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A bridge over troubled water: The effect of democratic innovations on populist attitudes
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319168.pdf (Publisher’s version ) (Open Access)
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319168 Appendices.pdf (Publisher’s version ) (Open Access)Radboud University, 17 juni 2025Promotores : Jacobs, K.T.E., Ham, C.T. van209 p
ABCDE-Frailty for critical presentations: summary of the 2025 ESICM expert consensus recommendations.
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318949.pdf (Publisher’s version ) (Open Access
Quantitative Trace Analysis of Dilute Mixtures Using a Benchtop NMR System with SABRE Hyperpolarization
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319845.pdf (Publisher’s version ) (Open Access)4 p
Does the type of oral anticoagulant matter for stroke prevention or bleeding in patients with atrial fibrillation after cardiac surgery? A systematic review and meta-analysis.
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320297.pdf (Publisher’s version ) (Open Access)AIMS: Unlike in non-surgical settings, many centres continue to favour vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF) following major cardiac surgery. Current guidelines indicate insufficient data on the use of direct oral anticoagulants (DOACs) early after cardiac surgery. This study aims to evaluate whether DOACs are non-inferior to VKAs in terms of efficacy and safety for stroke prevention in post-operative AF. METHODS AND RESULTS: MEDLINE, EMBASE, CENTRAL, and Clinicaltrials.gov were searched from inception till 2 July 2024, and relevant reviews were screened as grey literature. Studies comparing DOACs with VKAs for stroke prevention in patients with (post-operative) AF after major cardiac surgery were included. Studies on patients with mechanical valve replacement or moderate to severe mitral stenosis were excluded. Outcomes of interest included thromboembolic events, major bleeding and mortality up to 6 months after cardiac surgery. Eleven studies, including two randomized controlled trials, reporting on >18,000 patients were analyzed. There were no significant differences between DOACs and VKAs in thromboembolic events (OR: 0.96; CI: 0.62-1.50; I(2): 0%), any stroke (OR: 1.44; CI: 0.61-3.41; I(2): 0%), major bleeding (OR: 0.97; CI: 0.60-1.56; I(2): 48%), all-cause mortality (OR: 1.00; CI: 0.73-1.37; I(2): 0%) or admission duration (MD: -0.33; CI: -1.16-0.49; I(2): 0%) in the first 6 months after cardiac surgery. CONCLUSION: There is no high-quality evidence that DOACs and VKAs differ in efficacy or safety for stroke prevention in AF after cardiac surgery. While awaiting high-quality randomized data, our meta-analysis found no evidence to support routinely avoiding DOACs or favouring VKAs in this setting. REGISTRATION: Review registration number: CRD42023412592
If they can do it, so can I: When vicarious experiences of coworker voice create a spiral of voice
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319370.pdf (Publisher’s version ) (Open Access)This study examines how vicarious experiences of voice, i.e., observing or hearing about coworkers’ voice experiences, can affect worker voice, i.e., expressing dissatisfaction about a work-related issue. Using data of 829 Dutch workers, the authors find that vicarious experiences of supervisor support of coworker voice are positively related to voice efficacy and perceived supervisor responsiveness. Conversely, vicarious experiences of supervisor suppression of coworker voice are associated with lower levels of perceived supervisor responsiveness. Furthermore, the authors find that workers’ voice efficacy is positively related to worker voice. These vicarious learning effects show how voice can spill over to other actors within an organization.09 april 202530 p
Current nicotine use and the development of depressive symptoms across adolescence and adulthood: A multi-dataset study exploring moderation effects of body mass index and sex
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318686.pdf (Publisher’s version ) (Open Access)Nicotine use is a risk factor for developing depressive symptoms among adults, though findings are mixed in younger samples. To shed new light on this, we examined temporal associations between current nicotine use and the development of depressive symptoms using structural equation models and existing 3-wave datasets from the Netherlands of adolescents (n = 2.003, Mage = 13.81, 48% female), young adults (n = 8.545, Mage = 21.57, 71% female), and adults (n = 713, Mage = 45.29, 73% female). Results indicate no strong support for temporal associations between current nicotine use and the development of depressive symptoms among adolescents (βW1→W2 = .02, pW1→W2 = .555; βW1→W3 = .01, pW1→W3 = .792; βW2→W3 = .02, pW2→W3 = .685), young adults (βW1→W2 = .003, pW1→W2 = .871; βW1→W3 = .04, pW1→W3 = .009) nor adults (βW1→W2 = .02, pW1→W2 = .574; βW1→W3 = .05, pW1→W3 = .306). Additionally, we revealed that (z)BMI did not moderate this longitudinal link across all developmental stages (β between -.04 and 0.03, p between .272 and .637), while a non-robust and inconsistent small sex-specific moderation effect of BMI was observed in the young adults sample (βW1→W2 = .04, pW1→W2 = .047). Importantly, our additional exploratory analyses among adults supported a sex-specific interaction (β = -.10, p = .039), suggesting that nicotine use tends to increase the risk of depressive symptoms among adult females, but not males, indicating a possible adult female susceptibility that requires further exploration. These findings can guide follow-up research and further age-specific tailoring of smoking prevention efforts and public health policies.15 april 202519 p
The association between urgency level and hospital admission, mortality and resource utilization in three emergency department triage systems: an observational multicenter study.
