Jurnal Sain Veteriner
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Efek Protektif Andrografolid terhadap Kejadian Kardiotoksisitas Pasca Aplikasi Doksorubisin pada Tikus
Get PDFCardiotoxicity is one of the important side effects of doxorubicin, an anthracycline antibiotic and chemotherapeutic drug. The aim of this study was to explore the potential protective effect of andrographolide (Andro), an anti-inflammatory and anti-oxidant agents, against cardiotoxicity induced by doxorubicin (DXR). Thirty Sprague Dawley rats (80-100 g) were divided into four groups: (a) Control (b) DXR (4 mg/kg intraperitoneally (IP) were made weekly for 4 weeks), (c) DXR+Andro20 (low dose andro; 20 mg/kg IP weremade daily for 4 weeks, 24 h after DXR), (d) DXR+Andro100 (high dose andro; 100 mg/kg IP were made daily for 4 weeks, 24 h after DXR). Furthermore, at the end of experimental period, all rats were euthanized and hearts were removed for hispatological analyses. Hematoxylin-eosin (HE) and Masson Trichrome (MT) staining were used to observe the histomorphological alterations and fibrosis of hearts, respectively. Our results showed that andrographolide treatment (20 mg/kg) augmented the detrimental effects of DXR such as decreased body weight and heart weight, as compared with those in DXR-treated rats. Histopathologically, heart tissue from control group showed compact myocardial architecture without any noticeable lesions. Histopathological analysis fromDXR group showed severe inflammation and fibrosis, whereas DXR+Andro20 group showed almost normal heart morphology. Andrographolide at a dosage of 100 mg/kg did not show protective effects against doxorubicin,and even aggravated myocardial inflammation, as compared with DXR-treated rats. These results indicate that low dose of andrographolide compromised doxorubicin-induced decreased body weight, heart inflammation, andfibrosis
Deteksi Spesies Brucella pada Kambing di Rumah Potong Hewan Jakarta
Get PDFBrucellosis is a zoonosis and occupational diseases transmision. The diseases caused by bacterial and attack multiple species of animals. Common species that infects goats as the most pathogenic species (zoonotic) is Brucella melitensis; however, the species B. abortus could also infect goats. The study purposed to find out the brucellosis seropositive in goat in Jakarta slaughterhouse and to detect caused agent of brucellosis. Sampling was done through slaughtered goats that come from brucellosis endemic area. The samples were collected fromslaughtered mature female goats i.e serum, goat milk, vaginal swab, mamary gland, limphoglandula supramamary, limph, and uterus. The detection method was used i.e patological lession, serological, culture and PolymeraseChain Reaction (PCR) technique. The serological detection of brucellosis in goats was done parallelly between Rose Bengal Test (RBT), Complement Fixation Test (CFT) and Enzyme Linked Immunosorbent Assay (ELISA). The results of this study demonstrated that out of the 119 serum samples serologically tested, negative for RBT, one was positive for CFT and none were positive with ELISA. Patological observation in the Brucella predilection organs, there were 5 goat carcases showed pathological lession (vagina discharge, hemoragy at limphand limphoglandula, crumbly limph and there were pus in uterus). The serum samples that had reacted positively and the organs with pathological lesion were confirmed further with PCR, bacterial isolation and identification.The PCR test results and the culture of milk samples, vaginal swabs and organs did not reveal any Brucella spp bacteria (B. abortus, B. melitensis, B. ovis dan B. suis) and also vaccine strains of RB51. Based on these results, it was concluded that brucellosis in goats on Java Island was a 0.84% seropositive (confidence interval 95%; 0.00826 - 0.00854) (1/119), although the species of Brucella that had infected them remains unknown
Konsumsi, Kecernaan Nutrien, Perubahan Berat Badan dan Status Fisiologis Kambing Bligon Jantan dengan Pembatasan Pakan
