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Proniosomes as Nano-Carrier for Transdermal Delivery of Atenolol Niosomal Gel
No full textAvailable online on www.ijddt.com
International Journal of Drug Delivery Technology 2017; 7(4); 283-297Objective of the study is to prepare Proniosomes that refers to a flexible vesicular carrier with the potential for drug administration through the transdermal route. Medthod: Proniosomes were prepared by the coacevation-phase separation technique The prepared formulations were evaluated for vesicle size, entrapment efficiency. The optimal poniosomes formula (A8) was prepared with different aqueous phase, incorporated in a gel base and studied for pH, viscosity, spredapility, stability, in vitro drug release and ex vivo permeation. Results: Niosomes formulations prepared with Span 40 and 60 have spherical and smaller Nano size. 25 mg atenolol loading has resulted 190.9 ± 15.033 nm sizes. EE% of the optimum formula prepared with distilled water was 62.11 to 92.38 .Rheological behavior showed combined shear thinning and thixotropic and gel was spreadable . Tested formulations were stable on cooling (4-8 oC) . In vitro drug release followed zero order kinetic, and gave sustained release. Release rate was significantly higher across cellulose membrane compared with rate skin. Amount of drug obtained after skin extraction was 92.6 ± 0.5% indicate enhanced permeation rate. Conclusion: All the proniosomal gel formulations were found through the acceptable range of vascular size and entrapment efficiency. Formulation A8 has been selected as an optimized therapeutic system of atenolol
Future Journal of Pharmaceutical Sciences
No full textFuture Journal of Pharmaceutical Sciences issued under the auspicious of Future University in Egypt. The Journal publishes communications, original research articles, review articles and case studies on all aspects of the pharmaceutical sciences and related clinical subjects that are of interest to all health professionals with strong emphasis on originality and scientific quality. Specifically, the journal publishes original researches in all fields that interest Pharmacists as drug absorption & metabolism, pharmacokinetics & dynamics, drug delivery including gene delivery, drug targeting and nano-technology, Pharmacotherapeutics, community and hospital pharmacy as well as Pharmaceutical and hospital management. The scope will also cover researches in toxicology, cell and molecular biology, biomedical research, basic & clinical and pharmaceutical microbiology, Pharmaceutical biotechnology, medicinal chemistry, Phytochemistry and nutraceuticals.Proceedings of scientific meetings may be published as special issues or supplements to the Journal. Manuscripts submitted to the Journal are only accepted on the understanding that: they are subject to editorial review (generally by two independent referees); they have not been, and will not be, published in whole or in part in any other journal
Acyclovir Loaded Solid Lipid Nanoparticle Based Cream: A Novel Drug Delivery System
No full textObjective of the present investigation was enthused by the possibility to develop solid lipid nanoparticles (SLNs) of
hydrophilic drug acyclovir. Also study vitro and vivo drug delivery. Methods: Drug loaded SLNs (ACV-SLNs) were
prepared by high pressure homogenization of aqueous surfactant solutions containing the drug-loaded lipids in the melted
or in the solid state with formula optimization study (Different lipid concentration, drug loaded, homogenization / stirring
speed and compritol 888ATO: drug ratio). ACV - SLN incorporated in cream base. The pH was evaluated and rheological
study. Drug release was evaluated and compared with simple cream- drug, ACV – SLN with compritol 888ATO and
marketed cream. The potential of SLN as the carrier for dermal delivery was studied. Results: Particle size analysis of
SLNs prove small, smooth, spherical shape particle ranged from 150 to 200 nm for unloaded and from 330 to 444 nm for
ACV loaded particles. The EE% for optimal formula is 72% with suitable pH for skin application. Rheological behavior is
shear thinning and thixotropic. Release study proved controlled drug release for SLNs especially in formula containing
compritol88 ATO. Stability study emphasized an insignificant change in SLNs properties over 6 month. In-vivo study
showed significantly higher accumulation of ACV in stratum corneum, dermal layer, and receptor compartment compared
with blank skin. Conclusion: AVC-loaded SLNs might be beneficial in controlling drug release, stable and improving
dermal delivery of antiviral agent(s)
Isolation, Characterization and Bioactivities of an Extracellular Polysaccharide Produced from Streptomyces sp. MOE6.