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318951.pdf (Publisher’s version ) (Open Access)BACKGROUND: Effective triage systems are crucial for prioritizing patients based on urgency and optimizing resource utilization. An ideal triage system is expected to have low resource utilization, hospitalization and mortality among patients classified at low urgency levels. Furthermore, it should exhibit an increase in the risk of hospitalization and mortality as urgency levels increase, ensuring the most critically ill patients receive priority care first. However, it is unclear which triage system performs best. OBJECTIVE: To compare the performance of the Manchester Triage System (MTS), the Emergency Severity Index (ESI), and the Netherlands Triage Standard (NTS) by investigating the association between urgency levels and resource utilization, hospitalization and in-hospital mortality in Emergency Department (ED) patients. METHODS: Observational multicenter cohort study using data from the Netherlands Emergency department Evaluation Database, comprising seven representative EDs in six Dutch hospitals. All consecutive ED patients with a registered urgency level were included. Resource utilization, hospitalization and mortality were measured across all urgency levels. In each triage system, multivariable logistic regression was used to assess the association between urgency level and in-hospital mortality and hospitalization, adjusting for age, sex, presenting complaints and hospital type. RESULTS: A total of 696,518 ED visits (MTS 320,406 (46.1%), ESI 214,267 (30.8%), NTS 161,845 (23.3%) patients) were included. Resource utilization was substantially lower in the lowest urgency level of the ESI compared to the MTS and NTS. Hospitalization to a regular ward, cardiac, medium or intensive care unit in the least urgent level was 3.9% in the ESI, considerably lower than in the MTS (23.1%) and NTS (34.3%) (P < 0.05). Mortality in the lowest urgency level of the ESI was 0.8%, while in the MTS and NTS this was 6.3% and 12.4%, respectively (P < 0.05). In the ESI, the risk (Adjusted Odds Ratios) for hospitalization and mortality increased much more with increasing urgency levels compared to the MTS and NTS. CONCLUSION: This study suggests that the ESI may be more effective in distinguishing between patients with low and high urgency, with a reduced risk of undertriage when compared to the MTS and NTS
The Impact of Hydrostatic Pressure on Fractional Flow Reserve in Saphenous Vein Grafts.
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320708.pdf (Publisher’s version ) (Open Access)BACKGROUND: The relationship between height differences related to graft anatomy and physiological pressure indices in coronary bypass grafts has not been studied. We sought to study the impact of hydrostatic pressure on fractional flow reserve (FFR) in saphenous vein grafts (SVGs). METHODS: Included were 66 symptomatic patients (76 SVGs) with prior coronary artery bypass grafting who underwent coronary computed tomography angiography (CCTA) preceding invasive coronary angiography with FFR interrogation of ≥ 1 SVGs. The graft course and height excursion were reconstructed based on CCTA images. The impact of hydrostatic pressure on FFR (corrected FFR) was calculated by adding or subtracting 0.077 mmHg to the distal coronary pressure for every millimeter height difference in a supine position between the SVG ostium and the pressure wire tip position. RESULTS: The height difference (mm) between the SVG ostium and pressure wire tip position was largest for single SVGs to the circumflex artery (Cx; -55.1 ± 17.0), followed by sequential SVGs to the Cx (-51.8 ± 17.3) and the right coronary artery (RCA; -36.7 ± 21.6). The correlation between height difference and uncorrected FFR was -0.59 (p < 0.001). Corrected FFR was lower as compared to uncorrected FFR in the overall cohort (0.86 ± 0.17 vs. 0.88 ± 0.18), in single SVGs to Cx (0.85 ± 0.17 vs. 0.90 ± 0.18), and in sequential SVGs to Cx (0.92 ± 0.14 vs. 0.96 ± 0.15) and RCA (0.82 ± 0.17 vs. 0.85 ± 0.21) (p < 0.001 for all). CONCLUSIONS: Hydrostatic pressure related to height differences along the course anatomy of SVGs can impact FFR measurements, with corrected FFR being significantly lower in SVGs to the Cx and sequential SVGs to the RCA.01 juli 202
Dataset Selective ion binding and uptake shape the microenvironment of biomolecular condensates
No full textItem does not contain fulltextBiomolecular condensates modulate various ion-dependent cellular processes and can regulate subcellular ion distributions by selective uptake of ions. However, the molecular grammar governing condensate-ion interactions is poorly understood. Here, we use NMR spectroscopy of ions and model condensate components to quantify and spatially resolve selective ion binding to condensates and show that these interactions follow the law of matching water affinities, resulting in strong binding between proteins and chaotropic anions, and between nucleic acids and kosmotropic cations. Ion uptake into condensates directly follows binding affinities, resulting in selective uptake of strong-binding ions, but exclusion of weak-binding ions. Ion binding further shapes the condensate microenvironment by altering the composition, viscosity and interface potential. Such changes can have profound effects on biochemical processes taking place inside condensates, as we show for RNA duplex formation. Our findings provide a new perspective on the role of condensate-ion interactions in cellular bio- and electrochemistry and may aid design of condensate-targeting therapeutics