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European Consensus on Functional Bloating and Abdominal Distension-An Esnm/Ueg Recommendations for Clinical Management
Hammer, Heinz F./0000-0001-8683-4951; Barba Orozco, Elizabeth/0000-0002-5986-6592;Introduction: Abdominal distension is an objective visible sign of increased abdominal girth. Bloating is a feeling of abdominal fullness and discomfort. Bloating may be associated or not with abdominal distension. Bloating and abdominal distension are among the most commonly reported gastrointestinal symptoms and may be associated with both organic and functional disorders. Nevertheless, specific consensus and recommendations on diagnosis, underlying mechanisms, assessment and management of functional bloating and abdominal distension are still lacking. The aim of this European consensus, then, is to provide expert opinions and recommendations on the epidemiology, diagnosis, pathophysiology and treatment of functional bloating and abdominal distension. Methods: A multidisciplinary team of experts in the field, including European specialists and national societies, participated in the development of this consensus. Relevant questions were formulated and addressed through a literature review and statements were developed and voted using a Delphi process. Results: Functional bloating and abdominal distension are common and frequently overlap with other disorders of gut-brain interaction. Diagnosis is made according to the Rome IV criteria after the exclusion of organic disease, based on the physical examination and assessment of the patient's medical history and alarming signs. In the absence of alarming signs or any relevant finding, clinical laboratory, imaging or endoscopic tests are unnecessary. The pathophysiology of functional bloating and abdominal distension is multifactorial and involves visceral hypersensitivity, abdomino-phrenic dyssynergia, intestinal dysmotility and dysbiosis. Treatment may include dietary modifications (e.g. lactose-limiting diet and low FODMAP diet), probiotics, antispasmodics (e.g., otilonium bromide, peppermint oil), rifaximin, secretagogues (e.g., linaclotide), neuromodulators (e.g., serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, buspirone), and plethysmography-based biofeedback. Moreover, cognitive behaviour therapy and hypnotherapy can be used in case of functional bloating associated with irritable bowel syndrome. Conclusion: This consensus provides an evidence-based framework for the evaluation and treatment of patients with functional bloating and abdominal distension.This project was funded by The United European Gastroenterology Activity Grant in Support of Standards ; Guidelines initiatives.United European Gastroenterology Activity Grant in Support of Standards ; Guidelines initiative
Future Circular Collider Feasibility Study Report: Volume 3 Civil Engineering, Implementation and Sustainability
Volume 3 of the FCC Feasibility Report presents studies related to civil engineering, the development of a project implementation scenario, and environmental and sustainability aspects. The report details the iterative improvements made to the civil engineering concepts since 2018, taking into account subsurface conditions, accelerator and experiment requirements, and territorial considerations. It outlines a technically feasible and economically viable civil engineering configuration that serves as the baseline for detailed subsurface investigations, construction design, cost estimation, and project implementation planning. Additionally, the report highlights ongoing subsurface investigations in key areas to support the development of an improved 3D subsurface model of the region. The report describes the development of the project scenario based on the ‘avoid-reduce-compensate’ iterative optimisation approach. The reference scenario