No full textA Streptomyces strain was isolated from soil and the sequence of 1471 nucleotides of its 16S rDNA showed 99% identity to Streptomyces sp. HV10. This newly isolated Streptomyces strain produced an extracellular polysaccharide (EPS) composed mainly of glucose and mannose in a ratio of 1:4.1, as was characterized by Fourier transform infrared spectroscopy (FTIR), HPLC and ¹H-NMR. The antioxidant activities of the partially purified MOE6-EPS were determined by measuring the hydroxyl free radical scavenging activity and the scavenging of 2,2-diphenyl-2-picryl-hydrazyl (DPPH) radicals. In addition, the partially purified MOE6-EPS showed high ferrous ion (Fe2+) chelation activity which is another antioxidant activity. Interestingly, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays that were colorimetric assays for NAD(P)H-dependent cellular oxidoreductases and a proxy of the number of viable cells, showed that the partially purified MOE6-EPS inhibited the proliferation of the human breast cancer cells (MDA-MB-231). The scratch wound assay showed that MOE6-EPS reduced the migration of mouse breast cancer cells (4T1). This study reports the production of EPS from Streptomyces species with promising antioxidant, metal chelating and mammalian cell inhibitory activities
E-COMMERCE AGENTS AND ONLINE NEGOTIATION PROCESS
No full textE-commerce agents have become more powerful tools for
buying, selling and searching for products through the intemet.
Significantly, making use of these computer agents reduces the
time users spend on trading. E-commerce agents should have the
ability to negotiate with each other and search the internet for
new products. Negotiation has become very interesting research
issue. Therefore, this paper introduces an implementation of a
formal model for E-commerce agent negotiation. The negotiation
model takes into consideration parameters and utility functions to
evaluate the transaction after each negotiation state
Olmesartan Medoxomil-Loaded Self-Nanoemulsifying Drug Delivery Systems: Design, In-Vitro Characterization, and Pharmacokinetic Assessments in Rabbits Via LC-MS/MS
No full textOlmesartan medoxomil (OLM) is a lipophilic (log P = 4.31) antihypertensive drug suffering from limited oral bioavailability in humans (26%) due to its low aqueous solubility, uncontrolled enzymatic conversion to the active metabolite (olmesartan; OL) and efflux by drug resistance pumps. Surmounting such limitations via incorporation of OLM into self-nanoemulsifying drug delivery systems (SNEDDS). Based on OLM-equilibrium solubility studies in various oils, surfactants and co-surfactants, Capmul® MCM, Tween® 20, Cremophor® EL and polyethylene glycol-400 (PEG) were combined in different ratios to plot ternary phase diagrams. OLM-loaded SENDDS were developed and evaluated for particle size, polydispersity index (PDI), zeta potential, self-emulsification time, morphology, drug released percentages after 5-min (Q5min%), 1-hour (Q1h%) and dissolution efficiency percentages (DE1h%). The OL pharmacokinetics from SNEDDS (F6) and Benicar® tablets were evaluated (LC-MS/MS) in rabbits. Spherical OLM-loaded SNEDDS were developed. The best-achieved SNEDDS (F6) showed short emulsification time (13 s), fine droplet size (60.00 nm), low PDI (0.25), negative zeta potential (-14.4 mV), promising dissolution parameters; Q5min% (29.78%), Q1h% (66.69%) and DE1h%(47.96%) and enhanced in vivo absorption characteristics; shorter Tmax, higher Cmax and larger AUC(0−48h; suggesting its potential for the enhancement of the oral absorption of practically insoluble drugs; like OLM
Comparison of classification techniques applied for network intrusion detection and classification
No full textJournal of Applied Logic
