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The role of relational work in promoting safe community participation by people with mild intellectual disabilities and severe challenging behaviour living in residential facilities
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321126.pdf (Publisher’s version ) (Open Access)Background: Promoting the level of community participation by people with mild intellectual disabilities who exhibit severe challenging behaviour is complex due to a variety of safety issues. Method: This qualitative study explored what residential facilities for people with intellectual disabilities as well as their external stakeholders do to promote safe community participation, taking feelings of safety of service users and their environment into account. Interview and focus group data from professionals of residential facilities and stakeholders from the police and municipality were thematically analysed, resulting in the identification of two main themes. Results: The first theme concerns taking risks responsibly together, by identifying, weighing up, and managing risks, whilst the second pertains to residential facilities and stakeholders’ ongoing efforts to change the perceptions and attitudes of the public and each other. Overall, the significance of relational work in promoting safe community participation was found. Conclusions: Residential facilities and external stakeholders should invest in strengthening their relationship.10 p
The Fluid Brain: Exploring the Crucial Role of Neurofluids in Health and Disease.
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319057.pdf (Publisher’s version ) (Open Access
Complottheorieën en complotdenkers: Een alternatief perspectief
No full textItem does not contain fulltextCompagnonscursus TEDD, 11 april 2025Treant, Elann en Dokter Drenthe (TEDD)Invited lectur
Freud's theory of sexuality part 1
No full textItem does not contain fulltext19 april 2025Siavoushan Institut
Maxilla-first patient-specific osteosynthesis vs mandible-first bimaxillary orthognathic surgery using splints: a randomized controlled trial.
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320717.pdf (Publisher’s version ) (Open Access)Patient-specific osteosynthesis plates and three-dimensional virtual surgical planning with patient-specific surgical guides have significantly advanced orthognathic surgery, enhancing surgical accuracy. This study compares the outcomes of the mandible-first approach using an intermediate splint and manually bent osteosynthesis plates with the maxilla-first approach utilizing patient-specific osteosynthesis fixation in bimaxillary orthognathic surgery. This multi-centre randomized controlled trial included 88 patients, with 77 completing the study. Patients were randomly assigned to either the 'mandible-first' group (mandible-first with an intermediate splint) or the 'maxilla-first with PSO' group (maxilla-first with patient-specific osteosynthesis). Postoperative evaluation using cone beam computed tomography images showed significantly lower deviations from the preoperative plan in the maxilla-first with PSO group compared to the mandible-first group, for anteroposterior (median 1.0 mm vs 1.8 mm, P = 0.008) and left/right translations (median 0.4 mm vs 0.8 mm, P = 0.003), and yaw rotation (median 0.5° vs 1.0°, P = 0.013). Regarding clinical accuracy (categorized as optimal, good, or suboptimal), 59.5% of the patients in the maxilla-first with PSO group had an optimal or good result compared to 17.5% in the mandible-first group. The study findings suggest the maxilla-first PSO approach offers enhanced accuracy, supporting its adoption in orthognathic surgery for better surgical outcomes.01 augustus 202
Boosting oxytocin in postpartum depression: Intranasal oxytocin enhances maternal positive affect and regard for the infant
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320833.pdf (Publisher’s version ) (Open Access)Although oxytocin has been recognized for its affiliative and anxiolytic properties, dysregulation of this system may contribute to the link between depressed mood and insensitive maternal care in mothers with postpartum depression (PPD). This double-blind, randomized, within-subject control study investigated the effects of intranasal oxytocin on caregiving behaviors, mood and physiology in mothers with (subclinical) PPD. The study included 45 mothers with 3- to 9-month-old infants who exhibited clinically relevant scores on the Edinburgh Postnatal Depression Scale, with 35 mothers even fulfilling the criteria of a major depressive episode assessed with the SCID-5. We assessed oxytocin’s effects on maternal sensitivity, positive regard toward the infant, self-reported positive and negative mood, and physiological responses, including salivary cortisol, heart rate, and heart rate variability during mother-infant interactions. We found that oxytocin significantly increased maternal positive regard for the child and self-reported positive affect. No effects on maternal sensitivity, negative mood, or physiological responses were found. Our findings suggest that oxytocin may enhance positive maternal emotions in PPD. Future research should explore oxytocin’s therapeutic potential in larger, more diverse populations, considering individual differences such as PPD severity or childhood trauma.10 p
Noot bij: Hof Arnhem-Leeuwarden 22 oktober 2024, JOR, 2025, 118 (Bescherming tegen beschikkingsonbevoegdheid en aan mededeling te stellen eisen bij abc-cessie)
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320810.pdf (Publisher’s version ) (Open Access)22 oktober 202
Carry-over effects in GAG therapy efficacy trial solution for bladder pain syndrome/interstitial cystitis (GETSBI study): an interim analysis.
