Publications scientifiques de l'Université de Reims Champagne-Ardenne
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Chronic cadmium exposure promotes TRPM7-dependent acquisition of a myofibroblast-like phenotype in pancreatic stellate cells
No full textInternational audienceCadmium (Cd) is a metallic pollutant which has been classified as a possible pancreatic carcinogen. Cd uses similar ion channels than divalent cations to accumulate into the cells. These include the Transient Receptor Potential Cation Channel Subfamily M Member 7 (TRPM7) which has been also shown as a biomarker of pancreatic cancer. Pancreatic carcinogenesis is associated with the establishment of a fibrous stroma induced by pancreatic stellate cell (PSC) activation. Although several stress factors have been identified as activators of PSCs, the impact of pollutants, particularly Cd, is still unknown. Here, we chronically exposed human PSCs to Cd and we observed that Cd-exposed cells acquired a myofibroblast-like phenotype. Moreover, TRPM7 expression and activity were upregulated following Cd exposure. Both TRPM7 inhibition by silencing or NS8593 treatment prevented the Cd-induced PSC cell migration indicating that TRPM7 regulated PSC activation. We used a model of indirect co-culture to study the impact of PSC on MIA PaCa-2 cancer cell migration. Interestingly, we showed that Cd-exposed PSCs stimulated MIA PaCa-2 cancer cell migration to a greater extent than non-exposed PSCs. TRPM7 inhibition in PSCs abolished the migration of cancer cells. Finally, in a mouse model with the KRASG12D mutation inducing spontaneous pancreatic intraepithelial neoplasia, Cd exposure aggravates collagen deposition in fibrotic areas showing high α-SMA and TRPM7 expressions. In summary, our study showed that Cd exposure upregulates TRPM7 leading to PSC activation and aggravation of precancerous pancreatic fibrosis in viv
LiDAR-Based Analysis of 19th-Century Fortifications in the Reims Region (France): Morphogenesis, Geoheritage, and Environmental Impact
No full textInternational audienceFollowing the Franco-Prussian War (1870–1871), the French government launched the ex nihilo construction of 234 forts, built using a variety of geomaterials and covered with massive earthworks involving several tens of thousands of cubic meters of fill. In Reims (northeastern France), a belt of 13 detached forts was constructed and modernized between 1875 and 1892, later integrated into the defensive networks of the WW1. This PhD research offers a morphological analysis of the "Séré de Rivières" fortifications, anchored in the broader field of geomorphological studies on the environmental imprint of warfare.Using high-resolution airborne LiDAR data covering the entire Reims fortification belt, this study aims to (1) analyze the morphological structures resulting from the hybridization of topography and fortification design, (2) investigate the morphogenesis of these war-related anthropogenic landforms to decode the « palimpsest » of the current landscape, and (3) assess their multifaceted legacy— geomorpological, biogeographical, historical, architectural, military, and cultural—with implications for heritage conservation, ecological dynamics, and environmental risk assessment. These contrasting territorial trajectories—ranging from ruin and reforestation to abandonment, preservation, or museographic valorization—reflect the diverse outcomes of military landform integration into peri-urban environments.The complexity of these artificial terrains calls for an interdisciplinary GIS-based approach combining geomorphology with archaeology, history, military and historical geography, geo-history, biogeography, and spatial planning, to explore past, present, and potential future landscape transformations.This research situates war landforms within anthropogeomorphology, where war is considered a powerful shaping force of contemporary landscapes. It also contributes to the recognition of these inherited reliefs as geoheritage objects—carrying scientific, historical, and ecological value—and calls for their inclusion in landform classification frameworks, as well as in heritage management policies and strategies addressing the long-term environmental impacts of conflict-altered terrains, particularly in post-conflict and rapidly urbanizing areas
Symposium : les séries télé à l’université : temps d’évasion, lieu de contrainte ou nouvel espace d’apprentissage
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Radiomic analysis of pathologically confirmed mandibular osteoradionecrosis to identify cases with associated recurrence: a multicentric retrospective study
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Sketches and lessons of past and evicted ‘biogeochemical policies’ in twentieth century France
No full textInternational audienceAccording to the Stockholm Resilience Centre, cycles of biogenic elements (nitrogen, phosphorus) are massively disrupted. This disruption manifests the ‘metabolic rift’ between industrial society and its environment. Using a geohistorical approach, this paper explores French evicted socio-technical trajectories that can be considered as past ‘biogeochemical policies’ i.e., policies which can respond to this disruption of natural cycles: municipal composting, sewage farms, fish ponds, the use as fertiliser of urine and faecal matter. By outlining the factors of their disappearance, which constitute locks that have now to be overcome, it aims to reopen the future of both urban sanitation and agriculture
Design, optimization, and characterization of a thermo-responsive hydrogel as submucosal injection agent for endoscopic resection
No full textInternational audienceSubmucosal injection is essential during endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) to create a protective cushion and enable safe lesion removal. However, commonly used solutions such as normal saline diffuse rapidly and provide only transient mucosal elevation. This study aimed to develop and characterize a thermosensitive hydrogel based on poloxamer 407 (P407) to achieve a more sustained submucosal lift. A design of experiments approach identified an optimized formulation containing 20% (w/v) P407 in water for injection, exhibiting suitable gelation temperature, gelation time, osmolality, and pH. Rheological analyses demonstrated low viscosity at room temperature, rapid sol-gel transition near 30°C, and the formation of a stable elastic network at 37°C. In vitro degradation showed progressive erosion, with complete dissolution within 24 h. Sterile filtration and needle passage produced only minor changes in viscoelastic moduli and did not alter gelation kinetics. Ex vivo studies using porcine gastrointestinal tissues confirmed that the hydrogel generated an initial mucosal lift comparable to 0.9% NaCl but maintained the elevation significantly longer. These findings demonstrate that P407-based thermosensitive hydrogel displayed favorable physicochemical, rheological, and functional properties for submucosal injection, supporting its potential as a next-generation lifting agent for EMR and ESD. Further in vivo studies are warranted to assess performance, safety, and clinical applicability
Le notaire et la protection des majeurs vulnérablesLes enseignements des droits belge et allemand
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Rankin--Cohen brackets in Representation Theory
No full textThe Rankin-Cohen brackets provide a basic example of "non-elementary" differential symmetry breaking operators. They can be interpreted as bi-differential operators remarkable for reflecting the structure of fusion rules for holomorphic discrete series representations of the Lie group SL(2, R) and are intimately connected to classical special polynomials.In this introductory article, we explore the combinatorial structure of these operators and discuss a general framework for constructing their higher-dimensional analogues from the representation-theoretic perspective on branching problems. The exposition is based on lectures delivered by the authors during the thematic semester "Representation Theory and Noncommutative Geometry", held in Spring 2025 at the Henri Poincaré Institute in Paris
Mentir sur ton CV, tu ne feras pas…
No full textInternational audienceNote sous CAA Bordeaux, 27 mai 2025, no 23BX0127
Errements du représentant syndical et déplacement d'office
No full textInternational audienceNote sous CAA Versailles, 15 mai 2025, no 22VE0204