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Differentiated thyroid cancer: comparison between papillary and follicular cancer in one institution
No full textThe purpose of our study was to assess survival rates and prognostic factors in a retrospective review of 1167 patients (pts), female (f): male (m) ratio 4:1 with papillary thyroid cancer (PTC) and 191 pts (f:m ratio 3.2:1) with follicular thyroid cancer (FTC)
Skin and nipple-areola complex sparing mastectomy in breast cancer patients: 15-year experience
No full textSkin and nipple-areola complex sparing mastectomy (SNSM) and primary reconstruction have been popular for breast cancer treatment in the last decade. An advantage of the SNSM technique is the removal of all breast tissue as a radical surgical procedure while preserving native breast integrity, nipple-areola complex (NAC), and submammary fold. This retrospective 15-year clinical study analyzes medical records from our breast surgery database collected at our department between 1997 and 2012. A total number of 3757 patients were treated for breast cancer; 411 (10.9%) patients had a skin-sparing mastectomy with the median (range) length follow-up of 63 months. This is the longest follow-up for SNSM in breast cancer patients; 3.7% of patients who underwent SNSM developed disease local recurrence, whereas occult NAC involvement with cancer occurred in 7.7% and local recurrence in the NAC in 1.2%. Partial necrosis of the NAC developed in 9.4% and total necrosis in 0.7% of operated breasts. All disease recurrences occurred in the first 10 years of the follow-up period. Local recurrence developed as first recurrence event has longer median cancer-specific survival time of 70 months than those with only distant metastases with 50 months and locoregional plus distant metastases with 35.5 months. The ‘‘Omega’’ pattern incision combines an oncological radical procedure with a lower incidence of skin flap necrosis. Patients reconstructed with autologous tissue were the group most satisfied. SNSM is an oncological safe procedure for breast cancer treatment with low recurrence in properly selected patients
Serotonin risk factors for the development of hypertension in pregnancy
No full textPurpose: To determine platelet serotonin (5-HT) concentrations and genotype and allele frequencies of serotonergic type 2A receptor gene (HTR2A) and 5-HT transporter gene (SLC6A4) in women with pre-eclampsia, gestational hypertension without proteinuria (PIH) and in control normotensive pregnant women.
Methods: The study included 96 control women, 131 women with PIH and 84 women with pre-eclampsia (ICD-10 criteria) in the last trimester of pregnancy. Variants of the HTR2A T102C (rs6313) and SLC6A4 (5-HTTLPR and rs25531) were determined by the PCR and real-time PCR procedures. Platelet 5-HT concentrations were analyzed by the spectrofluorimetric method.
Results: The frequency of the 5HTTLPR and of HTR2A T102C genotypes or alleles was similar between three groups of pregnant women and was not associated with low platelet 5-HT concentrations observed in pregnant women with PIH or pre-eclampsia.
Conclusions: The results confirm alterations in the peripheral 5-HT system in pregnancy-induced hypertension. Low platelet 5-HT concentration is a common feature of both PIH and pre-eclampsia. The results did not support the hypothesis that hypertension in pregnancy is a trait associated with polymorphic variants of the HTR2A and SLC6A4 or that they have a role in the predisposition to hypertensive disorders in pregnancy. The further studies are necessary to elucidate the role of 5-HT and genetic factors in the development of hypertensive disorders in pregnancy
Avulzijski prijelom tibijalnog tuberkla - rijetka lokacija prijeloma koljena u odraslih: prikaz slučaja s pregledom literature
No full textAvulzijska fraktura tuberositasa tibije je rijetka ozljeda sa samo 170 stučajeva opisanih od 1853. godine. Obično nastaje kod djece, a iznimno rijetko u odrasloj dobi. Kod djece najčešće nastaje kao posljedica kontrakcije kvadricepsa, dok je u odraslih obično posljedica izravne traume tuberositasa tibije, a rjeđe nastaje indirektno kao posljedica kontrakcije kvadricepsa
Value of combined use of Tc99m MIBI SPECT/ CT scintigraphy and ultrasonography in the detection of parathyroid lesions
No full textTo evaluate the usefulness of Tc99m sestamibi (Tc-MIBI) SPECT/CT scintigraphy and neck ultrasonography (US) with fine-needle aspiration cytology (FNAC) and parathormon (PTH) determination in aspirate (FNA-PTH) in detection of pathologicaly changed parathyroid glands
18F-FCH PET/CT compared with standard diagnostic imaging procedures in restaging of prostate cancer patients
No full textThe aim of this study was to evaluate the contribution of 18F-fluorocholine PET/CT in restaging of prostate cancer patients and to compare it with conventional diagnostic imaging modalities
Prikaz slučaja pendulirajućeg hemangioma jetre
No full textPrikaz slučaja 54. godišnje pacijentice primljene na odjel abdominalne kirurgije zbog obrade i operativnog liječenja na gastroskopiji i MSCT-u abdomena opisanog suspektnog stromalnog tumora uz želudac - dif.dg. GIST. Pacijentica nije gubila na tjelesnoj težini, negira mučninu i povraćanje, nije imala niti drugih tegoba