Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"
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    PLASMONIC BIOSENSING PLATFORMS FOR SALIVARY CYTOKINE ANALYSIS: TOWARD POINT-OF-CARE ORAL DISEASE DIAGNOSTICS

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    Association Between Isolated Postprandial Dyslipidemia And Erectile Dysfunction

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    Background: Postprandial lipid testing is increasingly recognized as a marker of vascular health. However, its relationship with erectile dysfunction (ED) remains largely unexplored. Isolated postprandial dyslipidemia (IPD), in particular, may evade detection using conventional fasting-based assessments, despite potential atherogenic effects. Objectives: To evaluate the association between IPD and erectile function, comparing the prevalence and severity of ED among men with IPD, combined dyslipidemia (CD), and those without dyslipidemia (WD). Materials and Methods: In this cross-sectional study, sexually active men aged ≥18 years underwent same-day fasting and postprandial lipid testing, as well as erectile function evaluation using the International Index of Erectile Function – Erectile Function domain (IIEF-EF) questionnaire. Dyslipidemia was defined according to the 2019 European Society of Cardiology/European Atherosclerosis Society criteria. Patients were categorized as WD (no dyslipidemia), IPD (postprandial abnormalities only), or CD (both fasting and postprandial abnormalities). Multivariable logistic regression was performed, adjusting for age, smoking status, BMI, and hypertension. The primary outcome was the prevalence of ED (IIEF-EF ≤25); secondary outcomes included ED severity and comparisons across lipid profile subgroups. Results: Among 351 men, ED prevalence was higher in the IPD (55.1%) and CD (57.0%) groups compared to WD (32.8%; p < 0.001). Median (IQR) IIEF-EF scores were 26 (25–28) in the WD group, 22 (20–23) in the IPD group, and 21 (19–23) in the CD group. The differences between WD and both IPD and CD exceeded the minimal clinically important difference (4 points) and were statistically significant (p < 0.001). Adjusted analyses confirmed increased odds of ED in IPD (odds ratio [OR] = 2.36; 95% confidence interval [CI]: 1.41–3.96) and CD (OR = 2.58; 95% CI: 1.43–4.65) versus WD. ED severity was also greater in the IPD and CD groups. No differences emerged between IPD and CD in any outcome. Among IPD subtypes, elevated postprandial triglycerides were most common, but no single lipid abnormality was independently associated with ED severity. Conclusion: IPD is associated with both the prevalence and severity of ED, paralleling the impact of chronic dyslipidemia. Postprandial lipid testing may reveal hidden metabolic risks relevant to sexual health and should be considered in the evaluation of ED

    A Hybrid and Adaptive Decision Support System for Protection from Radioactive Threats

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    Protecting society and the environment from radioactive threats is a multidimensional challenge that spans natural and artificial sources, medical and industrial applications, and long-term infrastructure monitoring. Modern radiological protection requires methodologies that can integrate heterogeneous information, adapt to evolving conditions, and combine physics-based understanding with data-driven intelligence. This thesis proposes a hybrid, adaptive, and heterogeneous framework for radioactive risk protection, structured around four foundational pillars: (P1) Monitoring, (P2) Modelling \& Assessment, (P3) Prediction, and (P4) Decision Support. The hybrid nature of the approach lies in the integration of formal modelling techniques (e.g., Bayesian networks, Petri nets, simulation-based methods) with data-driven and AI approaches for time series analysis and inference. Adaptivity is achieved through continuous recalibration of models and predictions as new data and environmental conditions emerge. Heterogeneity is explicitly addressed at multiple levels, including sensor technologies, data sources, physical processes, and decision-making contexts, enabling the framework to operate across diverse scenarios and scales. This general framework is applied to the domain of radioactive waste pre-disposal within the European PREDIS project. Here, custom low-power monitoring architectures (P1) are developed using scintillating fibre (SciFi) and solid-state neutron (SiLiF) detectors for long-term deployment in hostile environments. A modelling and assessment layer (P2) formalises source behaviour, sensor performance, and safety/sustainability metrics through scenario analysis and simulation. The prediction pillar (P3) incorporates simulation-based inference and machine learning to characterise and forecast process dynamics with quantified uncertainty. Finally, the decision support pillar (P4) integrates these elements within a novel hybrid architecture inspired by Kahneman’s Fast and Slow Thinking, combining expert rules with adaptive data-driven reasoning to support both immediate responses and strategic planning. Together, these contributions establish a unified, methodological and technological basis for modern radioactive protection, bridging the gap between real-time monitoring, predictive modelling, and operational decision-making in complex and heterogeneous scenarios

    Le Gorgoni sui tetti: le antefisse di Capua dentro e fuori il Museo Campano

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    The collection of Archaic tongue-frame antefixes depicting the Gorgon mask in the Museo Provinciale Campano in Capua comprises approximately two hundred specimens, only a select few of which are currently displayed in Rooms XXII and XXIII on the second floor of the museum. A significant number of these artifacts, however, have been relocated to various Italian and international museums. This corpus is further expanded by finds unearthed during the 1995 excavations at Fondo Patturelli, as well as comparable examples documented in several centers of Etruria and Latium, alongside more recent discoveries and rediscoveries at Cuma. The ongoing re-examination of this remarkable corpus of material from Capua thus requires expanding beyond the confines of the museum, in order to activate new pathways of knowledge and define the future of research within the Museo Campano

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