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From Rehab to Routine: Ensuring Lasting Lifestyle Changes After Cardiac Rehabilitation – First Experiences from the “Love Your Heart” Program
No full textObjective. The study assesses how well patients follow secondary prevention measures after completing an outpatient cardiac rehabilitation (CR) program. Materials and Methods. This research involves 63 patients who completed an outpatient CR pro-gram between 2018 and 2020 at the Istrian Health Center in Pula, Croatia. Socio-demographic characteristics, levels of physical activity, adherence to a Mediterranean diet, and compliance with medical recommendations were assessed in a survey to gather data. Results. Out of the 63 patients surveyed, 51 responded (34 males, 17 females, average age 68.25 years). After completing a cardiac rehabilitation program, 78.4% maintained appropriate levels of physical activity but showed low adherence to a Medi-terranean diet, with an average score of only 3.94 out of 9. Only a small percentage (2%) effectively followed medical recom-mendations. Conclusion. Despite the fact that patients maintain physical activity, there are still challenges regarding adherence to nutritional recommendations and medical advice. Long-term adherence can be improved by utilizing technology, involving family members, and offering education. Future research should focus on identifying obstacles to adherence and developing approaches to achieve lasting behavioral change
Determinants of managing visitors´ satisfaction of wellness tourism destinations
No full textIstraživački model uključuje namjeru ponovnog posjeta destinaciji kao zavisnu varijablu s prediktorima zadovoljstva posjetitelja, afektivnog imidža destinacije i percepcije iskustva brenda destinacije. Vrijednost za novac promatra se kao moderirajuća varijabla u odnosu zadovoljstva i ponovne namjere posjeta wellness destinaciji. Empirijsko istraživanje je obuhvatilo 292 ispitanika koji su tijekom svog odmora u hrvatskim wellness destinacijama u 2023. i 2024. godini koristili wellness usluge u hotelima, toplicama i talasoterapiji. Primijenjene metode testiranja istraživačkog modela su eksploratorna faktorska analiza s Varimax rotacijom i modeliranje strukturnih jednadžbi metodom parcijalnih najmanjih kvadrata (PLS-SEM). Modelom je sveukupno zadovoljstvo wellness posjetitelja objašnjeno s 11,4 % varijance nezavisnih latentnih varijabli, a namjera ponovne posjete destinaciji s 64,2 % varijance nezavisnih latentnih varijabli. Koeficijent determinacije tumači umjerenost utjecaja latentnih varijabli na varijancu sveukupnog zadovoljstva wellness posjetitelja i jak utjecaj nezavisnih latentnih varijabli na varijancu zavisne varijable namjera ponovne posjete destinaciji. Značajnost koeficijenata determinacije za konstrukte sveukupno zadovoljstvo wellness posjetitelja i namjeru ponovne posjete destinaciji ukazala je na reprezentativnost modela. Između konstrukata afektivni imidž destinacije i sveukupno zadovoljstvo wellness posjetitelja te afektivni imidž destinacije i namjera ponovne posjete destinaciji utvrđeno je da ne postoji statistički značajna povezanost dok je statistička značajnost utvrđena u odnosima konstrukata iskustvo brenda turističke wellness destinacije i sveukupno zadovoljstvo wellness posjetitelja, konstrukata iskustvo brenda destinacije i namjera ponovne posjete destinaciji i konstrukata sveukupno zadovoljstvo wellness posjetitelja i namjera ponovne posjete wellness turističkoj destinaciji. Nije utvrđena statistička značajnost moderirajućeg učinka konstrukta vrijednost za novac. Kvantitativno istraživanje kombinirano je s kvalitativnim istraživanjem stavova deset menadžera i drugih relevantnih dionika u wellness turizmu o wellness turističkoj ponudu u Republici Hrvatskoj. Provedeno istraživanje dopunjuje teoriju i smanjuje jaz u postojećoj literaturi o determinantama zadovoljstva posjetitelja destinacija wellness turizma.The doctoral thesis extends theoretical knowledge about visitors' satisfaction and intention to revisit a destination in the wellness tourist segment. The main objective of the research is is to classify the importance of the attributes of the wellness offer for the satisfaction of wellness visitors by factor analysis and to examine the relationships between the overall satisfaction of the visitor, the affective image of the wellness tourist destination, the brand experience of the wellness tourist destination, the value for money and the intention to return to the wellness tourist destination within the structural model of the research. The research model includes destination revisit intention as a dependent variable with predictors of tourist satisfaction, affective image of a destination, and perception of a destination brand experience. Value for money is observed as a moderating variable in the relation between satisfaction and revisit intention for a wellness destination. The empirical research included 292 respondents who used wellness services in hotels, spas and