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Early Predictive Analysis of Coronary Heart Disease Using Patient Medical Record Data
No full textCoronary heart disease (CHD) remains one of the leading causes of death worldwide and poses a major challenge for healthcare systems, particularly in developing countries such as Indonesia. This study aims to develop an early risk prediction model for CHD using a machine learning–based approach through hybrid integration of Neural Network (Multi-Layer Perceptron/MLP) and Random Forest (RF) to enhance both accuracy and interpretability. The dataset consists of 1,000 patient records containing demographic and clinical attributes, including age, blood pressure, cholesterol levels, smoking history, diabetes, and hypertension. The research process includes data preprocessing (imputation, outlier detection using the IQR method, and normalization with MinMaxScaler), feature engineering, and dimensionality reduction using Principal Component Analysis (PCA). The models were evaluated using Accuracy, Precision, Recall, F1-Score, and ROC-AUC metrics across three approaches: MLP, RF, and hybrid integration. The results show that the hybrid model achieved the best performance, with an Accuracy of 0.9958 and ROC-AUC of 0.9991, outperforming the individual models. These findings demonstrate that integrating the two algorithms produces a more stable, accurate, and clinically relevant predictive system, thereby supporting early detection of CHD in a more effective and human-centered manner.92 PagesTesis Magiste
The Influence of User Interface, Flash Sale, and Free Shipping on the Purchasing Decisions of Universitas Sumatera Utara Students Who Uses Tokopedia
No full textThe development of e-commerce in Indonesia has encouraged competition among
platforms to attract consumers, especially students as an active group of online
shoppers. Tokopedia, as one of the largest e-commerce platforms, continues to
present various digital marketing strategies, such as user interface development,
flash sale programs, and free shipping offers to influence users' purchasing
decisions. However, the extent to which these factors influence the purchasing
decisions of University of North Sumatra students still needs to be examined
empirically. This study aims to determine and analyze the influence of user
interface, flash sales, and free shipping on the purchasing decisions of University
of North Sumatra students who use Tokopedia. This study is an associative study
with a quantitative approach. The population in this study are University of North
Sumatra students who use the Tokopedia application. The sampling technique used
is purposive sampling with a sample size of 100 respondents, with the criteria being
students from the Faculty of Economics and Business, Faculty of Medicine, Faculty
of Social and Political Sciences, and Faculty of Computer Science and Information
Technology, who have made purchases through the Tokopedia application. The data
analysis method used was multiple linear regression analysis with the help of SPSS
software. The results showed that simultaneously, user interface, flash sale, and free
shipping had a positive and significant effect on the purchasing decisions of
University of North Sumatra students who use Tokopedia. Partially, user interface,
flash sale, and free shipping also had a positive and significant effect on purchasing
decisions. Based on the coefficient of determination, the user interface, flash sales,
and free shipping were able to explain 62.9% of the variation in purchasing
decisions, while the rest was influenced by other variables outside the scope of this
study.133 PagesSkripsi Sarjan
Juridical Analysis of Unlawful Acts in Copyright Infringments of the Song “Obuk Celleng” (A Study of Supreme Court Design No. 464 K/Pdt.Sus-HKI/2024)
No full textThe proliferation of song copyright infringement in the digital era, particularly on the YouTube platform—where works are frequently used or altered without the original creator's permission—serves as the background of this research. The primary issues examined include the legal regulation of copyright, the legal consequences of Unlawful Acts (Perbuatan Melawan Hukum/PMH) within the context of copyright, and a juridical analysis of the judges' considerations in the Supreme Court Decision Number 464 K/Pdt.Sus-HKI/2024.
This research uses a normative juridical with a descriptive-analytical approach. Data collection was conducted through library research, utilizing primary, secondary, and tertiary legal materials. The data were analyzed qualitatively to draw deductive conclusions.
