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A guideline-based preference elicitation tool to enhance shared decision-making in supervised exercise therapy for patients with intermittent claudication: a process evaluation.
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322172.pdf (Publisher’s version ) (Open Access)BACKGROUND: To facilitate person-centered physical therapy for patients with intermittent claudication, we introduced a preference elicitation tool to Dutch physical therapists. The tool is designed to support the patient-therapist dialogue and enhance collaborative treatment planning. Successful integration of this tool into practice requires a thorough understanding of factors that influenced therapists' (non)adoption. OBJECTIVES: To evaluate whether therapists adopted the preference elicitation tool, assess the tool's reach, and identify perceived barriers and facilitators by therapists that influenced adoption. METHODS: A multi-method process evaluation was conducted following a series of implementation activities. Routinely collected quantitative data were used to assess adoption and reach. Adoption was measured by the percentage of therapists who completed the tool's e-learning module and the percentage of therapists who started using the tool. Reach was measured by the percentage of eligible patients with whom therapists actually used the tool. To identify barriers and facilitators, qualitative semi-structured interviews with eleven therapists were conducted and deductively analysed using the Tailored Implementation for Chronic Diseases framework. RESULTS: Of the 1,130 therapists eligible to use the preference elicitation tool, 64% completed the e-learning. Among these, 45% started using the tool in clinical practice. Therapists used the tool with 38% of eligible patients. In total, 39 barriers and 37 facilitators for tool adoption were identified. Barriers included time investment, discomfort with the formal communication setting, and conflicts with activity-oriented role perceptions. Facilitators included the tool's user-friendliness, flexible use of the tool, and enhanced patient engagement. CONCLUSION: Modest adoption and reach rates indicate opportunities for improving uptake and sustainable implementation of the preference elicitation tool. Therapists' decisions to adopt the tool were influenced by various factors. Providing therapists with strategies to maintain a flexible approach to using the tool could address key barriers. Future research should explore patients' perspectives on the preference elicitation tool.01 december 202
A comparison of anomaly detection algorithms with applications on recoater streaking in an additive manufacturing process
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Risk conditions for invasive pneumococcal disease in adults: a systematic review and meta-analysis.
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325120.pdf (Publisher’s version ) (Open Access)BACKGROUND: The burden of invasive pneumococcal disease (IPD) in adults remains high despite vaccination programs. Age is currently the prime criterion used to define target groups for prevention. To support effective intervention programs, we investigated the relative importance of risk conditions associated with adult IPD. METHODS: We conducted a systematic search in PubMed and Embase and included all original studies published before March 24th 2025 that reported risk estimates for adult IPD in individuals with risk conditions, compared to the general population (PROSPERO ID 417980). Risk estimates were extracted and meta-analyses were performed for conditions supported by more than one study. Pooled incidence rate ratios with 95% confidence intervals (IRRs (95% CIs)) were calculated as the primary outcome using random-effects models. The risk of bias and the certainty of the evidence were assessed using the ROBINS-E tool and GRADE system respectively. FINDINGS: Of the 2983 reports screened, 58 were included in the systematic review, and 46 supported the meta-analyses. More than 50 different risk conditions for adult IPD were identified, which we synthesized in 22 risk domains for meta-analyses. The highest IRRs (95% CIs) for adult IPD were reported in immunocompromising conditions: transplant recipients 30.75 (17.64-53.60), asplenia 24.29 (18.63-31.65), people living with human immunodeficiency virus (PLWH) 21.87 (15.72-30.43), and haematological malignancy 19.63 (11.10-34.71). Increasing age itself mediated minor risk sizes. At lower age the risk conditions conferred relatively higher risk ratios. Chronic kidney disease in adults 10 were also observed for compromised cerebrospinal fluid barrier and Down syndrome. The overall quality of evidence was very low, mainly due to high risk of bias and considerable between-study heterogeneity. Several studies suggested cumulative risk in individuals with multimorbidity, although data on interactions between conditions were limited. INTERPRETATION: This systematic review and meta-analysis quantify the relative importance of risk conditions for adult IPD. Understanding how these risk conditions interact in cases of multimorbidity remains an important area for future research. FUNDING: Radboudumc Community for Infectious Diseases encouragement Grant.01 november 202
Altered reversal and extinction learning in the DMSXL mouse model of type I myotonic dystrophy (DM1): An exploratory study.
