276557 research outputs found
Sort by
Reproducibility of three 6-min walk tests in patients with COPD referred for pulmonary rehabilitation
No full textContains fulltext :
314466.pdf (Publisher’s version ) (Closed access
Using SARS-CoV-2 nucleoprotein antibodies to detect (re)infection
No full textContains fulltext :
318298.pdf (Publisher’s version ) (Open Access
Revision of Two-temperature Magnetically Arrested Flows onto a Black Hole
No full textContains fulltext :
317533.pdf (Publisher’s version ) (Open Access)20 p
Budget Impact Analysis: Digital Workflow Significantly Reduces Costs of Implant Supported Overdentures (IODs).
No full textContains fulltext :
316386.pdf (Publisher’s version ) (Open Access)01 februari 202
Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet's disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protocol.
No full textContains fulltext :
316993.pdf (Publisher’s version ) (Open Access)INTRODUCTION: Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) faces significant challenges, including small patient populations, complex clinical trial design and difficulties in patient recruitment. Patients with Behçet's disease (BD), idiopathic inflammatory myopathies (IIM) and IgG4-related disease (IgG4-RD) typically undergo treatment involving prolonged administration of high-dose glucocorticoids and immunosuppressants. Both are associated with an increased risk of infection. Additionally, glucocorticoids carry long-term toxicity risks. Thus, there is an urgent need to develop more targeted and effective anti-inflammatory treatments. Given the activation of the type 1 interferon pathway in BD, IIM and IgG4-RD, inhibition of the Janus kinase (JAK) STAT pathway emerges as a promising therapeutic strategy. The Drug Rediscovery in IMIDs (DRIMID) consortium aims to conduct a prospective pilot basket trial to investigate the effects of filgotinib, a JAK1 preferential inhibitor approved for ulcerative colitis and rheumatoid arthritis, on disease activity, quality of life and safety in patients with refractory BD, IIM and IgG4-RD. METHODS AND ANALYSIS: In this investigator-initiated, multicentre, open-label phase 2 study, up to 60 patients with rare IMIDs will be enrolled for a 26-week treatment period with filgotinib 200 mg once daily. The trial consists of two stages, each involving a consecutively treated cohort of up to 20 patients per disease. An interim analysis is conducted between these stages, where the trial will proceed only in diseases showing potential effectiveness. Baseline, 3-month and 6-month assessments will include data on quality of life, disease activity, corticosteroid toxicity and biomarkers. The coprimary endpoints are disease activity and quality of life across and within each disease. ETHICS AND DISSEMINATION: The study received approval from the Medical Research Ethics Committee in Utrecht, Netherlands. A Data Safety Monitoring Board has been established to monitor the trial's safety and progress. TRIAL REGISTRATION NUMBER: NCT06285539
Internationale Bildungskooperationsforschung im Fach Deutsch als Fremdsprache: Annäherung an ein Forschungsfeld
No full textContains fulltext :
313418.pdf (Publisher’s version ) (Open Access
The King and the Individual or the Individual King in Parthian Art. Hung-e Azhar, Hatra, and beyond
No full textItem does not contain fulltextCarving the individual; self-representations in Parthian rock art, 06 maart 2025Invited lectur
A commentary on Bazzoli (2024): Toward a nuanced and rigorous model evaluation
No full textContains fulltext :
311292.pdf (Publisher’s version ) (Open Access)11 p
With A Little Help From Your Friends: Semi-Cooperative Games Via Joker Moves
No full textContains fulltext :
317942.pdf (Publisher’s version ) (Open Access