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The Influence of Two Instrumentation Techniques with Two Sealers on Post-Operative Pain After Endodontic Treatment "Randomized Clinical Trial"
No full textThis clinical study was conducted to assess the degree of Post-Operative Pain after
Endodontic Treatment done using two different instrumentation techniques with
combination of two different sealers in single visit root canal treatment after 12, 24
and 48 hours utilizing a modified visual analogue scale
PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis
No full textPoly(ADP-ribose) polymerase (PARP) enzyme
contributes to nephropathy, a serious diabetic complication
which may lead to end-stage renal disease. The study aims
to investigate the effect of PARP over-activation on kidney
functions in a type 2 diabetic rat model. The study also tests
the therapeutic use of PARP inhibitors in diabetic nephropathy.
Type 2 diabetes was induced in adult male rats by highfructose/high-fat
diet and low streptozotocin dose. Then, the
PARP inhibitor 4-aminobenzamide (4-AB) was administered
daily for 10 weeks. At the end, urine samples were collected to
measure urine creatinine, albumin, and total proteins. PARP
activity, superoxide dismutase (SOD) activity, and nitrite content
were measured in kidney tissue homogenate. Glucose,
fructosamine, insulin, and tumor necrosis factor-alpha
(TNF-α) were measured in serum. Furthermore, histological
studies, collagen deposition, and immunofluorescence of nuclear
factor kappa B (NFκB) and transforming growth factor
beta1 (TGF-β1) were carried out. PARP enzyme activity was
significantly higher in the diabetic group and was significantly
reduced by 4-AB administration. Diabetic animals had clear
nephropathy indicated by proteinuria and increased albumin
excretion rate (AER) which were significantly decreased by
PARP inhibition. In addition, PARP inhibition increased creatinine
clearance in diabetic animals and reduced renal
TGF-β1 and glomerular fibrosis. Moreover, PARP inhibition
alleviated the elevated serum TNF-α level, renal NFκB, nitrite,
and the decrease in SOD activity in diabetic animals.
However, PARP inhibition did not significantly affect neither
hyperglycemia nor insulin sensitivity. PARP enzyme inhibition
alleviates diabetic nephropathy through decreasing inflammation,
oxidative stress, and renal fibrosi
Data Mining Approach for Detecting Key Performance Indicators
No full textKey performances indicators (KPIs) are an integral part of business intelligence systems as the choice of KPIs
are critical to success. This study aimed to propose a solution to detect KPIs from historical organizational data using data mining
algorithms and analyzes the relation between factors that will affect the performance to help organizations execute their business
strategy. This approach does not involve domain experts to identify or validate KPIs. Materials and Methods: Information gain algorithm
implemented with Weka (InfoGainAttributeEval) used for feature selection to rank the attributes that affect the performance. Moreover,
an improved FP-growth algorithm was used to find the correlation between attributes. Results: The KPIs detection model was tested
using 6 years of banking data. To detect the non-performing loans KPI the model indicates strong correlation between non-performing
loans and attributes such as accounts with low salaries, young clients and accounts with a monthly issuance of statements. Conclusion:
The proposed KPI detection approach can make the process of selecting KPIs more efficient; it can be used as a method to determine the
most appropriate KPIs. This model will enable decision makers to make timely and appropriate strategic decision
Analysis of paracetamol, pseudo-ephedrine andbrompheniramine in comtrex tablets using chemometric methods
No full textParacetamol (PAR), pseudoephedrine hydrochloride (PSE) and brompheniramine maleate (BRM) are co-formulated drugs that are widely used in the Egyptian market for the relief of symptoms
associated with common cold. Their severely overlapped spectra were resolved by two simple, accurate and precise chemometric techniques, principal component regression method (PCR) and partial Least
Squares methods (PLS). The proposed methods were rapid, cost effective and were successfully applied for the analysis of laboratory prepared mixtures and the combined dosage form. Good recoveries
were obtained for PCR method, 100.42, 100.05 and 98.96 % and for PLS method 100.04, 99.95 and 100.36 % for PAR, PSE and BRM, respectively. The methods were validated according to the ICH
guidelines. Comparison of the applied methods with the reported method was done and no significant difference was found regarding accuracy and precision
EFFECT OF REPRESSING AND GLAZING ON COLOR REPRODUCTION, TRANSLUCENCY AND SURFACE ROUGHNESS OF LITHIUM DISILICATE GLASS-CERAMICS
No full textStatement of problem: During heat-pressing of lithium dislilicate glass-ceramics, It is more economical to press several restorations from one ingot at the same time. However, this is often not possible and may result in a considerable amount of leftover material (The sprues and button). It has been reported that the leftover materials after heat-pressing are reused (repressed) in some dental laboratories. Sufficient knowledge about the consequences of such procedure is not available. The issue is thereby raised whether the leftover material should be discarded or reused.
