276557 research outputs found
Sort by
Cell-free characterization of posttranscriptional regulators for the development of dynamic gene circuits
No full textContains fulltext :
319911.pdf (Publisher’s version ) (Open Access)Radboud University, 02 juli 2025Promotores : Greef, T.F.A. de, Huck, W.T.S.216 p
Populism, Representation, and Ideological Congruence
No full textContains fulltext :
320108.pdf (Publisher’s version ) (Closed access
De mogelijkheden voor gemeenten om de snelheid van (fat-)e-bikes te reguleren met adaptive-speed-control-technologie
No full textContains fulltext :
321100.pdf (Publisher’s version ) (Open Access
Neural correlates of well-being in young adults
No full textContains fulltext :
318581.pdf (Publisher’s version ) (Open Access)Subjective experiences of well-being are multifaceted in nature, but the behavioral and neural correlates of subdomains of well-being are not yet well understood. Prior neuroimaging studies have primarily focused on single aspects of well-being (e.g., happiness). In the present study, we differentiated between five domains of well-being based on prior research (Green, van de Groep, et al., 2023): (a) family relationships; (b) dealing with stress; (c) self-confidence; (d) having impact, purpose, and meaning; and (e) feeling loved, appreciated, and respected. Young adults (age range = 20-25 years; n = 34) completed a self-evaluation functional magnetic resonance imaging task addressing the applicability of the items to the self on a scale of 1 to 4, followed by whether this item addressed a desire for change on a scale of 1 to 4. Behavioral ratings showed that young adults were least positive about dealing with stress and reported the highest degree of desired change for this domain. Higher positivity ratings in all five domains of current well-being were negatively associated with burnout symptoms. More burnout symptoms were associated with higher desire for future changes in the impact, confidence, and loved conditions. More depressive symptoms were associated with higher desire for future changes in all domains, except for confidence. Neural results showed increased activity in the precuneus for items addressing "positive family relations" and the dorsolateral prefrontal cortex for items addressing "dealing with stress," relative to the other domains, which did not result in distinct neural patterns. Together, these findings highlight the importance of assessing various components of well-being, which show distinct behavioral and neural patterns.13 p
Geant4 Simulations of a Scintillator Cosmic-Ray Detector
No full textContains fulltext :
321065.pdf (Publisher’s version ) (Open Access)17 p
The impact of extended invitation intervals on stage distribution of screen-detected and interval cancer within the Dutch colorectal cancer screening program.
No full textContains fulltext :
319464.pdf (Publisher’s version ) (Open Access)This study investigates the impact of extended invitation intervals on the stage distribution of screen-detected and interval colorectal cancers (CRCs) in the Netherlands' fecal immunochemical test (FIT)-based screening program during the COVID-19 pandemic. Using data from individuals with negative FIT results in 2017-2019 and subsequent screening round in 2019-2021, we examined whether delays of up to 6 months affected CRC stage at diagnosis. We performed multivariate logistic regression to assess the association between invitation intervals and cancer stage. Our analysis found no significant difference in stage distribution for both screen-detected and interval CRCs despite the delays. Specifically, odds ratios for late-stage cancer remained close to 1 across various intervals, indicating minimal impact of extended invitation times. These results suggest that the short-term delays caused by the pandemic did not significantly affect the performance of the CRC screening program. This highlights the program's ability to adapt to temporary disruptions while maintaining effective early cancer detection. Our findings support the notion that such disruptions, when managed appropriately, do not substantially compromise the quality of screening outcomes, reinforcing the resilience and flexibility of CRC screening programs in the face of health crises
Identity-Preserving Lax Extensions and Where to Find Them
No full textContains fulltext :
319351.pdf (Publisher’s version ) (Open Access)STACS 202
The regional development and implementation of home-based stroke rehabilitation using participatory action research.
