Carleton University Institutional Repository
Not a member yet
20816 research outputs found
Sort by
Evaluation of the Mode of Action of Sulfated Lactosyl Archaeol Adjuvant: Interaction with L-selectin and Impact of Administration Route
Get PDFSulfated lactosyl archaeol (SLA) based semi synthetic archaeosomes are a novel vaccine adjuvant system developed by the National Research Council. There is limited understanding of its mode of action (MOA) and how it interacts with the immune system. SLA is suspected to engage lectin pattern recognition receptors for activation of innate immune cells and subsequently the adaptive immune system. SLA was shown to still able to perform adjuvant activities in L-selectin deficient mice such as immune cell recruitment and induction of antigen-specific antibodies and T cells, demonstrating that SLA activity was not solely dependent on L-selectin. SLA’s ability to induce mucosal immunity was evaluated through oral and intranasal vaccine administration using wild-type mice. Mice immunized intranasally with SLA adjuvanted vaccine formulations elicited strong antigen specific IgG antibodies with neutralizing functionality. This further indicates the utility of SLA as an effective subunit vaccine adjuvant when delivered by various routes
Migration Governance in North America : Policy, Politics, and Community
No full textThis book is available in open access to all readers.
Please download the book and consult the copyright page and acknowledgments to determine the organizations responsible for financially supporting that access, in addition to McGill-Queen's University Press (https://www.mqup.ca) and Local Engagement Refugee Research Network (https://carleton.ca/lerrn) with the assistance of the Carleton University Library.
The series editors would really appreciate hearing about readers' experiences and uses of this edition of the ebook. To share, please write to [email protected] comprehensive and cross-disciplinary assessment of the contemporary politics of North American migration, refugee, and asylum governance.
Millions of people arrive in North America each year, including highly skilled immigrants and temporary workers, refugees, and international students. Migration, border control, and asylum are ongoing flashpoints in Canadian, American, and Mexican relations, and deeply affect the domestic politics and economies of each country.
While migration has emerged as an only increasingly charged topic in public discourse, research has largely focused on North America’s lack of regional integration around mobility, often neglecting aspects of regional cooperation, hierarchy, and global engagement. Migration Governance in North America advances that conversation by examining the complex dynamics of mobilities across the continent through contemporary analysis and historical context. Situating North America within the global migration landscape, contributors from Canada, the United States, Mexico, and Europe unpack such issues as temporary labour mobility, border security, asylum governance, refugee resettlement, and the role of local actors and activists in coping with changing policies and politics.
In the wake of a series of significant and likely enduring changes across the continent this flagship volume puts policy developments and migrant organizing in conversation across borders, investigates often contentious domestic, regional, and global migration politics, and reveals how intersecting policy frameworks affect the movement of people
Singing In Harmony: Conceptualizing Queer Feminist Musicking
No full textThis thesis explores queer-feminist musicking within In Harmony: A Women’s Choir, based in Ottawa, Ontario. In Harmony: A Women’s Choir, founded in 1991 is dedicated to performing the richness and diversity of women’s experience. Originally a lesbian chorus, the choir has expanded its membership to include trans women, genderqueer and nonbinary people. By situating In Harmony within the broader histories of queer and feminist choral movements, this study examines the cultural shifts and evolving dynamics within these communities, particularly how they inform the choir’s value system and ethos. In my research I employed queer and feminist methodologies that centred relationality, reflexivity and care ethics. I also participated in the choir as a member during the 2023-2024 season and draw on my experiences and observations as a member. Drawing on José Esteban Muñoz’s concept of queer utopia (2009), I conceptualize how queer-feminist musicking shapes the choir’s inclusive practices
Permafrost climate services
No full textThis is an extended abstract of a paper presented as part of ICOP 2024
The Berrichon Language in France: Social Context, Language Vitality, and Documentation
No full textThis dissertation investigates the language vitality of Berrichon, a regional language spoken in central France. Like many other regional languages, and especially languages belonging to the langues d’oïl language family, Berrichon is endangered. The last speakers of the language are older adults (60 and plus), and there is barely any intergenerational language transmission of Berrichon. While most people in the area know that Berrichon is endangered and will likely disappear soon, there is no data on its vitality status. To understand the vitality of Berrichon, a language vitality survey was designed and used to gather data on language competence, language use, and language attitudes of Berrichon people. 717 people participated in the questionnaire, and 10 participated in interviews to complement the answers to the questionnaires. The results of this survey show that most people express positive language attitudes and pride towards Berrichon, even if they do not speak it. For example, even if most participants do not use Berrichon, they believe it is important to preserve it due to its cultural significance. At the same time, while maintaining the language is seen as important, participants are often not ready to be the ones initiating it. Multiple reasons explain this lack of use, such as the dominance of Standard French, movement of population to cities, the perceived negative stereotypes around Berrichon, and the perception of Berrichon as a language of the past. As such, Berrichon appears as a postvernacular language (Shandler, 2005), where it represents an important aspect of the culture of the Berry area, but is not used as a means of communication. The example of Berrichon is not unique but presents an excellent case study of the language situation in France as well as other languages in different parts of the world. This dissertation also includes a detailed analysis of the properties of language vitality surveys, and a small documentation project on Berrichon
