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Artificial medial and lateral meniscus prostheses mimic kinematics of the native meniscus without affecting knee joint motion: A cadaveric study
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321595.pdf (Publisher’s version ) (Open Access)14 p
Prediction of listening effort ratings for habitual and clear-Lombard speech presented in noise
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322635.pdf (Publisher’s version ) (Open Access)Interspeech 2025, 17 augustus 202
Molecular identification and antifungal susceptibility testing of Aspergillus species among patients with chronic pulmonary aspergillosis in Nigeria.
No full textItem does not contain fulltextBACKGROUND: Triazole resistance in Aspergillus spp. has therapeutic implications for managing chronic pulmonary aspergillosis (CPA) worldwide. However, antifungal susceptibility testing (AFST) is not routinely performed in Nigeria, a country with a high CPA burden. OBJECTIVE: This study aimed to confirm the identity of Aspergillus spp. isolated from patients with CPA using molecular methods, determine their antifungal susceptibility profile, and ascertain phylogenetic relatedness. METHODS: This study examined 47 Aspergillus isolates from sputum samples obtained in a prospective longitudinal study of CPA prevalence among 141 consenting symptomatic tuberculosis patients in Lagos, Nigeria, between June 2021 and May 2022. The preliminary phenotypically identified Aspergillus spp. were further identified by amplifying the calmodulin gene and performing AFST against seven antifungal agents using the Clinical Laboratory Standard Institute (CLSI) micro-dilution method, as well as determining their phylogenetic relatedness. RESULTS: The 51 patients who met the diagnostic criteria for CPA included 30 (59.0%) male and 21 (41.0%) female patients (age range: 17-68 years). Thirty-six (71.0%) had positive Aspergillus cultures. An isolate, initially identified phenotypically as A. fumigatus, was reidentified as A. pseudonomiae. Phylogenetic analysis on A. fumigatus and A. flavus isolates suggested the absence of clonal transmission. All isolates were susceptible to the tested antifungals. CONCLUSION: Clinical Aspergillus isolates from azole-naïve patients with CPA did not demonstrate triazole resistance. Nonetheless, AFST is required for patients on long-term azole therapy and systematic surveillance of clinical and environmental isolates is recommended to detect the emergence of azole-resistant phenotypes. WHAT THIS STUDY ADDS: This study underscores the importance of routine surveillance for antifungal resistance to detect the occurrence of resistance strains early in clinical settings, as this has therapeutic implications for patients harbouring resistant phenotypes
Fibula free flap reconstruction: improving the accuracy of virtual surgical planning using titanium inserts.
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324321.pdf (Publisher’s version ) (Open Access)Although advancements in three-dimensional (3D) modelling techniques have significantly reduced deviations between planned and actual clinical outcomes in fibula free flap reconstructions, discrepancies between the virtual surgical plan (VSP) and postoperative results persist. In this study, three head and neck surgeons performed 10 fibula osteotomies using conventional cutting templates and 10 osteotomies using more rigid cutting templates with titanium inserts. Differences in 3D angles and segment lengths between the planned and achieved osteotomy planes were calculated. The use of the titanium inserts resulted in a decrease in 3D angular deviation by 0.5° and a reduction in fibula segment length deviation by 0.2 mm for both the short and long sides. The use of the inserts enhanced guidance of the saw and diminished the risk of creating a false route, resulting in a better alignment with the VSP. This may lead to better reconstructive results, decreased operation times, and a potential reduction in complications in a cost-effective manner.01 november 202
Computational Pathology for Early Breast Cancer Diagnostics
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325463.pdf (Publisher’s version ) (Open Access)Radboud University, 05 november 2025Promotores : Laak, J.A.W.M. van der, Litjens, G.J.S., Karssemeijer, N.viii, 179 p
Assisting teachers in the design of feedback for online learning using large language models: A theory-driven approach
No full textItem does not contain fulltextThis poster paper explores the extent to which Large Language Models (LLMs) could help teachers of online courses to design feedback interventions based on their learning designs. Using real course learning designs as input, together with predefined catalogs of potential problems, indicators, and feedback reactions grounded in feedback theories, our research showcases how ChatGPT-o1 is capable of suggesting feedback design decisions that are meaningful to human instructional designers. The results suggest that state-of-the-art LLMs, when asked to base their answers on a theory-driven design space, may assist novice teachers and instructional designers in incorporating pedagogically sound feedback interventions in their courses.20th European Conference on Technology Enhanced Learning, EC-TEL 2025 (Newcastle upon Tyne and Durham, UK, September 15-19, 2025
Say Hello to Metamodernism! Understanding Today’s Culture of Ironesty, Felt Experience, and Empathic Reflexivity
No full textItem does not contain fulltextG. Dember Say Hello to Metamodernism! Understanding Today’s Culture of Ironesty, Felt Experience, and Empathic Reflexivity Boise:Exact Rush Publishing ,2024 979898982353
Vulnerability of Elections
No full textItem does not contain fulltextThe Dutch Data Protection Authority Meets Academia, 09 september 202
Navigating stereotypical audiovisual content: Qualitative insights into the necessity of moral disclaimers
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3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats.
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324416.pdf (Publisher’s version ) (Open Access)The pathophysiology of diaphragm dysfunction in mechanically ventilated patients has yet to be fully understood, and adequate animal models are required to accommodate further research. Mechanical ventilation settings, such as the level of positive end-expiratory pressure (PEEP), play a crucial role. The goal was to develop a method to image 3D thoracic movement during mechanical ventilation of mice and rats at different respiratory pressure settings. Rats (Wistar) and mice (C57BL/6) were anesthetized with a mix of ketamine, atropine, and dexmedetomidine. Anesthesia was maintained by continuous infusion through a peritoneal catheter. Next, a tracheostomy was performed to enable mechanical ventilation of the animals. Animals were placed in a 7T MR system while ventilated with an MR-compatible ventilator. 3D cine imaging of the thorax was conducted using a 3D gradient echo sequence with pseudo-spiral k-space filling. A navigator signal, generated by the slice selection rewinder gradient, was recorded every TR. Retrospective binning and reconstruction of the data in 12 respiratory cine time frames was performed using in-house developed software. We successfully visualized thoracic movement in 3D in both species during mechanical ventilation, enabling the investigation of changes in thorax geometry throughout the respiratory cycle at varying PEEP levels. We found that retrospective binning of respiratory frames was highly facilitated by the fixed respiration rate. The protocol presented here can be used to study cardiac and thoracic geometry and movement in mechanically ventilated mice and rats