thalassotherapy during their vacation in Croatian destinations with a strong focus on the development of wellness tourism in 2023 and 2024. The applied methods for testing the research model were Exploratory Factor Analysis with Varimax rotation and Structural Equation Modeling using the Partial Least Squares Method (PLS-SEM). The model explained overall wellness tourist satisfaction with 11.4 % of the variance of the independent latent variables, and destination revisit intention with 64.2 % of the variance of the independent latent variables. The coefficient of determination explains the moderate influence of the latent variables on the variance of overall wellness tourist satisfaction and the strong influence of the independent latent variables on the variance of the dependent variable, destination revisit intention. Between the constructs affective image of the destination and overall satisfaction of wellness tourists and affective image of the destination and intention to revisit the destination, it was determined that there is no statistically significant connection, while statistical significance was determined in the relationships between the constructs destination brand experience and overall satisfaction of wellness tourists, the constructs destination brand experience and intention to revisit the destination, and the constructs overall satisfaction of wellness tourists and the intention to revisit the destination. There is no statistical significance of the moderating influence of the construct Value for Money on the relationship of the constructs overall wellness tourist satisfaction and intention to revisit the destination. The quantitative research was combined with a qualitative survey of the attitudes of ten managers and other relevant stakeholders in wellness tourism on the wellness tourism offer in the Republic of Croatia. The conducted research complements the theory and reduces the gap in the existing literature on the determinants of tourist satisfaction of wellness tourism destinations
Osnovne funkcije doktorskog studija
No full textPrezentacija predstavlja dio recenziranog materijala kolegija Metodologija znanstveno-istraživačkog rada na doktorskom studiju Građevinarstvo na Građevinskom fakultetu u Rijeci. Materijal predstavlja uvodni dio u doktorski studij te predstavlja osnovi dio metodologije i tehnologije znanstveno-istraživačkog rada koji doktorski studenti obrađuju u sklopu kolegija. Cjeloviti recenzirani materijal je dostupan na LMS-u Merlin te osposobljava studente za znanstveno-istraživački rad u gospodarstvu i industriji ta na sveučilištu
The Cell Biologist Potential of Cytomegalovirus to Solve Biogenesis and Maintenance of the Membrane Recycling System
No full textCytomegalovirus (CMV) is an important pathogen that extensively remodels the nucleus and cytosol of an infected cell to establish a productive infection [1,2,3,4]. Nuclear events include the formation of large structures that are known as nuclear replication centers (NRCs), where viral DNA replication and nuclear capsid assembly occur. Cytosolic events include the complete reorganization of the cytoskeleton and the membrane system (Figure 1). The reorganized membrane system (RMS) of the infected cell involves the relocation of the Golgi into a ring-like configuration that encloses a large perinuclear region containing early endosomes (EEs), recycling endosomes (REs), the trans-Golgi network (TGN), and expanded membrane structures of membrane intermediates at the EE-RE/ERC-TGN interface (Figure 1B) [5,6,7,8]. This structure, which is as large as the nucleus of the infected cell, is referred to as the cytoplasmic assembly complex (cAC) and is likely the site of the final steps of CMV virion assembly, including the envelopment of the tegumented capsids by cellular membranes and the establishment of the pathway for virion egress from the cell [2]. The endoplasmic reticulum (ER) and late endosomes (LEs) are extruded together with the secretory system of the cell from the AC towards the cell periphery (Figure 1B) [2,5,8]. This extensive reorganization of the membrane system, which is often accompanied by a compaction of the cell due to the restructuring of the cytoskeleton, obviously involves a redirection of membrane flux that is difficult to compare with that in the flat cell. Overall, little is known about the transport pathways, membrane flux, and remodeling of membrane organelles in such a reorganized membrane system
Classification of cyclic peptides using graph convolutional networks
No full textCiklički peptidi postaju sve popularniji u dizajnu lijekova, primarno zbog njihove
sposobnosti za djelovanje na mete koje su se prethodno smatrale nedostupnima za
lijekove. Unatoč njihovom potencijalu, učinkovitost cikličkih peptida protiv unutarstaničnih meta ograničena je zbog činjenice da ciklički peptidi generalno teže prolaze
kroz stanične membrane. Eksperimentalne metode za određivanje permeabilnosti
staničnih membrana skupe su i dugotrajne, što usporava rane faze razvoja lijekova.
