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Does e-grocery shopping reduce CO 2 emissions for working couples’ travel in England?
No full textInternational audienc
Kaleidoscopic collegiality and the use of performance research metrics. The case of French universities
No full textInternational audienceThe extent to which collegiality conflicts or merges with managerial ideas and practices has recently given rise to a lively scholarly debate: have universities surrendered to managerialization or, on the contrary, do they continue to exhibit collegial traits? Part of this debate arises from the lack of a clear definition of “collegiality” in prior studies, where it is either reified or viewed through a limited number of different and possibly loosely coupled dimensions. We therefore deconstruct the collegial model and its structural and behavioral aspects, i.e., professional autonomy, organizational citizenship, faculty participation in decision-making, and academic units’ decision-making power. We examine the links between these dimensions of collegiality and performance metrics applied to research activities and outputs (PRM), because they are concrete artifacts of managerial practices seen as particularly deleterious to collegiality. We address this issue by undertaking a quantitative study of all French public universities (1,334 questionnaires analyzed). Our study draws two important conclusions. Firstly, it finds a mix of both conflict and hybridity depending on the dimension considered: the use of PRM is negatively linked with professional autonomy but compatible with organizational citizenship and faculty participation in decision-making. Secondly, we find that academic units’ reputation strengthens thepositive link between PRM and faculty participation, but on the other hand, mitigates the increase of organizational citizenship and academic units’ decision-making power. In sum, we suggest that faculty participation in decision-making is the only aspect of collegiality that resists the advance of managerial logics in universities
Olive Oil Traceability Studies Using Inorganic and Isotopic Signatures: A Review
No full textInternational audienceThe olive oil industry is subject to significant fraudulent practices that can lead to serious economic implications and even affect consumer health. Therefore, many analytical strategies have been developed for olive oil’s geographic authentication, including multi-elemental and isotopic analyses. In the first part of this review, the range of multi-elemental concentrations recorded in olive oil from the main olive oil-producing countries is discussed. The compiled data from the literature indicates that the concentrations of elements are in comparable ranges overall. They can be classified into three categories, with (1) Rb and Pb well below 1 µg kg−1; (2) elements such as As, B, Mn, Ni, and Sr ranging on average between 10 and 100 µg kg−1; and (3) elements including Cr, Fe, and Ca ranging between 100 to 10,000 µg kg−1. Various sample preparations, detection techniques, and statistical data treatments were reviewed and discussed. Results obtained through the selected analytical approaches have demonstrated a strong correlation between the multi-elemental composition of the oil and that of the soil in which the plant grew. The review next focused on the limits of olive oil authentication using the multi-elemental composition method. Finally, different methods based on isotopic signatures were compiled and critically assessed. Stable isotopes of light elements have provided acceptable segregation of oils from different origins for years already. More recently, the determination of stable isotopes of strontium has proven to be a reliable tool in determining the geographical origin of food products. The ratio 87Sr/86Sr is stable over time and directly related to soil geology; it merits further study and is likely to become part of the standard tool kit for olive oil origin determination, along with a combination of different isotopic approaches and multi-elemental composition
Tissue P Systems with Vesicles of Multisets
No full textInternational audienceWe consider tissue P systems working on vesicles of multisets with the very simple operations of insertion, deletion, and substitution of single objects. With the whole multiset being enclosed in a vesicle, sending it to a target cell can be indicated in those simple rules working on the multiset. As derivation modes we consider the sequential derivation mode, where, if possible, one rule is applied in a derivation step, and the set maximally parallel derivation mode, where in each derivation step a non-extendable set of rules indicating the same target cell is applied. With the set maximally parallel derivation mode, computational completeness can already be obtained with tissue P systems having a tree structure, whereas tissue P systems even with an arbitrary communication structure are not computationally complete when working in the sequential mode. Adding polarizations — only the three polarizations [Formula: see text], [Formula: see text], [Formula: see text] are sufficient — allows for obtaining computational completeness even for tissue P systems working in the sequential mode
Comparison of methods computing the distance between two ellipsoids
No full textInternational audienc
CCR5 Blockade in Inflammatory PML and PML-IRIS Associated With Chronic Inflammatory Diseases' Treatments
