Publications scientifiques de l'Université de Reims Champagne-Ardenne
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CD40/PI3K/FOXO1 axis rewiring drives microenvironment-dependent BIM silencing to sustain lymphoma growth and survival
No full textInternational audienceBoth solid and hematological malignancies are recognized as complex ecosystems in which the tumor microenvironment (TME) plays a pivotal role in mediating therapeutic resistance. TME-driven modulation of BCL2-family proteins has emerged as a key determinant of treatment response in B-cell malignancies. Here, we focused on the regulation of the pro-apoptotic BH3-only protein BIM, using mantle cell lymphoma (MCL), an aggressive and incurable B-cell neoplasm, as a cellular model. Comparative analysis of circulating and lymph node samples highlighted selective BIM downregulation in malignant cells within the nodal TME, contrasting with BIM upregulation observed with normal B cells. TME-mimicking ex vivo co-culture of primary samples recapitulated this tumor-specific and microenvironment-dependent mechanism. Mechanistically, we found that BIM downregulation is driven by a lymphoma-specific CD40L-mediated rewiring of the PI3K/AKT pathway, which in turn inhibits the transcriptional activity of FOXO1. Functionally, CRISPR/Cas9-mediated deletion of BIM in MCL primary cells was sufficient to bypass their dependence on microenvironmental survival cues, leading to long-term autonomous expansion ex vivo. Moreover, BIM loss conferred broad resistance to chemotherapy and clinically relevant targeted agents. In contrast, treatment with bispecific T-cell engagers elicited robust cytotoxic responses regardless of BIM expression, underscoring the potential of immunotherapies to overcome TME-induced apoptotic resistance
Synchrotron imaging of full mouse aortas – Acquisition, volume stitching, and analysis
No full textNational audienc
Cultivating methodological resonance in agri-food futuring
No full textAgri-food systems must shift toward sustainability, justice, and resilience, however analytical tools informing transformations are frequently siloed, limiting reciprocal learning. Drawing on Hartmut Rosa’s theory, we introduce methodological resonance: structured interactions among diverse agri-food futuring approaches and their shaping conditions that preserve difference while enabling shared transformative capacity – defined by mutual transformability, rigorous plurality, and situated responsiveness. We identify five sites where resonance is consequential: stakeholder engagement, quantitative–qualitative dialogue, bridging scales, radical imaginaries, and reflexivity. We outline pathways for researchers, funders, and institutions to embed methodological resonance in agri-food futures research that can be translated into scalable, operational practice
q-RATIONALS, LINK INVARIANTS AND WEBS
No full textWe investigate the role of q-rationals in the context of link invariants. This leads us to introduce and study web categories that q-deform Deligne's categories
Décote et surcote. Evolutions des conditions de départ au régimegénéral d’assurance vieillesse
No full textInternational audienc
Early osteopathic treatment delivered to patients with an acute lateral ankle sprain improves recovery: an investigative study
No full textInternational audienceAbstract Context Acute lateral ankle sprain (ALAS) is responsible for short-term disability, increased risk for future acute ankle sprain, and chronic ankle instability. Several studies highlighted that manipulative therapy may reduce pain and increase the range of motion (ROM) of the injured ankle, but not all of them targeted acute injuries. Some studies focused their interest on a specific manipulative technique or utilized either physiotherapy or chiropractic techniques. Objectives The objectives of this study were to evaluate the effectiveness of osteopathic care in ALAS, to assess pain, edema, and functional stability of the injured ankle, and to assess and comparing mobility between the injured and noninjured ankle. Methods We conducted an interventional randomized controlled trial (RCT) in the emergency department (ED) of a French University Hospital. Fifty patients were enrolled in this study. They had to be ≥18 years old, consulting in the ED for a single ALAS (<72 h) stage 1 or 2, and must have had preliminary consultation with an emergency physician. Patients with an ALAS stage 3 or fractured, or with history of homolateral ankle surgery, were excluded. Patients were randomized either in the medical treatment (MT) group or in the medical and osteopathic treatment (MOT) group and had a 3-week follow-up. In the MOT group, the intervention consisted of a single osteopathic treatment (manual intervention) at Day 0, depending on the tissue affected and on the intensity of the tissular tension found, and individualized advice provided at Days 0, 7, and 21. Comparisons between groups were investigated utilizing the chi-square or Fisher’s exact test, or Student’s t -test or Mann Whitney U-test, as appropriate. Results Forty-five patients completed the study. The patients’ median age was 29.5 years old (23–40 years). At Day 21, 95.7 % of patients in the MOT group had equivalent capacity of unloaded dorsal flexion between the injured and noninjured ankle, vs. 50.0 % of patients in the MT group (p=0.0005). Between Day 0 and Day 21, the pain with the injured ankle loaded and unloaded decreased more significantly in the MOT group (p=0.001 and p=0.0007, respectively), while the loaded and unloaded dorsal flexion, and the unloaded plantar flexion, increased (p=0.003, p<0.0001 and p=0.02, respectively). Between Day 0 and Day 0 postosteopathic treatment, all judgment criteria showed improvement in the MOT group. At Day 7, all the functional stability tests were performed better by patients in the MOT group. Conclusions Early osteopathic treatment associated with usual MT, delivered to patients with an ALAS, may improve mobility and functional stability, and may reduce pain and edema, in the 3 weeks postintervention. These promising findings require confirmation in a larger controlled trial
Cutaneous leukocytoclastic vasculitis leading to extensive digital necrosis as the only COVID-19 clinical manifestation
No full textInternational audienceDigital necrosis is now a well-established complication of COVID-19 infection, but data are sparse regarding the pathophysiology. We present the case of digital necrosis secondary to cutaneous leukocytoclastic vasculitis in a patient with COVID-19 infection. After histologic confirmation of vasculitis, the patient was given methylprednisolone leading to an improvement that enabled limited amputation
Autour du Monasticon Gallicanum : représentation de l'architecture monastique dans la France du XVIIe siècle
No full textInternational audienc
On the computation of the canonical basis for irreducible highest weight -module
No full textWe study canonical basis elements in higher-level Fock spaces associated with the quantum group , which are conjecturally related to Calogero-Moser theory for complex reflection groups. We generalize the Leclerc-Miyachi formula to arbitrary levels by introducing new explicit constructions based on symbols, including a column removal theorem and closed formulas in several cases. These results provide explicit descriptions of canonical basis elements with applications to Calogero-Moser cellular characters and to the decomposition matrices of Ariki-Koike algebras