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    461 research outputs found

    Computing groundwater recharge and saturated storage dynamics: a Richards equation-based recipe

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    I/O files of all the CATHY simulations reported, described, and discussed in the paper "Computing groundwater recharge and saturated storage dynamics: a Richards equation-based recipe", by Matteo Camporese, Claudio Paniconi, and Mario Putti, currently under review for possible publication in Water Resources Research

    Geotechnical investigation of Tagliamento, Panaro and Grizzaga levee soils: CPTs, Boreholes and Laboratory tests

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    This dataset contains the results of a geotechnical investigation conducted along the Tagliamento, Panaro, and Grizzaga river levees. The dataset includes: Investigation point locations (kmz file); Cone Penetration Test (CPTu) results, providing continuous profiles of tip resistance, sleeve friction, and pore pressure; Borehole data, including stratigraphic logs and position of undisturbed samples. Laboratory test results obtained from undisturbed soil samples, comprising: Grain size distribution analyses; Triaxial shear tests (CU, CD); Direct shear tests; Residual shear tests; Soil Water Retention Curves (SWRC). All data have been processed and organized to support further geotechnical, hydro-mechanical, and numerical analyses related to riverbank and levee stability assessment

    When antioxidant defences collapse: Gen-X induced oxidative stress in Procambarus clarkii hepatopancreas and gills.

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    Gen-X (ammonium salt of hexafluoropropylene oxide dimer acid) was introduced as a safer alternative following restrictions on perfluorooctanoic acid. Although its short-chain structure reduces its bioaccumulation potential, research suggests it may mimic some toxic effects of legacy perfluoroalkyl substances. Its persistence and high mobility in freshwater ecosystems amplify concerns about impacts on biota. This study investigates whether sub-chronic Gen-X exposure can induce oxidative stress, leading to cellular damage and antioxidant responses in the hepatopancreas and gills of Procambarus clarkii, a resilient, invasive crayfish. Individuals were maintained for 28 days in four experimental tanks: three Gen-X doses (0.5, 1, 10 µg/L) and one control. Chemical analyses revealed dose-dependent accumulation in tissues, mostly in the hepatopancreas. Oxidative biomarkers showed evidence of cellular damage, including early lipid peroxidation in the hepatopancreas at 1 µg/L and protein and lipid oxidation in both organs at the highest concentration. Enzymatic assays revealed tissue-specific responses. In the hepatopancreas, superoxide dismutases (SODs) activity was inhibited at the two highest doses, suggesting enzyme impairment, while it was activated in gills. In both organs, Se-dependent glutathione peroxidases (Se-GPxs) exhibited a biphasic response, with activation at low exposure and collapse at higher doses, coinciding with macromolecular injury. Catalase was alternatively inhibited at 0.5 µg/L in the hepatopancreas and activated at 1 µg/L in gills, indicating compartment-specific detoxification. These results demonstrate that Gen-X disrupts redox homeostasis in P. clarkii through organ-specific accumulation and differential antioxidant modulation, with enzyme inhibition marking critical thresholds beyond which antioxidant defences fail and oxidative damage becomes irreversible

    ONLINE APPENDIX OF: PETTRACHIN, 2025 (ITALIAN JOURNAL OF PUBLIC POLICY - RIPP)

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    This is the Online Appendix of the article: Pettrachin A. 2025. "The local strength of radical right parties and pro-migrant local elites’ responsiveness to public opinion in the refugee integration policy field. A mixed-methods study". Italian Journal of Public Policy. Online First

    CODE: Generalized unit hydrogrpah theory for dynamic river networks

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    This deposit collects the MATLAB code written to implement the flowrate simulation based on the dynamic IUH that emerges on non-perennial river networks, as reported in the paper "Generalized unit hydrogrpah theory for dynamic river networks"

    Peer feedback in early childhood education: educational role and implications for teaching practices