No full textInternational audienceBackground and objectives: Progressive multifocal leukoencephalopathy (PML) is a disabling neurologic disorder resulting from the infection of the CNS by JC polyomavirus in immunocompromised individuals. For the last 2 decades, increasing use of immunotherapies leads to iatrogenic PML. Iatrogenic PML is often associated with signs of inflammation at onset (inflammatory PML) and/or after treatment withdrawal immune reconstitution inflammatory syndrome (PML-IRIS). Although immune reconstitution is a key element for viral clearance, it may also be harmful and induce clinical worsening. A C-C chemokine receptor type 5 (CCR5) antagonist (maraviroc) has been proposed to prevent and/or limit the deleterious immune responses underlying PML-IRIS. However, the data to support its use remain scarce and disputed.Methods: We conducted a multicenter retrospective cohort study at 8 university hospitals in France and Switzerland by collecting clinical, biological, and radiologic data of patients who developed inflammatory PML (iPML) or PML-IRIS related to immunosuppressive therapies used for chronic inflammatory diseases between 2010 and 2020. We added to this cohort, a meta-analysis of individual case reports of patients with iPML/PML-IRIS treated with maraviroc published up to 2021.Results: Overall, 27 cases were identified in the cohort and 9 from the literature. Among them, 27 met the inclusion criteria: 16 treated with maraviroc and 11 with standard of care (including corticosteroids use). Most cases were related to MS (92.6%) and natalizumab (88%). Inflammatory features (iPML) were present at onset in 12 patients (44.4%), and most patients (92.6%) received corticosteroids within the course of PML. Aggravation due to PML-IRIS was not prevented by maraviroc compared with patients who received only corticosteroids (adjusted odds ratio: 0.408, 95% CI: 0.06-2.63). Similarly, maraviroc did not influence time to clinical worsening due to PML-IRIS (adjusted hazard ratio = 0.529, 95% CI: 0.14-2.0) or disability at the last follow-up (adjusted odds ratio: 2, 95% CI: 0.23-17.3).Discussion: The use of CCR5 blockade did not help to keep deleterious immune reconstitution in check even when associated with corticosteroids. Despite maraviroc's reassuring safety profile, this study does not support its use in iPML/PML-IRIS.Classification of evidence: This study provides Class IV evidence showing that adding maraviroc to the management of iatrogenic iPML/PML-IRIS does not improve the outcome
Characterising The Structure and Dynamics of Ecosystem Orchestration: A Literature Review
No full textInternational audienceIn the past years, the ecosystem concept has gained importance in the strategy and management fields. Originated by Moore in 1993, ecosystems have since then been analysed and critically reviewed by many scholars. The biological metaphor used to describe the variety of actors suggests that artificial ecosystems emerge by themselves, a point for which it has been criticised. Past research showed that ecosystems need to be orchestrated to develop and renew over time. Although research on ecosystems flourished, our understanding of ecosystem orchestration remains limited. Reviewing the literature on ecosystem orchestration, this paper summarises the current research on the structure and dynamics of orchestration. In particular, the article reviews a recent research stream that addresses dynamic capabilities in ecosystems, thus laying the ground for further research
Nano/micro implant debris affect osteogenesis by chondrocytes: Comparison between ceramic and UHMWPE from hip walking simulator
No full textBayesian Rationality Revisited: Integrating Order Effects
No full textInternational audienceBayes’ inference cannot reliably account for uncertainty in mental processes. The reason is that Bayes’ inference is based on the assumption that the order in which the relevant features are evaluated is indifferent, which is not the case in most of mental processes. Instead of Bayes’ rule, a more general, probabilistic rule of inference capable of accounting for these order effects is established. This new rule of inference can be used to improve the current Bayesian models of cognition. Moreover, it should play an essential role in the search for artificial emotional intelligence
How brands mobilize status, reputation, and legitimacy cues to signal their social standing: The case of luxury watchmaking
No full textInternational audienceWhile social evaluations have gained prominence in the field of marketing, few studies have investigated how brands strategically mobilize their social evaluations. This study aims to further explore the potential of social evaluations to shed light on brand management processes. Through a qualitative content analysis of 420 unique magazine ads of 36 fine watchmaking brands over a four-year period, we show how brands strategically draw from the distinct repertoires of status, reputation, and legitimacy to signal their social position and increase their appeal to consumers. We find that brands mobilize and combine cues from the three repertoires in different ways and that these variations stem from differences in the brands’ strategic intent and extent of market embeddedness. We discuss the contributions of these findings to the marketing literatures on social evaluations and on the role of advertising in brand building and conclude by outlining avenues for future research