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Modern diplomacy / R.P. Barston.
No full textIncludes bibliographical references and index.xxi, 432 p.
Renewable energy integration : practical management of variability, uncertainty and flexibility in power grids / Lawrence E. Jones.
No full textengineering bookfair2015Includes bibliographical references and index.474 P. :"Renewable Energy Integration is a ground-breaking new resource, the first to offer a distilled examination of the intricacies of integrating renewables into power grid and electricity markets. It offers informed perspectives from internationally renowned experts on the challenges to be met, and solutions based on demonstrated best practices developed by operators around the world. The book's focus on practical implementation of strategies provides real-world context for theoretical underpinnings and the development of supporting policy frameworks. The book considers a myriad of wind, solar, wave and tidal integration issues, thus ensuring that grid operators with low or high penetration of renewable generation can leverage the victories achieved by their peers. Renewable Energy Integration highlights, carefully explains, and illustrates the benefits of advanced technologies and systems for coping with variability, uncertainty, and flexibility"-- Provided by publisher
Simultaneous determination of ezetimibe and atorvastatin calcium in spiked human plasma using SPE coupled to HPLC-MS/MS
No full textCombination drug products containing ezetimibe (EZB) and atorvastatin calcium (ATVC) are widely used for treatment of hyperlipidemia. A rapid, simple and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS)method for determination of EZB and ATVC in spiked human plasma has been developed and validated.Plasma samples were subjected to solid phase extraction before analysis with an extraction recovery of 90.59 - 98.02%. Chromatographic separation was performed on a C18 col- umn using isocratic elutionwithin 2 min run time. The mobile phase con- sisted of acetonitrile: 1% of formic acid in water (8: 2, v/v) and was pumped at a flow rate of 0.8 mL/min. Detection of analytes was achieved by with electrospray ionization (ESI) in negative ion mode for EZB and positive ion mode for ATVC. The calibration curves were linear over the range of 1.67 83.33 ng/mL for both drugs. The precision at the lower limit of quantitation for EZB (12.97%) and ATVC (8.99%) was determined. The intra- and inter- day precisions were within 9.16%, while the accuracy ranged from 94.18 to 106.94%. The validated LC-MS/MS method was successfully employed for thedetermination of EZB and ATVC in spiked human plasma for application in therapeutic drug monitoring. 2014 Trade Science Inc. - INDI
Electrical machines, drives, and power systems / Theodore Wildi.
No full textIncludes bibliographical references and index.iv, 920 pages
Advanced ceramics for dentistry / [edited by] James Zhijian Shen and Toma(QC(Bz Kosma(QC(Bc.
No full textIncludes bibliographical references and index.xiv, 402 p. :The growth of implant and fixed prosthodontics practices in dentistry has created a rapidly increasing demand for advanced ceramics and ceramic processes. Innovations in ceramics and ceramic processes are vital to ensure reliable and affordable dental-restoration solutions with aesthetically pleasing outcomes. The work aims to engage the bioceramics and engineering communities to meet the challenges of modern dental restoration using advanced ceramics. Incorporating fundamental science, advanced engineering concepts, and clinical outcomes, the work is suitable for bioceramicists, ceramics manufacturers, dental clinicians and biologists. State-of-the-art-coverage encompasses bioresorbable ceramics for bone regeneration and bioactivating surfaces of inert, high-strength ceramics for implantation, keeping research knowledge appropriately updatedDiscusses transition from the baseline stable and physically stiff ceramics research into engineering of highly coherent laminate composites for prosthetic crowns and bridgesShowcases current feasible techniques for producing, in cost-effective and materials-saving ways, long-lasting individualized ceramic components with biocompatibility, complexity and high precision
Single-dose linezolid pharmacokinetics in critically ill patients with impaired renal function especially chronic hemodialysis patients
No full textRenal failure patients were treated with linezolid (LZD) for proven or suspected infections by multi-resistant Gram-positive cocci. The aim of this study was to determine if dose adjustment of LZD is needed as a function of renal impairment or not, especially that a significant component of LZD is eliminated unchanged in urine. Methods: The single dose pharmacokinetics of LZD was investigated. Eighteen non-infected male subjects with various degrees of renal impairment ranged from normal to severe chronic impairment were enrolled, including end-stage renal disease (ESRD) patients maintained on hemodialysis (HD). LZD was administered as a single oral 600 mg dose, and blood samples were drawn at different times and analysed by a validated HPLC assay method. Plasma profiles were evaluated by non-compartmental and compartmental approaches. Results and Discussion: A similar