Purpose. The aim of the present study was to evaluate the effect of repressing and glazing on the color reproduction, translucency and surface roughness of lithium dislilicate pressable glass- ceramics (IPS e.max Press). As well as to describe the microstructural features present in pressed, and repressed material using Xray diffraction, EDAX and SE
Intelligent Methodology for Brain Tumors Classification in Magnetic Resonance Images
No full textRecently, a lot of researches have been made in the
area of automatic detection and diagnosing the brain tumor type
based on different medical imaging techniques. This paper presents a
new intelligent methodology applying k-means segmentation
technique and a hybrid support vector machine (SVM) classifier
based on Linear-SVM and Multi-SVM using two feature extraction
techniques, namely : Gray level co-occurrence matrix (GLCM) and
discrete wavelet transform (DWT) followed by Principle component
analysis (PCA) to detect brain tumors in brain magnetic resonance
images (MRIs) and differentiate between three types of malignant
brain tumors: glioblastoma, sarcoma and metastatic bronchogenic
carcinoma. The results of the two feature extraction techniques were
compared according to their accuracy, sensitivity and specificity
showing good results and high robustness
THE EFFECT OF REPEATED HEAT-PRESSING ON THE BIAXIAL FLEXURAL STRENGTH AND SURFACE ROUGHNESS OF LITHIUM DISLILICATE GLASS-CERAMICS
No full textStatement of problem: During heat-pressing of lithium dislilicate glass-ceramics, It is more economical to press several restorations from one ingot at the same time. However, this is often not possible and may result in a considerable amount of leftover material. It has been reported that the leftover materials after heat-pressing are reused in some dental laboratories. Sufficient knowledge about the consequences of such procedure is not available. The issue is thereby raised whether the leftover material should be discarded or reused.Purpose: The aim of the present study was to evaluate the effect of repeated heat-pressing on biaxial flexural strength and surface roughness of lithium dislilicate pressable glass-ceramics (IPS e.max Press). As well as to describe the microstructural features present in fresh-pressed, and repressed material using Xray diffraction, EDAX and SEM Materials and methods: Twenty pressed and repressed samples were prepared following the manufacturers’ recommendations measuring 15 mm × 1 mm per material. Biaxial flexure (piston on 3-ball method) was used to assess strength. X-ray diffraction was performed to identify the crystalline phases, and a scanning electron microscope was used to disclose microstructural features. Also surface roughness was evaluatedResults: BFS for pressed and repressed respectively; (375.8± 4.55) and (389.4±12.12) MPa; no significant difference was found between the Pressed and Repressed groups. Surface roughness for pressed glazed and unglazed respectively (0.27±0.05, and 1.14±0.16) – for repressed glazed and unglazed respectively (0.21±0.06 and 1.33±0.20) - for both groups, significant difference was found between Glazed and Un-Glazed ceramics. No statistical significant difference was found between Pressed and Repressed groups. Xray diffraction revealed the material is predominantly crystalline structure; lithium disilicate was identified to be the main crystalline phase, peaks after pressing and repeating pressing are similar, the crystalline phase assemblage did not change; however their radiation intensities (height) has, the dominant peak (highest peak) for the represse
Stem cells research is a wide world challenge
