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Continuous flow thin film microfluidic mediated nano-encapsulation of fish oil
Get PDF© 2018 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/
This author accepted manuscript is made available following 12 month embargo from date of publication (December 2018) in accordance with the publisher’s archiving policyA facile process has been developed for the encapsulation of fish oil using a thin film vortex fluidic device (VFD) operating under continuous flow, allowing control over the size of the encapsulated particles which are spheroidal in shape with diameters ranging from 50 to 250 nm. This microfluidic platform simplifies the processing procedure of water-in-oil-in-water (w/o/w) encapsulation, as now a time and cost saving one-step process devoid of any organic solvents, in contrast to the conventional homogenization process which is inherently complex, involving multiple-steps and the use of organic solvents. Moreover, use of homogenization (as a benchmark to encapsulate fish oil) afforded much larger macro-particles, ranging in size from 2 to 4 μm. Smaller encapsulated particles fabricated using VFD processing could lead to improved absorption from fish oil. Overall, VFD processing provides a new alternative bottom–up approach to easy, scalable processing, without the need for organic solvents which are counterproductive in the food industry
How does policy framing enable or constrain inclusion of social determinants of health and health equity on trade policy agendas?
No full text© 2018 Informa UK Limited, trading as Taylor & Francis GroupTrade agreements influence the distribution of money, goods, services and daily living conditions – the social determinants of health and health equity, which ultimately impacts differentially on health within and between countries. In order to advance health equity as a trade policy goal, greater understanding is needed of how different actors frame their interests in order to shape government priorities, thus helping to identify competing agendas across policy communities.
This paper reports on a study of how policy actors framed their interests for the Trans Pacific Partnership agreement. We analysed 88 submissions made by industry actors, not for profit organisations, unions, researchers and individual citizens to the Australian government during treaty negotiations. We show that policy actors’ ideas of the purpose of trade agreements are shaped by competing underlying assumptions of the role of the state, market and society. We identify three primary framings: a dominant neoliberal market frame, and counter frames for the public interest and state sovereignty. Our analysis highlights the potential enabling and constraining impact of policy frames for health equity. In particular, the current dominant market framing largely excludes the social determinants of health and health equity. We argue that advocacy needs to tackle head on the underlying assumptions of market framings in order to open up space for the social. We identify successful examples of health framing for equity as well as opportunities for engagement with ‘non-traditional’ allies on shared issues of concern
Media multitasking, impulsivity and dual task ability
Get PDF© 2018 Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/
This author accepted manuscript is made available following 24 month embargo from date of publication (November 2018) in accordance with the publisher’s archiving policyWith recent developments in technology, media multitasking is an ever-increasing phenomenon. Although most studies associate media multitasking with high impulsivity and poorer cognitive performance, findings in the literature have been mixed, with some studies suggesting the opposite. The aim of this study was to investigate the relationship between media multitasking and the capacity to exert inhibitory control, as well as the ability to multitask in a multisensory setting. Results showed that media multitasking was associated with high attentional impulsivity and lower initiatory self-control, but not with inhibitory self-control. Relatedly, heavy media multitaskers were slower and showed more omission errors on the go/no-go task, suggestive of inattention; however, they were better at inhibiting already initiated motoric responses in the stop signal task. Media multitasking was further associated with faster responses when a letter and a tone task were temporally separated, but not when they were presented closer in time. Taken together, the results suggest a more nuanced relationship between media multitasking, personality and cognitive ability than has previously been thought. This has important real life implications for media multitasking, showing both advantages and disadvantages
Sustainability of telecentres in developing countries: Lessons from Union Digital Centre in Bangladesh
Get PDF© 2018 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license:
http://creativecommons.org/licenses/by-nc-nd/4.0/
This author accepted manuscript is made available following 24 month embargo from date of publication (May 2018) in accordance with the publisher’s archiving policyThis study examines operational sustainability of a major telecentre initiative - the Union Digital Centre (UDC) in Bangladesh - from the perspective of public-private-people’s partnership (PPPP). Given the rising incidence of dropout of private entrepreneurs causing premature closure of telecentres, it is important to understand and identify key variables that affect sustainability of the scheme. In appreciation of the difficulty associated with operationalisation of the term ‘sustainability’ in this study we adopt ‘operational sustainability’ as an alternative to investigate the dynamics of sustenance. We have reviewed key literature about various dimensions of sustainability and their interrelationships in order to develop hypotheses about sustainability of the UDC and factors associated with it. Drawing on data collected from a survey of 538 private entrepreneurs and 41 interviews with government officials we show the extent to which various elements of the UDC eco-system contribute to its sustainability. The application of a structural equation model confirms that both financial and social outcomes of the UDC depend largely on inputs and contributions of various stakeholders. The paper concludes that effective engagement of private entrepreneurs is critical, as is governmental patronage, for ensuring operational sustainability of partnership-based telecentres like the UDC
Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels
Get PDFCrown Copyright © 2018 Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/
This author accepted manuscript is made available following 24 month embargo from date of publication (March 2019) in accordance with the publisher’s archiving policyBoth N- and T-type calcium ion channels have been implicated in pain transmission and the N-type channel is a well-validated target for the treatment of neuropathic pain. An SAR investigation of a series of substituted aminobenzothiazoles identified a subset of five compounds with comparable activity to the positive control Z160 in a FLIPR-based intracellular calcium response assay measuring potency at both CaV2.2 and CaV3.2 channels. These compounds may form the basis for the development of drug leads and tool compounds for assessing in vivo effects of variable modulation of CaV2.2 and CaV3.2 channels
Rebuttal to “The case of the Biscayne Bay and aquifer near Miami, Florida: density-driven flow of seawater or gravitationally driven discharge of deep saline groundwater?” by Weyer (Environ Earth Sci 2018, 77:1-16)
Get PDF© The Author(s) 2018
This article is distributed under the terms of the Crea-tive Commons Attribution 4.0 International License (http://creat ivecommons .org/licen ses/by/4.0/), which permits unrestricted use, distribu-tion, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.A recent paper by Weyer (Environ Earth Sci 2018, 77:1–16) challenges the widely accepted interpretation of groundwater heads and salinities in the coastal Biscayne aquifer near Miami, Florida, USA. Weyer (2018) suggests that the body of saltwa-ter that underlies fresh groundwater just inland of the coast is not a recirculating wedge of seawater, but results instead from upward migration of deep saline groundwater driven by regional flow. Perhaps more significantly, Weyer (2018) also asserts that established hydrologic theory is fundamentally incorrect with respect to buoyancy. Instead of acting along the direction of gravity (that is, vertically), Weyer (2018) claims, buoyancy acts instead along the direction of the pressure gradient. As a result, Weyer (2018) considers currently available density-dependent groundwater flow and transport modeling codes, and the analyses based on them, to be in error. In this rebuttal, we clarify the inaccuracies in the main points of Weyer’s (2018) paper. First, we explain that Weyer (2018) has misinterpreted observed equivalent freshwater heads in the Biscayne aquifer and that his alternative hypothesis concerning the source of the saltwater does not explain the observed salinities. Then, we review the established theory of buoyancy to identify the problem with Weyer’s (2018) alternative theory. Finally, we present theory and cite successful benchmark simulations to affirm the suitability of currently available codes for modeling density-dependent groundwater flow and transport
The effectiveness of a web 2.0 physical activity intervention in older adults – a randomised controlled trial
Get PDF© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise statedBackground
Interactive web-based physical activity interventions using Web 2.0 features (e.g., social networking) have the potential to improve engagement and effectiveness compared to static Web 1.0 interventions. However, older adults may engage with Web 2.0 interventions differently than younger adults. The aims of this study were to determine whether an interaction between intervention (Web 2.0 and Web 1.0) and age group (<55y and ≥55y) exists for website usage and to determine whether an interaction between intervention (Web 2.0, Web 1.0 and logbook) and age group (<55y and ≥55y) exists for intervention effectiveness (changes in physical activity).
Methods
As part of the WALK 2.0 trial, 504 Australian adults were randomly assigned to receive either a paper logbook (n = 171), a Web 1.0 (n = 165) or a Web 2.0 (n = 168) physical activity intervention. Moderate to vigorous physical activity was measured using ActiGraph monitors at baseline 3, 12 and 18 months. Website usage statistics including time on site, number of log-ins and number of step entries were also recorded. Generalised linear and intention-to-treat linear mixed models were used to test interactions between intervention and age groups (<55y and ≥55y) for website usage and moderate to vigorous physical activity changes.
Results
Time on site was higher for the Web 2.0 compared to the Web 1.0 intervention from baseline to 3 months, and this difference was significantly greater in the older group (OR = 1.47, 95%CI = 1.01–2.14, p = .047). Participants in the Web 2.0 group increased their activity more than the logbook group at 3 months, and this difference was significantly greater in the older group (moderate to vigorous physical activity adjusted mean difference = 13.74, 95%CI = 1.08–26.40 min per day, p = .03). No intervention by age interactions were observed for Web 1.0 and logbook groups.
Conclusions
Results partially support the use of Web 2.0 features to improve adults over 55 s’ engagement in and behaviour changes from web-based physical activity interventions
The contribution of a MOOC to community discussions around death and dying
Get PDFOpen Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background
Advances in medicine have helped many to live longer lives and to be able to meet health challenges. However death rates are anticipated to increase given the ageing population and chronic disease progression. Being able to talk about death is seen to be important in normalising death as part of life and supporting preparedness for death. Massive Open Online Courses (MOOCs) provide opportunities for the community to engage in collaborative learning. A 5 week MOOC was developed covering four main topics (language and humour, representations of death, medicalisation of dying, and digital dying) aiming: To enable participants to openly and supportively discuss and learn about issues around living, death and dying, To explore the normally unheard opinions and views of Australians around death and dying, and To determine what effect online learning and discussions offered through the MOOC had on participants’ feelings and attitudes towards death and dying.
