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Le Quatuor à cordes se met en quatre pour nous faire aimer la musique : 3. Ludwig Van Beethoven. Le Quatuor N°16 : Muss es sein, es Musssein
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A2M (alpha-2-macroglobulin)
Get PDFAlpha-2-Macroglobulin (A2M) was first recognized as a broad-spectrum protease inhibitor and is a pan-proteinase inhibitor that can mechanistically inhibit all proteinase families. It plays an important role in the clearance of proteinases from circulation, regulation of fibrinolysis, coagulation and complement activation. A2M is also known to act as a transport/carrier protein. In general, A2M is produced by the liver as an acute-phase protein during stress conditions and then secreted into the blood and extracellular environments where it functions. It is also locally produced by macrophages, fibroblasts, and epithelial cells. A2M gene mutations play a role in the pathogenesis of diseases such as Alzheimer's disease, parkinson's disease, and prostate cance
ALDH1A1 (Aldehyde Dehydrogenase 1 family member A1)
Get PDFAldehyde dehydrogenase 1A1 (ALDH1A1) is a member of the ALDH gene superfamily. Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endogenous) through NAD(P)+-dependent oxidation to their corresponding carboxylic acids or CoA esters. Different biological functions have been attributed to the different ALDH family members. The cytosolic enzyme ALDH1A1 is involved in the catalysis of retinol (vitamin A) metabolite retinaldehyde to retinoic acid (RA). RA acts as a ligand for the nuclear receptors retinoic receptor (RAR) and the retinoid X receptor (RXR) and therefore regulates the transcriptional activity of genes involved in multiple important processes including proliferation, differentiation, and apoptosis
t(2;11)(p23;q12.3) EEF1G/ALK
Get PDFReview on the translocation t(2;11)(p23;q12.3) EEF1G/ALK involving EEF1G (alias, eukaryotic translation elongation factor 1 gamma) gene and ALK (alias, anaplastic lymphoma kinase) gene. The novel fusion gene and correspondent chimeric protein were observed in pediatric anaplastic large cell lymphoma (ALCL) patients. EEF1G/ALK translocation carries an unfavorable prognosis
Juvenile myelomonocytic leukemia (JMML)
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Le dauphin à dents de requin Squalodon (Cetacea: Odontoceti) du remarquable assemblage de vertébrés marins de Montagna della Majella (Formation de Bolognano, Italie centrale).
Get PDFThe extinct family Squalodontidae consists of heterodont, medium-sized odontocetes, featuring a long rostrum that houses large, procumbent incisors and heavily ornamented postcanine teeth carrying accessory denticles, hence their vernacular name, "shark-toothed dolphins". These longirostrine toothed whales are often seen as bridging the anatomical gap between archaic Oligocene odontocetes and their late Miocene to Holocene relatives. Possibly among the major marine predators of their time, the shark-toothed dolphins are important components of several lower Miocene marine-mammal assemblages from the North Atlantic and Mediterranean/Paratethysian realms. In the present work, a partial skull of Squalodontidae is described from the strata of the Bolognano Formation cropping out in the northeastern sector of the Montagna della Majella massif (Abruzzo, central Italy), which has previously yielded a rich lower Miocene marine-vertebrate assemblage, including eleven taxa of elasmobranchs as well as subordinate teleosts and very fragmentary remains of marine reptiles and mammals. The specimen consists of the anterodorsal portion of a rostrum, preserving parts of both premaxillae and left maxilla, and the anteriormost seven upper left teeth. This partial skull is here identified as belonging to the genus Squalodon, whose presence in the Montagna della Majella vertebrate assemblage had already been tentatively proposed on the basis of two fragmentary teeth. The paleontological significance of this find is discussed in the broader framework of the Euromediterranean record of Squalodon.La famille éteinte des Squalodontidae comprend des odontocètes de taille moyenne, hétérodontes, présentant un long rostre qui abrite de grandes dents incisives procombantes et de post-canines très ornées comportant des denticules accessoires, d'où leur nom vernaculaire "dauphins à dents de requin". Ces odontocètes longirostres sont souvent perçus comme des formes intermédiaires comblant le fossé anatomique entre les odontocètes oligocènes archaïques et leurs parents du Miocène tardif jusqu'à l'Holocène. Probablement parmi les principaux prédateurs marins de leur époque, les dauphins à dents de requin sont d’importants éléments au sein de plusieurs assemblages de mammifères marins du Miocène inférieur des domaines nord-atlantique et méditerranéen/para-téthysien. Dans le présent travail, un crâne partiel de Squalodontidae est décrit dans les couches de la Formation de Bolognano affleurant dans le secteur nord-est du massif de Montagna della Majella (Abruzzes, Italie centrale), qui a livré par le passé un riche assemblage de vertébrés marins du Miocène inférieur, comprenant onze taxons d'élasmobranches, ainsi que des téléostéens moins nombreux et des restes très fragmentaires de reptiles et de mammifères marins. Ce spécimen comprend la partie antéro-dorsale du rostre, comportant des parties des deux prémaxillaires et du maxillaire gauche, et les sept dents supérieures gauches les plus antérieures. Ce crâne partiel est identifié ici comme appartenant au genre Squalodon, dont la présence dans l'assemblage de vertébrés de Montagna della Majella avait déjà été proposée provisoirement sur la base de deux dents fragmentaires. La signification paléontologique de cette découverte est discutée dans le contexte plus large du registre euro-méditerranéen du genre Squalodon
BIRC8 (baculoviral IAP repeat containing 8)
Get PDFBIRC8, also known as ILP-2, is a homologous protein of BIRC4, however, its function has seldom been addressed. Despite the similarity with other Inhibitory Apoptosis Proteins (IAPs), there is evidence that BIRC8 acts in a peculiar manner, by impeding apoptosis induced by BAX without directly inhibiting the activity of caspases. BIRC8 expression has been detected in testis and lymphoblastic normal cells and, furthermore, it has been reported in different cancers, including breast carcinoma, hematological neoplasms, hepatocellular carcinoma, nasopharyngeal carcinoma, and neuroblastoma. However, the specific implications of such protein for treatment and prognosis must be further evaluated. In this review, current data on RNA, DNA, protein and the association of BIRC8 in cancer are presented
t(14;19)(q32;q13) IGH/Various Partners
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