The results of the study indicate that the act of duplicating the lyrics, notation, chords, and arrangement of the song "Nasib Force One Buruk" owned by Rahman Efendi into the song "Obuk Celleng" without permission constitutes an Unlawful Act as regulated under Article 1365 of the Indonesian Civil Code (KUHPerdata). In its decision, the Supreme Court declared that Rahman Efendi is the legitimate creator and copyright holder, and subsequently annulled the copyright registrations made unlawfully by other parties. The conclusion of this research confirms that the PMH instrument is highly effective in protecting the economic and moral interests of creators in intellectual property rights disputes in Indonesia.96 PagesSkripsi Sarjan
Hubungan Tipe Cerebral Palsy Dengan Gangguan Pendengaran Berdasarkan Pemeriksaan Otoacoustic Emission (OAE), Timpanometri dan Brainstem Evoked Response Audiometry (BERA) di Yayasan Cerebral Palsy Kota Medan
No full textPendahuluan :Cerebral palsy (CP) merupakan gangguan neurologis non-progresif yang sering dikaitkan dengan keterlambatan perkembangan dan komunikasi. Gangguan pendengaran dapat memperburuk hambatan tersebut. Penilaian pendengaran dini dan akurat pada anak dengan CP sangat penting, namun sering kali sulit dilakukan karena keterbatasan kerja sama dalam pemeriksaan perilaku. Penelitian ini bertujuan untuk menentukan prevalensi dan pola gangguan pendengaran pada anak dengan CP serta mengevaluasi hubungannya dengan faktor risiko dan subtipe CP. Bahan dan Metode: Penelitian potong lintang ini melibatkan 31 anak dengan diagnosis CP di Medan. Kriteria inklusi mencakup anak berusia di bawah 17 tahun dengan persetujuan orang tua. Data yang dikumpulkan meliputi karakteristik demografis, riwayat perinatal, serta subtipe CP berdasarkan klasifikasi klinis dan topografis. Pemeriksaan pendengaran dilakukan menggunakan timpanometri, otoacoustic emissions (OAE), dan Brainstem Evoked Response Audiometry (BERA). Analisis statistik menggunakan uji chi-square dengan tingkat signifikansi p < 0,05. Hasil:Rerata usia responden adalah 7,45 ± 3,46 tahun, dengan mayoritas berusia 7–14 tahun (61,3%) dan berjenis kelamin laki-laki (64,5%). Sebagian besar memiliki berat badan lahir normal (74,2%) dan lahir cukup bulan (83,9%). Hasil timpanometri menunjukkan tipe A pada 83,9% telinga kanan dan 87,1% telinga kiri. Pemeriksaan OAE menunjukkan 71% pass dan 29% refer. Hasil BERA menunjukkan 71% normal, 25,8% mengalami gangguan pendengaran sensorineural (SNHL), dan 3,2% gangguan campuran. Anak dengan berat badan lahir abnormal memiliki prevalensi gangguan pendengaran lebih tinggi (62,5%) dibandingkan dengan berat lahir normal (17,4%) (p = 0,027). CP tipe non-spastik secara signifikan berhubungan dengan gangguan pendengaran (p = 0,045; PR = 5,7).
Kesimpulan: Meskipun sebagian besar anak dengan CP memiliki pendengaran normal, terdapat proporsi bermakna dengan gangguan pendengaran sensorineural. CP tipe non-spastik dan berat badan lahir abnormal berhubungan secara signifikan dengan peningkatan risiko gangguan pendengaran, sehingga diperlukan skrining audiologis dini dan komprehensif pada kelompok berisiko tinggitidak ada96 halamanTesis Magiste
Pre Design of Fatty Acid Manufacturing Plant by Direct Hydrolysis of Palm Oil Fruit with Triglyceride By-Product with Production Capacity of 35.000 Tons/Year
No full textFatty acids are organic compounds produced from plant and animal processing. Fatty acids are widely used in the leather, waxes, foundries, rubber, soaps and detergents, paints and coatings, electronics, paper and printing, health and body care,
lubricating oils, and so on, so this potential can be utilized to establish a fatty acid plant to meet the needs of various industries for raw materials. The main purpose of this preliminary plant is to apply the discipline of chemical engineering, so that it will provide an overview of the feasibility of establishing a fatty acid plant and
designing a direct fatty acid production process from palm oil fruit without going through a crude oil producing plant first. Preliminary plant design of a fatty acid from palm oil fruit uses a direct hydrolysis reaction of palm oil fruit by activating
the lipase enzyme in the seeds with a capacity of 35.000 tons/year. The main process in this preliminary plant design consists of two stages, namely the direct hydrolysis reaction stage of palm oil fruit by activating the lipase enzyme in the seeds and the
separation stage consisting of extraction, centrifugation, and distillation processes. The plant will be planned to be established in Siak District, Siak Regency, Riau Province with a land area of 14,000 m2 ; the required labor is 202 people with a
business entity in the form of a limited liability company led by a director with a functional organization system. The establishment and operation of the plant required capital investments of Rp.1.504.748.174.225 and total production costs of Rp. 1.094.562.773.699. Based on economic analysis, the plant has a PM of 21,62%, BEP of 28,29%, ROI of 22,39%, RON of 37,32%, POT for 4,37 years, and IRR of 22,94%. From the results of economic analysis, it can be concluded that the preliminary plant design of fatty acid from palm oil fruit with a production capacity of 35.000 tons/year is feasible.558 PagesSkripsi Sarjan
