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In itinere infections covertly undermine localized epidemic control in metapopulations
Get PDFMetapopulation models have traditionally assessed epidemic dynamics by emphasizing local (in situ) interactions within defined subpopulations, often neglecting transmission occurring during mobility phases (in itinere). Here, we extend the Movement–Interaction–Return metapopulation framework to explicitly include contagions acquired during transit, considering agents traveling along shared transportation networks. We reveal that incorporating in itinere contagion entails a notable reduction of the epidemic threshold and a pronounced delocalization of the epidemic trajectory, particularly significant in early-stage outbreaks
Impact of focal hand dystonia on hand function—a case report with carpal tunnel syndrome and mirror dystonia video
Get PDFBackground
Focal hand dystonia is a movement disorder that causes involuntary and painful contractions in the muscles of the forearm and hand, affecting fine manual dexterity and activities such as playing instruments or writing. In contrast, carpal tunnel syndrome is a neuropathy that leads to tingling and weakness in the hand due to compression of the median nerve.
Case presentation
We present the case of a woman with a clinical history of compressive syndrome of the median nerve of 2 years’ duration and a diagnosis of focal dystonia of the flexor pollicis longus. Botulinum toxin injections were administered, resulting in an improvement of symptoms.
Clinical discussion
Despite the improvement from botulinum toxin treatment, carpal tunnel release surgery could not be avoided due to the persistent involvement of the median nerve. Botulinum toxin injection appears to be a useful treatment in such cases and may help to manage symptoms effectively if applied early.
Conclusion
In this case, early administration of botulinum toxin might have improved the patient’s quality of life by delaying or avoiding the need for surgery, underscoring the importance of timely diagnosis and intervention
Gastropod-rich lacustrine carbonate deposits in N Iberia: a depositional, climatic and ecological record of the Late Miocene
Get PDFThe Tortonian Peña Adrian Formation represents the youngest depositional unit of the Miranda-Trebiño basin (Basque-Cantabrian Pyrenees), which developed on the Southern Basque-Cantabrian Pyrenees from late Eocene to Late Miocene times. The formation is a 50–160 m thick succession of alluvial detrital grading to lacustrine carbonates that contain rich and varied calcareous fossil biota (gastropods, ostracods and charophytes). The fossil association characterizes warm temperate, shallow lakes with vegetated bottoms and well‑oxygenated and alkaline fresh waters. Integration of stratigraphic, sedimentological, paleontological and Csingle bondO stable isotopic data allows the differentiation of a wide range of sedimentary facies, the construction of a depositional model and the definition of distinct evolutionary phases and relation to allogenic processes. Up to 3 metre-thick facies sequences record repetitive water-level changes, likely reflecting short-term climate changes. Overall, the succession outlines an asymmetric cycle of gradual expansion and faster contraction of a shallow ramp-like lake system evolving under oscillating climatic conditions. C and O stable isotopes are consistent with decreasing salinity and increasing precipitation/evaporation balance trough time. Excellent preservation of aragonitic and bimineralic gastropods characterizes the open lacustrine deposits, whereas shell dissolution and neomorphism are distinct in the palustrine ones. This contrasting degree of preservation of calcareous biota clearly reflects changes in the physico-chemical conditions that prevailed during sedimentation and early burial. The findings add to the knowledge of carbonate lake basins, help discern the factors that controlled their evolution and highlight specific depositional and preservation conditions for gastropod-rich carbonate records
Tuning the liquid crystal behavior of subphthalocyanines: effects of substitution, chirality, and hydrogen bonding
Get PDFBowl-shaped aromatics that self-assemble into columnar liquid crystals (LCs) are key components for developing polarized semiconductors. However, progress in this field has been sluggish, as the limited set of available π-conjugated curved scaffolds has left structure–property relationships poorly understood. Herein the role that substitution pattern, substituent nature, and chirality play in the LC columnar organization of subphthalocyanines (SubPcs) is explored. Remarkably, it is revealed that enantiopure SubPcs exhibit a reduced tendency to form LC phases compared to their racemic counterparts, whereas higher substitution density increases flexibility within the columns, compromising coaxial alignment. Moreover, we find that the use of conformationally flexible, π-extended peripheral substituents enables efficient π–π stacking, and that the incorporation of hydrogen-bonding amide groups leads to highly stable mesophases with elevated melting points, although the mesophase remains at room temperature after thermal treatment. These trends are further rationalized through theoretical modeling. Overall, this work provides valuable synthetic and design guidelines for advancing bowl-shaped aromatics toward next-generation functional columnar liquid crystals
3D Temperature Mapping During Photothermal Therapy in Cellular Assemblies