Stoga se predlaže model strojnog učenja temeljen na grafovima i konvolucijskim
mrežama za predviđanje permeabilnosti staničnih membrana kod cikličkih peptida.
Ciklički peptidi predstavljeni su grafovima izvedenim iz formata SMILES i za treniranje proslijeđeni modelu temeljenom na mreži Deep Graph Convolutional Neural
Network. Model je postigao točnost od 78.1%, F1 vrijednost od 0.863 i ROC-AUC
od 0.756, čime se pokazuje potencijal primjene metoda strojnog učenja temeljenih
na grafovima u domeni otkrivanja lijekova.Cyclic peptides are becoming more popular in drug design, primarily because of their
ability to interact with targets that were previously considered undruggable. Despite their potential, the effectiveness of cyclic peptides against intracellular targets
is limited by the fact that cyclic peptides generally struggle to penetrate cell membranes. Experimental methods of determining the membrane permeability of cyclic
peptides are costly and time-consuming, inhibiting the early stages of drug development. Thus, a machine learning model for prediction of cyclic peptide membrane
permeability based on graph convolutional networks is proposed. The cyclic peptides
are represented by graphs derived from SMILES format and passed to a Deep Graph
Convolutional Neural Network based model for training. The model achieved an
accuracy of 78.1% with an F1-score of 0.863 and ROC-AUC of 0.756, demonstrating
the potential graph-based machine learning techniques have in drug discovery
Kako komunicirati o tradicijskom ovčarstvu: primjer otoka Cresa
No full textTradicionalno ovčarstvo godinama je predstavljalo poticaj razvoju otoka Cresa. U novije doba drugi prioriteti i djelatnosti dobivaju primat u tome razvoju. Iako se još jedan dio stanovništva i dalje bavi uzgojem ovaca na tradicionalan način, sama ideja uzgoja ovaca uvelike se promijenila u posljednjih tridesetak godina. Promjene u okruženju, nužnost usmjeravanja na
održivi razvoj na globalnom nivou, strateško usmjeravanje otoka Cresa na održivi razvoj te očuvanje kulturne i povijesne baštine doveli su do nužnosti usmjeravanja komuniciranja prema ključnim javnostima na drukčiji način. S obzirom na navedeno, postavlja se pitanje kako se o tradicijskom ovčarstvu na otoku Cresu može komunicirati prema zainteresiranoj
javnosti s fokusom na održivi razvoj. Kroz primjere dobre prakse komuniciranja o tradicijskom ovčarstvu na otoku Cresu identificiraju se elementi za učinkovitu komunikaciju s fokusom na održivost. Različite aktivnosti poput manifestacija, projekata i gospodarskih aktivnosti usmjerenih na tradicijsko ovčarstvo pridonosi se usmjerenosti otoka na održivi razvoj zajednice
Imunoregulatorna uloga proteina PrPC u imunološkom antivirusnom odgovoru i otpornosti na citomegalovirusnu infekciju : plan upravljanja istraživačkim podacima
No full textBeta thalassemia syndromes: New insights
No full textBeta thalassemia (β-thalassemia) syndromes are a heterogeneous group of inherited hemoglobinopathies caused by molecular defects in the beta-globin gene that lead to the impaired synthesis of beta-globin chains of the hemoglobin. The hallmarks of the disease include ineffective erythropoiesis, chronic hemolytic anemia, and iron overload. Clinical presentation ranges from asymptomatic carriers to severe anemia requiring lifelong blood transfusions with subsequent devastating complications. The management of patients with severe β-thalassemia represents a global health problem, particularly in low-income countries. Until recently, management strategies were limited to regular transfusions and iron chelation therapy, with allogeneic hematopoietic stem cell transplantation available only for a subset of patients. Better understanding of the underlying pathophysiological mechanisms of β-thalassemia syndromes and associated clinical phenotypes has paved the way for novel therapeutic options, including pharmacologic enhancers of effective erythropoiesis and gene therapy
