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Light-Driven Artificial Cell Micromotors for Degenerative Knee Osteoarthritis
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318897.pdf (Publisher’s version ) (Open Access
Information transfer and recovery for the sense of touch
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318571.pdf (Publisher’s version ) (Open Access)20 p
Evaluating the occupation-based complex intervention for living well with anxiety and Parkinson's disease (OBtAIN-PD) in community rehabilitation teams in the UK: a feasibility cluster randomised controlled trial protocol.
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318968.pdf (Publisher’s version ) (Open Access)INTRODUCTION: Anxiety is a common non-motor symptom of Parkinson's that is associated with reduced life quality, independence and health outcomes. Current anxiolytic medications and the most promising behavioural interventions have inconclusive and mixed results. Occupational therapy is effective at promoting participation in activities of daily living and is recommended in national guidelines. This cluster randomised controlled trial aims to test the feasibility and fidelity of a new occupation-based complex intervention for living well with anxiety in Parkinson's disease (OBtAIN-PD). No such evidence-based intervention currently exists. METHODS AND ANALYSIS: 50 people with Parkinson's will be recruited from Devon, UK, to undertake the OBtAIN-PD or usual care delivered by community-based occupational therapists across two National Health Service sites. Recruitment, attrition rates and feasibility of proposed outcome measures (Canadian Occupational Performance Measure, Generalised Anxiety Disorder-7, The Parkinson's Disease Questionnaire-39, Activity Card Sort, Barthel Index and fall logs) will be tested. Resource data will be collected to aid in the feasibility assessment. Fidelity to content will be assessed using process evaluation. Subjective experiences will be explored qualitatively (10 participants, occupational therapists and decliners). ETHICS AND DISSEMINATION: This trial has been registered with the ISRCTN registry. Ethical approval has been obtained from the North East - York Research Ethics Committee (reference 23/NE/0027) before data collection. Participants will receive a summary of the results at the end of the data analysis. We will publish the results in a peer-reviewed journal and on institution websites. TRIAL REGISTRATION NUMBER: ISRCTN62762494
Feasibility of the MMPI-2-RF in patients with borderline intellectual functioning and psychopathology
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321130.pdf (Publisher’s version ) (Open Access)Empirically evaluated instruments to assess personality characteristics and psychopathology in patients with borderline intellectual functioning (BIF) are lacking. Because of their high risk of psychopathology, additional psychological assessment of personality characteristics and psychopathology is highly relevant for treatment planning. In this study, we aimed to determine whether the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) is applicable for diagnostic assessment in patients with BIF and comorbid psychopathology. We examined scores on the validity scales of the MMPI-2-RF of patients with BIF and compared these scores to those of a matched (i.e., age and gender) community sample with average intellectual functioning without psychopathology. Scores on the MMPI-2-RF validity scales indicated that patients with BIF report consistently and demonstrated no indications of over-reporting or under-reporting. Compared to a matched community sample they demonstrated an equally consistent item response but report significantly more psychopathology. The results indicated that the MMPI-2-RF is feasible for the diagnostic assessment of personality characteristics and psychopathology in patients with BIF and comorbid psychopathology.8 p
Real-time six degrees of freedom grasping of deformable poultry legs in cluttered bins using deep learning and geometric feature extraction
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318582.pdf (Publisher’s version ) (Open Access)Grasping deformable natural food products in pick-and-place applications presents a challenging problem in robotics, particularly in cluttered environments. Traditional techniques, such as centroid-based grasping and grasping along the principal axis, often fail when applied to deformable and complex-shaped objects. A real-time grasp pose estimation algorithm was proposed in this paper for robotic pick-and-place tasks involving deformable objects. Instance segmentation, keypoint detection, and stable six degrees of freedom (6-DoF) grasp pose estimation were jointly performed within a unified framework, while avoiding collisions using deep learning and geometric features. Grasp candidates on the objects were generated based on maximum curvature and convex hull methods, which were then filtered to identify the most stable grasp. By projecting 2D keypoints into the depth image, the grasping points were obtained in 3D. The keypoints were used to estimate the 3D orientation of the grasp. The success rate of grasp pose estimation was found to be 83.3 %, which increased to 93.7 % when object segmentation failures were removed. The algorithm was evaluated on a real robotic platform, demonstrating its ability to accurately grasp real poultry legs from a pile, with success rates of 93.8 % for simple scenes and 75.0 % for cluttered scenes. These results highlight state-of-the-art performance and showcase the efficacy and robustness of the proposed system.17 p
Reducing surgical instrument usage: systematic review of approaches for tray optimization and its advantages on environmental impact, costs and efficiency.