Legal Protection for Notaries Against Criminal Fraud Charges Related to Formal Obligations in Deed Execution (Case Study of Decision No. 196/Pid.B/2019/Pn Dps Jo. Decision No. 27/Pid/2019/Pt.Dps Jo. Decision No. 20 Pk/Pid/2020)
No full textNotarial deeds that become the subject of disputes between parties or third parties often result in the notary being implicated as an accomplice or facilitator of a criminal act. This study analyzes the notary’s liability in cases of fraud committed by one of the appearing parties in a power of attorney deed executed before a notary (the judicial considerations in Decision No. 196/Pid.B/2019/PN DPS Jo. Decision No. 27/Pid/2019/PT.DPS Jo. Decision No. 20 PK/Pid/2020, and the forms of legal protection available to notaries involved in fraud-related criminal cases. This research employs a normative legal study approach with a descriptive-analytical method. The data used in this study consists of secondary data, including primary, secondary, and tertiary legal materials. Data collection was conducted through a literature review, and the analysis was carried out using qualitative methods. The findings reveal that the liability of a notary in cases of fraud committed by an appearing party in a power of attorney deed must first be assessed to determine whether the notary was actively involved in the fraudulent act. The judicial considerations in Decision No. 196/Pid.B/2019/PN DPS were based on Article 378 in conjunction with Article 55(1) of the Indonesian Penal Code (KUHP). In Decision No. 20 PK/Pid/2020, the panel of judges concluded that the defendant had indeed been negligent in the execution of the power of attorney for the sale of land between the victim and witness Mansyur Tambunan. However, the court ruled that such negligence fell within the realm of administrative law as a notary’s professional responsibility, rather than constituting a criminal offense. The forms of legal protection afforded to the notary in this case involved seeking judicial review, which was ultimately granted by the court. The defendant was acquitted of all charges, as the court determined that the act in question did not constitute a criminal offense. The Supreme Court’s ruling in Decision No. 20 PK/Pid/2020 explicitly stated that the defendant’s rights, name, and dignity must be fully restored.171 PagesTesis Magiste
The Effect of Antioxidant Ethanol Extract of African Leaves (Vernonia amygdalina Del.) on the Resilience of Stainless Steel Orthodontic Wire.
No full textStainless steel orthodontic wire is a commonly used wire in orthodontic treatment. Oral conditions such as pH, temperature, and exposure to a substance can affect the resilience of orthodontic wires. This study aimed to determine the effect of stainless steel orthodontic wire resilience before and after immersion in artificial saliva and ethanol extract of African leaf (Vernonia amygdalina Del.) 1560 ppm for 7 days. This study used stainless steel orthodontic wire (American Orthodontics®) in 30 samples with a diameter of 0.016 inches and a length of 5 cm. There were 3 groups: before immersion, after immersion in artificial saliva and after immersion in African leaf ethanol extract (Vernonia amygdalina Del.) 1560 ppm. Samples were immersed in the solution and stored in an incubator at 37°C for 7 days. Wire resilience testing was conducted using a universal testing machine. The results of Paired T-test showed that there was a significant difference between before and after immersion artificial saliva (p<0,05) and there was a significant difference between before and after immersion African leaf ethanol extract (Vernonia amygdalina Del.) 1560 ppm (p<0,05). The results of Independent T-test showed that there was a significant difference in resilience after immersion in artificial saliva and African leaf ethanol extract (Vernonia amygdalina Del.) 1560 ppm (p<0.05).This study concludes that there is a significant difference in the resilience of stainless steel orthodontic wires in artificial saliva immersion and ethanol extract of African leaves (Vernonia amygdalina Del.) 1560 ppm.93 PagesSkripsi Sarjan
Factors Associated with Accurate Inhaler Use in Patients with Chronic Obstructive Pulmonary Disease at Prof. dr. Chairuddin P. Lubis Universitas Sumatra Utara Hospital
No full textBackground. Chronic Obstructive Pulmonary Disease (COPD) is one of the
leading causes of mortality in the world, and its prevalence keeps increasing every
year, including in Indonesia. Inhalers are the main therapy for COPD, but many
patients still use them with incorrect techniques, which can reduce treatment
effectiveness and increase the risk of exacerbations. Objective. To identify
respondent characteristics, accuracy of inhaler use based on device type, the most
frequent errors, and analyze factors associated with the accuracy of inhaler
technique among COPD patients. Methods. This study was an analytical
observational study with a cross-sectional design, involving 88 samples of COPD
patients who used inhalers at Prof. dr. Chairuddin P. Lubis Universitas Sumatera
Utara Hospital, Universitas Sumatera Utara, Medan, 20155, INDONESIA. Results.
