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Integrative medical biochemistry : examination and board review / Michael W. King.
No full textIncludes index.pharmacy bookfair2015xv, 892 p. :A rigorous full-color review for any type of biochemistry or medical biochemistry examination!
Integrative Medical Biochemistry Examination and Board Review is a fast and effective way for you to prepare for regular course examinations in biochemistry and medical biochemistry, as well as medical board exams and the USMLE Step 1. A unique feature of this review is the integration of medical biochemistry with physiology, pathophysiology, pathology, and anatomy, making it perfect for today's rapidly changing medical school curriculum.
Integrative Medical Biochemistry Examination and Board Review is logically divided into four sections:
Section 1 covers the basics of the major building blocks of all cells and tissues
Section 2 discusses metabolic biochemistry with a strong emphasis on clinical correlations and clinical disorders related to these all important pathways
Section 2 reviews the Cellular and Molecular Biology topics associated with medical biochemistry, physiology, and pathology
Section 4 includes 10 chapters with high-yield integrative topics of value not only to medical students, but to all students of the discipline
Packed with valuable learning aids:
1,100 multiple-choice questions, half of which are USMLE Step 1 style
Thorough explanations for each answer
350 full-color illustrations
Every chapter includes:
An outline listing the major topics covered
A list of high-yield terms related to the content
Numerous explanatory figures and tables designed to increase your understanding of must-know material
A checklist that recaps important and high-yield concepts
Most chapters include detailed clinical boxes that present high-yield information concerning diseases and disorders related to defects in the pathways being discusse
LC–MS/MS method for the determination of clodronate in human plasma
No full textClodronate belongs to the class of bisphosphonates which are used for the treatment of bone disorders. Due to its high polarity it has a low and highly variable oral bioavailability which results in low plasma con- centrations and requires sensitive bioanalytical methods to characterize its pharmacokinetics in human. Here, we describe for the first time the development and validation of a LC–MS/MS assay for the quan- tification of clodronate in human plasma. The bisphosphonate was isolated from the biological matrix by protein precipitation using perchloric acid (10%), and derivatized with trimethylorthoacetate prior sample clean-up with liquid–liquid extraction using methyl tert-butyl ether.
The chromatography was performed using an isocratic elution with ammonium acetate 5 mM (85% v/v, pH 3.8) and acetonitrile (15% v/v) as mobile phase with a flow rate of 300 l/min on a reversed-phase
column (Supelco Ascentis® , C18) temporized at 50 ◦ C. The mass spectrometric detection was done using
the API4000 triple quadruple mass spectrometer monitoring the mass/charge transitions 301.0/145 for clodronate and 305.2/137.1 for the internal standard etidronate.
The analytical range was set to 5–800 ng/ml, allowing an evaluation of the plasma concentration–time profiles of clodronate for approximately 7–8 half-life (∼24 h). The method was validated according to cur-
rent FDA/EMA guidelines on bioanalytical method validation with respect to specificity, linearity, intra- and inter-day accuracy and precision, matrix effect, recovery as well as stability. The precision of the assay was 0.6–6.9% and 0.6–8.1% for the intra-day and inter-day variability, respectively. The intra-day and inter-day accuracy (error) was 0.6–8.8% and 2.2–4.5%. The recovery of the analyte was low (2–3%) but reproducible over the entire validation range and sufficient to monitor the target concentrations in
human plasma. The drug was shown to be stable in plasma at room temperature for at least 3 h (96.0 ± 6%)
and for at least 24 h when stored in the cooled autosampler at 4 ◦ C (102.4 ± 4.5%). Clodronate can also
undergo up to three freeze–thaw cycles without impaired stability. Thus, the method was shown to
possess sufficient specificity, sensitivity, accuracy, precision and stability to measure plasma concen- trations of clodronate. Finally, the developed method was successfully applied to study the clodronate serum levels in a pharmacokinetic study in healthy volunteers
Cancer genomics and proteomics : methods and protocols / edited by Narendra Wajapeyee.
No full textpharmacy bookfair2015Includes bibliographical references and index.xi, 262 pages
Natural gas processing : technology and engineering design / Alireza Bahadori.
No full textIncludes bibliographical references and index.xx, 872 pages :Natural gas is considered the dominant worldwide bridge between fossil fuels of today and future resources of tomorrow. Thanks to the recent shale boom in North America, natural gas is in a surplus and quickly becoming a major international commodity. Stay current with conventional and now unconventional gas standards and procedures with Natural Gas Processing: Technology and Engineering Design. Covering the entire natural gas process, Bahadori's must-have handbook provides everything you need to know about natural gas, including:
Fundamental background on natural gas properties and single/multiphase flow factors
How to pinpoint equipment selection criteria, such as US and international standards, codes, and critical design considerations
A step-by-step simplification of the major gas processing procedures, like sweetening, dehydration, and sulfur recovery
Detailed explanation on plant engineering and design steps for natural gas projects, helping managers and contractors understand how to schedule, plan, and manage a safe and efficient processing plan
Analytical chemistry.
No full textPart VII chapters only available on the Web: http://www.cengage.com/chemistry/skoog/fac9.pharmacy bookfair2015Includes bibliographical references and index.1 volume (various pagings)
A NEW TECHNIQUE FOR SKETCHING EPICYCLIC GEAR MECHANISMS USING ACYCLIC GRAPH
No full textIn this paper, an algorithm for reverse transformation process of enumerated graphs of epicyclic gear mechanisms into a functional representation has been introduced using acyclic graph method. The displacement graph is divided into its elementary gear units which are then connected to form the functional representation of such a mechanism. Transformation of displacement graphs with up to 11-link mechanisms having at least 4 coaxial links and up to 8 coaxial links can be performed using the proposed algorithm
Cryptography and network security : principles and practice / William Stallings.
No full textIncludes bibliographical references (pages 710-719) and index.xix, 751 pages
Java WebSocket programming / Danny Coward.
No full text"Oracle Press."Includes index.computer bookfair2013xxii, 230 p.
Macroeconomics / Andrew B. Abel, Ben S. Bernanke.
No full textIncludes bibliographical references and indexes.672 p.
Renewable energy systems : a smart energy systems approach to the choice and modeling of 100% renewable solutions / [edited] by Henrik Lund.
No full texteconomic&political bookfair2015Includes bibliographical references (pages 343-350) and index.xx, 362 pages