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322122.pdf (Publisher’s version ) (Open Access)BackgroundCognitive changes in type 1 myotonic dystrophy (DM1) have a pronounced negative effect on quality of life measures. Despite this, the neural basis of these changes is poorly understood. DM1 patients demonstrate deficits in motivation and cognitive flexibility, reflective of apathy and obsessive-compulsive / autistic-like traits.ObjectiveThese traits can be readily assessed using reversal learning and appetitive extinction tasks. Reversal learning assesses the ability to learn following a change in a rule and can evaluate cognitive flexibility and habitual responding, while appetitive extinction assesses the ability to suppress a stimulus-action response following the change in the stimulus-reward relationship from rewarded to non-rewarded.MethodsIn this study we evaluated the performance of a mouse model of DM1, the DMSXL mouse in reversal learning and appetitive extinction tasks.ResultsSimilar to C57/BL6 wild type (WT) mice, DMSXL mice were able to learn stimulus reward relationships, however, in the late phase of reversal learning experiment DMSXL mice demonstrated increased habit-like behavior (increased number of correct responses). Following rule switching, DMSXL mice produced an increased number of errors compared to WT and showed increased latency to deliver correct responses. In the extinction task, DMSXL mice showed the ability to more rapidly extinguish a previously rewarded response than WT mice.ConclusionsThese findings constitute differences in cognitive flexibility, rule learning and motivation between DMSXL and WT mice which may inform our understanding of cognitive changes in DM1.01 juli 202
Drones Over Europe
No full textItem does not contain fulltextRadboud Reflects, 08 oktober 2025Radboud UniversityInvited lectur
Explaining the relationship between agency and communion by means of lay personality theories and connectionist modeling
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326555.pdf (Publisher’s version ) (Closed access)Research on the relationship between the "Big Two" dimensions of social perception - Agency and Communion - has produced inconsistent findings, from independence to positive, negative, or curvilinear associations. We propose that these inconsistencies stem from individual differences in cognitive representations of how traits interrelate, i.e., lay personality theories (LPTs). Using connectionist modeling, we simulated impression formation processes based on individuals’' unique networks of associations between Agency and Communion traits. Indeed, Simulation Study 1 successfully recreated the various relationships found in the literature. Second, an experiment demonstrated that individual differences in LPTs predicted social judgments. Simulation Study 2 showed that changes in the composition of a sample of individuals with heterogeneous LPTs result in different outcomes in the relationship between Agency and Communion. Our findings suggest that taking into account variability in LPTs helps resolve apparent contradictions in the literature, offering a new and unifying framework for understanding social perception.28 p
Impact factors for quantifying country-level terrestrial biodiversity intactness footprints (IBIF)
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326437.pdf (Publisher’s version ) (Open Access)11 p
EndoCompass project: research roadmap for adrenal and cardiovascular endocrinology.
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324837.pdf (Publisher’s version ) (Open Access)BACKGROUND: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in adrenal endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. RESULTS: For adrenal disorders, research priorities span primary and secondary adrenal insufficiency, adrenal tumours, and endocrine hypertension. Key areas include development of biomarkers and replacement therapies, improved understanding of disease mechanisms, diagnostic procedure optimization, and establishment of pan-European registries. Special emphasis is placed on personalized treatment approaches. CONCLUSIONS: The adrenal component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into adrenal disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of adrenal disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health
Religious belief as make-belief: what else?
No full textItem does not contain fulltextFaculty LectureFaculty of Philosophy, Theology and Religious StudiesInvited lectur
Mind the Clinic-Community Gap: Re-evaluation of Test Performance and False Positive Results in Community-Wide Tuberculosis Screening.
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322834.pdf (Publisher’s version ) (Open Access)Community-wide screening for bacteriologically confirmed pulmonary tuberculosis may reduce the tuberculosis burden, although concerns of overtreatment remain because of false positive diagnoses due to subpar specificity of current bacteriological tests for screening. Our review and data analysis show that clinic-based test specificity estimates of Xpert against culture underestimate performance in communities, for both Xpert MTB/RIF(99.8% for community vs 98.4% for clinic) and Xpert Ultra (99.4% vs 95.6%, respectively), reducing the presumed false positivity of sputum Xpert, using culture as the reference, by 86.8% and 85.4%, respectively, compared with clinic-based specificity estimates. These findings support large-scale evaluation of community-wide screening for tuberculosis