Most respondents were male, aged ≥60 years, had a secondary education level, and
were unemployed. The majority had been diagnosed with COPD for ≥2 years,
belonged to group E, had GOLD stage 2 obstruction, and one comorbidity. There
was a significant relationship between education level and inhaler use accuracy (p
<0.0001), and between inhaler type and accuracy (p=0.043). The SMI device was
used more correctly, while the pMDI device was most frequently used incorrectly.
Patients with higher education levels were seven times more likely to use inhalers
correctly than those with lower–middle education levels (OR = 7.284). Conclusion.
Education level and inhaler type were significantly associated with the accuracy of
inhaler technique among COPD patients. These findings highlight the importance
of continuous education and evaluation of inhaler use to improve therapeutic
effectiveness in COPD management.99 PagesSkripsi Sarjan
Molecular Docking of Diterpenoid Compounds from The Sambiloto Plant (Andrographis paniculata L.) Against Protein Programed Cell Death-Ligand 1 in Lung Cancer Therapy
No full textBackground: Lung cancer is a disease caused by genetic changes in epithelial cells of the respiratory tract that are uncontrolled in lungs. Factors that trigger the risk of lung cancer include a decline in the body's immune system in killing cancer cells. Excessive PD-L1 expression on PD-1 receptors can inhibit the performance of the immune system by suppressing T cell function. Sambiloto (Andrographis paniculata L.) has potential as anti-lung cancer agent. In silico is a research method to analyze chemical compounds using computational-based software.
Objective: To determine whether the chemical compound content of the plant andrographis meets the Lipinski's rule of five parameters and can bind to the PD-L1 receptor in silico.
Method: Prediction of biological activity using the online PASS, testing Lipinski's rule of five using Swiss ADME, preparation and optimisation of ligand-receptor using AutoDock Tools 1.5.7, molecular docking with AutoDock Vina, validation with PyMOL and visualisation using Biovia Discovery Studio Visualizer. Downloading the PD-L1 receptor via Protein Data Bank (PDB) with code 8P1O. Two and three-dimensional models were downloaded using the PubChem website. Docking parameters were assessed based on the docking score.
Results: The content of the chemical compound terpenoid from the sambiloto plant meets the Lipinski's rule of five parameters and can bind to PD-L1 receptor in silico.
Conclusion: The chemical compound content terpenoid plant Andrographis paniculata is capable of binding to the PD-L1 receptor in silico, thus showing potential as a candidate for lung cancer treatment.100 PagesSkripsi Sarjan
Legal Analysis Of A Lawsuit Being Declared Inadmissible (Niet Ontvankelijke Verklaard) In Ownership Disputes Over Land Rights That Have Not Been Resolved Through Village Customary Court Proceedings (A Case Study Of Decision Number 8/Pdt.G/2021/PN Lgs)
No full textA NO (Niet Ontvankelijke Verklaard) verdict is a decision that declares a lawsuit inadmissible due to formal defects. Although a ruling stating that a lawsuit is inadmissible is not specifically regulated by legislation, it is frequently encountered in court practice. One such example occurred in case Number 8/Pdt.G/2021/PN Lgs. This decision involved a civil case concerning a land dispute located in the city of Langsa, Aceh Province. What is particularly interesting is the panel of judges’ consideration that the Plaintiff’s lawsuit was premature because a customary legal remedy through village-level resolution had not yet been pursued.
This research employs normative legal research methods. The data used includes primary, secondary, and tertiary data, collected through a literature study technique (library research). The data is then analyzed using a qualitative data analysis method.
The findings of the study indicate that the customary court process at the village level in Langsa City refers to Aceh Qanun Number 9 of 2008 on the Development of Customary Life and Traditions and Aceh Governor Regulation Number 60 of 2013 on the Implementation of Dispute/Conflict Resolution in Customs and Traditions. A land ownership dispute that does not go through the village customary court process may result in the lawsuit being declared inadmissible in court, as the judge may consider it premature. Such a lawsuit is deemed premature because it bypasses the proper procedures, thus the judge may declare the Plaintiff’s claim inadmissible. The judge's considerations in ruling on Decision Number 8/Pdt.G/2021/PN Lgs by the Langsa District Court concerning an unlawful act claim over a land dispute are appropriate and correct. This is grounded in Article 135a HIR / Article 161a RBG and connected with Aceh Qanun Number 9 of 2008 on the Development of Customary Life and Traditions, Aceh Qanun Number 10 of 2008 on Customary Institutions, and Aceh Governor Regulation Number 60 of 2013 on the Implementation of Dispute/Conflict Resolution in Customs and Traditions. The Aceh government plays a strategic role in sustaining and strengthening the customary law system in Aceh. By providing comprehensive training to customary officials, this training will help them perform their duties more effectively, increase their capacity in handling disputes, and create peace and justice within the Acehnese community.108 PagesSkripsi Sarjan