balances optimal physics performance with territorial compatibility, implementation risks, and costs. Environmental field investigations covering almost 600 hectares of terrain—including numerous urban, economic, social, and technical aspects—confirmed the project’s technical feasibility and contributed to the preparation of essential input documents for the formal project authorisation phase. The summary also highlights the initiation of public dialogue as part of the authorisation process. The results of a comprehensive socio-economic impact assessment, which included significant environmental effects, are presented. Even under the most conservative and stringent conditions, a positive benefit-cost ratio for the FCC-ee is obtained. Finally, the report provides a summary of the studies conducted to document the current state of the environment. © 2025 Elsevier B.V., All rights reserved
A Bifunctional Electrocatalyst for Energy-Efficient Hydrogen Production and Ethanol Upgrading into Acetate via Hybrid Seawater Splitting
The sluggish kinetics of the oxygen evolution reaction (OER) and the competing chlorine evolution reaction (CER) significantly limit the efficiency of seawater electrolysis for hydrogen production. Replacing OER/CER with thermodynamically more favorable anodic reactions presents a promising strategy for reducing energy consumption and overcoming chlorine-based toxic products. This study reports a hybrid seawater electrolysis system that couples the ethanol oxidation reaction (EOR) with the hydrogen evolution reaction (HER), enabling the co-production of green hydrogen and value-added potassium acetate in alkaline seawater. Utilizing bimetallic NiCu hierarchical nanostructures supported on nickel foam (NiCu–HNS@NF) as a bifunctional electrocatalyst, this promising system required 220 mV less potential for EOR compared to OER to achieve a current density of 20 mA cm−2. Meanwhile, the HER required a low overpotential of only 97 mV to attain the same current density, with a faradaic efficiency (FE) of 97.6%. The COinf>2/inf>-free selective conversion of ethanol into acetate, along with the high faradaic efficiency (FE) for Hinf>2/inf>, may be attributed to the bubbles-templated interconnected hierarchical nanostructures and the bimetallic synergistic effect. This study highlights the potential of ethanol-assisted seawater electrolysis as an energy-efficient and economically viable platform for sustainable hydrogen production and biomass valorization. © 2025 Elsevier B.V., All rights reserved
A Novel Approach to Correction of Features from Image Matching in Unmanned Aerial Vehicle Navigation Through Clustering and Triangular Similarity
Antalya Bilim University; IEEEFeature extraction and matching are critical in image-based models, particularly for the navigation of unmanned aerial and ground vehicles. While classical methods have been widely used, deep learning techniques are increasingly favored due to their superior performance. However, both approaches are sensitive to perspective differences, often resulting in incorrect matches, sometimes outnumbering correct ones. Although various traditional and deep learning-based algorithms exist to mitigate this issue, they do not consistently yield optimal results. This paper presents a novel method to eliminate high-density outlier matches to enhance matching accuracy. The proposed approach leverages triangular similarities among matched features and groups randomly selected feature sets. A three-dimensional simulation environment was developed, and a dataset was prepared to evaluate the algorithm. The performance of the proposed method was compared with existing algorithms using simulation images and real-life public datasets captured from various aerial angles. © 2025 Elsevier B.V., All rights reserved
Preferred Retinal Locus in Juvenile Macular Dystrophy
