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Des 'casati episcopi' aux 'pares Cameracenses':les mutations de la vassalité épiscopale à Cambrai aux XIe–XIIe siècles
No full textImpact of asundexian on a panel of coagulation assays
No full textBACKGROUND: During the last few years, the small, oral, activated factor XI inhibitor, asundexian, has been investigated in different cardiovascular disorders. However, little is known about its impact on laboratory coagulation assays.OBJECTIVES: To describe the effects of asundexian on a panel of laboratory coagulation assays.METHODS: The following assays were performed in normal pooled plasma spiked with increasing concentrations of asundexian (0-2000 ng/mL): activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen quantification (PT-derived and Clauss method), one-stage aPTT and PT-based coagulation factor assays, chronometric protein C and immunoturbidimetric protein S assays, reptilase time, chromogenic ecarin assay, dilute Russell's viper venom time assays, thrombin generation assay initiated by tissue factor (1, 5, and 20 pM) and ellagic acid (0.42 μM), rotational thromboelastometry intrinsically- and extrinsically-triggered assays, kaolin-activated clotting time, and glass bead-activated clotting time. This latter assay was also carried out in whole blood.RESULTS: Asundexian up to 2000 ng/mL impacted aPTT and one-stage aPTT-based coagulation factor assays, with high variability between reagents and methodologies. Asundexian reduced thrombin generation triggered by ellagic acid and 1 or 5 pM tissue factor. The rotational thromboelastometry intrinsically-triggered assays and kaolin- and glass bead-activated clotting time assays were affected by asundexian 2000 ng/mL, while overall, no significant interference was observed with any of the remaining assays.CONCLUSION: Despite this study including a comprehensive panel of coagulation assays, asundexian may still affect other coagulation assays not assessed here. Further investigations in patients treated with asundexian are therefore warranted.</p
Trapped by trails:How different types of recreational trails influence seasonal space use of wildlife in a densely visited national park
No full textProtected areas face the challenge of balancing conservation goals with increasing recreational use, which can strongly influence behavioural changes of wildlife and, consequently, affect ecosystem functioning. Understanding the impacts of various recreational activities on wildlife behaviour is essential for guiding targeted management strategies and supporting sustainable conservation practices. In the 60 km2, highly visited Hoge Kempen National Park (Belgium), we assessed habitat preferences and the seasonal impact of hiking, mountain biking, and tarmac cycling trail densities on the land use of roe deer, wild boar, and red fox. From May 2018 until May 2019, camera traps were used to monitor wildlife. Since individual animals could not be uniquely identified and the detection is imperfect, we used N-mixture models to estimate spatial variation in their land use, given their detection probability. We revealed species-specific seasonal differences in the impact of recreational trails and habitats. From all recreational trail types, hiking had the most negative impact on land use of roe deer and wild boar, while the impact of cycling and mountain biking trails was only negative in Spring. Furthermore, hiking and cycling trails had a more negative impact on land use of roe deer during the day than at night. In contrast, red fox selected areas with high recreational trail density in multiple seasons. These findings underscore the difference and seasonality in the impact of various recreation types on wildlife land use, highlighting the need for recreation monitoring and adaptive management strategies to mitigate or leverage recreational pressures on wildlife.</p
Pore structure modulation and defect engineering of soft carbon@coal-derived hard carbon for enhanced sodium storage application in SIBs
