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Memefying mental illness. A qualitative content analysis of mental illness portrayals in #depressionmemes on Instagram
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319096.pdf (Publisher’s version ) (Open Access)26 p
Controlling ferroelectric polarization with infrared laser pulses
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318542.pdf (Publisher’s version ) (Open Access)With the advent of increasingly intense lasers, new interaction processes between light and matter can be studied. An interesting category comprises lasers that produce infrared light. This light can naturally make atoms in matter vibrate. When you use very intense light, the atoms can vibrate strongly, which can (temporarily) change the structure of the matter. FELIX free electron lasers produce intense infrared light and have been used to study this interaction. In this study, we showed how to permanently switch ferroelectric polarisation by shining infrared light on matter.Radboud University, 13 mei 2025Promotor : Kirilyuk, A.I. Co-promotor : Davies, C.S.VIII, 104 p
Formele sponsorprogramma's als instrument voor gendergelijkheid in de zakelijke dienstverlening
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321113.pdf (Publisher’s version ) (Open Access)Abstract NL: Dit artikel draagt bij aan de literatuur over gendergelijkheidsinterventies door de rol van formele sponsorprogramma’s te onderzoeken. Hoewel er uitgebreid wetenschappelijk onderzoek is gedaan naar zowel de positieve als negatieve gevolgen van informele sponsorrelaties, bestaat er nog weinig kennis over de (onbedoelde) effecten van formele sponsorprogramma's. Dit onderzoek, uitgevoerd bij een professionele dienstverlener in Nederland, volgt 21 vrouwen uit zowel etnische minderheids- als meerderheidsgroepen en hun sponsors binnen een formeel programma. Er zijn vijf sponsorpraktijken geïdentificeerd: spiegelen, adviseren, netwerken en zichtbaar maken, beschermen, en pleiten voor promotie. Echter, de meeste sponsors neigen naar meer passieve praktijken die dicht bij mentoring liggen. De studie concludeert dat het formaliseren van sponsorrelaties moeilijk is vanwege macht- en vertrouwenskwesties en zelfs contraproductief kan zijn als dominante gegenderde opvattingen over 'leiderschap' en 'potentieel' niet worden aangepakt. Abstract ENG: This article contributes to the literature on gender equality interventions for women leaders by examining the role of formal sponsorship programs. Despite considerable scholarly attention given to the positive and negative gender implications of informal sponsorship relations, there remains a gap in knowledge regarding formal sponsorship programs and their (un)intended effects. Drawing on a longitudinal field study conducted in a professional service firm in the Netherlands, the research follows 21 women, encompassing both ethnic minorities and majorities, and their sponsors within a formal sponsorship program. Five sponsorship practices were identified from the data: mirroring, advising, connecting and making visible, protecting and advocating. However, the majority of sponsors tended to gravitate towards the more passive practices closely aligned with mentoring. The study concludes that sponsorship relations are hard to formalize due to issues of power and trust and can be even counterproductive when dominant gendered constructions of 'leadership' and 'potential' are not addressed.21 p
Understanding Hydration Transitions of CaBr2
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318545.pdf (Publisher’s version ) (Open Access
Bilingualism: Not all we know now is old news
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319552.pdf (Publisher’s version ) (Open Access)The advent of personal computers in the late twentieth century introduced new research methodologies, transforming experimental bilingualism into a robust field. At the time, language research relied on modular, largely monolingual bottom-up approaches like the Language User Framework. Harris’s Cognitive Processes in Bilinguals (1992) marked a turning point, stimulating inquiries into core issues concerning bilingual representation, co-activation, and cross-linguistic interaction. Here, we discuss how the experimental study of bilingualism has both quantitatively and qualitatively evolved since this book’s publication. Some book topics have become mature research foci of their own (e.g., cross-language processing effects, bilingual cognitive control, computational modeling of bilingual processing), while others have shifted direction (e.g., from cerebral laterality to the bilingual brain more broadly). By highlighting advances in research on language membership and markedness, and addressing the value of computational models over recent large language models, we show how cognitive bilingualism research remains highly relevant today.8 p
An analysis of characteristics and associated factors for re-contacts after EMS non-conveyance: a retrospective cohort study in the Netherlands.
