Among asymptomatic children, only 0.3% developed severe or profound LO-SNHL in the best ear.In multivariate logistic regression analysis, ventriculomegaly [odds ratio (OR): 7.503 (1.78-27.9)], white matter abnormalities [OR: 3.19 (1.010-9.01)], and splenomegaly [OR: 3.679 (1.56-8.506)] at birth were associated with the development of LO-SNHL ( Fig. 1 ).
Among this large cohort of children with cCMV and a first normal audiological assessment, the risk of LO-SNHL was 6.5%. Asymptomatic children developed LO-SNHL in 3.7% of the cases versus 10.1% in symptomatic cases. In multivariate logistic regression analysis, ventriculomegaly, white matter abnormality, and splenomegaly at birth were associated with LO-SNHL.
Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc
Retour vers le vivant : valoriser les archives filmiques et sonores des arts du spectacle
No full textLes archives filmiques et sonores qui documentent les spectacles et d’autres aspects des arts vivants connaissent aujourd’hui une multiplicité d’usages. Qu’il s’agisse de captations de spectacle, avec ou sans public, de moments de répétitions ou de rencontres avec des artistes, elles fournissent des sources précieuses aux historiennes et historiens intéressés par les pratiques performatives du passé. Le plus souvent sous forme d’extraits, on les retrouve sur les cimaises des expositions, sur les sites internet des institutions à vocation patrimoniale, dans des bases de données élaborées pour la recherche académique et au cœur de nombreuses activités d’enseignement et de médiation culturelle. Elles contribuent aussi à la formation des artistes de la scène et nourrissent une création contemporaine volontiers réflexive, critique ou mélancolique. Cet ouvrage assemble les contributions de chercheurs et chercheuses, de pédagogues, d’artistes et de médiateurs et médiatrices, qui portent sur les obstacles particuliers que rencontre tout projet de valorisation des archives filmiques et sonores dans le domaine des arts du spectacle, qu’il s’agisse de recherche, d’enseignement, de médiation ou de création.
Avec les contributions de : Giacomo Alliata, Romain Bionda, Stéphane Bouquet, Robert Cantarella, Sylvie Chalaye, Danielle Chaperon, Lorena Ehrbar, Romain Fohr, Isabelle Galey, Marisa Godoy, Tomas Gonzalez, Céline Hersant, Sandrine Kuster, Juliette Loesch, Aurélien Maignant, Elsa Marty, Aurélie Mouton-Rezzouk, Sarah Neu, Anne Pellois, Marie Quiblier, Beate Schlichenmaier, François Vallotton, Nelly Valsangiacomo, Julia Wehren et Tommaso Zaccheo
Rationale and design of European microcirculatory resistance and absolute flow team: The Euro-CRAFT registry
No full textCoronary microvascular dysfunction (CMD) is increasingly recognized as an important cause of anginal symptoms and poor outcomes. Angina with nonobstructive coronary arteries (ANOCA) is often related to CMD. While physiological assessment of microcirculatory function by coronary bolus thermodilution is widely practiced, more precise and reproducible methodology as well as systematic assessment are necessary. Recently, absolute flow measurements by coronary continuous thermodilution and the concept of Microvascular Resistance Reserve (MRR) have been introduced.
The European microCirculatory Resistance and Absolute Flow Team (EuroCRAFT) registry aims to compare major adverse cardiac and cerebrovascular events (MACCE)-rates in patients with and without CMD based on MRR at 1-year follow-up.
This prospective international, investigator-initiated, multicenter study is enrolling patients with stable chest pain suggestive of angina and nonobstructive epicardial coronary arteries on invasive coronary angiography, defined as fractional flow reserve >0.80. Patients will undergo coronary angiography and microvascular assessment using bolus and continuous thermodilution methods. The primary endpoint is to compare the rate of MACCE in patients with and without CMD assessed with MRR at 1 year. Based on the sample size estimation, 671 patients are initially planned for enrollment. We hypothesize that coronary continuous thermodilution-derived MRR has superior prognostic value for MACCE at 1 year compared to bolus thermodilution-derived microvascular metrics.
Study recruitment started in September 2022 and has been completed in May 2025, resulting in a total of 678 patients enrolled.
Copyright © 2025 Elsevier Inc. All rights reserved
Peupler la scène. Effets de foule dans le théâtre sérieux français (1634-1691)
No full textLa tragédie française du XVIIe siècle n’a pas seulement été l’apanage des héros. Citoyens, suivantes, gardes, soldats, juges, janissaires, anges et députés n’ont cessé de traverser les pièces de Corneille, Rotrou, Racine, mais aussi de Bernard, Abeille ou Deshoulières. Archives à l’appui, cet ouvrage dévoile l’ampleur et la portée de ces phénomènes de groupe. Il montre comment, par le biais de figurants, de bruitages, de récits ou de discours rapportés, les « effets de foule » entraient pleinement dans les logiques de composition et de réception des pièces des années 1630 aux années 1690. En réinscrivant l’élément collectif au cœur de la dramaturgie du théâtre sérieux, cette étude désindividualise ainsi le genre en renouvelant notre compréhension même du pathétique : elle offre à saisir différemment les rapports entre scène et salle. Et elle contribue, plus largement, à démontrer la valeur poétique et esthétique du « commun » dans l’art dramatique
Harnessing Artificial Intelligence in Head and Neck Oncology Practice: Data, Diagnosis, and Therapy
No full textArtificial intelligence (AI) has emerged as a transformative tool across the various domains of head and neck oncology. From early screening and risk stratification to diagnosis, staging, personalized treatment, rehabilitation, and research support, AI enhances precision, efficiency, and patient outcomes. AI-powered mobile applications and wearable devices facilitate remote monitoring during the follow-up care and rehabilitation, and Large Language Models accelerate research workflows and data synthesis. This article comprehensively explores AI applications in head and neck oncology and outlines their clinical impact, implementation barriers, and future directions.
Copyright © 2025 Elsevier Inc. All rights reserved
