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Industrial automated guided vehicle
No full textA manufacturing job spends a small portion of its total flow time being processed on machines, and during the remaining time, either it is in a queue or being transported from one work center to another. In a fully automated material-handling environment, automated guided vehicles (AGV) perform the function of transporting the jobs between workstations, and high operational costs are involved in these material-handling activities. Consequently, the AGV route schedule dictates subsequent work-center scheduling. For an AGV job transportation schedule to be effective, the issue of collisions amongst AGV during travel needs to be addressed. Such collisions cause stalemate situations that potentially disrupt the flow of materials in the job shop, adding to the non-value time of job processing, and thus, increase the material handling and inventory holding costs. The current research goal was to develop a methodology that could effectively and efficiently derive optimal AGV routes for a given set of transportation requests, considering the issue of collisions amongst AGV during travel. As part of work, many safety Sequences was formulated in the capability of optimally predicting the AGV routes for a deterministic set of transportation requests. Collision avoidance constraints were developed in this model the solution approach in the proposedMohamed badra
Therapeutic Potential of Mesenchymal Stem Cells and Vitamin E on Experimental Hepatocellular Carcinoma
No full textPurpose: This study evaluated the influence of human mesenchymal stem cells (h-MSCs) and/or vitamin E (vit E) on experimental hepatocellular carcinoma (HCC). Methods: Eighty five rats were divided into; group 1: twenty rats served as control group and group 2: sixty five rats received Diethyl Nitrosamine (DENA) followed by carbon tetra chloride (CCl4) to induce HCC. Five rats were scarified after 2 months to assess the induction of HCC. The other sixty rats were further subdivided into; group 2: fifteen HCC were untreated rats, group 3: fifteen HCC rats were treated by injection of 107 h-AMSCs, group 4: fifteen HCC rats were treated by vitamin E and group 5: fifteen HCC rats were treated by injection of 107 h-AMSCs and vitamin E. Histological, arginase-1 immunohistochemical examination were assessed and serum albumin and α-fetoprotein were estimated. Results: Histopathological examination of group 2 revealed presence of anaplastic carcinoma, focal nodular hyperplasia. Group 5 showed improvement in histopathological picture relative to group 3 and 4. Positive arginase-1 IHC reaction was observed in group 2 with decrease reactivity in all other groups. Conclusion: Combined treatment with h-AMSCs and vitamin E has tumor suppressive effect with ameliorating HCC histopathological picture and liver function
Nameless Field Bahariya Formation Western Desert of Egypt
No full textThis field is faulted anticline structure located in the western desert. The field produces from different layers mainly shaly sand and sand with different thickness. The main producing formation is Baharyia which will present the main target formationThis study aims to evaluate the hydrocarbon potentiality of this reservoir as oil producer and rank theses reservoir according to their potentialities using the available logging data
Millimeter-wave digitally intensive frequency generation in CMOS / Wanghua Wu, Robert Bogdan Staszewski, John R. Long.
No full textIncludes bibliographical references and index.xi, 188 p.
Inactivation of rabies virus by hydrogen peroxide
No full textDevelopment of safe and protective vaccines against infectious pathogens remains a challenge. Inactivation of rabies virus is a critical step in the production of vaccines and other research reagents. Beta-propiolactone (βPL); the currently used inactivating agent for rabies virus is expensive and proved to be carcinogenic in animals. This study aimed to investigate the ability of hydrogen peroxide (H2O2) to irreversibly inactivate rabies virus without affecting its antigenicity and immunogenicity in pursuit of finding safe, effective and inexpensive alternative inactivating agents. H2O2 3% rapidly inactivated a Vero cell adapted fixed rabies virus strain designated as FRV/K within 2 h of exposure without affecting its antigenicity or immunogenicity. No residual infectious virus was detected and the H2O2-inactivated vaccine proved to be safe and effective when compared with the same virus harvest inactivated with the classical inactivating agent βPL. Mice immunized with H2O2-inactivated rabies virus produced sufficient level of antibodies and were protected when challenged with lethal CVS virus. These findings reinforce the idea that H2O2 can replace βPL as inactivating agent for rabies virus to reduce time and cost of inactivation process
Evaluation and screening of mRNA S100A genes as serological biomarkers in different stages of bladder cancer in Egypt
No full textCalcium-binding proteins S100A are multifunctional proteins that show altered expression in various diseases and cancers. This study aimed at validating an easier and less time-consuming technique to evaluate the value of combined use of messenger RNA (mRNA) S100A genes in comparison and combination with voided urine cytology in detection of bladder cancer patients. Blood and urine specimens were collected from patients (n = 120) with histologically confirmed bladder carcinoma who are classified according to bladder cancer stage into four groups and from healthy volunteers (n = 30). Histopathology examination, bilharzias antibody detection, urine cytology, and mRNA expression of S100A genes were estimated for all subjects by real time polymerase chain reaction (RT-PCR). Results indicate that each of the investigated S100A genes can be used as diagnostic marker for bladder cancer. Both S100A4 and S100A6 can be used to differentiate between different stages of bladder cancer. S100A7 can be used for the diagnosis of squamous cell carcinoma. Both S100A8 and S100A9 can be used for detection of invasive bladder carcinoma while S100A11 can be used for early detection of superficial bladder carcinoma. The overall sensitivity and specificity for the studied S100A genes ranged from 73 to 90 and 84 to 92, respectively. The combined use of urine cytology with the investigated S100A genes increased sensitivity from 56 % up to a range of 87-96 %. In conclusion, serum S100A genes can be useful as potential serological biomarkers for bladder cancer, and combined use of urine cytology with S100A genes can improve the sensitivity for detection of bladder cancer
Novel liquid chromatographic methods for the determination of varenicline tartrate.
