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PLGA Nanoparticles as Subconjunctival Injection for Management of Glaucoma
No full textNanoparticles fabricated from the biodegradable and biocompatible polymer,
polylactic-co-glycolic acid (PLGA), could be a promising system for targeting ocular drug
delivery. The objective of this work was to investigate the possibility of encapsulating
brinzolamide in PLGA nanoparticles in order to be applied as a subconjunctival injection
that could represent a starting point for developing new therapeutic strategies against
increase in ocular pressure. The brinzolamide-loaded PLGA nanoparticles were fabricated
using emulsion-diffusion-evaporation method with varying concentrations of Tween 80 or
poloxamer 188 (Plx) in aqueous and organic phases. The nanoparticles were characterized in
terms of particle size and size distribution, entrapment efficiency and in-vitro drug release
pattern as well as DSC and X-ray analysis. Nanoparticles prepared using Tween 80 in the
aqueous phase showed higher encapsulation efficiency and smaller particle size-values
compared to those prepared using Plx. Furthermore, the addition of Plx 188 or Brij 97 to the
organic phase in the formulation containing Tween 80 in the aqueous phase led to an increase
in the particle diameter-values of the obtained nanoparticles. The nanoparticles had the
capacity to release the brinzolamide in a biphasic release profile. The nanoparticles were
spherical in shape and the drug was entraped in the nanoparticles in an amorphous form.
Selected nanoparticles, injected subconjunctivally in normotensive Albino rabbits, were able
to reduce the IOP for up to 10 days. Nanoparticles loaded with brinzolamide with lower
particle size were able to reduce the IOP for longer period compared to those with higher
particle size. Histopathological studies for the anterior cross sections of the rabbits’ eyes
revealed that the tested nanoparticles were compatible with the ocular tissue. The overall
results support that PLGA nanoparticles, applied as subconjunctival injection, can be
considered as a promising carrier for ocular brinzolamide delivery with targeting delivery of
the drug to the eye tissues
Effect of the various types of reinforcement particles on the mechanical and physical properties of pure copper and copper-nickel alloy
No full textThis thesis studies the physical and mechanical properties of pure copper powder and Copper-Nickel Alloy with various reinforcement materials at different volume fraction. . The used reinforcements materials are multi wall carbon nanotubes CNT (0.5-2 wt. %) as nano particles, aluminium oxide (Al2O3) (1-4 wt. %) and Silicon Carbide (SiC) (1-4 wt. %) as micro particles. Many of testes are applied on the obtained specimens such as microstructures, density, relative density, electrical conductivity, thermal conductivity, hardness, and compression stress tests to investigate the suitable reinforcement percentage that will achieve the best physical and mechanical properties.Faculty of engineering, cairo university mm
A study of the allosteric inhibition of HCV RNA-dependent RNA polymerase and implementing virtual screening for the selection of promising dual-site inhibitors with low resistance potential
No full textJournal of Receptors and Signal Transduction Volume 37, 2017 - Issue 4Structure-based pharmacophores were generated and validated using the bioactive conformations of different co-crystallized enzyme-inhibitor complexes for allosteric palm-1 and thumb-2 inhibitors of NS5B. Two pharmacophore models were obtained, one for palm-1 inhibitors with sensitivity = 0.929 and specificity = 0.983, and the other for thumb-2 inhibitors with sensitivity = 1 and specificity = 0.979. In addition, a quantitative structure activity relationship (QSAR) models were developed based on using the values of different scoring functions as descriptors predicting the activity on both allosteric binding sites (palm-1 and thumb-2). QSAR studies revealed good predictive and statistically significant two descriptor models (r2 = .837, r2adjusted = .792 and r2prediction = .688 for palm-1 model and r2 = .927, r2adjusted = .908 and r2prediction = .779 for thumb-2 model). External validation for the QSAR models assured their prediction power with r2ext = .72 and .89 for palm-1 and thumb-2, respectively. Different docking protocols were examined for their validity to predict the correct binding poses of inhibitors inside their respective binding sites. Virtual screening was carried out on ZINC database using the generated pharmacophores, the selected valid docking algorithms and QSAR models to find compounds that could theoretically bind to both sites simultaneousl
Construction management Graduation Project
No full textProject management is the discipline of carefully projecting or planning, organizing, motivating and controlling resources to achieve specific goals Project scope: is the part of project planning that involves determining and documenting a list of specific project goals deliverable, tasks, costs and deadlines
Advising Approach to Enhance Students' Performance Level in Higher Education Environments
No full textIntended Learning Outcomes (ILOs) is a major new approach to
enhance students' performance level at any higher education institution.
Moreover, it supports decision making based on the extracted information.
