Publications scientifiques de l'Université de Reims Champagne-Ardenne
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Combination of ertapenem and penicillin M or cefazolin in the treatment of methicillin-susceptible Staphylococcus aureus bacteremia: multicenter case series
No full textInternational audienc
Development and Validation of EVANpedia for the assessment of Perioperative Experience in Pediatric Patients
No full textInternational audienceBackground: Patient-Reported Outcome and Experience Measures are essential for advancing pediatric patient-centered care in the perioperative context. Combining complementary patient-centered instruments supports a broader, multidimensional evaluation of perioperative care.The Pediatric Scale for Quality of Recovery is a patient-reported outcome measure assessing quality of recovery after surgery and anesthesia in children and represents an important step in this field. This study aimed to develop and validate a self-reported instrument, the Evaluation du Vécu de l'Anesthésie Générale en Pédiatrie (EVANpedia), designed to assess experience in children and adolescents within 24 hours after surgery.Methods: The study included a developmental phase to generate items and a psychometric validation phase. The multidimensional structure of EVANpedia was explored using factor analysis, item internal consistency, and discriminant analyses. The Rasch model assessed the unidimensionality of each dimension, and reliability was evaluated using McDonald's ω coefficient. Convergent and external validity were examined using concurrent self-report instruments and clinical data.Results: Six hundred patients (7-17 years) were included across four anesthesia departments. Following the development and validation phases, EVANpedia comprised 26 items grouped into six dimensions: Anxiety, Thirst and Hunger, Loss of Autonomy, Pain, Nausea and Vomiting, and Confusion. Internal construct validity was high, with excellent fit statistics across all dimensions (from 0.95 to 1.03). Correlations between EVANpedia scores and all concurrent measures supported convergent validity. Nine percent of children reported disappointment with their perioperative experience, showing significantly lower overall EVANpedia scores (50.1 ± 12.1 vs. 62.8 ± 15.1; P < 0.001). Overall and all dimensional EVANpedia scores demonstrated excellent sensitivity to clinical change, supporting the responsiveness of the instrument.Conclusion: EVANpedia is a psychometrically robust self-reported instrument for assessing perioperative experience in children and adolescents
Tuning the specific surface area of pure monophasic hydroxyapatite nanoparticles synthesized by sol-gel method using a capillary-based microfluidic process
No full textInternational audienceThe surfactant-free sol-gel synthesis of hydroxyapatite nanoparticles was adapted for in-flow production using a capillary-based microfluidic device. Different parameters have been investigated, including the capillary arrangements (core-shell and side-by-side), the capillary diameter, and the flow rate of the precursor solutions. The nanoparticles synthesized were characterized by X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and specific surface area measurement according to the Brunauer-Emmett-Teller (BET) theory. The results were compared with those of hydroxyapatite nanoparticles obtained by the conventional batch sol-gel synthesis method. The morphology of the nanoparticles changed due to the use of different capillary arrangements and thus exhibited a higher specific surface area than the batch process. The highest specific surface area was observed when using a side-by-side arrangement using a capillary with an internal diameter of 100 μm and a flow rate of 100 μL/min reaching an increase of the specific surface area by two-fold (61 m2/g) as compared to the conventional batch sol-gel method (29 m2/g) without affecting any of their other properties including cell viability
A qui profite la régression environnementale ?