Get PDFThis study were aimed to determine the dry matter and organic matter intake, nutrients digestibility, body weight gain and physiological status of male Bligon goats treated with feed restriction. Six Bligon goats average age of 12 months and an average body weight of 23.6 kg were fed 40% of peanut raughages (rendeng) and 60% concentrate. Goats were divided into two (2) treatment groups. Control goat treatment were fed diets based on dry matter (DM) requirements 3.5% of body weight, and feed restriction goat treatment were fed diets with 50% reduction of DM requirement. Feed restriction was conducted for 35 days. The variables measured were dry matter (DM) and organic matter (OM) intake, total digestibility nutrient (TDN) intake, body weigh gain, dry matter (DM) and organic matter (OM) digestibility, rectal temperature, respiration frequency, and heart rate. Data were analyzed by independent samples T-test. The results showed that the feed restriction significantly decreasedconsumption of DM (676.07 ± 14.76 into 372.30 ± 53.08) and OM (639.38 ± 15.89 into 349.88 ± 49.35), consumption of TDN (461.60 ± 10.23 into 253.99 ± 36.17), DM digestibility (74.39 ± 1.60 into 71.27 ± 0.89) and OM digestibility (79.42 ± 1.54 into 76.34 ± 0.24), but had no significant effect on body temperature, respiration frequency and heart rate (pulsus) of male Bligon goat. Value of ADG was 55.24 g/day (P0) then increased to 131.43 g/day when the feed was filled back. A feed restriction up to 50% decreased goat production performance, but did not interfere with the health status of livestock (can be indicated from physiological status of goat still in the normal range)
Kinerja Anak Kambing Bligon Setelah Introduksi Pejantan Unggul di Kelompok Ternak Purwo Manunggal, Gunungkidul
Get PDFGoats have become increasingly popular among smallholder mixed-crop-livestock farmers, such as in Gunungkidul District. Farmers in this district have good access to the market. However, farmers keep local breed,Bligon, without any improvement within breed. This study was started by introducing superior bucks to local does and aimed to evaluate the productivity of their progenies. Nineteenth kids, resulted from mating of local does andlocal bucks and 28 kids, resulted from mating of local does and superior Ettawa crossbred bucks were used in this study. Birth and weaning weights, average daily gain and body size of pre-weaning kids were measured. Birth andweaning weights of pre-weaning crossbred kids tended to be higher than local those of local kids but not significantly different. The average daily gain of crossbred kids were significantly higher than local kids. Body sizes interms of girth of chest (GC), height at the wither (HW) and length of the body (LB) of crossbreed kids were significantly higher than those of local kids. Productivity of pre-weaning kids in the preliminary phase of the introductionof superior bucks were highly varied. Continuous improvement of breeding system is then needed. Introduction of superior bucks has to be supported by good keeping management
Ancaman Masuknya Virus Penyakit Mulut dan Kuku Melalui Daging Ilegal di Entikong, Perbatasan Darat Indonesia dan Malaysia
No full textThis study was aimed to analyze the risk of FMD virus to enter Indonesia by the presence of illegal meat at Entikong, a borderland between Indonesia and Malaysia. The primary datas were collected using questionnaires method to collect expertise, in-depth interviews, and direct field observations. Secondary datas were obtained from scientific publications and articles or unpublished datas (statistics, goverment documents and reports). The respondents were choosen by purposive sampling. The circulating illegal meat was possibly originate fromdifferent countries, including FMD-endemic countries/zones such as Peninsular Malaysia, Thailand, India and even unidentified countries/zones according to our respondends. The types of illegal meat such as frozen deglanded bonein-meat and frozen deglanded offal that enter Entikong carry the risk of becoming a source of FMD infection. Based on the entry route, delivery frequency, and meat volume, ilegal meat was possibly also entered into Indonesia using non-vehicular transportation. These conditions indicated that the entrance of illegal meat could pose risk of the FMD virus entry to Indonesia, especially at the borderland between Indonesia and Malaysia at Entikong. It is highly recommended to apply strict inspection at the border entraces and increase collaboration with related institutions to prevent the entrance of illegal meat and to reduce the entry risk of FMD virus
