Repository of the Sestre milosrdnice University Hospital Center
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Study of Schizophrenia comorbid with Alcohol addiction
No full textThe aim of this study was to investigate: the prevalence rate of current alcohol dependence, the family anamnesis of alcohol addiction, social and demographic characteristics, number of hospitalizations and degree of compliance with psychopharmacotherapy, as predictors for poor outcome of schizophrenia comorbid with alcohol addiction. Our results show that men with schizophrenia have higher prevalence rates of comorbid alcohol addiction than women. Comorbidity of alcohol addiction and schizophrenia in men is related with higher rate of divorce and age. In women comorbid alcohol addiction and schizophrenia relate with lower education, higher rate of unmarried women and family health insurance. There is strong evidence of alcohol addiction in first line relatives of schizophrenics with comorbid alcohol addiction, both male and female. Alcohol addiction comorbid with schizophrenia in men and women is related with poor compliance with psychopharmacotherapy and higher rate of hospitalization than with schizophrenia alone
Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite
No full textBackground: Treatment of cancer-bearing mice and dogs with micronized zeolite clinoptilolite (MZ) led to improvement of the overall health status, prolongation of life span and decrease of tumor size in some cases. It also reduced lipid peroxidation in the liver of mice. Materials and Methods: The experiments were performed on various tumor cell cultures and tumor-bearing animals. Immunohistochemistry was used to analyze if MZ could interfere with Doxorubicin-induced lipid peroxidation and consequential production of 4-hydroxynonenal (HNE). Results: MZ reduced the metabolic rate of cancer cells and increased binding of HNE to albumin in vitro. It selectively reduced generation of HNE in vivo in tumor stroma after Doxorubicin treatment leaving onset of lipid peroxidation intact in malignant cells. Combined treatment with Doxorubicin and MZ resulted in strong reduction of the pulmonary metastasis count increasing anticancer effects of Doxorubicin. Conclusion: Interference of MZ with lipid peroxidation might explain some of the beneficial effects of this particular zeolite in combined cancer therapy
Promjene u pojavnosti karcinoma debelog crijeva s obzirom na dob, spol, anatomsku lokalizaciju i preživljavanje (1989. - 2002.)
No full textRecent epidemiological studies have suggested that the anatomic distribution of colorectal carcinoma, especially in developed countries may have undergone a distal to proximal shift over several decades, which has been attributed variously to environmental and genetics factors as well as preventive measures. The aim of the study was to compare some colorectal cancer features (age and sex distribution, anatomic localization, and survival) during fourteen years, in order to assess the possible changing trends of these disease during the observed period and to compare observed data with our previous study published in 1985 as well as with similar colorectal cancer features reported worldwide. The mean age of patients with right-sided carcinomas was slightly higher than in patients with left-sided colorectal carcinomas (65.9 vs+ 65.2). Sex distribution showed male predominance (57.3% vs. 42.7%). Males and females had similar anatomic distribution. Recto-sigmoid was the most common site (77.9%) followed by transverse colon cancers (6.8%), ascending colon cancers (6.5%), cancers in cecum (6.2%) and descending colon cancers (2.6%). In the last four years of the observed period (1999 to 2002) the incidence of right-sided cancers was increased compared to the previous period. Our study showed a continuing trend of the increased incidence of right-sided carcinomas that is similar with reports from western European countries and North America.Novije epidemiološke studije pokazuju da je u razvijenim zemljama došlo do pomaka sijela karcinoma debelog crijeva iz sigme i rektuma prema desnoj strani, odnosno prema cekumu i uzlaznom kolonu što se u prvom redu pripisuje promjenama u načinu prehrane, genetskim čimbenicima te preventivnim mjerama. Svrha ovog istraživanja je da usporedi određene karakteristike karcinoma debelog crijeva i njihove promjene tijekom četrnaest promatranih godina (1989 do 2002) te da ih usporedi s našim prethodnim istraživanjem provedenim 1985. godine i novijim svjetskim istraživanjima. Prosječena dob pacijenata s karcinomom smještenim u desnoj polovini crijeva bila je neznatno viša od dobi pacijenata s lijevostranim karcinomima (65,9 vs. 65,2). Muškarci su obolijevali češće od žena (57.3% vs. 42.7%) međutim anatomska lokalizacija karcinoma u oba spola bila je podjednaka. Rektosigmoidni dio crijeva bio je najčešće zahvaćen tumorom (77.9%), zatim slijedi poprečni kolon (6.8%), uzlazni kolon (6.5%), cekum (6.2%) i silazni kolon (2,6%). U posljednje četiri godine promatranog razdoblja (1998. do 2002.) vidljiv je stalni porast incidencije karcinoma smještenih u desnoj polovini debelog crijeva. Ovo istraživanje pokazalo je da je broj karcinoma desne strane debelog crijeva u naših pacijenata u stalnom porastu što se podudara s istraživanjima provedenim u razvijenim zemljama Europe i Sjeverne Amerike