No full textStem cells research is becoming a very interesting field for investigation and experimental studies. Although, scientists from all over the world started studying and investigating stem cells more than 30 years ago, scientists in Egypt started their research in this field not before the year 2000. My first research was about using stem cells in bone remodeling after making bone defect in mandible. My second research was about using stem cells in healing of soft tissue ulcer. In both researches, dogs were used as animal model. I was very interested to explore the efficacy of stem cells in treatment and repairing of different body organs, that’s why I decided to orient my research towards the body organs and the using of stem cells as treatment of defected or diseased organs
The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells
No full textBackground. Glufosfamide (GLU) is a glucose conjugate of ifosfamide in which isophosphoramide mustard is glycosidically linked to the β-D-glucose molecule. Based on GLU structure, it is considered a targeted chemotherapy with fewer side effects. The main objective of the current study is to assess the cytotoxic potential of GLU for the first time in prostate cancer (PC) cells representing different stages of the tumor. Furthermore, this study examined the potential synergistic activity of GLU in combination with docetaxel (DOC).
Methods. Two different cell lines were used, LNCaP and PC-3. Concentration-response curves were assessed. The tested groups per cell line were, control, GLU, DOC and combination. Treatment duration was 72 h. Cytotoxicity was assessed using sulforhodamine B (SRB) assay and half maximal inhibitory concentration (IC50) was calculated. Synergy analyses were performed using Calcusyn®software. Subsequent mechanistic studies included β-glucosidase activity assay, glucose uptake and apoptosis studies, namely annexin V-FITC assay and the protein expression of mitochondrial pathway signals including Bcl-2, Bax, Caspase 9 and 3 were assessed. Data are presented as mean ± SD; comparisons were carried out using one way analysis of variance (ANOVA) followed by Tukey-Kramer’s test for post hoc analysis.
Results. GLU induced cytotoxicity in both cell lines in a concentration-dependent manner. The IC50 in PC-3 cells was significantly lower by 19% when compared to that of LNCaP cells. The IC50 of combining both drugs showed comparable effect to DOC in PC-3 but was tremendously lowered by 49% compared to the same group in LNCaP cell line. β-glucosidase activity was higher in LNCaP by about 67% compared to that determined in PC-3 cells while the glucose uptake in PC-3 cells was almost 2 folds that found in LNCaP cells. These results were directly correlated to the efficacy of GLU in each cell line. Treatment of PC cells with GLU as single agent or in combination with DOC induced significantly higher apoptosis as evidenced by Annexin V-staining. Apoptosis was significantly increased in combination group by 4.9 folds and by 2.1 Folds when compared to control in LNCaP cells and PC-3 cells; respectively. Similarly, the expression of Bcl-2 was significantly decreased while Bax, caspase 9 and 3 were significantly increased in the combined treatment groups compared to the control.
Conclusion. GLU has a synergistic effect in combination with DOC as it increases the cell kill which can be attributed at least partially to apoptosis in both the tested cell lines and it is suggested as a new combination regimen to be considered in the treatment of the prostate cancer. Further experiments and clinical investigations are needed for assessment of that regimen
Development of a hovercraft
No full textThis thesis presents a complete study of that are covering Hovercraft concept are presented. A mechanical parts of Hovercraft is through different materials used to build Hovercraft st methodology is developed and applied through micro controller movement through various types of sensors and is established between Hovercraft and PC to control its program developed through a Lab-view program. concepts provided through the thesis chapters. As electing the structure is discussed also. A control actuators. A wireless communication motion through a user interfacefoda , salah
Adbellatif , mohame