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Evaluating Treatment Response, Biomarkers, and Outcome Reliability in Duchenne Muscular Dystrophy
Get PDFDuchenne Muscular Dystrophy (DMD) is an X-linked, rare, progressive, and fatal disease. Multiple clinical trials of a new steroid, vamorolone, recently approved internationally provided data used to a) assess the reliability of motor function and strength outcomes, b) study the impact of vamorolone and prednisone on the HPA-axis, and c) to identify treatment-response biomarkers, particularly those involved in bone turnover. Issues with reliability and missingness in younger age groups were found for several commonly used outcome measures. Vamorolone was confirmed to have similar adrenal suppression issues to prednisone, and seven novel bone biomarkers responsive only to prednisone were defined. The impact of this is in reducing patient and clinical site burden, and facilitating better understanding of the treatment responsive biological pathways. This work is relevant to improving the quality of life in DMD, identifying new avenues for drug development, and improving the statistical power of future therapeutic trials
Subversive Social Heritage & Adaptive Infill: The Future of Kensington Market
Get PDFThe Kensington Market Land Trust is a community organization which protects affordability and neighborhood character. Resisting gentrification by acquiring properties and returning them to collective community ownership. In examining the opportunity of land trusts, and the unique character of Kensington Market, my thesis asks how development can be regenerative and simultaneously meet the needs of an aging heritage district while accommodating a rapidly growing population? As the thesis addresses this question it considers inclusive and adaptive design that challenges the traditional methods of planning and housing. This framework prioritizes social heritage and envisions a different reality for affordable housing, one that empowers residents with flexible living opportunities. This approach will integrate with Kensington’s mixed-use community and pedestrian-friendly culture, reinforcing the neighborhood’s unique character and resilience
I Will Go to the End of the World
No full textArtist: Henrieta Cernajovba
Age: 12
Notes: 2025-160 / SK-
Craft In Transition: Integrating Digital Fabrication with Traditional Ceramics in Canadian Design
Get PDFThis research explores how digital fabrication—specifically 3D clay printing—shapes the meaning and practice of craftsmanship in Canadian ceramic design. The study investigates how digital tools interact with traditional processes and how emerging designers engage with this hybrid way of making. Emphasizing material knowledge, tactile experience, and authorship, it examines the evolving role of the maker in a digitally mediated environment. Using a practice-led approach—including autoethnographic reflection, object reconstruction, and semi-structured interviews—the study found that digital fabrication reframes rather than replaces traditional craft knowledge. While 3D printing offers precision and efficiency, it also requires material sensitivity and iterative problem-solving. Findings show that craftsmanship now involves a blend of physical and digital skills, shaped through experimentation, reflection, and collaboration. This hybrid practice opens new pathways for redefining craft in design education and practice. Keywords: 3D Clay Printing, Craftsmanship, Digital Fabrication, Canadian Ceramics, Material Knowledge, Hybrid Practic
Classifying Quiver Representations
Get PDFLet Q be a finite quiver. We give an exposition of the various disparate techniques used from a wide range of mathematical areas such as root systems and algebraic geometry to classify the indecomposable representations of Q, which are equivalent to the indecomposable modules of some basic, finite-dimensional K-algebra A. While most of the ideas presented are defined and proved, some familiarity with commu- tative/noncommutative algebra, representation theory, and algebraic geometry is assumed. The material, terminology, and proof techniques presented in large part is a fusion of coming from [1], [2], and [3]