No full textContains fulltext :
320034.pdf (Publisher’s version ) (Open Access)PURPOSE: This study aims to overcome the challenges experienced in the regional development and implementation of home-based stroke rehabilitation (HBSR) and to understand the change process needed. MATERIALS AND METHODS: Using participatory action research (PAR), participants and researchers collaboratively produced knowledge and took action to improve the offered HBSR. Different methods for data generation and analysis were used, depending on the aim of the PAR phase and the participants' stages of change. The Consolidated Framework for Implementation Research (CFIR) was used to select implementation strategies and to evaluate the implementation process. RESULTS: Developing and implementing HBSR resulted in multiple products that promoted the implementation of a regional stroke network and affiliated work arrangements. Work arrangements were embodied in a stroke care pathway, follow-up tool, and expertise requirements. Evaluating the PAR process identified participants being able to take the lead, being facilitated by others, and making progress visible, as implementation facilitators. Collaborating within a primary care project can be challenging but is considered essential and has a positive impact on multiple levels. Also, the implementation of HBSR calls for multiple implementation strategies reflecting multiple CFIR constructs. CONCLUSION: This study highlights the complexity and achievements of developing and implementing HBSR using PAR.01 juni 202
Patient Reported Outcome Measurements in Adult Spinal Deformity: A Narrative Review.
No full textContains fulltext :
320993.pdf (Publisher’s version ) (Open Access)Study DesignNarrative review.ObjectivesTo review the current state-of-the-art in patient reported outcome measurements (PROMs) in adult spinal deformity (ASD) surgery.MethodsPubMed was queried for publications related to PROM usage in ASD. PROM properties including responsiveness to change and thresholds for clinically relevant change were reviewed.ResultsDespite many reports using PROMs in ASD, there are little data to support superiority of any particular PROM. The Scoliosis Research Society-22r is a disease-specific measure that is responsive to change across pain, function, and self-image domains. The Patient Reported Outcome Measurement Information System (PROMIS) is a domain-specific measure available in computer adaptive tests, which may reduce question burden and ease administration for both patients and providers. Minimum clinically important differences, minimum detectable changes, and patient-acceptable symptom states have been proposed.ConclusionsPROMs are an essential component of modern, value-based ASD care, irrespective of academic pursuits. The SRS-22r is a validated disease specific measure, though this may be supplanted by computer-adaptive tests such as PROMIS to reduce the question burden. There is no PROMIS question set for self-image, which must be developed to cover all pertinent ASD domains.01 juli 202
Mutational profile dynamics in follicular lymphoma and large cell transformation.
No full textContains fulltext :
320552.pdf (Publisher’s version ) (Open Access)AIMS: Follicular lymphoma (FL) is characterised by significant heterogeneity in both the clinical trajectories and the molecular profiles. This study aimed to investigate clonal dynamics in FL by analysing mutation profiles at various time points during the disease course including at histological transformation (HT), to gain insight into the mutational changes over time. METHODS: We retrospectively analysed 76 biopsies from 25 patients, including 13 cases with three or more FL biopsies and 12 cases with subsequent HT. Hybrid capture-based Next-Generation Sequencing (NGS) with the EuroClonality-NGS DNA capture (EuroClonality-NDC) assay was used to examine clonal rearrangements and mutations. RESULTS: A total of 204 (potentially) pathogenic mutations were identified. Only 40% of mutations remained stably present during a median follow-up period of 139 months (range 9-198). KMT2D and CREBBP were the most frequently mutated genes at diagnosis, exhibiting relative stability in follow-up biopsies. Conversely, EZH2 displayed a dynamic pattern of mutations gained and lost during the disease course. At HT, pathogenic mutations affecting B2M, MYC and TP53 emerged. Changes in mutational burden were observed in both FL-sequential and diagnosis-transformation cohorts, with more pronounced changes in the latter. CONCLUSIONS: This real-world study provides insights into the complex molecular pathogenesis of FL and HT. As targeted therapies emerge as treatment modalities, mutational profiles could influence treatment decisions in the future. Therefore, recognising the significant changes occurring in the mutational landscape of FL throughout the disease course is crucial