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Aging Well in Harmony Toolkit: Personalised care to residents with dementia in rural aged care facilities
Full text link© 2020 Flinders University Rural Health SA, Flinders UniversityThis toolkit is an outcome of a non-pharmacological intervention, ‘Harmony in the Bush’, conducted by Flinders University Rural Health SA in five rural aged care facilities over two years, funded by the Australian Department of Health under the National Aged Care Services Program. We aimed to demonstrate that a co-designed personalised care model, based on the Progressively Lowered Stress Threshold principles and personalised and group music activities, is effective in reducing behavioural and psychological symptoms of residents with dementia while also reducing caregiver stress
Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma
Full text link© 2020 by the American Academy of Ophthalmology. This is an open access article under the CC BY-NC-ND licensePurpose
Developmental abnormalities of the ocular anterior segment in some cases can lead to ocular hypertension and glaucoma. CPAMD8 is a gene of unknown function recently associated with ocular anterior segment dysgenesis, myopia, and ectopia lentis. We sought to assess the contribution of biallelic CPAMD8 variants to childhood and juvenile open-angle glaucoma.
Design
Retrospective, multicenter case series.
Participants
A total of 268 probands and their relatives with a diagnosis of childhood or juvenile open-angle glaucoma.
Purpose
Developmental abnormalities of the ocular anterior segment in some cases can lead to ocular hypertension and glaucoma. CPAMD8 is a gene of unknown function recently associated with ocular anterior segment dysgenesis, myopia, and ectopia lentis. We sought to assess the contribution of biallelic CPAMD8 variants to childhood and juvenile open-angle glaucoma.
Methods
Patients underwent a comprehensive ophthalmic assessment, with DNA from patients and their relatives subjected to genome, exome, or capillary sequencing. CPAMD8 RNA expression analysis was performed on tissues dissected from cadaveric human eyes.
Main Outcome Measures
Diagnostic yield within a cohort of childhood and juvenile open-angle glaucoma, prevalence and risk of ophthalmic phenotypes, and relative expression of CPAMD8 in the human eye.
Results
We identified rare (allele frequency < 4×10−5) biallelic CPAMD8 variants in 5.7% (5/88) of probands with childhood glaucoma and 2.1% (2/96) of probands with juvenile open-angle glaucoma. When including family members, we identified 11 individuals with biallelic variants in CPAMD8 from 7 unrelated families. Nine of these individuals were diagnosed with glaucoma (9/11, 81.8%), with a mean age at diagnosis of 9.22±14.89 years, and all individuals with glaucoma required 1 or more incisional procedures to control high intraocular pressure. Iris abnormalities were observed in 9 of 11 individuals, cataract was observed in 8 of 11 individuals (72.7%), and retinal detachment was observed in 3 of 11 individuals (27.3%). CPAMD8 expression was highest in neural crest–derived tissues of the adult anterior segment, suggesting that CPAMD8 variation may cause malformation or obstruction of key drainage structures.
Conclusions
Biallelic CPAMD8 variation was associated with a highly heterogeneous phenotype and in our cohorts was the second most common inherited cause of childhood glaucoma after CYP1B1 and juvenile open-angle glaucoma after MYOC. CPAMD8 sequencing should be considered in the investigation of both childhood and juvenile open-angle glaucoma, particularly when associated with iris abnormalities, cataract, or retinal detachment
Water supply security for the township of Biggenden : A GMDSI worked example report
Full text link© Flinders University 2020
Copyright: This work is copyright. Apart from any use permitted under the Copyright Act 1968, no part may be reproduced by any process, nor may any other exclusive rights be exercised, without the permission of Flinders University, GPO Box 2100, Adelaide 5001, South Australia, 2020.The Groundwater Modelling Decision Support Initiative (GMDSI) is an industry-funded and industry-aligned project focused on improving the role that groundwater modelling plays in supporting environmental management and decision-making. Over the life of the project, it will document a number of examples of decision-support groundwater modelling. These documented worked examples will attempt to demonstrate that by following the scientific method, and by employing modern, computer-based approaches to data assimilation, the uncertainties associated with groundwater model predictions can be both quantified and reduced. With realistic confidence intervals associated with predictions of management interest, the risks associated with different courses of management action can be properly assessed before critical decisions are made.