PENGARUH PEMBATASAN PAKAN DAN PEMENUHAN KEMBALI PAKAN TERHADAP KONSUMSI NUTRIEN KECERNAAN NUTRIEN, STATUS FISIOLOGI DAN PERUBAHAN BERAT BADAN KAMBING BLIGON
No full textPenelitian ini bertujuan untuk mengetahui kecernaan nutrien pakan dan status fisiologi pada kambing Bligon yang diberi perlakuan pembatasan pakan (feed restriction). Enam ekor kambing Bligon jantan umur rata-rata 12 bulan dengan bobot badan rata-rata 23,6 kg diberi pakan yang terdiri dari hijauanjerami kacang tanah (rendeng)dan konsentrat. Kambing dibagi menjadi 2 kelompok perlakuan. Tiga ekor kambing untukperlakuan kontrol diberi pakan berdasarkan kebutuhan bahan kering (BK) 3,5% dari bobot badan, dan tiga ekor kambing untuk perlakuan pembatasan pakandilakukan pembatasan pakan dengan pengurangan pakan 50% dari kebutuhan bedasarkan BK selama 35 hari. Variabel yang diamati adalah konsumsi bahan kering (BK), konsumsi bahan organik (BO), konsumsi total digestible nutrients (TDN), perubahan berat badan, kecernaan bahan kering (BK), kecernaan bahan organik (BO), temperatur tubuh, frekuensi respirasi, dan frekuensi detak jantung. Data yang diperoleh dianalisis dengan independent samplesT-Test. Hasil penelitian yang telah dilakukan, dapat disimpulkan bahwa pembatasan pakan (feed restriction) berpengaruh nyata terhadap penurunan konsumsi bahan kering (BK), konsumsi bahan organik (BO), konsumsi total digestible nutrients (TDN), kecernaan bahan kering (BK) dan bahan organik (BO), tetapi tidak berpengaruh nyata pada temperatur tubuh, frekuensi respirasi, dan frekuensi detak jantung (pulsus) kambing Bligon. Pemenuhan kembali (refeeding) pakan berpengaruh nyata (P<0,05) menaikan kembali konsumsi BK dan konsumsi BO. Perubahan berat badan kambing mengikuti pola jumlah pemberian pakan. Saat pembatasan pakan, berat badan kambing perlakuan turun 55,24 g/hari dan ketika pakan dipenuhi kembali berat badannya meningkat 131,43 g/hari
Sonogram Pemeriksaan Kebuntingan Dini pada Kambing Kacang (Capra hircus)
Get PDFThis study was conducted to determine the earliest day of pregnancy diagnosis in kacang goat using transrectal ultrasonography. The goat were synchronized by using prostaglandin in the luteal phase. Pregnancy was determined by isoechogenic visualization surrounded by hypoechogenic. Early pregnancy was detected on days 20 of embryonic vesicle diameter 1.2±0.1 cm. Fetus was detected on days 22 with a long gestation fetus 0.4±0.1 cm. Average increase until days 30 pregnancy was 0.19 ± 0.1 cm per day. Development of fetus was followed by an increasing the diameter and thickness of uterus. The diameter of uterus increased from days 14 (0.8 ± 0.3 cm) until days 30 (3.6 ± 0.2 cm), and thickness of uterus increased from days 14 (0.4 ± 0, 2 cm) until days 30 (1.8 ± 0.2 cm). It could be concluded that the earliest pregnancy diagnosis showed positive sign on days 20 and fetus was earliest observed on days 22
Potensi Ekstrak Daun Sage (Salvia officinalis.L) sebagai anti-Streptococcus suis Penyebab Zoonotik Meningitis
