Future Repository
Not a member yet
2157 research outputs found
Sort by
Synthesis, biological evaluation and molecular modeling study of some new thiazolodiazepine analogs as CNS active agents
No full textNew derivatives of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124,
3), were synthesized as continuation to our previous patented efforts. Compounds 15 and 20 showed
marginal hypnotic potency compared to 3. Compounds 15 (0.78 mmol/kg) and 20 (0.39 mmol/kg)
showed remarkable 100% protection against PTZ induced convulsions with two and four fold increase
in activity than sodium valproate (1.38 mmol/kg), respectively. Molecular modeling studies
showed hydrogen bonding interaction between 15 and Thr56 residues at the binding site of GABA
.
Superposition, flexible alignment and surface mapping of 15, 20 and diazepam supports their biological
resemblance where ADMET study suggested that those compounds could be used as oral anticonvulsants
An Adaptive Framework for Applying Cloud Computing In Virtual Learning Environment at Education a Case Study of “AASTMT”
No full textThis study aims to provide a Cloud Computing (CC) proposed framework using Application programming interface (API’s) to deliver connectivity and interaction of Software as a Service (SaaS) in Virtual Learning Environment (VLE) system at higher education institute. The framework is adopted and implemented to enhance the existing VLE to meet the incremental increasing of users’ needs and expectations. Different research's methodologies and techniques are used to measure the students and instructors satisfaction, and to measure the impact of the adoption of CC on business value for VLE as well. In addition, the study identifies and explores the idea of covering the gap between the advance of adopting CC as a new technology and the benefits of implementing cloud techniques in education. The findings of implementing the adopted framework equate the study expectations, where the user’s satisfaction significantly increased compared with the existing system. The users found that the system performance and response to their tasks are improved. Meanwhile, the users found that the new adopted system make it easier for them to achieve their academic activities and goals.© 2015 The Authors. Published by Elsevier B.V.Peer-review under responsibility of Universal Society for Applied Research
Stability-indicating methods for the determination ofgemifloxacin in presence of its acid degradation product(s)
No full textBrilliant, valid and simple five UV spectrophotometricstability indicating techniques are adopted for the determination of Gemifloxacin (GEM) in presence of its acid degradation products over a concentration range of 2-12 μg mL . The first method is an application of the first derivative ( 1 D) spectrophotometry, that allows the determination of GEM without interference of its acid degradation products at zero crossing wavelength (254.6 nm). The second method depends on the first-derivative of the ratio spectra spectrophotometry ( 1 DD) for determination of GEM in presence of its acid degradation products at a maximum of 273.0 nm and a minimum of 284.0 nm, While the third dual wavelength method offers a superior stability indicating procedures for the determination of GEM in the zero order spectra at the wavelength pair of 271.8 nm and 325.0 nm. The fourth method is the ratio difference one, with the advantages of minimal data processing and wide range of application. It is applied for the analysis of intact drug in presence of its acid degradation products by measuring the difference in the peak amplitude at the ratio spectra at 355.0 nm and 270.0 nm. The last method is based on the quantification of GEM through the bivariate calibration at 255.0 nm and 277.0 nm by adopting simple mathematic algorithm that provides simplicity and rapidity
Elementary mechanics using Matlab : a modern course combining analytical and numerical techniques / Anders Malthe-S©ırenssen.
No full textIncludes index.engineering bookfair20161 online resource (xiii, 590 pages) :This book - specifically developed as a novel textbook on elementary classical mechanics - shows how analytical and numerical methods can be seamlessly integrated to solve physics problems. This approach allows students to solve more advanced and applied problems at an earlier stage and equips them to deal with real-world examples well beyond the typical special cases treated in standard textbooks. Another advantage of this approach is that students are brought closer to the way physics is actually discovered and applied, as they are introduced right from the start to a more exploratory way of understanding phenomena and of developing their physical concepts. While not a requirement, it is advantageous for the reader to have some prior knowledge of scientific programming with a scripting-type language. This edition of the book uses Matlab, and a chapter devoted to the basics of scientific programming with Matlab is included. A parallel edition using Python instead of Matlab is also available. Last but not least, each chapter is accompanied by an extensive set of course-tested exercises and solutions
Nuclear thermal hydraulics.