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    Feedback is a construct extensively investigated in pedagogical and assessing literature, particularly within the context of higher education, where it is recognised as an effective tool for supporting and enhancing learning. From a socio-constructivist perspective, feedback assumes a relational and social significance, functioning as a crucial learning resource and the development of reflective and self-regulatory processes. Despite its importance, a recent literature review highlighted that feedback, especially peer feedback, remains underexplored in early childhood educational contexts. Building on this gap, the present study aims to examine the presence and characteristics of peer feedback in interactions among preschool children (aged 3–6 years), adopting Hattie and Timperley’s (2007) feedback level model as a theoretical reference. The study further aims to design and pilot an observational tool specifically tailored to the preschool context, capable of supporting the observation and analysis of peer feedback dynamics while fostering awareness and professional competencies among educators. The research employs a qualitative approach within a socio-constructivist paradigm, using an ethnographic case study methodology. Data were collected through participant observations, video recordings, and semi-structured interviews across five selected preschools, four in Veneto and one in the United Kingdom. Questionnaires were administered to a broader sample of early childhood educators in the provinces of Padua, Venice, and Vicenza. Expected outputs include the development of a codebook for peer feedback forms, the formulation of an appropriate definition for the preschool age, the preparation of a report identifying educators’ knowledge, practices, and professional development needs regarding peer feedback, and the production of key principles to support teaching practices. This dataset contains: The long abstract of the project; A table systematising data on the number of sessions, timing, and modifications made during the creation of the observational protocol; An Excel file reporting intercoder agreement for eight observational protocols representative of the coding process; A table presenting the overall agreement among researchers for 23 observational protocols. All data has been processed in compliance with current personal data protection regulations, in accordance with Regulation (EU) 2016/679 (GDPR). The research project received ethical approval from the Ethics Committee of the Department at the University of Padova

    Python codes for STM data analysis

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    Python codes were conceived to work with ASCII .txt files with XYZ arrays, both as input and output. This makes codes highly compatible and universally usable. Code A provides an example of conversion from a .s94 data format to the requested ASCII .txt. Image analysis software always allow to export source files to .txt files with XYZ arrays, sometimes placing a text header before the data values to indicate the data scales. The script (code A) is created to convert raw STM files (.s94) into XYZ-type ASCII files, that can be opened by the WSxM software The script (code B) is developed to read the XYZ-type ASCII files and perform the flattening and equalizing filters by operating with an entire input file folder. The script (code C) was conceived with the possibility of optimizing the number of clusters The script (code D) reads a sample of images starting from the first one to the number N, which is selected by the user, it calculates the maximum extension of the Z values distribution for every image and returns an average extension value The script (code E) correct the drift affecting STM image

    European survey on metabolic and cardiovascular risk in Cushing syndrome - Supplementary data

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    Background: Cushing's syndrome (CS) is associated with increased metabolic and cardiovascular (CV) risk factors and morbidities. Evidence-based guidelines for the management of these issues in active or remitted CS are not available, so best practice is derived from guidelines developed for the general population. We aimed to evaluate the awareness and practice variation for CV comorbidities of CS across reference Centres (RCs) of the European Reference Network on Rare Endocrine Conditions (Endo-ERN). Methods: A dedicated online survey was distributed from June 2022 to December 2022 to Endo-ERN RCs with recognized expertise in adrenal and/or pituitary diseases. Results: 19 centres provided complete responses to the survey, accounting for an estimated pool of around one thousand chronically cared CS patients across Europe. Most ERN experts consider patients with CS at high CV risk irrespectively of remission status. Preoperative cortisol-lowering treatment was a common practice, especially for severe cases, and deemed effective in reducing CV risk by many. Most comorbidities were regularly evaluated at diagnosis and during follow-up, although a lack of provocative testing to diagnose diabetes (used only in 26% of RCs) was evidenced. A strict glycaemic control was encouraged although the glycaemic target differed. On the contrary, a less stringent approach to dyslipidaemia and overweight emerged. Preferred initial compounds for patients presenting comorbidities were angiotensin converting enzyme inhibitors, metformin and statins; lifestyle changes were preferred over drugs to control weight excess after cure. Screening for asymptomatic vascular disease was performed routinely and regularly repeated during follow-up by only half of the centres. Important heterogeneity in some responses emerged, especially regarding the effect of remission or medical treatment on comorbidities and CV risk. Discussion: Our survey highlights the awareness of ERN experts on management of metabolic and CV risk factors or disease in CS. Most of them use the current European guidelines and apply strategies for high CV risk patients, although not all these recommendations were fully applied. Since several CV risk factors seem to persist after disease remission, they should be adequately and promptly addressed. Population-specific studies are required to identify the optimal management of CV and metabolic comorbidities of CS patients

    Nuclear trafficking of Anelloviridae capsid protein ORF1 reflects modular evolution of subcellular targeting signals

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    This folder contain original Gel Mobility Shift Assays original gels, quantification of Fluorecense Polarization Assays, and single cell data analysis from Confocal Laser Scanning Microscopy

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