No full textHard carbon (HC) is regarded as the most promising commercial anode material for sodium-ion batteries (SIBs) due to its low cost, abundant sources, large reversible capacity, and suitability. Nevertheless, HC suffers from low initial coulombic efficiency (ICE), poor rate performance, and long-term cycling performance, significantly restricting its practical application. Herein, we proceed with defined regulation of the microcrystalline structure of coal-derived HC, which leads to reduced surface defects and increased interlayer spacing, further enhancing the sodium storage capacity of coal-derived HC as an anode material for SIBs by coating porous HC with soft carbon (SC). Meanwhile, we successfully synthesized high-performance SC@HC composite materials through chemical crosslinking reactions by innovatively adopting the sol-gel method and SC coating for the complex composition of coal. The SC@HC composite material as an anode in SIBs can deliver a reversible capacity of 320 mA h g−1 at 0.01 A g−1, a high ICE of 89%, and good cycling stability (capacity retention of 80% after 400 cycles at 1 A g−1). This work can rationally guide the design of low-defect and much more closed pore coal-derived HC materials and provide a feasible route for the development of high-performance HC-based anode materials for SIB applications.</p
MoS<sub>2</sub>@C-Modified Separator as an Efficient Polysulfide Barrier for High-Performance Li-S Batteries
No full textDue to the promising energy density (2800 Wh kg-1) and high theoretical specific capacity (1675 mAh g-1), there has been significant research interest in lithium-sulfur batteries (LSBs) recently. However, the shuttle effect and sluggish redox kinetics impede the commercial application of LSBs. In this work, a MoS2@C interlayer-modified commercial polypropylene (PP) (MoS2@C-PP) separator is designed to improve the electrochemical performance of LSBs. The active sites provided by MoS2 are conducive to enhancing the absorption of polysulfide lithium and improving the electrochemical performance. The N-doped carbon not only facilitates electrolyte penetration but also enhances ion transfer to promote reaction kinetics. Additionally, the formation of C-S bonds significantly reduces the shuttle effect. These factors largely accelerate the redox kinetics and decrease the shuttle effect, thereby improving the electrochemical performance of LSBs. As a consequence, the LSB with the MoS2@C-PP separator achieves a high discharge capacity of 860.5 mAh g-1 at 0.5 C after 200 cycles and a superior rate performance of 711.5 mAh g-1 at 2 C. This work offers a promising direction for enhancing the electrochemical performance of LSBs through separator modification .</p
A Fair Enhanced Bayesian Personalized Ranking Using Adversarial Learning
No full textThe ranking task is the critical step performed during a recommendation process to predict the top-list of most-wanted products for users. Learn-to-rank algorithms have been developed to refine the ranking process. However, the underrepresentation of some demographic user categories leads to unwanted biased ranking performances that affect the fairness aspects of the recommendation. Bayesian Pairwise Ranking (BPR) is among the most popular ranking algorithms for its important ranking accuracy performance. BPR with machine learning recommendation models can unfairly perform for minority user groups. We tackle the unfairness in the recommendation by proposing the FEBPR method. Our proposal is a fair pairwise Bayesian ranking in which the data debiasing is performed by using adversarial learning fed by enriched embeddings. In our proposal, user and item embeddings are learned to obey the adversarial constraint and mislead the adversary classifier that should not be able to have a priori assumptions about user membership. Extensive experiments are performed on real-world datasets and show that the performances of the proposed debiasing method improve fairness ranking aspects, and therefore the recommendation fairness. It is also shown that our proposal outperforms state-of-the-art fairness ranking methods and presents an interesting trade-off between the fairness aspects and ranking accuracy
Phase Transition in Halide Double Perovskites for Solar-To-Chemical Energy Conversion
No full textHalide double perovskites have recently garnered significant interest in solar energy conversion applications owing to their non-toxic and high solar absorption properties. However, unanticipated structural distortion within these materials can compromise their performance, suppressing the structural distortion is essential and remains challenging. Here, it is reported that using phenylethylamine triggering the disorder-order phase transition can largely increase the ordering extent of octahedra in double perovskite Cs2AgBiBr6, which can suppress self-trapped exciton and defect and enable rapid charge separation, leading to exceptional photo-physics/chemistry properties with over sixfold photoactivity enhancement in the photocatalytic C−H bond activation compared to less ordered structures. This work provides an effective strategy to solve the challenging problem of the disorder phenomenon of halide double perovskites for boosting solar-to-chemical energy conversion.</p