It works as a framework for continuous improvement and evaluation in
higher education environments. This study intends to achieve many benefits
including; minimize wastages education through selecting the appropriate
decision for students to increase education values. Additionally, the study
presents the Proposed Advising Approach to support students during the
course registration process. The study is applied in the faculty of
Commerce and Business Administration, Business Information System
program (BIS) at Helwan University, Egypt. The experimental results have
shown that the students who used the proposed advising approach have the
highest percentage of the score from pre-test to post- test
Validity and reliability of three-dimensional palatal superimposition of digital dental models
No full textObjective: To evaluate the validity and reliability of three-dimensional (3D) landmark-based palatal superimposition of digital dental models using Ortho Mechanics Sequential Analyzer (OMSA). Methods: The sample consisted of pre- and post-treatment digital maxillary dental models of 20 orthodontic cases. For each case, the pre- and post-treatment digital models were superimposed using surface-based methods utilizing 3dMD Vultus and Invivo 5 software as well as a landmark- based method utilizing OMSA. The same set of parameters were measured on the superimposed 3D data by the three softwares for comparison. Agreement in the superimposition outcomes among the three superimposition methods was evaluated with intraclass correlation coefficients (ICCs), Bland-Altman plots, and repeated measures ANOVA. A P value of ≤ 0.05 was considered statistically significant.Results: Repeatability was acceptable for all methods based on the ICCs. Agreement as measured by the ICCs and repeated measures ANOVA was high among the three methods.Conclusion: The results indicate that OMSA offers a valid and reliable tool for 3D landmark- based digital dental models superimposition using 3 points marked along the midpalatal raphe as reference
Nile Corniche Towers
No full textConstruction of the exclusive development. The 200,000 m2 hospitality and hotel- serviced residential complex debuts the global St. Regis brand to Africa. It encompasses two towers and a retail atrium with sweeping views of the River Nile. The Cairo Nile Corniche Towers include luxurious residential apartments and penthouses, serviced apartments, offices, retail units, restaurants, and a five-star hotel. Towering as high as 38 floors, St. Regis contains 226 furnished rooms suites, 98 serviced apartments, 16 luxurious serviced apartments, 102 luxurious hotel- serviced apartments, and a penthouse. Other amenities offered include more than 8,000 ft2 of meeting and conference spaces, a business center, retail units, four restaurants, a lounge, an outdoor pool, a luxury spa, a fitness center, and an 800-slo underground parking area. In a prime location along the banks of the Nile on Nile Corniche Street in Cairo city Centre, construction of a building is currently underway that will eventually reach a height of 136 m. The complex will include a five star St. Regis Hotel as well as exclusive apartments and offices. The project investor is the globally operating Qatari Diar Real Estate Investment Company , which is a 100 % subsidiary of the state - owned QIA ( Qatar Investment Authority). The QIA from Doha, Qatar is primarily active in the international investment business The Podium building will be our model for developing the WBS as follow
Fuzzy Control of a Large Crane Structure
No full textThe usage of tower cranes, one type of rotary cranes, is common in many industrial structures,
e.g., shipyards, factories, etc. With the size of these cranes becoming larger and the motion expected to
be faster and has no prescribed path, their manual operation becomes difficult and hence, automatic
closed-loop control schemes are very important in the operation of rotary crane. In this paper, the plant of
concern is a tower crane consists of a rotatable jib that carries a trolley which is capable of traveling over
the length of the jib. There is a pendulum-like end line attached to the trolley through a cable of variable
length. A fuzzy logic controller with various types of membership functions is implemented for controlling
the position of the trolley and damping the load oscillations. It consists of two main types of controllers
radial and rotational each of two fuzzy inference engines (FIEs). The radial controller is used to control the
trolley position and the rotational is used for damping the load oscillations. Computer simulations are used
to verify the performance of the controller. The results from the simulations show the effectiveness of the
method in the control of tower crane keeping load swings small at the end of motion
The anorectic agent, lorcaserin, disturbs estrous cyclicity and produces endometrial hyperplasia without affecting ovarian population in female rats
No full textAims: The present study aims to investigate the effect of the new anorectic agent, lorcaserin, on estrous cyclicity, reproductive hormones and folliculogenesis in female mature rats. Materials and methods: Rats were divided into four groups; Group i: control group. Group ii-iv: rats treated with lorcaserin (5, 10 or 30 mg/kg/day, p.o.), respectively. The treatment continued for 28 days. Key findings: Lorcaserin (5 or 10 mg/kg) caused estrous cycle disturbance in 40% of treated rats while the high dose (30 mg/kg) produced disturbances in 100% of the treated rats. Lorcaserin (5–30 mg/kg) altered some of female hormones where it enhanced estradiol but reduced luteinizing hormone. Minimal edema with congested vessels was observed in the medulla of ovarian sections. Further, epithelial and uterine sections showed hyperplasia. Significance: Taken together, the present results demonstrated that lorcaserin affected some reproductive hormones, disturbed estrous cyclicity and induced histopathological changes in the ovaries and uteri without affecting the ovarian populations. Therefore, lorcaserin should be used with caution in women of child bearing potential until adequate clinical safety data are available
Adaptive Per-spatial Stream Power Allocation Algorithms for Single-User MIMO-OFDM Systems
No full textWireless Personal Communications · November 2017 This paper presents adaptive per-spatial stream power allocation algorithms for Single User Multiple-Input Multiple-Output Orthogonal Frequency Division Multiplexing (SU MIMO-OFDM) systems. Three efficient and low-complexity Greedy Power Allocation (GPA) algorithms are proposed to maximize the throughput and spectral efficiency of the SU MIMO-OFDM systems. Firstly, the low-complexity pre-coded GPA algorithms are developed for the MIMO systems. The spatial sub-channels are created by applying the so-called Singular Value Decomposition (SVD) technique on the MIMO channel matrix, and then the Pre-GPA algorithms are applied to exploit the multi-path and spatial diversities. Secondly, the spatial and frequency diversities are exploited by adaptively allocating the system sub-carriers to the spatial sub-channels followed by Per-Spatial GPA (PSGPA). Finally, spatial multiplexing-based GPA algorithms are proposed to optimize the spectral efficiency of the SU MIMO-OFDM system. An optimal two-dimensional Spatial-Frequency GPA (SFGPA) algorithm is proposed to efficiently improve the average system spectral efficiency. The high computational complexity of the optimal SFGPA solution is simplified by proposing a low-complexity Per-Spatial GPA with Excess Power Moving down (PSGPA-EPMd) algorithm, which moves the per-spatial excess power downwards to enhance the spectral efficiency of the spatial multiplexing-based SU MIMO-OFDM systems. The proposed algorithms achieve better spectral efficiency and maximize the throughput in comparison with conventional algorithms