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319994.pdf (Publisher’s version ) (Open Access)OBJECTIVES: The double blind, multicentre, randomised, placebo-controlled GAG-therapy Efficacy Trial Solution for Bladder pain syndrome/Interstitial cystitis (GETSBI) study aims to evaluate the efficacy of intravesical glycosaminoglycans therapy with hyaluronic acid and chondroitin sulfate in symptomatic bladder pain syndrome/interstitial cystitis (BPS/IC) patients with Hunner lesions. This trial encompasses multiple methodologies, including a standard randomised controlled trial (RCT), a cross-over trial and an N-of-1 trial. An N-of-1 trial is a multiple crossover trial, usually randomised and often blinded, conducted in a single patient (1). The N-of-1 methodology is, however, only valid under the condition that there is no carry-over effect, meaning a carry-over of effect from an a-priori intervention period into the placebo period. Therefore, it is important to examine any potential carry-over effects to determine the validity of the study protocol concerning the N-of-1 trial part and thereby justifying recruitment. DESIGN: Interim analysis for potential carry-over effects. SETTING: Secondary care, 21 participants. PARTICIPANTS: 21 participants, participants concluded part one from the GETSBI study at time of this analysis (October 2023). OUTCOME MEASURE: The primary outcome of the study is the change from baseline in pain intensity, measured by visual analogue scale (VAS) pain. To assess for carry-over effects, the placebo responses on VAS pain were compared between groups with (n=10) and without (n=11) potential carry-over effects. The threshold for a clinically relevant carry-over effect was set at a difference on VAS pain >0.50 points. Data were analysed using descriptive statistics, T-tests, effect sizes and 95% CI. Statistical significance was set at α=0.05. RESULTS: The mean baseline VAS pain did not differ (p=0.12) between group A (n=10, VAS 7.52, SD=0.52) and group B (n=11, VAS 6.02, SD=2.47). The mean placebo responses on VAS pain for groups A and B were 0.97 (SD=1.85) and 1.47 (SD=1.81), respectively. The mean carry-over effect was 0.50 (SD=1.83), which was not statistically significant with a 95% CI of -1.17 to 2.17 and p=0.5369. CONCLUSIONS: This interim analysis shows that an N-of-1 trial probably will be feasible for evaluating non-curative treatment efficacy in chronic disease using only half the patients as are required for a classic RCT. Future analysis will provide a direct comparison of outcomes between the RCT, crossover and the N-of-1 part for a complete evaluation. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov, NCT05518864 (GETSBI study)
'MY BOSS MAKES THE MOST OUT OF IT': The predictive validity of learning climates for employability
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320251.pdf (Publisher’s version ) (Open Access)This study aims to examine to what extent the employability of followers and their managers is equally supported by organizational learning climates. Studies often assume that managers and their followers benefit equally from these climates. However, this assumption overlooks the distinct roles and positions that managers hold in comparison with their followers. Managers typically have more freedom to engage in learning activities, make decisions about their professional development and leverage organizational resources to support their growth. Consequently, they may have better positions to reap the benefits of learning climates than followers, whose roles may be constrained by organizational hierarchies. Using an actor–partner interdependence model, in a dyadic study among 205 manager-follower dyads, we investigated how three specific learning climates—appreciation, facilitation and error avoidance—relate to managers' and followers' employability. Our findings revealed that managers' employability benefits from all three climates. Contrastingly, followers' employability is enhanced only by a facilitating learning climate. These results suggest that learning climates primarily enhance managers' career potential, while followers depend more on direct facilitation to improve their employability.16 p
Prediction for cardiac and pulmonary toxicity in a multicentric cohort of advanced stage NSCLC patients using sub-regions of the heart
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318765.pdf (Publisher’s version ) (Open Access)7 p