Methods
Data was captured on engagement rates in the various MOOC activities. Death Attitudes were measured by five items representing the MOOC’s learning objectives and completed at enrolment and conclusion. MOOC Satisfaction was measured with six items at the end of the MOOC. Descriptive statistics were produced for each variable and Chi-Square Tests of Independence assessed the extent of the relationship between categorical variables. Socio-demographic variables were examined as predictors of the outcome variables of MOOC engagement, MOOC satisfaction, and death attitudes. Ethical approval was received from Flinders University Social and Behavioural Research Ethics Committee (Project No. 7247).
Results
One thousand one hundred fifty six people enrolled in the Dying2Learn MOOC with 895 participating in some way. Enrolees were primarily female (92.1%). Age ranged from 16 to 84 (mean = 49.5, SD = 12.3). MOOC satisfaction scores were high. Responses to the experience of participating in the MOOC were very positive, with mean scores ranging from 4.3 to 4.6 (aligning with agreement and strong agreement to statements on the value of participating). Death Attitudes were positive at commencement but increased significantly following participation.
Conclusions
The Dying2Learn MOOC provided an environment that enabled open and supportive discussion around death and dying and influenced attitudinal change
Data Descriptor: Australia’s continental-scale acoustic tracking database and its automated quality control process
Get PDFOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files made available in this article.Our ability to predict species responses to environmental changes relies on accurate records of animal movement patterns. Continental-scale acoustic telemetry networks are increasingly being established worldwide, producing large volumes of information-rich geospatial data. During the last decade, the Integrated Marine Observing System’s Animal Tracking Facility (IMOS ATF) established a permanent array of acoustic receivers around Australia. Simultaneously, IMOS developed a centralised national database to foster collaborative research across the user community and quantify individual behaviour across a broad range of taxa. Here we present the database and quality control procedures developed to collate 49.6 million valid detections from 1891 receiving stations. This dataset consists of detections for 3,777 tags deployed on 117 marine species, with distances travelled ranging from a few to thousands of kilometres. Connectivity between regions was only made possible by the joint contribution of IMOS infrastructure and researcher-funded receivers. This dataset constitutes a valuable resource facilitating meta-analysis of animal movement, distributions, and habitat use, and is important for relating species distribution shifts with environmental covariates
Integration of machine learning and metaanalysis identifies the transcriptomic biosignature of mastitis disease in cattle
Get PDFThis is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.Gram-negative bacteria such as Escherichia coli (E. coli) are assumed to be among the main agents that cause severe mastitis disease with clinical signs in dairy cattle. Rapid detection of this disease is so important in order to prevent transmission to other cows and helps to reduce inappropriate use of antibiotics. With the rapid progress in high-throughput technologies, and accumulation of various kinds of ‘-omics’ data in public repositories, there is an opportunity to retrieve, integrate, and reanalyze these resources to improve the diagnosis and treatment of different diseases and to provide mechanistic insights into host resistance in an efficient way. Meta-analysis is a relatively inexpensive option with good potential to increase the statistical power and generalizability of single-study analysis. In the current meta-analysis research, six microarray-based studies that investigate the transcriptome profile of mammary gland tissue after induced mastitis by E. coli infection were used. This meta-analysis not only reinforced the findings in individual studies, but also several novel terms including responses to hypoxia, response to drug, anti-apoptosis and positive regulation of transcription from RNA polymerase II promoter enriched by up-regulated genes. Finally, in order to identify the small sets of genes that are sufficiently informative in E. coli mastitis, the differentially expressed gene introduced by meta-analysis were prioritized by using ten different attribute weighting algorithms. Twelve meta-genes were detected by the majority of attribute weighting algorithms (with weight above 0.7) as most informative genes including CXCL8 (IL8), NFKBIZ, HP, ZC3H12A, PDE4B, CASP4, CXCL2, CCL20, GRO1(CXCL1), CFB, S100A9, and S100A8. Interestingly, the results have been demonstrated that all of these genes are the key genes in the immune response, inflammation or mastitis. The Decision tree models efficiently discovered the best combination of the meta-genes as bio-signature and confirmed that some of the top-ranked genes -ZC3H12A, CXCL2, GRO, CFB- as biomarkers for E. coli mastitis (with the accuracy 83% in average). This research properly indicated that by combination of two novel data mining tools, meta-analysis and machine learning, increased power to detect most informative genes that can help to improve the diagnosis and treatment strategies for E. coli associated with mastitis in cattle