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MLUH-E-40_1, Falco eleonorae Géné, 1839, eggshell
No full textInventory No.: MLUH-E-40_1, Object: eggshell, Species: Falco eleonorae Géné, 1839, Preservation: complete preservation, Locality_loc.: Cykladen, Locality today: Cyclades, Country: GreeceCollector_leg.: Dr. T. J. Krüper, Date: ?, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 191, Identification by: M. Schönwetter, ex Collection: ex. Coll. Dr. T. J. Krüpe
Young unrelated donors confer a survival advantage for patients with myeloid malignancies compared to older siblings
No full textDonor age is one factor to optimize allogeneic hematopoietic cell transplantation (alloHCT). Therefore, we investigated whether young unrelated donors (UD) provide a benefit for older patients with myeloid malignancies compared to HLA-identical sibling donors (MSD). We performed a retrospective registry study on patients ≥50 years who received a first alloHCT between 2010 and 2020. We compared event-free survival (EFS) of patients who were transplanted from MSD aged ≥50 years versus UD aged ≤35 years who were HLA-compatible for HLA-A, -B, -C, and -DRB1. In total, we analyzed data from 3460 patients. With multivariable adjustment EFS (HR 0.86, p = 0.003), OS (HR 0.82, p < 0.001), and risk of relapse (HR 0.84, p = 0.018) were significantly better for HLA-compatible UD compared to MSD. No survival advantage was found, when UD with unfavorable sex or CMV constellation were compared to MSD with favorable constellations. In a meta-analysis on 9905 patients with myeloid malignancies, including ours, we found reduced risk of relapse (pooled HR 0.78, p = 0.006) and better EFS (pooled HR 0.89, p < 0.001) for young matched UD versus MSD. To select young HLA-compatible UD over older MSD may reduce relapse risk and improve survival for older patients with myeloid malignancies
MLUH-E-181_1, Accipiter badius (Gmelin, JF, 1788), eggshell
No full textInventory No.: MLUH-E-181_1, Object: eggshell, Species: Accipiter badius (Gmelin, JF, 1788), Preservation: complete preservation, Locality_loc.: Siam, Locality today: Thailand, Country: ThailandDate: 19/05/1885, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 159, Identification by: M. Schönwetter, Aquisition: 1910, Aquired from: Dr. Rey, ex Collection: ex. Coll. Dr. Re
MLUH-E-12_1, Falco perigrinus cassini Sharpe, 1873, eggshell
No full textInventory No.: MLUH-E-12_1, Object: eggshell, Species: Falco perigrinus cassini Sharpe, 1873, Preservation: good preservation, Locality_loc.: Bolivien, Locality today: Bolivia, Country: BoliviaCollector_leg.: J. Steinbach, Date: 01/11/1927, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 190, Identification by: M. Schönwetter, Aquisition: 1928, Aquired from: J. Steinbach, ex Collection: ex. Coll. J. Steinbac
MLUH-E-83_5, Falco tinnunculus Linnaeus, 1758, eggshell
No full textInventory No.: MLUH-E-83_5, Object: eggshell, Species: Falco tinnunculus Linnaeus, 1758, Preservation: slight damage, Locality_loc.: Lauterbach; Thüringen, Locality today: Lauterbach, Country: GermanyCollector_leg.: M. Schönwetter, Date: 01/05/1908, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 192, Identification by: M. Schönwetter, Aquisition: 1908, Aquired from: M. Schönwette
MLUH-E-414_1, Pernis apivorus (Linnaeus, 1758), eggshell
No full textInventory No.: MLUH-E-414_1, Object: eggshell, Species: Pernis apivorus (Linnaeus, 1758), Preservation: complete preservation, Locality_loc.: Boxberg bei Gotha, Locality today: Thuringia, Country: GermanyCollector_leg.: R. Essiger, Date: ?, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 155, Identification by: M. Schönwetter, Aquisition: 1904, Aquired from: R. Essiger, ex Collection: ex. Coll. R. Essige
Predicting Caco-2/MDCK intrinsic membrane permeability from HDM-PAMPA-derived hexadecane/water partition coefficients
No full textReliable membrane permeability data are essential in early drug development. Therefore, there is a strong need for robust experimental high-throughput screening methods, or ideally, accurate predictive tools, to assess membrane permeability. In a previous study, we demonstrated that the solubility-diffusion model can successfully predict passive permeability across biological Caco-2 and MDCK membranes, provided accurate hexadecane/water partition coefficients (Khex/w) are available.
In this study, we investigated the HDM-PAMPA method for determining Khex/w. We measured our own data (64 compounds) using this assay and compared the results with established methods such as black lipid membrane (BLM) experiments and classical two-phase systems. Our results show good agreement across methods, with both our data and literature values aligning closely.
Using these experimentally determined Khex/w values, we achieved accurate predictions of permeability in Caco-2 and MDCK cell membranes (RMSE = 0.8, n = 29) based on a previously calibrated equation. We further evaluated the in silico prediction of Khex/w using the UFZ-LSER database and the software COSMOtherm. COSMOtherm performed nearly as well as experimental measurements (RMSE = 1.20, n = 29), while the LSER approach (RMSE = 1.63, n = 29) is best applied when experimental descriptors are available or as a complement to COSMOtherm. This work highlights the practical utility of Khex/w in high-throughput permeability estimation, which can support efficient screening and prioritization of drug candidates in pharmaceutical research
MLUH-E-147_1 , Circus spilonotus Kaup, 1847, eggshell
No full textInventory No.: MLUH-E-147_1 , Object: eggshell, Species: Circus spilonotus Kaup, 1847, Preservation: complete preservation, Locality_loc.: Saukinskaja-Schlucht; Mittlerer Tian Shan, Locality today: Tian Shan, Country: China/Kazakhstan/Kyrgyzstan/Uzbekistan/TajikistanDate: 29/04/1905, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 176, Identification by: M. Schönwetter, Aquisition: 1905, Aquired from: O. Bamberg, ex Collection: ex. Coll. O. Bamberg, Additional Information: C. spilonotus spilonotus does not have breeding range toda
MLUH-E-165_3, Circus aeruginosus aeruginosus (Linnaeus, 1758), eggshell
No full textInventory No.: MLUH-E-165_3, Object: eggshell, Species: Circus aeruginosus aeruginosus (Linnaeus, 1758), Preservation: good preservation, Locality_loc.: Brandenburg an der Havel, Locality today: Brandenburg an der Havel, Country: GermanyCollector_leg.: G. Benke, Date: 27/04/1921, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 176, Identification by: M. Schönwetter, Aquisition: 1921, Aquired from: G. Benke, ex Collection: ex. Coll. G. Benk