Objectives: To evaluate foveal lesion and preferred retinal locus (PRL) locations and their effects on visual acuity in juvenile macular dystrophy (JMD) patients. Materials and Methods: In this retrospective study, 14 JMD patients (28 eyes) with bilateral central vision loss were examined using scanning laser ophthalmoscope/optical coherence tomography. Best-corrected visual acuity (BCVA), dimensions and location of the macular lesion, PRL location, and PRL stability were evaluated. Results: Mean BCVA was 0.84 +/- 0.17 logarithm of the minimum angle of resolution. PRL was superiorly located in 64.3% of eyes and nasally located in 35.7%. PRL location was significantly associated with patient age (r=0.541, p=0.002); nasally located PRLs were more common in younger patients (mean age 15.1 +/- 2.8 years) while superiorly located PRLs were more common in older patients (mean age 22.4 +/- 6.9 years). Superiorly located PRLs were significantly closer to the fovea than nasally located PRLs (p=0.014). Visual acuity worsened as lesion size increased and PRL-fovea distance increased. PRL-fovea distance was longer in younger patients and positively correlated with lesion dimensions and PRL-lesion distance. Conclusion: In JMD patients, PRLs are predominantly located superiorly or nasally. In younger patients, PRLs are typically located nasally and farther from the fovea, with poorer visual acuity compared to older patients. Cortical adaptation mechanisms may play a role in changing PRL location with age. Understanding PRL characteristics in JMD is crucial for developing effective low-vision rehabilitation strategies
Characterising the Higgs Boson with ATLAS Data From the LHC Run-2
Kontaxakis, Pantelis/0000-0002-4860-5979; Keeler, Richard/0000-0002-0510-4189; Stark, Giordon/0000-0001-6616-3433; Zivkovic, Lidija/0000-0003-4236-8930; Martinez-Agullo, Pablo/0000-0001-8925-9518; Martoiu, Sorin/0000-0002-4963-9441; Kowalewski, Robert/0000-0002-7314-0990; Mondal, Santu/0000-0002-6965-7380; Bouhova-Thacker, Evelina/0000-0002-5103-1558; Pettee, Mariel/0000-0001-9208-3218; Di Luca, Andrea/0000-0002-9074-2133; Bahmani, Marzieh/0000-0003-4173-0926; Novak, Tadej/0000-0002-3053-0913; Rompotis, Nikolaos/0000-0003-2577-1875; Berta, Peter/0000-0003-0780-0345; Elsing, Markus/0000-0002-1213-0545; Beck, Hans Peter/0000-0001-7212-1096; Merlassino, Claudia/0000-0002-5445-5938; Price, Darren/0000-0003-2750-9977; Sahinsoy, Merve/0000-0002-7400-7286; Gaudio, Gabriella/0000-0002-6833-0933; Terzo, Stefano/0000-0003-3388-3906; Kaji, Toshiaki/0000-0002-6532-7501; Pleier, Marc-Andre/0000-0002-9461-3494; Kretzschmar, Jan/0000-0002-8515-1355; Cunha Sargedas Sousa, Mario Jose/0000-0001-7991-593X; Fox, Harald/0000-0003-3089-6090; Islam, Wasikul/0000-0002-5624-5934; Bruschi, Marco/0000-0002-4319-4023; Bhatta, Somadutta/0000-0002-9045-3278; Stanislaus, Beojan/0000-0001-9007-7658; Sampsonidou, Despoina/0000-0003-0384-7672; Leblanc, Matt/0000-0001-5977-6418; Konstantinidis, Nikolaos/0000-0002-4140-6360; Gwilliam, Carl/0000-0002-9401-5304; De La Torre Perez, Hector/0000-0002-4516-5269; Munoz Sanchez, Francisca/0000-0002-6374-458X; Lacasta, Carlos/0000-0002-2623-6252; Worm, Steven/0000-0002-3865-4996; Doglioni, Caterina/0000-0002-1509-0390; Redlinger, George/0000-0002-6437-9991; Nikolopoulos, Konstantinos/0000-0002-3048-489X; Mitsou, Vasiliki A./0000-0002-1533-8886; Carmignani, Joseph (Joe)/0000-0002-1705-1061; Jia, Jiangyong/0000-0002-5725-3397; Winter, Benedict Tobias/0000-0001-9606-7688; Hance, Michael/0000-0001-8392-0934; Vincter, Manuella/0000-0002-5338-8972; Vecchio, Valentina/0000-0002-1351-6757; Schmitt, Stefan/0000-0001-8387-1853; D'Uffizi, Matteo/0000-0003-2499-1649; Klein, Lucas/0000-0002-0145-4747; Smirnova, Oxana/0000-0003-2517-531X; Azuelos, Georges/0000-0003-4241-022X; Meloni, Federico/0000-0001-7075-2214; Beau, Tristan/0000-0002-2022-2140; Kumar, Mukesh/0000-0003-3681-1588; Schultz-Coulon, Hans-Christian/0000-0002-0860-7240; Koch, Simon