276557 research outputs found
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Noot bij: Rb. Oost-Brabant 10 december 2024, JOR, 2025, 41 (Vaststelling van hoogte van belastingschulden bij afwikkeling faillissement niet doorkruist door voorzieningenrechter)
No full textItem does not contain fulltext10 december 202
Of en wanneer heeft de eigen insolvabiliteit invloed op de winstverantwoording bij schulden?
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325041.pdf (Publisher’s version ) (Closed access)11 p
Asteroseismology of the young open cluster NGC 2516 II. Constraining cluster age using gravity-mode pulsators
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326339.pdf (Publisher’s version ) (Open Access
Shifting perspectives: Majority members' perceptions of the prevalence of ethno-racial minority discrimination
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322829.pdf (Publisher’s version ) (Open Access)The prevalence of ethno-racial minority discrimination in Europe is well established, both through research and the experiences of those affected. Yet, less is known about the extent to which members of the majority group perceive this discrimination to be prevalent. This dissertation addresses this gap by examining the extent to which majority populations in Europe, and particularly in the Netherlands, believe that discrimination against ethno-racial minorities is widespread. These understudied perceptions are explored through the development and application of a theoretical framework that foregrounds the role of exposure to external sources of information. Across the empirical chapters, the associations between majority perceptions and political elite discourses, newspaper coverage, and intergroup contact are analysed. Drawing on large-scale European and Dutch survey data, media content analyses, and multilevel modelling techniques, the studies reveal substantial variation in perceptions across countries, over time, and between individuals. These differences are partially explained by varying levels of informational exposure.Radboud University, 18 september 2025Promotores : Scheepers, P.L.H., Lubbers, M. Co-promotores : Blommaert, E.C.C.A., Savelkoul, M.J.215 p
Co-creating justice in housing energy transitions through energy living labs
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324752.pdf (Publisher’s version ) (Open Access)Justice-oriented, context-sensitive approaches that go beyond technocratic top-down decision-making processes can facilitate and improve the retrofit and energy transition of housing. Urban living labs (ULLs) are emerging as valuable collaborative spaces for learning and co-creating strategies. Although increasingly adopted in urban planning and placemaking, their potential to operationalise procedural justice by facilitating inclusive and accessible processes in energy renovation remains unexplored. Drawing on fieldwork notes and expert interviews, this study examines the initial phases of four Dutch energy living labs (ELLs) implemented in vulnerable neighbourhoods to support housing retrofit and energy transition projects. It analyses how they foster residents’ inclusion and connect institutional agendas with residents’ everyday practices and living environments. The findings reveal how ELLs play a strategic role in enhancing residents’ visibility, creating multistakeholder relational arenas that stimulate interorganisational learning. Researchers in ELLs mediate between theory and situated practices, facilitating energy justice implementation by challenging established professional assumptions. Flexible, locally guided forms of ELLs help address process shortcomings, supporting more socially embedded retrofit and energy transitions, and notably contribute to a) resident engagement and representation, b) technical design and performance and c) collaborative and responsive governance approaches.20 p
Over het afpellen van oude etiketjes. Labels en signaturen op de boeken van het klooster Soeterbeeck als vormen van informatiemanagement
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SATURN: A Multinational, Multicentre, Prospective Surgical Registry for Male Urinary Incontinence Surgery Across Europe with Planned 10-year Follow-up.
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324436.pdf (Publisher’s version ) (Closed access)The SATURN registry captures data for 1090 parameters, including patient demographics, surgical techniques, and long-term postoperative outcomes of surgery for male stress urinary incontinence across Europe. Despite a high surgical revision rate, the AMS800 artificial urinary sphincter (AUS) was the commonest surgical procedure for male stress urinary incontinence and yielded the best improvements in symptom scores. Preliminary findings suggest that centre volume does not strongly influence complication rate or functional outcomes of AUS implantation
External Cross-validation of Two Ciprofloxacin Population Pharmacokinetic Models in Patients in Intensive Care.