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319477.pdf (Publisher’s version ) (Open Access)BACKGROUND: Operating rooms generate substantial waste and budget expenditure due to extensive material usage. Reusable instruments are often packaged in trays, which accumulate instruments over time. This review quantifies the advantages of tray optimization (removing redundant instruments), including reduced environmental impact, costs, operating room and processing time. METHODS: Following PRISMA guidelines, searches were conducted in PubMed, Embase, Web of Science and The Cochrane Library in August 2024 for studies on optimizing surgical trays in human surgeries. Studies were included if they reported on optimization approaches and outcomes related to environmental, economic or efficiency improvements. Exclusions included studies on disposable instruments, animal or veterinary research and patient-specific trays. Risk of bias was assessed using the ROBINS-I (Risk Of Bias In Non-randomised Studies - of Interventions) tool. RESULTS: The search identified 4511 studies, with 45 meeting the inclusion criteria. Half of the studies showed a serious risk of bias, while the rest had a moderate risk. Three main optimization strategies were identified, with expert analysis being the most common (n = 29), followed by mathematical modelling. Environmental benefits were reported in all three included studies, although limited in number. Studies reported that 19 to 89% of instruments could be removed from trays, with 31 studies unanimously reporting cost reductions. Additionally, 17 studies demonstrated improved operational efficiency. CONCLUSION: Tray optimization strategies effectively reduce resource use, resulting in environmental and economic benefits. Although no standard method exists, effective strategies such as procedure observation and clinician feedback may eliminate over half of the instruments, offering a significant opportunity to minimize resource consumption in the operating room
Counterintuitive Behavior of Clustering Quality: Findings for K-Means on Synthetic and Real Data
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319674.pdf (Publisher’s version ) (Open Access)IDA 202
The COVID-19 crisis as a ‘hospital issue’. The impact of COVID-19 measures on Dutch nursing homes
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Social health and prevention of dementia: Integration of human and mice studies.
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320181.pdf (Publisher’s version ) (Open Access)OBJECTIVES: Prevention of dementia is considered a healthcare priority. We aimed to identify potentially modifiable risk factors and mechanisms within the social health domain to find novel avenues to prevent cognitive decline and dementia. DESIGN: We integrated the results of eight sub-studies of the Social Health in Mice and Men (SHiMMy) project that were separately published in specialized journals, but not yet jointly considered. We followed the integrative methodology of Whittemore and Knafl, using the conceptual framework for social health to structure and integrate the results of human epidemiological and qualitative studies and experimental mice studies. This is a novel multi-method approach. PARTICIPANTS: Participants of the population-based longitudinal cohort Rotterdam study were included in the epidemiolocal studies (ranging from N = 1259 to N = 3.720) and in the qualitative study (n = 17). Mice intervention studies were performed using a transgenic mouse model for Alzheimer's pathology and matched controls, under group and single housed conditions. MEASUREMENTS: Epidemiological studies include social health markers (loneliness, perceived social support, marital status) and magnetic resonance imaging of the brain. The semi-structured qualitative study used an interview guide. The mice study assessed behavioral and histological markers. RESULTS: In human and mice studies, we identified several similar potentially modifiable risk (e.g. marital status, social group size) and protective (e.g. perceived social support, behavioral responses) factors. This alignment of findings showing that social health may impact brain health lend further support to our social health hypothesis. CONCLUSION: These results allow us to propose evidence-based social health targets for preventive interventions.01 juni 202