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MLUH-E-381_2, Milvus milvus milvus (Linnaeus, 1758), eggshell
No full textInventory No.: MLUH-E-381_2, Object: eggshell, Species: Milvus milvus milvus (Linnaeus, 1758), Preservation: complete preservation, Locality_loc.: Leipzig, Locality today: Leipzig, Country: GermanyDate: ?, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 156, Identification by: M. Schönwetter, Aquisition: 1920, Aquired from: O. Fritsche, ex Collection: ex. Coll. O. Fritsch
Pancreatic cancer cells escape T/NK cell immune surveillance through the expressional separation of CD58
No full textBackground: Membrane (m) CD58 is a co-stimulatory
ligand
that binds to CD2, and the CD2-(
m) CD58 axis participates in
lymphocyte activation. In addition to mCD58, a soluble form
of CD58 (sCD58) has been reported in human serum, urine,
and in vitro cell culture supernatants. The role of sCD58 in
the tumor immune microenvironment of pancreatic ductal
adenocarcinoma (PDAC) is currently unknown.
Methods: The expression and prognostic role of CD58 in
PDAC tissues were analyzed using various public databases.
Then, the phenomenon of expressional separation of CD58
in PDAC cells induced by macrophages was observed by
flow cytometry and ELISA, where the decrease of mCD58
on the membrane surface is accompanied by the increase
of sCD58 in the supernatant. The molecular mechanisms of
the expressional separation of CD58 were further explored
by focusing on the TGF-β signaling pathway. The effects
of expressional separation of CD58 on the immune activity
and killing ability of T/NK cells for PDAC were determined
in co-culture
models. Furthermore, subcutaneous tumor-bearing
models, lung metastasis models, and intraperitoneal
dissemination models were used to confirm the in vitro data.
Finally, the diagnostic and prognostic roles of serum sCD58
were determined by using 561 samples from PDAC patients,
benign pancreatic disease patients, and healthy controls.
Results Elevated CD58 expression in PDAC tissues was
associated with worse clinical outcomes. After co-culture
with PDAC cells, macrophages adopted an M2 phenotype,
characterized by a high expression level of TGF-β. Co-cultured
macrophages could induce the expressional separation of
CD58 in PDAC cells. Activation of the TGF-β/Smad2/3 pathway
markedly promoted this separation, and pathway inhibition
largely blocked it. In vitro and in vivo assays revealed that
mCD58 engaged CD2 on T/NK cells, facilitated their activation,
enhanced their cytotoxicity, and stimulated the release of
the anti-tumoral
cytokines IFN-γ and TNF-α. Conversely,
local high concentrations of sCD58 accumulation in PDAC
tissues interfered with the CD2-CD58
axis by competitively
binding CD2, inhibited the activation of T/NK cells, reduced
T/NK cytotoxicity, and the secretion of IFN-γ and TNF-α.
Furthermore, serum sCD58 levels were higher in the PDAC
patients than in the healthy controls or patients with benign
pancreatic diseases. sCD58 improved the diagnostic and
prognostic power of CA199 in PDAC patients. A combined
model incorporating CA199, TGF-β1, and sCD58 yielded an
AUC (area under the curve) value of 0.946 for overall diagnosis.