Florian/0000-0002-2676-2842; Mckee, Shawn/0000-0002-4551-4502; Morii, Masahiro/0000-0001-9324-057X; Mindur, Bartosz/0000-0002-5511-2611; Butterworth, Jonathan/0000-0002-5905-5394; Lloyd, Stephen/0000-0002-5073-2264; Bella, Gideon/0000-0002-4009-0990; Held, Alexander/0000-0002-8924-5885; Citron, Zvi/0000-0003-1831-6452; Rousseau, David/0000-0001-7613-8063; Cheong, Sanha/0000-0002-2797-6383; Dong, Qichen/0000-0002-0117-7831; Grinstein, Sebastian/0000-0002-6460-8694; Alimonti, Gianluca/0000-0002-7128-9046; Kirk, Julie/0000-0001-8096-7577; Su, Dong/0000-0001-6980-0215; Mete, Alaettin Serhan/0000-0002-5508-530X; Quinn, Ryan/0000-0002-0879-6045; Hoppesch, Matthew/0000-0002-7773-3654; Cristoforetti, Marco/0000-0002-0127-1342; Mcpherson, Robert/0000-0001-9211-7019;The Higgs boson was discovered by the ATLAS and CMS Collaborations in 2012 using data from Run 1 of the Large Hadron Collider (2010-2012). In Run 2 (2015-2018), about 140 fb(-1) of proton-proton collisions at a centre-of-mass energy of 13 TeV were collected by the ATLAS experiment. This review presents the most important Run 2 results obtained by the ATLAS Collaboration regarding the properties of the Higgs boson and its interactions with other particles. The performed studies significantly enhance the understanding of the Higgs boson, while hunting for deviations from the predictions of the Standard Model of particle physics. (c) 2024 CERN for the benefit of the ATLAS Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW; FWF, Austria; ANAS; CNPq; FAPESP, Brazil; NSERC; CFI, Canada; NSFC, China; MEYS CR, Czech Republic; DNRF; DNSRC, Denmark; IN2P3-CNRS; CEA-DRF/IRFU, France; BMBF; MPG, Germany; RGC and Hong Kong SAR, China; ISF; Benoziyo Center, Israel; Istituto Nazionale di Fisica Nucleare, Italy; MEXT; JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW, Poland; FCT, Portugal; MNE/IFA, Romania; MESTD, Serbia; MSSR, Slovakia; SRC; Wallenberg Foundation, Sweden; SNSF and Cantons of Bern and Geneva, Switzerland; NSTC, Taipei; DOE; NSF, United States of America; BCKDF; CANARIE; CRC; DRAC, Canada [PRIMUS 21/SCI/017]; FORTE, Czech Republic; ERC; ERDF; Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex; ANR, France; DFG; AvH Foundation, Germany - EU-ESF; Greek NSRF, Greece; BSF-NSF; NCN [UMO-2019/34/E/ST2/00393, UMO-2020/37/B/ST2/01043, UMO-2021/40/C/ST2/00187, UMO-2022/47/O/ST2/00148]; La Caixa Banking Foundation; CERCA Programme Generalitat de Catalunya; PROMETEO [CIDEGENT/2019/023, CIDEGENT/2019/027]; Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; Royal Society [NIF-R1-231091]; Leverhulme Trust, United Kingdom; CERN: European Organisation for Nuclear Research (CERN PJAS); Chile: Agencia Nacional de Investigacion y Desarrollo (FONDECYT) [1190886]; FONDECYT [1230987]; China: Chinese Ministry of Science and Technology [MOST-2023YFA1605700]; National Natural Science Foundation of China [NSFC -12175119, NSFC 12275265, NSFC-12075060]; Czech Republic: Czech Science Foundation; Ministry of Education Youth and Sports [FORTE CZ.02.01.01/00/22_008/0004632]; PRIMUS Research Programme [PRIMUS/21/SCI/017]; EU [ERC -101002463]; European Union: European Research Council [ERC -948254, ERC 101089007, MUCCA -CHIST-ERA-19-XAI-00]; European Union [FAIR-NextGenerationEU PE00000013]; France: Agence Nationale de la Recherche [ANR-20-CE31-0013, ANR-21-CE31-0013, ANR-21-CE31-0022, ANR-22-EDIR-0002]; Investissements d'Avenir Labex; Germany: Baden-Wurttemberg Stiftung; Deutsche Forschungsgemeinschaft [DFG -469666862, CR 312/5-2]; Ministero dell'Universita e della Ricerca; Japan Society for the Promotion of Science (JSPS KAKENHI) [JP21H05085, JP22H01227, JP22H04944, JP22KK0227, RCN-314472]; Polish National Agency for Academic Exchange [PPN/PPO/2020/1/00002/U/00001]; Polish National Science Centre (NCN) [2021/42/E/ST2/00350]; NCN OPUS [2022/47/B/ST2/03059]; Slovenian Research Agency [J1-3010]; Spain: Generalitat Valenciana [NextGenEU PCI2022-135018-2]; FEDER [PID2021-125273NB, RYC2019-028510-I, RYC2020-030254-I, RYC2021-031273-I, RYC2022-038164-I]; Swedish Research Council (Swedish Research Council) [2023-04654, VR 2018-00482, VR 2022-03845, VR 2022-04683, VR 2023-03403, 2021-03651]; Knut and Alice Wallenberg Foundation [KAW 2018.0157, KAW 2018.0458, KAW 2019.0447, SNSF -PCEFP2_194658]; United Kingdom: Leverhulme Trust (Leverhulme Trust) [RPG-2020-004]We gratefully acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; Minciencias, Colombia; MEYS CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRI, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; Istituto Nazionale di Fisica Nucleare, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW, Poland; FCT, Portugal; MNE/IFA, Romania; MESTD, Serbia; MSSR, Slovakia; ARIS and MVZI, Slovenia; DSI/NRF, South Africa; MICIU/AEI, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; NSTC, Taipei; TENMAK, Turkiye; STFC/UKRI, United Kingdom; DOE and NSF, United States of America. Individual groups and members have received support from BCKDF, CANARIE, CRC and DRAC, Canada; PRIMUS 21/SCI/017, CERN-CZ and FORTE, Czech Republic; COST, ERC, ERDF, Horizon 2020, ICSC-NextGenerationEU and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and MINERVA, Israel; Norwegian Financial Mechanism 2014-2021, Norway; NCN and NAWA, Poland; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. In addition, individual members wish to acknowledge support from CERN: European Organisation for Nuclear Research (CERN PJAS); Chile: Agencia Nacional de Investigacion y Desarrollo (FONDECYT 1190886, FONDECYT 1210400, FONDECYT 1230812, FONDECYT 1230987); China: Chinese Ministry of Science and Technology (MOST-2023YFA1605700), National Natural Science Foundation of China (NSFC -12175119, NSFC 12275265, NSFC-12075060); Czech Republic: Czech Science Foundation (GACR -24-11373S), Ministry of Education Youth and Sports (FORTE CZ.02.01.01/00/22_008/0004632), PRIMUS Research Programme (PRIMUS/21/SCI/017); EU: H2020 European Research Council (ERC -101002463); European Union: European Research Council (ERC -948254, ERC 101089007), Horizon 2020 Framework Programme (MUCCA -CHIST-ERA-19-XAI-00), European Union, Future Artificial Intelligence Research (FAIR-NextGenerationEU PE00000013), Italian Center for High Performance Computing, Big Data and Quantum Computing (ICSC, NextGenerationEU); France: Agence Nationale de la Recherche (ANR-20-CE31-0013, ANR-21-CE31-0013, ANR-21-CE31-0022, ANR-22-EDIR-0002), Investissements d'Avenir Labex (ANR-11-LABX-0012); Germany: Baden-Wurttemberg Stiftung (BW Stiftung-Postdoc Eliteprogramme), Deutsche Forschungsgemeinschaft (DFG -469666862, DFG -CR 312/5-2); Italy: Istituto Nazionale di Fisica Nucleare (ICSC, NextGenerationEU), Ministero dell'Universita e della Ricerca (PRIN -20223N7F8K -PNRR M4.C2.1.1); Japan: Japan Society for the Promotion of Science (JSPS KAKENHI JP21H05085, JSPS KAKENHI JP22H01227, JSPS KAKENHI JP22H04944, JSPS KAKENHI JP22KK0227); Netherlands: Netherlands Organisation for Scientific Research (NWO Veni 2020 -VI.Veni.202.179); Norway: Research Council of Norway (RCN-314472); Poland: Polish National Agency for Academic Exchange (PPN/PPO/2020/1/00002/U/00001), Polish National Science Centre (NCN 2021/42/E/ST2/00350, NCN OPUS nr 2022/47/B/ST2/03059, NCN UMO-2019/34/E/ST2/00393, UMO-2020/37/B/ST2/01043, UMO-2021/40/C/ST2/00187, UMO-2022/47/O/ST2/00148); Slovenia: Slovenian Research Agency (ARIS grant J1-3010); Spain: Generalitat Valenciana (Artemisa, FEDER, IDIFEDER/2018/048), Ministry of Science and Innovation (MCIN ; NextGenEU PCI2022-135018-2, MICIN ; FEDER PID2021-125273NB, RYC2019-028510-I, RYC2020-030254-I, RYC2021-031273-I, RYC2022-038164-I), PROMETEO and GenT Programmes Generalitat Valenciana (CIDEGENT/2019/023, CIDEGENT/2019/027); Sweden: Swedish Research Council (Swedish Research Council 2023-04654, VR 2018-00482, VR 2022-03845, VR 2022-04683, VR 2023-03403, VR grant 2021-03651), Knut and Alice Wallenberg Foundation (KAW 2018.0157, KAW 2018.0458, KAW 2019.0447, KAW 2022.0358); Switzerland: Swiss National Science Foundation (SNSF -PCEFP2_194658); United Kingdom: Leverhulme Trust (Leverhulme Trust RPG-2020-004), Royal Society (NIF-R1-231091); United States of America: U.S. Department of Energy (ECA DE-AC02-76SF00515), Neubauer Family Foundation