rate and extent of LZD absorption and elimination and comparable body exposure was observed in both healthy subjects and acute renal failure patients. The extent of LZD exposure was significantly increased by 3-fold in ESRD patients in their off-dialysis day. Furthermore, the t1/2 and MRT values were significantly increased by ~5- and 3-fold, respec- tively. The Vd/F values of LZD did not change with renal function. A significant decrease in CL/F by ~3-fold was observed in ESRD patients in their off-dialysis day however, CL/F was significantly increased by ~4-fold during HD. Approximately half of the administered LZD dose was removed during the HD session in these selected cohorts of ESRD patients. LZD was generally well tolerated. Conclusions: The dose of LZD did not need to be adjusted for patients with acute renal dysfunction or ESRD on HD. One of the twice-daily doses should be administered after the dialysis session because almost half of the LZD dose was substan- tially removed by HD. During the first three dialysis sessions of the treatment course, to avoid potentially ineffective therapy, a supplemental dose of LZD might be given if necessary or the dose of LZD should be administered 4 h before the beginning of the HD session. This was to keep LZD levels above the MIC for the organism causing the infection being treated. Copyright © 2014 John Wiley & Sons, Ltd
Stem cells : scientific facts and fiction / edited by Christine Mummery, Anja Van De Stolpe, Bernard A.J. Roelen, Hans Clevers.
No full textpharmacy bookfair2016Includes bibliographical references and index.xi, 433 pages
GAs and Evolutionary Design in Architectural Heritage-The Case of Islamic Architecture
No full textThe cosmological nature of Islamic architecture makes it a useful case study for the capability of the adaptation, assimilation and accommodation with the development of evolutionary algorithms and their applications in archi- tectural design. Genetic algorithm derives its structure from the observation of nature. Since algorithmic art consists of generation of images on the basis of al- gorithms, algorithms can be viewed as a notation, and notation is something that music has but visual artifacts in general miss. This paper aims to discover the role of evolutionary algorithms in historical Islamic architecture. Also, we shall try to investigate the way in which the future development could occur not only through the discovery of new facts or theories, but also through the rise and dissemination of new visions having different explanation of Islamic archi- tecture that considers it as a result of serious application of formation through evolutionary genetic algorithm
Endodontic pain : diagnosis, causes, prevention and treatment / [edited by] Paul A. Rosenberg.
No full textdental bookfair2016xvi, 183 p. :Endodontic pain is a complex symptom that often drives a patient to a dentist in search of relief. In these circumstances, the patient is likely to pose a range of questions: Can you relieve my pain? Will the treatment be painful? How will I feel later? The answers to such questions often form the basis of the patient's assessment of the dentist. The combination of pain and a negative dental experience has physical and psychological sequelae for the patient that may last long after treatment. This book is a concise, well-structured guide to the assessment and treatment of patients who present with endodontic pain, in which step-by-step descriptions are complemented by informative images and flow charts. The advantages, disadvantages, and significance of specific diagnostic and treatment procedures are clearly described, as is a pharmacotherapeutic approach to the prevention and treatment of pain. In addition, the causes and biological basis of endodontic pain are explained and guidance is provided on further strategies for pain prevention. The crisp narrative, efficient design, and visual detail are notable features of this book that will make it an ideal chairside resource for the clinician and a dependable reference for the student
Electroanalytical Determination of Gemifloxacin Mesylate in Bulk, Tablets and Human Urine Using Gold Nanoparticles Modified Carbon Paste Electrode
No full textA simple, precise, inexpensive and sensitive voltammetric method has been developed for the determination of gemifloxacin mesylate (GEM) in the presence of tween 80 in the bulk, farmaceutical dosage forms and human urine at gold nanoparticles modified carbon paste electrode (GNCPE). The electrochemical behavior of GEM has been investigated by using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The electrochemical oxidation of GEM was an irreversible process which exhibited adsorption-diffusion controlled process behavior in Britton-Robinson (BR) buffer over the entire pH range of values from 2 to 9. The adsorptive stripping response was evaluated as a function of some variables such as pH, type of surfactant, scan rate and accumulation time. The anodic peak current varied linearly over the range from 8.0 × 10 -7 to 2.8 × 10 -5 M. The limits of detection and quantification were 7.32 × 10 M and 2.44 × 10 -7 M, respectively. The relative standard deviations and the percentage recoveries were found in the following ranges: 0.58-1.35% and 99.37-101.76%, respectively