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Metabolic reprogramming through polyphenol networks : a systems approach to metabolic inflammation and insulin resistance
No full textObesity-induced insulin resistance and type 2 diabetes mellitus (T2DM) represent complex systemic disorders marked by chronic inflammation, oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress. These pathophysiological processes disrupt insulin signaling and β-cell function, leading to impaired glucose homeostasis across multiple organs. Conventional therapies often target isolated pathways, overlooking the intricate molecular crosstalk and organelle-level disturbances driving disease progression. Citrus-derived polyphenols—including hesperidin, naringenin, nobiletin, and tangeretin—have emerged as promising agents capable of orchestrating a multi-targeted “metabolic reprogramming.” These compounds modulate key signaling pathways, including AMPK, PI3K/Akt, NF-κB, and Nrf2, thereby enhancing insulin sensitivity, reducing pro-inflammatory cytokine expression, and restoring redox balance. Furthermore, they improve mitochondrial biogenesis, stabilize membrane potential, and alleviate ER stress by modulating the unfolded protein response (UPR), thus supporting cellular energy homeostasis and protein folding capacity. Evidence from preclinical studies and select clinical trials suggests that citrus polyphenols can significantly improve glycemic control, reduce oxidative and inflammatory markers, and preserve β-cell function. Their pleiotropic actions across molecular and organ-level targets position them as integrative metabolic modulators. This review presents a systems-level synthesis of how citrus polyphenols rewire metabolic signaling networks and organelle resilience, offering a holistic therapeutic strategy to mitigate the root causes of obesity-induced insulin resistance
Clebopride stimulates 5-HT4-serotonin receptors in the human atrium
No full textClebopride resembles in its structural formula metoclopramide. Clebopride, an approved drug, is used to treat gastrointestinal diseases. Here, we tested the hypothesis that clebopride like metoclopramide acts as a partial agonist at human cardiac 5-HT4-serotonin-receptors. Clebopride enhanced the force of contraction (FOC) in isolated, electrically stimulated (1 Hz) left atrial preparations (LA) from transgenic mice with cardiac specific overexpression of the human 5-HT4-serotonin receptors (5-HT4-TG). Subsequently applied GR125487 (1 µM), a specific 5-HT4-serotonin-receptor antagonist, diminished this positive inotropic effect (PIE) of clebopride in LA from 5-HT4-TG. Clebopride failed to heighten FOC in LA from littermate wild-type mouse hearts (WT). Clebopride augmented the beating rate in isolated right atrial preparations (RA) from 5-HT4-TG but unable to do so in RA from WT. Clebopride alone (up to 10 µM) failed to augment FOC in isolated electrically stimulated (1Hz) human right atrial preparations (HAP) obtained during open heart surgery from adult patients with severe coronary heart disease. Interestingly, in the presence of the phosphodiesterase III inhibitor cilostamide, clebopride heightened FOC in HAP. GR125487 attenuated this PIE in HAP. Furthermore, when 1 µM serotonin had raised FOC in HAP, additionally applied 10 µM clebopride diminished FOC in HAP. We conclude that clebopride can act as an agonist and as an antagonist at 5-HT4-serotonin receptors in the human atrium.4 in 5-HT4-serotonin im Titel tiefgestell
MLUH-E-90_1, Falco tinnunculus Linnaeus, 1758, eggshell
No full textInventory No.: MLUH-E-90_1, Object: eggshell, Species: Falco tinnunculus Linnaeus, 1758, Preservation: complete preservation, Locality_loc.: Waren/ Mecklemburg, Locality today: Waren (Müritz), Country: GermanyCollector_leg.: Dr. R. Kuhk, Date: 30/04/1926, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 192, Identification by: M. Schönwetter, Aquisition: 1943, Aquired from: Dr. R. Kuhk, ex Collection: ex. Coll. Dr. R. Kuh
Primary succession and plant functional traits on an oceanic island
No full textThe discipline of functional island biogeography and studies on plant ecological strategies shaping island assemblages have emerged only recently. Due to volcanic activity, primary succession is an important natural process driving ecosystem dynamics on oceanic islands. However, our knowledge about plant functional traits in explaining the mechanism of ecological succession on these islands characterized by impoverished and disharmonic, but endemic-rich floras, is limited.
We investigated the distribution of plants with respect to nine functional traits related to resource use, reproduction, and growth as well as their overall functional diversity during primary succession using a chronosequence on 10 lava flows of La Palma, Canary Islands. We analysed changes of single traits with age using community-weighted trait means and applied ordination techniques to evaluate changes in trait composition. Based on ecological succession theory, we tested several hypotheses for changes of functional traits along the successional gradient. We also analysed the role of endemic and introduced plants in structuring successional communities.
Both the single-trait and trait compositional approach revealed that the composition of plants displaying core traits related to leaf economics and dispersal ability shifted with substrate age showing a change from acquisitive to conservative traits and from anemochory to zoochory along the gradient. These shifts were entirely driven by endemic shrubs, while other growth forms contributed to the increase in species and functional richness with lava age but little to vegetation structure. Introduced species were almost absent in successional trajectories. Functional dispersion increased whereas trait turnover was constant and low during succession.