Caught in the Middle: Examining Pedestrian and Driver Responses to Aggressive Driving
Bu çalışma, bireylerin trafikte hem yaya hem de sürücü olarak üstlendikleri çift rolleri incelemektedir. Bu roller bağlamında agresif sürüş davranışları ve trafikle ilgili diğer etkileşimlere yönelik algı ve tutumlarını araştırmaktadır. Rol Teorisi çerçevesinde, toplumsal beklentilerin ve rol çatışmalarının söz konusu tutumları nasıl şekillendirdiği derinlemesine ele alınmaktadır. Ayrıca, bireylerin bu ikili rol arasında yaşadığı psikolojik ve davranışsal zorluklara dair kapsamlı bir inceleme yapılması amaçlanmıştır. Toplamda 10 kadın ve 10 erkek katılımcıyla gerçekleştirilen görüşmeler aracılığıyla nitel araştırma yöntemi uygulanmıştır. Katılımcıların trafikle ilgili deneyimleri tematik analiz yöntemiyle incelenmiştir. Analiz sonucunda iki ana tema belirlenmiştir: Yaya Davranışları ve Sürücü Davranışları. Yaya davranışları, trafik akışı ve güvenliği etkileyen öngörülebilir ve öngörülemez hareket örüntüleri olmak üzere iki alt kategoriye ayrılmıştır. Sürücü davranışları ise olumlu davranışlar (örneğin, kurallara uyma, yayalara öncelik verme) ve olumsuz davranışlar (örneğin, agresif sürüş, yaya haklarını ihlal etme) şeklinde sınıflandırılmıştır. Elde edilen bulgular, yaya ve sürücü rollerinin dinamiklerini ve etkileşimlerinin karmaşıklığını ortaya koymaktadır. Bu bağlamda sonuçlar, daha güvenli ve iş birliğine dayalı trafik ortamlarının oluşturulmasında Rol Teorisi’nin sağlayabileceği katkılara ve buna yönelik eğitimsel ve politika odaklı müdahalelerin gerekliliğine dikkat çekmektedir
Software and Computing for Run 3 of the ATLAS Experiment at the LHC
The ATLAS experiment has developed extensive software and distributed computing systems for Run 3 of the LHC. These systems are described in detail, including software infrastructure and workflows, distributed data and workload management, database infrastructure, and validation. The use of these systems to prepare the data for physics analysis and assess its quality are described, along with the software tools used for data analysis itself. An outlook for the development of these projects towards Run 4 is also provided. © 2025 Elsevier B.V., All rights reserved
An Adaptation and Reliability Study of the Flemish CVI Questionnaire for the Screening of Cerebral Visual Impairment in Preschool-Age Children with Cerebral Palsy
Introduction: This study aimed to adapt the Flemish CVI Questionnaire (FCVIQ) Turkish form for screening cerebral visual impairment (CVI) in preschool-age children with cerebral palsy (CP). Additionally, it sought to explore the relationship between FCVIQ scores and visual abilities. Method: The study involved 137 preschool-age children. The FCVIQ’s test-retest reliability and construct validity were assessed, and its components were identified through factor analysis. Logistic regression analyzed the FCVIQ’s predictive power for Visual Function Classification System (VFCS) levels. Receiver Operating Characteristic (ROC) curves determined optimal cut-off values. Results: The FCVIQ demonstrated strong test-retest reliability and revealed three components. The first component showed a strong positive correlation with VFCS levels. ROC analysis yielded optimal cut-off values for scoring methods, indicating the FCVIQ’s robust predictive performance. Conclusion: This study identifies distinct characteristics of CVI cases in children with CP and highlights the FCVIQ’s reliability and three-component structure. Occupational therapists can effectively use the FCVIQ, with the Multifaceted Visual Processing and Perception Component being particularly important for CVI assessment. These findings hold promise for improving habilitation practice and guiding future research in CVI management and interventions. © 2025 Elsevier B.V., All rights reserved