Get PDFControl over temperature in three space dimensions and time is of utmost importance in many contexts, including photothermal therapies, where it is expected to provide valuable insights and enhance clinical outcomes. Current techniques for noncontact temperature mapping during hyperthermia are restricted to 2D imaging, due to the lack of strategies able to provide images in suitable time frames for the inevitable large amount of information encompassed in 3D tomography. Iron selenide nanoparticles (NPs) are developed with high temperature sensitivity that, in combination with low‐field magnetic resonance imaging, enable 3D temperature imaging in the ≈20 s time frame. This approach is suitable for monitoring and evaluating photothermal therapy applied to cellular assemblies, which typically occurs over a time frame of tens of minutes. In addition, iron selenide NPs behave, simultaneously, as photothermal and thermometric agents embedded in cellular models at concentrations where their cytotoxicity is low. This dual functionality enables to control the depth achieved by the therapy with a temperature accuracy ≤1 °C, enabling the detection and control of hot spots that would be otherwise overlooked. Overall, this is a universal approach for temperature mapping in 3D and for localized heating in virtually any living tissue
UNA APROXIMACIÓN AL VIDEO ANÁLISIS DEL CONOCIMIENTO CIENTÍFICO DEL DISCURSO DEL AULA
Get PDFResumen Este trabajo pretende describir un marco teórico-metodológico para el estudio del video-análisis del aula bajo dos perspectivas diferenciadas. La primera guarda relación con la necesidad de un análisis sistemático y transferible para comprender qué es lo que acontece dentro del aula. La segunda se relaciona con una decodificación del discurso producido por los alumnos cuando se trabajan determinados contenidos científicos. Para tal fin, se plantean tres escalas de análisis. Escala macro, donde se define qué y cómo se trabaja (medio didáctico), escala meso, donde se estructuran los objetivos y las reglas (juegos didácticos), y escala micro, donde se estudia el conocimiento involucrado en los enunciados verbales de los alumnos (facetas)
Multivariate analysis of performance indicators in elite women's futsal: A principal component approach to understanding game dynamics
Get PDFThe current study analysed Key Performance Indicators (KPIs) specific to high-performing female futsal players using univariate and multivariate statistical approaches to better understand team dynamics in conjunction with individual performance. Data were collected from a sample of 10 female futsal players (mean age: 23.9 ± 3.4 years) over 25 official matches of the Spanish first division. Twenty KPIs were selected in collaboration with coaches and researchers to represent diverse offensive and defensive aspects of play. This study used observational methods and principal component analysis (PCA) to reduce the dimensionality of data and determine key performance factors. Descriptive statistics and factor analysis were conducted, with Kaiser-Meyer-Olkin (KMO = 0.63) values and communalities evaluated for sampling adequacy. PCA shown two main components explaining 64.09% of the total variance. The first component, “Aggressiveness in Attack”, (47.02% variance), was strongly associated with offensive production, including high rates of goal plays, shots, goals, assists, and fouls received. The second component, “Forceful Defence” (17.07% variance), primarily reflected defensive effectiveness, characterized by high rates of successful disputes, ball recoveries, and defensive intensity indicators, along with fewer ball losses. Individual player profiles revealed distinct tactical roles, with some players showing strong tendencies toward either offensive or defensive abilities. In conclusion, the use of multivariate analyses provides valuable insights into the performance of women's futsal, offering practical implications for coaches and players seeking to improve strategies and enhance individual and team performance through data-informed training and tactical planning
Plan de empresa: “Namas Paw”
Get PDFCentro de yoga y pilates con servicios innovadores en Zaragoza<br /
Aburrimiento del Consumidor y la Organización de Empresas en el Ámbito del Consumo de Comida
Get PDFEste Trabajo de Fin de Grado investiga el aburrimiento del consumidor en el ámbito de los servicios de consumo de comida y los factores y estrategias más relevantes que las organizaciones deben tener en cuenta para gestionarlo. El aburrimiento es un sentimiento aversivo de insatisfacción con la actividad realizada en el momento, pero sin saber qué hacer al respecto. Empuja a la gente a buscar algo más atractivo, por lo que es crucial que las empresas sean conscientes de ello y lo gestionen para su propio beneficio. El estudio combina un marco teórico con una investigación empírica, que incluye una revisión bibliográfica, una entrevista con una experta del aburrimiento y una encuesta cuantitativa. Este trabajo contribuye a los campos de la psicología del consumidor y la gestión empresarial.Los métodos utilizados en este estudio permitieron determinar como causas principales del aburrimiento del consumidor los siguientes aspectos: infrautilización general de las capacidades cognitivas del consumidor, mala calidad del servicio al cliente y falta de variedad. Teniendo esto en cuenta, se formularon sugerencias para que las empresas afronten este reto. Las soluciones principales fueron que las organizaciones deben dar prioridad a la comodidad de los clientes frente al cambio y la innovación excesiva, que inviertan en los demás aspectos del servicio además del producto y garantizar el trato personalizado de los clientes.<br /
Variaciones en los valores de saturación de oxígeno de los colgajos en dependencia del vaso receptor.
Get PDFLa reconstrucción microquirúrgica con colgajos libres, como el colgajo anterolateral del muslo (ALT), es una técnica ampliamente utilizada en cirugía plástica por su versatilidad. Este estudio analiza si la localización anatómica del lecho receptor (cabeza y cuello vs extremidad inferior) influye en la viabilidad postoperatoria inmediata, medida mediante la saturación regional de oxígeno (rSO₂) con el sistema INVOS™. Se incluyeron 32 pacientes intervenidos entre 2020 y 2024. Los valores medios de rSO₂ post-anastomosis fueron similares en ambos grupos (77,05 ± 10,87 vs 74,64 ± 12,91; p = 0,580), sin asociaciones significativas con otras variables clínicas. Se concluye que la localización anatómica no afecta la viabilidad inmediata del colgajo ALT, lo que refuerza su uso como opción quirúrgica confiable y la utilidad del INVOS™ como herramienta de monitorización no invasiva.<br /