Per and Polyfluoroalkyl Substances (PFAS) in Indoor Airborne Particulate Matter
No full textPer- and polyfluoroalkyl substances (PFAS) have gained significant attention due to their persistence, bioaccumulative nature, and adverse health effects. PFAS contamination in indoor airborne particulate matter and associated risks remain relatively underexplored. This study aimed to characterize PFAS in indoor airborne particulate matter through the development of a combined ionic and neutral PFAS extraction for joint LC-MS/MS and GC-MS analysis. We report quality control spike and recovery experiments for the following PFAS: perfluorocarboxylic acids (PFCAs); perfuoroalkanesulfonic acids (PFSAs); polyfluoroalkyl phosphate monoesters (monoPAPs); polyfluoroalkyl phosphate diesters (diPAPs) and fluorotelomer alcohols (FTOHs) extracted from foil filter impactors. The optimized method results report recoveries ranging from 14 to 154%. The analysis of airborne particulate matter will lead to a better understanding of human PFAS exposure. This research contributes to a deeper understanding of PFAS distribution in indoor environments and highlights the importance of addressing airborne PFAS contamination for public health protection
Write to Return : Huguenot Refugees on the Frontiers of the French Enlightenment
No full textFree access to this e-book is available to readers, scholars, and students located in the Global South whose institutions lack the resources to purchase access to these books as well as to those in other regions who are part of non-profit or community organizations concerned with displacement and who lack alternate forms of access to the book or the resources needed to purchase these publications. Please see full access conditions below.How Huguenots invented the modern category of the refugee.
The revocation of the Edict of Nantes led more than 200,000 Huguenots to flee France after 1685. Many settled close to the country’s frontiers, where their leaders published apologetic texts arguing for their right to return to France and be recognized as French citizens. By framing their refugee experiences intentionally, even using the term “refugee” to describe their diaspora, Huguenots profoundly influenced Enlightenment debates on citizenship and religious tolerance.
Write to Return is a cultural history of these Huguenot apologetics in which Bryan Banks examines the work of four authors: Pierre Jurieu, Pierre Bayle, Antoine Court, and Jean-Paul Rabaut Saint-Étienne. Each author advanced his arguments using key ideas of the Enlightenment, appealing to reason to argue for freedom of conscience all while appealing to emotion in his descriptions of Huguenot victimhood. The authors’ campaign succeeded. In 1789, France’s revolutionary National Assembly granted repatriation to all expelled Huguenots, offering them citizenship regardless of place of birth or baptism, and even permitting them to reclaim ancestral lands.
International refugees played an overlooked role in shaping discourse around the nation and nationalism in the eighteenth century. Write to Return shows how early modern refugees could advocate for their interests, build international networks, and even craft a new collective identity. By presenting themselves as loyal citizens of France, Huguenots were at the forefront of constructing a French national identity
Investigating the Effect of Information Display Type on Performance and Experience in Virtual Reality First-Person Shooter Video Games
No full textThe first-person shooter (FPS) genre is highly popular in gaming, with established design strategies for conveying important information to players. The rise of virtual reality (VR) gaming platforms necessitates a re-evaluation of these strategies. To investigate this, we conducted two studies on information display strategies in VR FPS games. The first study compared different displays for aiming, ammo, and health in separate gameplay scenarios, revealing significant performance improvements with on-screen aiming displays and a preference for colocated displays within the game world. The second study examined three combined information displays in a realistic FPS scenario. While gameplay performance was largely unaffected by the type of display, significant differences in the quality of the subjective experience were found
Edge Effects do not Predict Effects of Fragmentation per se on Understory Forest Vegetation
No full textHabitat loss is the main cause of biodiversity loss. It is often closely associated with fragmentation, i.e. the breaking apart of habitat. Researchers interested in fragmentation effects on species/biodiversity often study processes in habitat patches (e.g. edge effects) and scale-up these effects to make conclusions about fragmentation at the landscape scale. However, such extrapolations could result in erroneous conclusions and incorrect management decisions if there is no (or a weak) relationship between effects of edge and fragmentation on species/biodiversity. Here we separately measured edge effects on understory forest plant species using 72 forest edge–interior transects and fragmentation effects on the same species across 70 forest sites, to test for a cross-species relationship between edge and fragmentation effects. We found that edge effects did not predict forest plant species responses to fragmentation at the landscape scale. Therefore, researchers should be cautious about scaling up from the patch to landscape scale