No full textInternational audienceEtude sur les dispositions juridiques et déclarations politiques dans la loi Duplom
Binding of the elastin peptide VGVAPG and lactose to the human elastin binding protein
No full textInternational audienceElastin-derived peptides (EDPs) interact with elastin-binding protein (EBP), a key component of the elastin receptor complex, modulating cellular processes such as protease activation, apoptosis, and chemotaxis via regulation of NEU-1 sialidase activity. Despite their therapeutic relevance, the structural basis of EDP-EBP interactions remains poorly understood. Here, we present the first full-length homology model of EBP (residues 29–516), constructed and validated through duplicate 1 microsecond long molecular dynamics (MD) simulations. Molecular docking of VGVAPG (as a representative EDP) and lactose (as a representative galactosugar) followed by MD simulations, allowed us to identify key binding residues: D98, E99, S104, and S136 for VGVAPG; and E99, S101, S104, N116, Q124, E137, and Y139 for lactose. These data reveal a shared binding region within residues 83–139, suggesting a competitive binding between EDPs and galactosugars. Furthermore, EBP residues P233 and I234 were implicated in potential interactions with PPCA or NEU-1, contributing to ERC assembly. These findings offer new insights into the molecular recognition mechanisms of EBP and provide a foundation for the design of EBP-targeted elastin peptide antagonists
Current knowledge and perspectives on the emerging Inquilinus limosus pathogen
No full textInternational audienceInquilinus limosus is a nonfermentative Gram-negative rod that has been reported as an emergent pathogen, particularly in chronic respiratory diseases. I. limosus was first isolated from the airways of a lung transplant patient suffering from cystic fibrosis (CF). As I. limosus is almost exclusively recovered from the airways of CF patients, its identification may be challenging for non-CF specialists. Indeed, I. limosus is mainly isolated from the airways of CF patients, and its pathogenesis and treatments are still debated. We have extensively reported and reviewed the different clinical cases described in the literature, the identification methods used, and the antimicrobial susceptibility testing performed. Therefore, we provide here an exhaustive description of the phenotypic features and antimicrobial susceptibilities of I. limosus . Only seven I. limosus genomes are currently available in public databases. These genomes are not fully assembled and therefore allow only partial genomic analyses, which could not unveil antimicrobial resistance determinants or virulence factors. They are approximately 7 Mb in size and encode between 6,036 and 7,483 genes. Given that the available genomes are incomplete, our genomic analyses are still limited and would undoubtedly benefit from further fully sequenced and annotated genomes to provide additional information on the antibiotic resistance and pathogenesis of I. limosus . We anticipate that our review will be a starting point for more genome sequencing studies, as well as epidemiological studies, to provide additional information on I. limosus for better management of patients
Impact of lymph node staging on survival in presumed early-stage ovarian cancer: a multicentric retrospective study
No full textInternational audienceObjective:This study aimed to assess the impact of comprehensive staging on survival outcomes in this population.Methods:Patients who underwent surgery for epithelial ovarian cancer in one of the 14 Francogyn cancer centers between 2000 and 2020 were included in the study. The primary analysis evaluated the impact of lymphadenectomy on overall survival and recurrence-free survival. Lymph node count was analyzed as a continuous variable, and its association with survival, considered as a continuous outcome was assessed using linear regression (secondary analysis). Survival was compared using the log-rank test, and multivariate analysis was performed using a Cox model.Results:A total of 467 patients with presumed early-stage epithelial ovarian cancer were included, of which 198 underwent complete lymphadenectomy and 266 did not. No significant association was found between lymph node staging and survival in the primary analysis, possibly due to limited statistical power and a selection bias, as patients without lymphadenectomy had more favorable disease profiles (p=0.600 and p=0.700, respectively). Complete lymphadenectomy was associated with a significantly higher risk of complications (34.5% vs. 14%, p<0.001). In secondary analysis, the number of para-aortic lymph nodes harvested was identified as an independent predictor of both overall survival and recurrence-free survival (p=0.007 and p=0.002, respectively). Histological characteristics and adjuvant chemotherapy also showed a significant correlation with improved survival outcomes.Conclusion:Extensive para-aortic lymphadenectomy in early-stage epithelial ovarian cancer is associated with better overall and recurrence-free survival but comes with an increased risk of complications
Design, synthesis, structural and theoretical investigation of novel aminonaphthol-based Betti derivatives with antioxidant activity
No full textInternational audienceIn this study, three new Betti-base derivatives were synthesized via a green and efficient one-pot multicomponent reaction under solvent-free conditions. The compounds were structurally characterized by spectroscopic techniques (FT-IR, NMR, HRMS), single-crystal X-ray diffraction, and supported by DFT calculations. Their antioxidant potential was evaluated using DPPH, ABTS, and ferric-phenanthroline assays. Crystallographic analysis revealed significant non-covalent interactions contributing to crystal packing stability, while theoretical investigations provided insights into electronic descriptors (HOMO-LUMO gap, electrophilicity, chemical hardness) and radical stabilization mechanisms through bond dissociation energy (BDE) and Fukui functions. Among the synthesized aminonaphthol derivatives, compound (1) exhibited promising antioxidant properties, correlating with its favorable electronic and structural parameters. This work demonstrates the synergy between green synthesis, crystallography, and quantum chemistry in the development of potential bioactive agents
