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共生社会創造を志向した前期中等歴史教育カリキュラム開発研究 : 「寛容」の機能と効果に着目した段階的な授業実践と分析を通して
Get PDF新潟大学Niigata University博士（教育学）新大院博(教)第38
オゾンウルトラファインバブル水は口腔および上気道の病原細菌に殺菌作用を示し，汚染された医療用品を消毒する
Get PDF新潟大学Niigata University博士（歯学）Takizawa F, Domon H, Hiyoshi T, Tamura H, Shimizu K, Maekawa T, et al. (2023) Ozone ultrafine bubble water exhibits bactericidal activity against pathogenic bacteria in the oral cavity and upper airway and disinfects contaminated healthcare equipment. PLoS ONE 18(4): e0284115. https://doi.org/10.1371/journal.pone.0284115新大院博(歯)第583
多血小板血漿由来細胞外小胞がマウスの肝硬変を改善する
Get PDF新潟大学Niigata University博士（医学）"Introduction: Cirrhosis remains a significant clinical challenge due to its poor prognosis and limited treatment options, creating a high unmet medical need for the development of novel therapies. In this study, we analyzed the effects of a novel approach to treat cirrhosis using platelet-rich plasma-derived extracellular vesicles (PRPEV) in mice.
Methods: PRPEV were collected from platelet-rich plasma using ultrafiltration, and their proteomes were analyzed. The carbon tetrachloride (CCl4)-induced cirrhosis model of mice was used to evaluate the effect of PRPEV administration and compared with the control group (n ¼ 8). In vitro and in vivo mechanistic analyses of PRPEV administration were confirmed using real time-PCR and immunostaining.
Results: Gene ontology analysis based on the proteome revealed that PRPEV contain many factors associated with EV and immune responses. In vitro, PRPEV polarize macrophages into an antiinflammatory phenotype. Following PRPEV administration, there was a decrease in serum alanine aminotransferase levels and reduction in liver fibrosis, while mRNA levels of regenerative factors were upregulated and transforming growth factor b-1 was downregulated. Furthermore, the number of antiinflammatory macrophages in the liver increased.
Conclusions: PRPEV may contribute to hepatocyte proliferation, anti-inflammation, and anti-fibrogenesis in the liver. This novel concept paves the way for cirrhosis treatment.""Yuichirou Maeda, Yusuke Watanabe, Natsuki Ishikawa, Tomoaki Yoshida, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai,
Platelet-rich plasma-derived extracellular vesicles improve liver cirrhosis in mice,
Regenerative Therapy,
Volume 26,
2024,
Pages 1048-1057,
ISSN 2352-3204,
https://doi.org/10.1016/j.reth.2024.10.010.
(https://www.sciencedirect.com/science/article/pii/S2352320424001883)"新大院博(医)第1236
胸椎後縦靭帯骨化症に対する後方除圧固定術後の骨化巣の三次元的形態変化
Get PDF新潟大学Niigata University博士（医学）Background
Using three-dimensional image analysis, we previously reported suppression of ossification progression following posterior fusion surgery for cervical ossification of the posterior longitudinal ligament (OPLL). Here, we aimed to evaluate the morphological changes in thoracic OPLL using three-dimensional analysis.
Methods
Seventeen patients (eight males and nine females; mean age, 56.9 years) who underwent posterior decompression and fusion (PDF) for thoracic OPLL were included. We evaluated the OPLL volume using a novel analysis involving creating a three-dimensional model from computed tomography images to measure the volume accurately. Additionally, OPLL thickness, width, and length were measured on sagittal and axial computed tomography planes. We investigated the morphological changes in OPLL after PDF. Furthermore, patients were classified into reduced volume and increased volume groups and associated factors were compared.
Results
The mean OPLL volume was 1,677 mm3 preoperatively and 1,705 mm3 at the final examination and did not significantly differ. Volume reduction was observed in 7 of 17 cases (41 %). Although OPLL width and length significantly increased postoperatively, OPLL thickness significantly reduced from 7.1 mm preoperatively to 6.5 mm postoperatively (all, p < 0.05). The annual thickness changes significantly differed (p <0.05) in the reduced volume group (−0.36 mm/year) compared to that in the increased volume group (−0.06 mm/year).
Conclusions
Thoracic OPLL after PDF becomes thinner in the anteroposterior direction but increases horizontally and craniocaudally. The reduction in OPLL thickness was related to a reduction in ossification volume. We believe that volume reduction in thoracic OPLL is influenced by pulsation of the dural sac.Yohei Shibuya, Keiichi Katsumi, Kei Watanabe, Masayuki Ohashi, Toru Hirano, Tomohiro Izumi, Hiroyuki Kawashima,
Three-dimensional morphological changes in ossification of the posterior longitudinal ligament of the thoracic spine following posterior decompression and fusion surgery,
Journal of Clinical Neuroscience,
Volume 127,
2024,
110764,
ISSN 0967-5868,
https://doi.org/10.1016/j.jocn.2024.110764.
(https://www.sciencedirect.com/science/article/pii/S0967586824002911)新大院博(医)第1252