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318660.pdf (Publisher’s version ) (Open Access)BACKGROUND: Non-conveyed patients are a significant population within ambulance care. To gain insight in patient safety for this population, ambulance re-contacts within 72 h are monitored. However, little is known about the background of these non-conveyance cases with a re-contact. This study aims to investigate the incidence of re-contacts, analyse characteristics, and identify factors associated with re-contacts following non-conveyance. METHODS: This was a retrospective cohort study of all non-conveyance cases and all associated re-contacts in two EMS regions in the Netherlands, Gelderland-Zuid and Gelderland-Midden. Data was collected from 1 January 2022 till 31 December 2022. Characteristics of non-conveyance cases with and without a re-contact within 72 h were compared and differences were analysed univariately. Logistic regression analyses were used to quantify bivariate and multivariable associations between characteristics of non-conveyance cases and EMS re-contact within 72 h. Associations are expressed in odds ratios with 95% confidence interval. RESULTS: In the analysis of 19.563 cases, the overall incidence for an EMS re-contact within 72 h was 5.0% (N = 984/19.563), with 3.4% (669/19.563) within 24 h, 1.0% (195/19.563) within 24-48 h and 0.6% (120/19.563) within 48-72 h. In a subset of 13.010 complete cases, significant multivariable associations were observed between re-contacts and age > 65 (OR 2.15, CI 1.82-2.53), male gender (OR 1.39, CI 1.18-1.63), and medical complaints related to specialism 'Pulmonology' (OR 2.45, CI 1.67-3.64), 'Neurology' (OR 1.81, CI 1.28-2.59) and 'Traumatology/surgery' (OR 0.51, CI 0.34-0.76). Other significant associations were noted with night-time cases (OR 1.49, CI 1.21-1.82) and cases in which consultation or handover to a general practitioner occurred (OR 1.25, CI 1.06-1.47). CONCLUSIONS: A low overall incidence of EMS re-contacts indicates that non-conveyance within the EMS system is relatively safe. The likelihood of re-contact is higher for age above 65, male gender, and medical complaints within the specialisms of 'Pulmonology' and 'Neurology'. Non-conveyance cases that involve consultation or handover to a GP and cases occurring at night are also more likely to have a re-contact. The findings inform non-conveyance decision-making, and could serve as a starting point to adapt EMS curricula, and develop guidelines and protocols. This may fuel the enhancement of non-conveyance decision-making, thereby improving the quality of healthcare within the EMS system
An introduction to pragmatism in the Roman Law of Secured Credit
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Translational Physiologically Based Pharmacokinetic Modeling to Predict Human Pulmonary Kinetics After Lung Delivery.
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319063.pdf (Publisher’s version ) (Open Access)Predicting human lung exposure with reasonable certainty of orally inhaled drugs based on preclinical studies remains a challenge for drug development. We have developed a comprehensive physiologically based pharmacokinetic (PBPK) framework tailored for the pulmonary pharmacokinetic (PK) behavior in both humans and rats, aiming to bridge the translational gap. In this study, we present a mechanistic pulmonary PBPK model for rats that integrates the pulmonary disposition processes, including drug deposition, dissolution, mucociliary clearance, and mass transfer in lung tissues. Apparent permeabilities were translated to effective permeabilities (P(eff)) with in vivo-in vitro correlation methods. Unbound tissue-plasma partition coefficients for lung (K(p,u,lung)) and P(eff) were estimated with plasma and lung PK profiles of salbutamol and fluticasone propionate in rats. The developed PBPK model was translated by keeping the estimated parameters and switching physiological and anatomical parameters from rats to humans. Based on PK observations in rats, the estimated typical P(eff) and K(p,u,lung) for salbutamol were 1.18 × 10(-5) cm/s and 8.83 and for fluticasone propionate 1.26 × 10(-4) cm/s and 1086, respectively. After interspecies translation, the model framework well predicted the mean epithelial lining fluid concentrations following oral inhalation of salbutamol and fluticasone propionate in human subjects, with fold-errors of lung-to-plasma ratios < 2. Thus, the proposed general pulmonary PBPK framework exhibits the potential to facilitate interspecies translation and can be used to predict safety and efficacy of lung-delivered therapeutics in human.01 april 202
Glycyl-tRNA sequestration is a unifying mechanism underlying GARS1-associated peripheral neuropathy
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318678.pdf (Publisher’s version ) (Open Access
Chorus: optimizing synchrotron transfer coefficients with weighted sums
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320372.pdf (Publisher’s version ) (Open Access