18 ve 19. Yüzyıl Sırp Aydınlanmasında Bilimsel Dönüşüm
This thesis examines the Serbian Enlightenment as a complex, hybrid movement shaped by imperial rule, religious tradition, and rationalist modernity. It was not merely an imitation of Western models but a culturally negotiated response to the challenges of being a non-sovereign Orthodox society caught between the Ottoman, Habsburg, and Russian empires. The study argues that vernacularization—using spoken Serbian to discuss science and education—was the primary way the Enlightenment ideas were adapted to local needs. This vernacular shift marks the scientific turn: a move from devotional learning toward empirical, utilitarian knowledge that re-centred Serbian intellectual life on observation, measurement, and public usefulness. Through close analysis of figures such as Dositej Obradović, Teodor Janković-Mirijevski, and Vuk Karadžić, the thesis employs a transnational and entangled history approach to trace shifts in language, intellectual networks, and pedagogy across imperial and cultural boundaries. It reveals how Orthodox institutions spread the Enlightenment ideas, how state-funded schools transformed them, and how literature and folklore made them accessible to the public. Reformers did not reject Orthodoxy but merged reason with Christian humanism to form a rational piety compatible with the Enlightenment values. By rethinking the links between imperial constraint, cultural innovation, and vernacular mobilization, the thesis repositions the Serbian Enlightenment within broader European and Balkan intellectual currents, challenging narratives that marginalize the 'peripheral' Enlightenments.Bu tez, Sırp Aydınlanmasını imparatorluk yönetimi, dini gelenek ve akılcı modernitenin şekillendirdiği karmaşık ve melez bir hareket olarak incelemektedir. Sırp Aydınlanması, Batılı modellerin basit bir taklidi değil; Osmanlı, Habsburg ve Rus imparatorlukları arasında sıkışmış, egemen olmayan bir Ortodoks toplum olmanın getirdiği zorluklara kültürel olarak müzakere edilmiş bir yanıttır. Çalışma, Aydınlanma fikirlerinin yerel ihtiyaçlara uyarlanmasının başlıca yolunun, bilim ve eğitimi konuşma dili olan Sırpçayla ifade etmek anlamına gelen 'halk diline geçiş' (vernacularization) olduğunu savunmaktadır. Bu dilsel dönüşüm, bilimsel bir dönüm noktasını temsil eder: dua merkezli öğrenmeden gözlem, ölçüm ve toplumsal fayda temelli ampirik ve faydacı bilgiye doğru bir geçiş. Dositej Obradović, Teodor Janković-Mirijevski ve Vuk Karadžić gibi figürlerin yakından incelenmesi yoluyla, tez; dil, entelektüel ağlar ve pedagojideki değişimleri imparatorluk ve kültürel sınırlar boyunca izlemek için ulusötesi ve iç içe geçmiş bir tarih yaklaşımını benimsemektedir. Ortodoks kurumların Aydınlanma fikirlerini nasıl yaydığı, devlet destekli okulların bu fikirleri nasıl dönüştürdüğü ve edebiyat ile halk kültürünün onları halka nasıl ulaştırdığı ortaya konulmaktadır. Islahatçılar Ortodoksluğu reddetmemiş; aklı Hristiyan hümanizmiyle birleştirerek Aydınlanma değerleriyle uyumlu bir 'rasyonel dindarlık' oluşturmuşlardır. Tez, imparatorluk kısıtlamaları, kültürel yenilik ve halk dilinin seferber edilmesi arasındaki ilişkileri yeniden düşünerek, Sırp Aydınlanmasını daha geniş Avrupa ve Balkan entelektüel akımları içinde yeniden konumlandırmakta ve 'çevresel' Aydınlanmaların dışlandığı anlatılara meydan okumaktadır