Clinical Features and Laboratory Findings of Hospitalized Children with Infectious Mononucleosis Caused by Epstein–Barr Virus from Croatia
No full textThe aim of this retrospective 6-year study was to analyze demographic, laboratory and clinical features of 212 patients (<18 years of age) with EBV-associated infectious mononucleosis (IM) hospitalized in a tertiary clinical care center in southeastern Europe and to identify possible predictors of complications. The median patient age was 14.7 years (IQR 7.7–16.5 years), with 59.4% of patients aged between 13 and 18 years. A total of 51.2% of patients were hospitalized within 7 days following the onset of symptoms (median duration of hospitalization was 9 days, IQR 7–11 days). The most common symptoms included fever (97.16%), tonsillitis (87.3%), lymphadenopathy (79.2%), hepatomegaly (77.4%) and splenomegaly (73.1%). Symptom distribution, maximal fever and fever duration did not differ among different age groups. The most common complications included tonsillar hypertrophy, thrombocytopenia, anemia, neutropenia and leukopenia but all patients showed favorable outcomes. Patients who developed three or more complications and those presenting with thrombocytopenia showed significantly longer hospitalization durations. Platelet count, bilirubin, ESR and AST were identified as the most accurate predictors of hospitalization duration using multiple linear regression analysis. Therefore, our results suggest that clinical assessment of individual patients remains the most reliable parameter for patient management and that laboratory findings play only a supporting role
Periarthritis Humeroscapularis – A Rare Radiological Case Report
No full textCilj: U ovome radu prikazujemo vrlo rijedak rendgenski i ultrazvučni nalaz u akutnoj egzacerbaciji periartritisa ramena. Prikaz slučaja: Temeljna lezija lokalizirana je tipično u tetivi m. supraspinatusa i inflamiranoj subakromijalnoj burzi u kojoj je radiološki dokazan izljev bogat otopljenim kalcijevim solima (engl. milk of calcium). Ovakav se rendgenski i ultrazvučni nalaz u kliničkom radu, a tako i u literaturi, rijetko zabilježi jer je vezan za tranzitornu, mehaničku fazu u evoluciji periartritisa tijekom koje solidni periartikularni vapneni depoziti prelaze u tekuću suspenziju. Zaključak: Radiološka dijagnostika, u prvom redu rendgenski i ultrazvučni pregled optimalne su metode za dijagnostiku, diferencijaciju i praćenje periartritisa.Aim: This paper presents a very rare X-ray and ultrasound finding in acute exacerbation of shoulder periarthritis. Case Report: The underlying lesion is typically localized in the tendon of the supraspinatus muscle and the inflamed subacromial bursa with calcium rich effusion – milk of calcium. Such X-ray and ultrasound findings are rarely recorded in clinical practice and in the literature, as they are associated with the transient, mechanical phase in the evolution of periarthritis during which solid periarticular calcium deposits transitions into a liquid phase. Conclusion: Radiological diagnostics, primarily X-ray and ultrasound examinations, are optimal methods for diagnosing, differentiating, and clinical monitoring of the shoulder periarthritis