In the CA199 negative cohort, the combined model of TGF-β
and sCD58 achieved an AUC of 0.955
MLUH-E-343_1, Haliastur indus indus (Boddaert, 1783), eggshell
No full textInventory No.: MLUH-E-343_1, Object: eggshell, Species: Haliastur indus indus (Boddaert, 1783), Preservation: complete preservation, Locality_loc.: [Juckvas] Darjeeling India, Locality today: Darjeeling, Country: IndiaCollector_leg.: O. Möller, Date: ?, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 157, Identification by: M. Schönwetter, Aquisition: 1935, Aquired from: Gowland, ex Collection: ex. Coll. Canon O. W. Sancock; ex. Col. E. C. S. Baker; ex. Coll. C. R. Wood; ex. Coll Mrs. W. Ager; ex. Coll. O. Mölle
MLUH-E-216_1 , Accipiter nisus nisus (Linnaeus, 1758), eggshell
No full textInventory No.: MLUH-E-216_1 , Object: eggshell, Species: Accipiter nisus nisus (Linnaeus, 1758), Preservation: complete preservationCollection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 160, Identification by: M. Schönwette
-modified Lie group generalized- methods for constrained multibody systems
No full textEfficient and accurate time integration methods are crucial for real-time simulation, optimization
and control of constrained multibody systems. This paper presents new Lie group
generalized- methods that improve accuracy for multibody systems with large rotations. The
proposed methods extend the widely used geom1 scheme by Brüls and Cardona by introducing
a -modification that allows to systematically eliminate a Lie group-specific part of the leading
error term without compromising second-order accuracy or zero stability. While optimal
accuracy is achieved for a specific choice of , the special case = 1 offers notable algorithmic
simplicity and minimal computational overhead. The original geom1 scheme is recovered by
setting = 0. Several numerical benchmarks demonstrate the potential of the proposed Lie
group integrators compared to both the original geom1 method and conventional formulations
based on Euler parameters or Cardan/Tait-Bryan angles
MLUH-E-83_1, Falco tinnunculus Linnaeus, 1758, eggshell
No full textInventory No.: MLUH-E-83_1, Object: eggshell, Species: Falco tinnunculus Linnaeus, 1758, Preservation: slight damage, Locality_loc.: Lauterbach; Thüringen, Locality today: Lauterbach, Country: GermanyCollector_leg.: M. Schönwetter, Date: 01/05/1908, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 192, Identification by: M. Schönwetter, Aquisition: 1908, Aquired from: M. Schönwette
MLUH-E-142_1, Falco peregrinus calidus Latham 1790, eggshell
No full textInventory No.: MLUH-E-142_1, Object: eggshell, Species: Falco peregrinus calidus Latham 1790, Preservation: slight damage, Locality_loc.: Radefka/Amur, Locality today: Russia/China, Country: Russia/ChinaDate: ?, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 189, Identification by: M. Schönwetter, Aquisition: 1919, Aquired from: R. Tancré, ex Collection: ex. Coll. R. Tancré, Additional Information: egg has fissur
MLUH-E-253_1, Buteo rufinus rufinus (Cretzschmar, 1829), eggshell
No full textInventory No.: MLUH-E-253_1, Object: eggshell, Species: Buteo rufinus rufinus (Cretzschmar, 1829), Preservation: complete preservation, Locality_loc.: Boetian, Locality today: Boeotia, Country: GreeceCollector_leg.: Dr. T. J. Krüper, Date: 27/03/1895, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 164, Identification by: M. Schönwetter, Aquisition: 1927, Aquired from: Dr. Henrici, ex Collection: ex. Coll. Dr. Henrici, ex. Coll. Dr. T. J. Krüpe
MLUH-E-51_2, Falco eleonorae Géné, 1839, eggshell
No full textInventory No.: MLUH-E-51_2, Object: eggshell, Species: Falco eleonorae Géné, 1839, Preservation: complete preservation, Locality_loc.: Cykladen, Locality today: Cyclades, Country: GreeceCollector_leg.: Dr. T. J. Krüper, Date: 23/08/1862, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 191, Identification by: M. Schönwetter, Aquisition: 1927, Aquired from: Dr. Henrici, ex Collection: ex. Coll. Dr. T. J. Krüper; ex. Coll. Dr. Henric
MLUH-E-323_2, Aquila chrysaetos chrysaetos (Linnaeus, 1758), eggshell
No full textInventory No.: MLUH-E-323_2, Object: eggshell, Species: Aquila chrysaetos chrysaetos (Linnaeus, 1758), Preservation: complete preservation, Locality_loc.: Muonioniska; Lappland, Locality today: Muonio; Fjell-Lappland, Country: FinlandDate: 07/05/1883, Collection_coll.: M. Schönwetter, published in Handbuch der Oologie, Schönwetter, Max: Vol. I, p. 171, Identification by: M. Schönwetter, Aquisition: 1938, Aquired from: Berlin, ex Collection: ex. Coll. W. Lietz; ex. Coll. Berli