No full textItem does not contain fulltextBACKGROUND: The population pharmacokinetic (popPK) variability of ciprofloxacin in patients in intensive care units (ICUs) is unclear. Two popPK models of ciprofloxacin in those in the ICU were externally cross-validated to determine if a published popPK model can be applied for model-informed precision dosing or if a new popPK model needs to be developed. The predictive performance of the 2 popPK models was evaluated. METHODS: Data were collected from patients in the ICU at Amsterdam University Medical Center (AUMC), and a popPK model for ciprofloxacin was developed using nonlinear mixed-effects modeling. The data and the published pharmacokinetic model from the ICU of the Radboud University Medical Center (RUMC) were used for cross-validation. The RUMC dataset was used to externally validate the AUMC model and vice versa. The predictive performance of the models was evaluated by comparing the population-predicted and corresponding observed concentrations in the dataset. The primary endpoints were bias and precision, calculated as the mean percentage error (MPE) and normalized root mean squared error (NRMSE), respectively. Visual predictive checks (VPCs) and Bland-Altman plots visualized predictive performance. RESULTS: The AUMC dataset consisted of 159 concentration-time data points from 32 patients, and the RUMC dataset consisted of 531 samples from 39 patients. A 2-compartment linear model with modification of diet in renal disease as a covariate for ciprofloxacin clearance most accurately fit both study populations. The final AUMC model predicted the RUMC population data with an MPE of -3.87% (95% CI, -7.56 to -0.185) and an NRMSE of 44.05% (95% CI, 39.48-48.19). The final RUMC model predicted the AUMC population data with a nonsignificant MPE of -31.29% (95% CI, -73.56 to -10.98) and an NRMSE of 64.02% (95% CI, 48.61-76.38). pcVPC indicated acceptable predictive performance because the observed data fell within the 95% prediction CIs; the AUMC model overestimated the variability. The Bland-Altman plots confirmed that both models were imprecise, overrepresenting large negative relative errors. CONCLUSIONS: Neither ciprofloxacin popPK model accurately predicted external data, and the AUMC model exhibited bias. The prior RUMC model is unsuitable for the AUMC ICU population and vice versa. We recommend either adapting an existing popPK model from literature or creating a new popPK model specifically tailored to the ICU population
Vitamin D3 encapsulated in polymeric nanoparticles to dampen the pro-inflammatory immune response
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325085.pdf (Publisher’s version ) (Open Access)10 p
Unravelling the art of developing skilled communication: a longitudinal qualitative research study in general practice training.
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322845.pdf (Publisher’s version ) (Open Access)Doctor-patient communication is a core competency in medical education, which requires learners to adapt their communication flexibly to each clinical encounter. Although conceptual learning models exist, information about how skilled communication develops over time is scant. This study aims to unpack this process of communication learning and to identify its facilitators. We conducted a longitudinal qualitative study employing a constructivist grounded theory approach in a General Practice training setting. Over a 6-month period, we closely monitored 8 first-year and 5 third-year trainees (n = 13) by means of clinical observations, stimulated recall interviews and audio diaries. In an iterative process of data collection and analysis, we triangulated these sources across trainees (horizontal analysis) and over time (vertical analysis) to identify how themes evolved. This analysis led us to the construction of a six-stage cyclic conceptual model during which trainees: (1) have an impactful experience; (2) become aware of own communication; (3) look for alternative communication behaviours; (4) experiment with new behaviours; (5) evaluate the effectiveness; and (6) internalise the new communication behaviours. Additionally, conditions were found to support learning and reflection. Becoming a skilled communicator seems to require a continuous approach, with repeated practice and reflection to adapt and internalise communication in the clinical encounter. Consequently, we recommend that trainees be supported with tailored feedback to strengthen their communication repertoire. Ideally, they should be guided by supervisors who serve as coaches in a safe learning environment with regular, planned learning activities.01 september 202