Brza negativizacija inhibitora faktora VIII nakon imunosupresivnog liječenja kod bolesnice s teškom stečenom postpartalnom hemofilijom- follow up
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Carolijeva bolest - prikaz bolesnika
No full textCarolijeva bolest/Carolijev sindrom je rijetko stanje karakterizirano kongenitalnom policističnom segmentalnom dilatacijom intra- hepatalnih žučnih vodova. Jednostavni tip (Carolijeva bolest) najčešće se klinički prikazuje slikom recidivirajućih kolangitisa, ili žučnih kamenaca praćenih bilijarnim kolikama uz popratnu opstruktivnu žuticu i epizode pankreatitisa u djetinjstvu ili u mlađoj životnoj dobi, dok se pri učestalijem tipu kombiniranom s kongenitalnom hepatalnom fibrozom (Carolijev sindrom), kao prva manifestacija bolesti pojavljuje krvarenje iz varikoziteta jednjaka kao posljedica portalne hipertenzije. Mogućnosti su liječenja, konzervativnog i kirurškog, relativno ograničene, a ovise o proširenosti promjena u jetri, kliničkoj slici i stadiju bolesti. Autori prikazuju slučaj 20-godišnjeg bolesnika s Carolijevom bolešću koji se prezentirao kolelitijazom i koledokolitijazom s recidivirajućim pankreatitisima u dobi od 16 godina. Dijagnoza je potvrđena endoskopskom retrogradnom kolangiografijom i kolangiografijom uz pomoć magnetske rezonancije, te je započeta terapija ursodeoksikolnom kiselinom. Nakon dvije godine praćenja bolest nije uznapredovala
Subcuticular catgut versus polyglactin 910 in scar formation in sheep
No full textThe aim of this double blind prospective experimental study was to compare the influence of polyglactin 910 (Vicryl, Ethycon) and plain catgut (Softcat-Plein, Braun) as subcuticular tissue sutures on wound healing and scar formation in sheep. Scar excision together with the surrounding tissue was made three months later. Scars were compared visually, photographed and examined under a light microscope. All scars were cosmetically acceptable, linearly hardly visible, aplanated and less than 1 mm in width with no difference between the parts in which plain catgut or polyglactin 910 were used. All photographs were examined by a plastic surgeon as well as by a dermatologist and they confirmed that all scars were cosmetically acceptable, hardly visible, planated and less than 1 mm in width. During the light microscopic examination done by the dermatologist foreign body granulomas were found in two scars where the subcuticular plain catgut was used. Concerning the plain catgut as an animal and foreign body granuloma inductor, the use of polyglactin 910 seems to be better
Pheochromocytoma - case report
No full textPrikazan je slučaj feokromocitoma desne nadbubrežne žlijezde u 13-godišnjeg dječaka koji je hospitaliziran zbog hipertenzivne krize. Heteroanamnestički smo doznali za dugotrajne glavobolje, gubitak tjelesne mase, učestala preznojavanja uz polidipsiju i poliuriju. Dijagnoza je postavljena na temelju povišenih vrijednosti kateholamina u urinu, a tumor je lokaliziran ultrazvučno, magnetskom rezonancijom (MR-om) te I131 -metajodobenzilgvanidin (I131 -MIBG) scintigrafijom. Zadovoljavajuća kontrola hipertenzije postignuta je kombinacijom blokatora alfa i beta-adrenergičkih receptora te ACE inhibitora, nakon čega je učinjena desnostrana torakofrenolaparotomija i adrenalektomija, bez većih intraoperativnih i postoperativnih komplikacija. Dječak se prati klinički i laboratorijski, a nalazi zasad upućuju na izlječenje.We present a 13 year-old-boy with pheochromocytoma localized in the right adrenal gland, who was hospitalized due to severe hypertension. For a long period of time he suffered from headaches, loss of weight, excessive sweating with polydipsia and polyuria. The diagnosis was made based on high urinary catecholamine excretion and the tumor was localized by ultrasonography, magnetic resonance imaging (MRI) and radionuclide scanning with iodine 131-labeled metaiodobenzylguanidine (I131 -MIBG scintigraphy). After acceptable control of hypertension was achieved by alpha and beta-adrenergic blocking agents and use of ACE inhibitors, right sided thoracophrenolaparotomy and adrenalectomy was performed, without any major intra-operative or postoperative complications. The boy was followed-up and his clinical and laboratory findings show no abnormalities so far