GMDSI worked example reports, one of which you are now reading, are deliberately different from other modelling reports. They do not describe all of the nuances of a particular study site. They do not provide every construction and deployment detail of a particular model. In fact, they are not written for modelling specialists at all. Instead, a GMDSI worked example report is written with a broader audience in mind. Its intention is to convey concepts, rather than to record details of model construction. In doing so, it attempts to raise its readers’ awareness of modelling and data-assimilation possibilities that may prove useful in their own modelling and management contexts
‘These Happy Effects on the Character of the British Sailor’: Family Life in Sea Songs of the late Georgian period.
Full text linkAuthor's version.Songs about sailors were popular during the late Georgian period in Britain. Some were directed towards men in the navy or potential recruits, but they were also part of the musical repertoire of the middle-class drawing room. A common theme is the importance of family life. With large numbers of men needed to serve in the military in this time of war and colonial expansion, it was essential for the home front that their families remained cohesive, and ballads were sometimes written with the express purpose of promoting fidelity and patience on the part of both men and women. This chapter examines the varieties of family and conjugal relations presented in the verbal and musical rhetoric of a selection of these songs
Beyond therapy: the multiple benefits of using a service-learning model to enhance paediatric therapy in a remote area school. An evaluation of physiotherapy student placements at a school for children with additional needs in Central Australia, 2019
Full text link© 2020 Flinders University. Material in this report is provided under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0).In 2019, physiotherapy students in their final year of university study provided two four-week blocks of intense physiotherapy services at Acacia Hill School (AHS) in Alice Springs. This school is the only education facility which caters specifically for children with additional needs in Central Australia. Of the 93 pupils at the school, 67% identify as Indigenous and 30% are in out of home care. These children are some of the nation’s most vulnerable.
This service-learning placement emerged in response to a dearth of physiotherapy services for pupils and their families at AHS. A lack of government-funded resourcing combined with a problematic transition for many families onto the National Disability Insurance Scheme (NDIS) had resulted in some school-aged children with significant neuro-disability not having had access to critical physiotherapy for up to five years
Breeding success in Southern Australian little penguins is negatively correlated with high wind speeds and sea surface temperatures
No full text© 2020 Flinders Universit
Pilbara groundwater dissolved gas data
No full textDataset made available with CC BY Creative Commons Attribution 4.0 International license.
https://creativecommons.org/licenses/by/4.0/This dataset pertains to groundwater samples collected from 55 wells associated with iron ore mining activities in the Pilbara. The table includes well details, analytical results for sulfur hexafluoride (SF6), chlorofluorocarbons (CFC-12), Argon and Nitrogen dissolved in groundwater, calculated excess air, and corrected SF6 and CFC-12 values for the sampled wells.
This data is referenced in:
Poulsen, D. L., Cook, P. G., & Dogramaci, S. (2020). Excess Air Correction of SF 6 and Other Dissolved Gases in Groundwater Impacted by Compressed Air From Drilling or Well Development. Water Resources Research, 56(8). https://doi.org/10.1029/2020wr02805
Genetic data of little penguins collected at eight colonies in South Australia between 2011 and 2014
No full textDataset made available according to CC BY 4.0 Creative Commons Attribution 4.0 International license
https://creativecommons.org/licenses/by/4.0/Genetic data of little penguins analysed with next generation sequencing. The data were obtained from 75 penguins across eight colonies in South Australia
Campaspe Catchment SW and GW Data (2016-2017)
No full textThis dataset is made available with a Creative Commons, Attribution license 4.0 International License. Copyright Flinders UniveristyThe dataset consists of Campaspe River discharge data as well as Campaspe river and groundwater geochemical data (major ions, water stable isotopes, 222 Radon) measured by our team between 2016 and 2017. The dataset also contains a link to all relevant information regarding the numerical model
SEAWAT input files - tidal propagation circular aquifer
No full textCopyright Cristina Solórzano-Rivas and Flinders University.
This dataset is available for reuse under a Creative Commons Attribution 4.0 International license (CC-BY 4.0)Input files that contain parameterization of the aquifer we are simulating (e.g., the hydraulic properties, geometry, etc.) as well as some information to solve the numerical model (e.g., solvers). These input files are standard files required by SEAWAT (model to simulate variable-density groundwater flow) in order to run the model, these can have free format or some standards specified by the model. In our case, we use free format. They can be read in any text editor and they have been created using some standard packages used in Python