Volume 24, Part A, November 2017, Pages 109-118a previous research, a multi-agent artificial immune system for network intrusion detection and classification was proposed and tested, where a multi-layer detection and classification process was executed on each agent, for each host in the network. In this paper, we show the experiments that were held to chose the appropriate classifiers by testing different classifiers and comparing them to increase the detection accuracy and obtain more information on the detected anomalies. It will be shown that no single classifier should be used for all types of attacks, due to different classification rates obtained. This is due to attacks representations in the train set and dependency between features used to detect them. It will also be shown that a basic and simple classifier such as Naive Bayes has better classification results in the case of low-represented attacks, and the basic decision trees such as Naive-Bayes Tree and Best-First Tree give very good results compared to well-known J48 (Weka implementation of C4.5) and Random Forest decision trees. Based on these experiments and their results, Naive Bayes and Best-First tree classifiers were selected to classify the anomaly-detected traffic. It was shown that in the detection phase, 90% of anomalies were detected, and in the classification phase, 88% of false positives were successfully labeled as normal traffic connections, and 79% of DoS and Probe attacks were labeled correctly, mostly by NB, NBTree, and BFTree classifiers
Reflections on Workplace Compassion and Job Performance
No full textJournal of Human Values 23(3) 234–243 © 2017 Management Centre
for Human Values SAGE Publications sagepub.in/home.nav DOI: 10.1177/0971685817713285Workplace compassion is one of the cornerstone remedies to employees’ suffering. Compassionate acts will directly affect the job performance of employees. This research study looks at the analysing relationship between workplace compassion and job performance, namely, task performance and contextual performance. Workplace compassion, task performance and contextual performance were explored from a previous literature perspective and were tested and analysed statistically. Self-administered questionnaires were distributed among teachers and co-teachers employed in international nurseries in Cairo and Giza governorates located in Egypt. Results revealed a positive relationship between workplace compassion and job performance (task and contextual constructs). Discussion of the results along with managerial implications and recommendations were addressed based on the research findings
Validity and reliability of three-dimensional palatal superimposition of digital dental models
No full textObjective: To evaluate the validity and reliability of three-dimensional (3D) landmark-based palatal superimposition of digital dental models using Ortho Mechanics Sequential Analyzer (OMSA). Methods: The sample consisted of pre- and post-treatment digital maxillary dental models of 20 orthodontic cases. For each case, the pre- and post-treatment digital models were superimposed using surface-based methods utilizing 3dMD Vultus and Invivo 5 software as well as a landmark- based method utilizing OMSA.
The same set of parameters were measured on the superimposed 3D data by the three softwares for comparison. Agreement in the superimposition outcomes among the three superimposition methods was evaluated with intraclass correlation coefficients (ICCs), Bland-Altman plots, and repeated measures ANOVA. A P value of ≤ 0.05 was considered statistically significant.Results: Repeatability was acceptable for all methods based on the ICCs. Agreement as measured by the ICCs and repeated measures ANOVA was high among the three methods.Conclusion: The results indicate that OMSA offers a valid and reliable tool for 3D landmark- based digital dental models superimposition using 3 points marked along the midpalatal raphe as reference
A Complete Study on Nameless Field AEB-3D
No full textPetroleum Engineering ls an engineering discipline that not only concerned of production of hydrocarbon but also related to many other disciplines such as Petroleum Geology, Drilling System, Reservoir and Formation Evaluation Development Plan and Economic study
This report is talking about evaluation and a profitable development study of a nameless field in Western desert in Egypt with several drilled wells. The major problem that was encountered through the project that the natural energy of the reservoir not be sufficient to lift the hydrocarbon and it lead to decrease recovery factor. To solve this problem we choose the Water Flooding as a development plan by converting existing wells from producers to injectors. Finally this development make increasing in recovery factorSupervision
Dr. Ismail Mahgoub
Dr. Khaled Abd-Elfattah
Dr. Ibrahim El-Dessoki
Dr. El-saied Eissa
Dr. Moataz El-Shafe