No full textTwo simple, sensitive, rapid, and stability-indicating liquid chromatographic (LC) methods have been developed for the determination of varenicline tartrate. They comprised the determination of varenicline (VRC) in the presence of its oxidative degradates and related impurity (N-formyl varenicline) (NFV). The first method was a LC with diode array detection (DAD) at 235 nm using Ristek-Ultra® C18 column (100 mm×2.1 mm, 5 µm). Isocratic elution of VRC was employed using a mobile phase consisting of buffer mixture (1.2% potassium dihydrogen phosphate and 0.08% octane sulphonic acid): acetonitrile (86:14, v/v), pH (5.0). In the second method; a fluorimetric detection technique was developed, based on precolumn derivatization of VRC using 7-chloro-4-nitrobenzo-2-oxa-1, 3-diazole (NBD-Cl). The fluorescence detector (FLD) was operated at 474 nm for excitation and 539 nm for emission. Isocratic elution was applied with a mobile phase consisting of methanol-distilled water (70:30, v/v). Separation was achieved using Symmetry® Waters C18 column (150 mm×4.6 mm, 5 µm). Linearity, accuracy and precision were found to be acceptable over the concentration ranges of 0.5–20.0 µg mL−1 and 0.2–20.0 µg mL−1 with the first and the second method, respectively. The optimized methods were validated and proved to be specific, simple, and accurate for the quality control of the drug in its pharmaceutical preparation
Physical geology / Charles C. Plummer.
No full textIncludes bibliographical references and index.xix, 595 p.
Simultaneous Determination of Metformin, Vildagliptin and 3-amino-1-adamantanol in Human Plasma: Application to Pharmacokinetic Studies
No full textMetformin (MET) and vildagliptin (VLD) are coformulated in tablets for the management of diabetes mellitus. The aim of this study is the development of a new fast ultraperformance liquid chromatography method with tandem mass detection (UPLC–MS/MS) for their simultaneous determination with 3-amino-1-adamantanol (starting compound for vildagliptin synthesis; VLI) in human plasma. Separation of MET, VLD, and VLI was performed on a 5 cm UPLC-C18 column using a mobile phase of 0.5% acetic acid in methanol and 0.02 M aqueous ammonium acetate (10:90, v/v). The injection volume was 10 µL and electrospray positive ionization was applied. Extraction from human plasma was carried out by acid precipitation of plasma proteins using pregabalin as an internal standard. The assay was validated according to ICH guidelines. The developed method is valid, fast, and simple and was successfully applied in pharmacokinetic studies in human volunteers
E-commerce 2015
No full textIncludes bibliographical references and index.908 p. :For undergraduate and graduate courses in business. Understanding The Vast And Expanding Field of E-Commerce Laudon's E-Commerce 2016: Business, Technology, Society emphasizes three driving forces behind the expanding field of e-commerce: technology change, business development, and social issues. A conceptual framework uses the templates of many modern-day companies to further demonstrate the differences and complexities in e-commerce today. An in-depth investigation of companies such as Uber, Pinterest, and Apple kick-off the course while preparing students for real-life scenarios. In the Twelfth Edition, Laudon and Traver add new or update existing case studies to match developments in the e-commerce field as they exist in today's tech world. They built in additional video cases for each chapter, making the material even more accessible to students as they prepare for their future roles in business