Get PDFThe phenomenon of microbial resistance to an antibiotic or some kind of specific antibiotics (multi drugs resistance) greatly complicate the treatment process, one of which is Streptococcus suis (S. suis) which is known to cause meningitis in animals and humans. Today, with rising bacterial resistance to a wide rangeof antibiotics, it takes an effort to assess the potential medicinal plants as an antibiotic that is appropriate and safe. Sage (Salvia officinalis.L) is reported to have antibacterial and fungicidal effect. Phenolic acids such assalvin and ether monomethyl salvin which isolated from the sage thought to have antimicrobial activity against several bacterial strains. The purpose of this study was to prove the ability of sage leaf extract as an antibacterialagainst S. suis causes streptococcal meningitis in vitro. In-vitro method used in this research through a two-stage dilution test and the diffusion test on Mueller Hinton Agar (MHA). S. suis isolates (code 225) were tested in vitro against 8 levels sage leaf extract concentration, ie a concentration of 1%, 3% 5%, 7%, 10%, 20%, 40% and 60%. The results of the test obtained by minimum inhibitory concentrations (MICs) and minimum sage known to potentially inhibit the growth of S. suis
Studi Respon Imun Humoral Mencit, Tikus, dan Ayam terhadap Infeksi Toxoplasma Gondii
Get PDFToxoplasmosis is a disease caused by the protozoan Toxoplasma gondii. T. gondii is an obligate intracellular parasite that is transmitted by congenital and acquisition. T. gondii can infect all warm-blooded animals and are zoonotic. It is estimated that more than a third of the world’s population is infected by T. gondii. Chicken is one of the animals that can be infected with T. gondii and plays an important role in the spread of this disease to humans because it is one of the animals used as a source of animal feed. Mice and rats are also play an important role in the spread of toxoplasmosis in the definitive host, especially in cats. T. gondii infection is usually asymptomatic, but in certain circumstances, such as when the host’s immune system is weakened, this parasite can causeserious illness. This study were aimed to determine the humoral immune response against T. gondii infection in mice, rats and chickens by serological Latex Agglutination Test (LAT) using Pastorex-Toxo® kit. Two weeks oldbroiler chickens were 8 heads, Wistar strain rats aged 8 weeks as many as 18 heads and strain Balb C mice aged 8 weeks as many as 13 cows used in this study. Animals were grouped into two groups, namely the control andinfection groups. Mice, rats, and chickens were infected each with 103, 107 and 105 takizoit by intra-peritoneal injection. Blood samples were taken from the animals and infection control from day to-1, 2, 3, 4, 5, 6 for mice,the to-1, 2, 3, 4, 5, 6, 7, 8 for rats, and day - 2, 4, 14 for chicken by intracardia 3 ml, then put in a non-EDTA tubes and centrifuged at a speed of 10,000 rpm for 5 minutes to collect serum. The results showed a humoral immuneresponse against T. gondii in rats began to appear on day 5 post-infection, chickens began to emerge the 2nd day post infection, whereas mice do not indicate a humoral immune response against T. gondii post infection
MPPA (Most Probable Producing Ability) Estimation of Kebumen Ongole Crossbred Cattle based on Offsprings Weaning Weight
Get PDFTujuan dari penelitian ini yaitu untuk menghitung nilai MPPA induk pada sapi PO Kebumen. Penelitian ini telah dilakukan pada bulan Juli sampai dengan Oktober 2015 di wilayah Urut Sewu, Kebumen. Materi penelitian yang digunakan adalah data recording tiga tahun terakhir (2013-2015) terdiri dari 41 ekor pejantan, 51 induk dan 244 pedet. Data berat sapih anak sebelumnya telah dikoreksi berdasarkan umur induk, jenis kelamin dan umur penyapihan 120 hari. Ripitabilitas dihitung menggunakan metode korelasi antarkelas. Nilai MPPA induk dihitung berdasarkan nilai ripitabilitas berat sapih keturunan. Hasil penelitian menunjukkan bahwa nilai ripitabilitas berat sapih anak termasuk dalam kategori tinggi (0.32 ± 0.15). Nilai MPPA induk sapi PO Kebumen kemudian dihitung menggunakan nilai tersebut dan juga rata-rata performan populasi (83.45 kg). Dihasilkan 10 besar induk sapi PO Kebumen dengan nilai MPPA tertinggi. Nilai MPPA kemudian diurutkan dari nilai tertinggi ke terendah. Nilai MPPA tertinggi dimiliki oleh SAJ0315078 (110.69) dan terendah dimiliki oleh TA1112020 (97.20). Hasil dari penelitian ini kemudian dapat digunakan sebagai dasar dalam seleksi induk sapi PO Kebumen di dalam populasinya