Synthesis. Our island system reflects a directional succession governed by the selection of functional traits related to environmental conditions and acquisitive-conservative strategies as well as to dispersal capacity in early stages followed by a gradual modification of the environment and an expansion of the niche space linked to functional divergence in later stages. Major changes in functional traits occurred five hundred years after the eruptions indicating that primary succession in this dry environment is very slow. The dominance of endemic shrubs and the lack of introduced plants at all successional stages highlight the importance of evolutionary processes in shaping species ecological strategies linked to disturbances like volcanism on this oceanic archipelago
MLUH-E-289_2, Buteo lagopus lagopus (Pontoppidan, 1763), eggshell
No full textInventory No.: MLUH-E-289_2, Object: eggshell, Species: Buteo lagopus lagopus (Pontoppidan, 1763), Preservation: complete preservation, Locality_loc.: Luleå Lappmarken; Quickjok, Locality today: [Kvikkjokk] Sweden, Country: SwedenDate: 02/06/1916, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 167, Identification by: M. Schönwetter, Aquisition: 1936, Aquired from: A. Kricheldorf
Comparative analysis of asphalt and geomembrane sealing systems for sustainable uranium pile remediation : Insights from hydrological modeling under climate change
No full textUranium ore mining heaps in Saxony and Thuringia (Germany) have been primarily covered with mineral layers as part of remediation efforts. However, aging processes in these covers—driven by climatic factors, vegetation, and root penetration—can create cracks and pathways that increase radon emissions. In residential areas, elevated radon levels may exceed the guideline values set by radiation protection regulations. While asphalt seals and geomembranes are well-established as effective long-term solutions for creating convection-tight surface systems in landfill applications, their use has rarely been considered for uranium legacy sites. This study evaluates the long-term water balance and sealing effectiveness of asphalt and geomembranes at historical uranium mining site under future climate scenarios. Using the Hydrologic Evaluation of Landfill Performance (HELP) model, we simulated water behavior and potential infiltration rates across several sealing configurations, considering current and future climate projections. Our findings reveal that both sealing systems effectively minimize infiltration, surface runoff, and seepage, with negligible infiltration even under worst-case scenarios. The results underscore the robust environmental protection offered by these systems in mitigating radon emission and ensuring long-term environmental safety. This study contributes critical insights for selecting appropriate sealing systems in mining site remediation, offering sustainable solutions that address water conservation, climate resilience, and cleaner production principles.DEAL Elsevie
MLUH-E-173_3, Accipiter gentilis gentilis (Linnaeus, 1758), eggshell
No full textInventory No.: MLUH-E-173_3, Object: eggshell, Species: Accipiter gentilis gentilis (Linnaeus, 1758), Preservation: slight damage, Locality_loc.: Hamburg, Locality today: Hamburg, Country: GermanyCollector_leg.: F. Woinke, Date: 04/05/1915, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 157, Identification by: M. Schönwetter, Aquisition: 1939, Aquired from: F. Woinke, ex Collection: ex. Coll. F. Woink
MLUH-E-159_1, Circus aeruginosus aeruginosus (Linnaeus, 1758), eggshell
No full textInventory No.: MLUH-E-159_1, Object: eggshell, Species: Circus aeruginosus aeruginosus (Linnaeus, 1758), Preservation: heavy damage, Locality_loc.: Brandenburg an der Havel, Locality today: Brandenburg an der Havel, Country: GermanyDate: 27/06/1891, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 176, Identification by: M. Schönwetter, Aquisition: 1938, Aquired from: Berlin, ex Collection: ex. Coll. Berlin, Additional Information: The 4th egg of this clutch was given 1950 to Gra
MLUH-E-396_1, Milvus migrans (Boddaert, 1783), eggshell
No full textInventory No.: MLUH-E-396_1, Object: eggshell, Species: Milvus migrans (Boddaert, 1783), Preservation: slight damage, Locality_loc.: Dagse-Gyantse, Locality today: Xizang Autonomous Region, Country: ChinaCollector_leg.: Dr. E. Schäfer, Date: 24/05/1939, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 157, Identification by: M. Schönwetter, Aquisition: 1940, Aquired from: Dr. E. Schäfer, ex Collection: ex. Coll. Dr. E. Schäfe
MLUH-E-359_1, Haliaeetus albicilla albicilla (Linnaeus, 1758), eggshell
No full textInventory No.: MLUH-E-359_1, Object: eggshell, Species: Haliaeetus albicilla albicilla (Linnaeus, 1758), Preservation: good preservation, Locality_loc.: Türkei, Locality today: Turkey, Country: TurkeyCollector_leg.: W. Schlüter, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 173, Identification by: M. Schönwetter, Aquisition: 1913, Aquired from: Rückert, ex Collection: ex. Coll. W. Schlüter; ex. Coll. Rücker