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Flattening Combinations of Arrays and Records
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317292.pdf (Publisher’s version ) (Open Access)TFP 202
Daytime sleepiness and health-related quality of life in patients with childhood-onset craniopharyngioma.
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317765.pdf (Publisher’s version ) (Open Access)Overall survival rates after craniopharyngioma (CP) are high (92%), but frequently quality of life (QoL) is impaired in patients with CP involving hypothalamic structures. Tumour- and/or treatment-related hypothalamic lesions may result in disturbances of circadian rhythms including increased daytime sleepiness. We investigated the relationship between health-related QoL and daytime sleepiness in patients with childhood-onset CP. After a median follow-up of 10 years (range: 1-39), 119 CP patients (63 female), who were recruited 2000-2022 in the KRANIOPHARYNGEOM 2000/2007 and KRANIOPHARYNGEOM Registry 2019 trials, were assessed for daytime sleepiness using the Epworth Sleepiness Scale (ESS) and for QoL by EORTC QLQ-C30 questionnaire. CP patients with increased daytime sleepiness (ESS score > 10, n = 34) had worse self-assessment of QoL (p = 0.003), when compared to CP patients with normal ESS scores (n = 85). Increased daytime sleepiness was negatively correlated with QoL (r=-0.395; p < 0.001). Surgical hypothalamic lesions, detectable after surgical intervention in 92.9% of the reference-assessed patients, were associated with significantly higher ESS scores, whereas such impact could not be observed for presurgical hypothalamic involvement of the CP (72.4% of the reference-assessed patients). Compared to patients with an ESS score in the normal range, patients with increased daytime sleepiness suffered from impaired QoL in all functional scales and the global QoL scale of the EORTC QLQ-C30. As increased daytime sleepiness plays an important role for QoL in survivors of CP, hypothalamus-sparing surgical treatment strategies should be considered as state of the art in patients with CP for prevention of increased daytime sleepiness.Clinical trial registration NCT01272622; NCT04158284, NCT00258453
Ultrasound Strain Imaging for Characterizing Atherosclerotic Plaque in the Carotid Arteries of Asymptomatic Subjects.
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314655.pdf (Publisher’s version ) (Open Access)OBJECTIVE: The rupture of vulnerable plaques in the carotid artery is a leading cause of strokes. While magnetic resonance imaging (MRI) is the standard for quantifying plaque composition, its high costs and lengthy procedure times limit large-scale use. Compound ultrasound strain imaging (CUSI) ultrasound offers a non-invasively alternative by assessing tissue deformation/strain within the arterial wall. Previous studies have demonstrated the relationship between strain values and plaque composition, primarily focusing on longitudinal acquisitions, which only image the proximal and distal parts of the wall. This study examines CUSI in transverse imaging planes, which enables visualization of the entire cross-section of the vessel wall. CUSI has already been validated on a symptomatic population. Therefore, the aim is to determine whether CUSI can differentiate plaque composition in asymptomatic individuals with an increased cardiovascular risk profile, validated by MRI. METHODS: This cross-sectional study included 42 plaques in 28 participants. Ultrasound data were acquired with a Samsung Medison Accuvix V10 with an L5-13IS transducer and RF-interface. An experienced neuroradiologist classified plaques with MRI using the Siemens 3.0T MAGNETOM Skyra MRI (Erlangen, Germany) with a dedicated coil. Strain differences were compared across four plaque categories (calcified, lipid, hemorrhagic, fibrous/aspecific) and for vulnerable versus stable plaques. RESULTS: A difference in strain values was found between lipid and calcified plaques (Kruskal-Wallis test, p < 0.05). Additionally, vulnerable plaques exhibited higher strain values than stable plaques (independent samples test, p < 0.05). CONCLUSION: CUSI values differ between lipid and calcified and between stable and vulnerable plaques. Minor differences were found between the other plaque types.01 februari 202
Solar flare observations with the Radio Neutrino Observatory Greenland (RNO-G)
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309800.pdf (Publisher’s version ) (Open Access
The impact on astrometry by solar-wind effect in pulsar timing
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314507.pdf (Publisher’s version ) (Open Access
The future of wastewater treatment plants? Macrophytes have the potential to counteract eutrophication and greenhouse gas emissions by effluent polishing
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314316.pdf (Publisher’s version ) (Open Access)Discharge of treated wastewater, called effluent, can lead to eutrophication and greenhouse gas emissions in receiving waters. Polishing the effluent before it is being discharged, using aquatic plants that take up nutrients and carbon for their growth, could aid in counteracting these effects.Radboud University, 17 januari 2025Promotores : Lamers, L.P.M., Smolders, A.J.P. Co-promotor : Veraart, A.J.252 p
Dust collapse and horizon formation in quadratic gravity
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316531.pdf (Publisher’s version ) (Open Access
Teachers and social cohesion in diverse secondary classrooms
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315486.pdf (Publisher’s version ) (Open Access)The present paper aims to examine how teachers contribute to social cohesion in terms of the three dimensions: social relations, group identification, and the common good. A qualitative study was conducted using interviews with teachers and students and observations in two Dutch secondary schools with diverse student populations. The results showed that the dimension most often addressed was the dimension of social relations, and teachers seemed to focus on individual students more than on the group as a whole. Bridging home and school, and group formation were main themes in the dimension of group identification. The main theme in the dimension of the common good was teacher practices with regard to rules, in which fairness was an important topic for students. The three dimensions of social cohesion are inter-related and should be considered alongside each other when schools are committed to strengthening social cohesion.19 p
Continuous Monitoring Enables Dynamic Biomarkers to Assess Resilience in Acute COVID-19 Patients.
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316628.pdf (Publisher’s version ) (Open Access)Background/Objectives: The effective management of acute illnesses like COVID-19 requires tools to dynamically assess a patient's resilience to health stressors. This study evaluates novel dynamic biomarkers from continuous blood oxygen saturation (SpO(2)) monitoring, exploring their association with patient outcomes to support clinical decision making. Methods: We examined 200 hospital admissions from 181 adults diagnosed with COVID-19. Two dynamic biomarkers reflecting the homeostatic regulation efficiency of SpO(2) were developed to assess their association with adverse hospital outcomes, specifically ICU admission or death, using binary logistic regressions. The resilience exponent α recorded the relative frequency of prolonged SpO(2) declines, while O(2) challenges quantified the dynamic response to changes in O(2) supplementation. Results: Increased resilience exponent α corresponded to decreased odds of adverse outcomes (OR [95% CI] = 0.59 [0.37-0.93], p = 0.03). Larger SpO(2) increases in response to O(2) supplementation were associated with increased odds of adverse outcomes (OR [95% CI] = 1.40 [1.04-1.83], p = 0.03). Additionally, the number of O(2) supplementation increases (OR [95% CI] = 2.91 [1.90-4.49]) and decreases (OR [95% CI] = 0.33 [0.20-0.55]) during hospitalization were independently linked to poorer and improved outcomes, respectively (both p < 0.001). Conclusions: The resilience exponent α and the O(2) challenge response provide insights into the dynamic regulation of SpO(2), reflecting physical resilience in COVID-19 patients. Continuous SpO(2) monitoring in acute care settings could support more informed clinical decisions during patient management
Combining different floating plants for optimal wastewater effluent polishing and carbon-capture
No full textItem does not contain fulltextWe tested four floating plant species and their efficiency in municipal wastewater effluent polishing (nutrient removal and greenhouse gas emission reduction). After that, we combined the most promising nitrogen removing plant species with the most promising phosphorus removal species to assess effluent polishing efficiency. We argue that combining species with different plant-specific traits results in optimal effluent polishing