No full textIncludes bibliographical references and index.xliii, 840 pages
A Novel Sensor for Determination of Dexamethasone Disodium Phosphate in Different Pharmaceutical Formulations
No full textA novel electrode was developed for potentiometric determination of dexamethasone sodium phosphate (DSP) using tetraheptyl ammonium bromide (THB) as an anionic exchanger in polyvinyl chloride (PVC) matrix and 2-nitrophenyl octyl ether (2- NPOE) as a plasticizer. Linear responses of 1×10−5 to 1×10−2 M with slope of -26.50±0.39 mV/decade within working pH range 8-12 were achieved. The percentage recovery of determination of DSP by the proposed DSP selective electrode was 99.96±0.95. Determination of DSP in its pharmaceutical formulations by the proposed electrode revealed its applicability for determination. Moreover, the electrode exhibits good selectivity for DSP with respect to a large number of interfering substances and co-formulated drugs. The fabricated sensor was validated according to ICH guidelines and successfully applied for determination of the studied drug in pure form and pharmaceutical formulations without any interference from additives either labeled or non-labeled. The obtained results have been statistically compared to that of an official spectrophotometric method to give a conclusion that there is no significant difference between the proposed methods and the official one with respect to accuracy and precision
Development and validation of LC–MSMS assay for the determination of the prodrug dabigatran etexilate and its active metabolites in human plasma
No full textDabigatran etexilate (DABE) is a low-molecular-weight prodrug that is converted after oral administration
to dabigatran (DAB)—a directly acting oral anticoagulant. In this study, an LC–MSMS assay was
developed and validated for the determination of DABE, free DAB and its equipotent O-glucuronide conjugates
in plasma. Owing to the susceptibility of DABE and DAB to chemical hydrolysis, cleavage of the
O-glucuronide moiety was carried out using -glucuronidase enzyme. Free and total plasma concentrations
of DAB were determined in incurred plasma samples before and after enzymatic cleavage (50 C and 3 h), respectively. RP-HPLC separation was carried out using acetonitrile: water (30:70, v/v), adjusted to pH 3.0 using formic acid. Tandem mass spectrometric detection at positive electrospray ionization in the MRM mode was then employed for the determination of DABE and DAB. The analysis was carried out within 5.0 min over a linear concentration range of 1.00–600.00 ng/mL for the prodrug and its active metabolite. Validation was carried out according to FDA guidelines for bioanalytical method. The recov- eries were higher than 89.48%, the accuracy was within 98.33–110.12% and the RSD was below 10% for the studied compounds in both incurred plasma and quality control samples. Results of incurred sample re-analysis and incurred sample stability revealed less than 10% variability. This indicated good assay precision and sufficient stability of target analytes in their real matrix at the employed experimental conditions. The applicability of the assay for therapeutic drug monitoring and the determination of the pharmacokinetic parameters were demonstrated
Software evolution and maintenance : a practitioner's approach / Priyadarshi Tripathy, Kshirasagar Naik.
No full textcomputer bookfair2016Includes bibliographical references and index.xxii, 393 pages
Properties of materials / P.F. Kelly.
No full textIncludes bibliographical references and index.xvi, 411 pages
Challenges and Proposed Solutions of Coverage Based Testing Tools
No full textAutomated test generation for object-oriented software typically consists of producing sequences of calls aiming at high code coverage. Test coverage is sometimes used as a way to measure how thoroughly software is tested. Coverage is used by software developers and sometimes by vendors to indicate their confidence in the readiness of their software. This survey studies and compares 7 coverage-based testing tools focusing on, but not restricted to coverage measurement. We also survey additional features, including program prioritization for testing, assistance in debugging, automatic generation of test cases, and customization of test reports. Such features make tools more useful and practical, especially for large-scale, real-life commercial software applications. This paper discusses the technical challenges that are testing tools need to address when handling Java classes coming from real-world open source projects, and when producing JUnit test suites intended for real users