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Improving outcomes by better reperfusion after endovascular treatment for acute ischemic stroke
Get PDFOutcomes of patients with an ischemic stroke caused by an intracranial large vessel occlusion of the anterior circulation can be improved further by modification of periprocedural antithrombotics, anesthesia type and blood pressure
Modifying Effects of Glucose and Insulin/Insulin-Like Growth Factors on Colon Cancer Cells
Get PDFThere are only a few experimental studies which have investigated effects of glucose alone, and glucose in combination with insulin/insulin-like growth factors (IGF) on the growth of colon cancer. In the present study, we studied in vitro in human colorectal cancer cells originating from four Dukes’ stages of colorectal cancer the effects of glucose, insulin and IGFs on proliferation, migration, cell cycle progression and gene expression of the IGF system. Growth of colon cancer cells originating from a Dukes’ stage A was glucose-dependent, whereas growth of cancer cells from Dukes’ stage B, C and D was glucose-independent. Stimulatory effects of insulin and IGFs on cell growth were observed only in colon cancer cells originating from Dukes’ stage C and D. IGF-II stimulated migration in Dukes’ stage B cells only. The growth stimulatory effects in Dukes’ stage C and D colorectal cancer cells were accompanied by G2/M arrest and associated with an increased IGF-IR/IGF-II receptor ratio. In conclusion, our in vitro data suggest that the stimulating effects of glucose, IGFs and insulin on proliferation differ between colorectal cancer cells from early and late Dukes’ stages. Stimulatory effects of glucose on proliferation appear predominantly present in stage Dukes’ stage A colorectal cancer cells, while in contrast growth factor-mediated stimulation of cell proliferation is more pronounced in Dukes’ late stage (metastasized) colorectal cancer cells. Moreover, our study suggests that a stringent glucose control may be important to control tumor growth in early stages of colorectal cancer, while inhibition of the endocrine actions of the IGFs and insulin become more important in the late (metastasized) stages of colorectal cancer to restrain growth of colon cancer cells
Comment on: Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes
Get PDFWith interest, we have read the article of Moriconi et al entitled “Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes.” A very low carbohydrate ketogenic diet is a popular, often effective dietary intervention for people with obesity related-type 2 diabetes mellitus (T2DM). However, ketogenic diets applied in T2DM studies differ significantly in nutrient composition (different percentages of carbohydrate, protein, fat and types of fatty acids), resulting in a heterogeneity that influences reproducibility and interpretation of their results. [...
Acromegaly: Current and Emerging Treatment Options
Get PDFThis thesis investigates the therapeutic efficacy of somatostatin analogues and in particular pasireotide in acromegaly patients through analysis of large datasets from international multicenter cohorts and a large-scale phase IV study. She considers setting up a proof-of-concept study applying a ketogenic diet to acromegaly patients, a potential new treatment option, as her most notable contribution to this field of researc
Risk Stratification in Adult Congenital Heart Disease: A blood biomarker-based approach
Get PDFThis thesis provides novel insights in the prognostic value of blood biomarkers and what role blood biomarkers can play in the risk stratification of adults with congenital heart disease and adults with pulmonary hypertension
Bridging the gaps in transitional pharmaceutical care
Get PDFThe research in this thesis shows that medication-related readmissions frequently occur despite several interventions. The findings of this thesis provide insight into the frequency and types of harm after discharge and could help with the implementation of pharmaceutical care for patients discharged from hospital to reduce medication-related har