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Association of Cardiac Sarcoidosis and Ulcerative Colitis: A Case Report and a Brief Review of the Literature
No full text: • CS is a rare inflammatory disease with immune-mediated pathogenesis. • The authors report a rare case of coexistence of CS and ulcerative colitis. • CS and ulcerative colitis may share common pathogenetic pathways. • A high level of suspicion for CS should be kept in patients with immune diseases
Negli occhi della distopia. Visioni, confini e fratture di un universo seriale
No full textThe essay analyzes the narrative universe of The Handmaid’s Tale as a paradigmatic expression of contemporary dystopia. It explores the central role of the visual image in activating the symbolic, dramaturgical, and ideological dimensions of the story, focusing on the evolution of the character June Osborne, the dialectic between past and future, and the function of flashbacks. Through an analysis of the aesthetic and narrative strategies of television seriality, the contribution reflects on forms of iconic control, totalitarian drift, and the ethical potential of dystopian storytelling
Integrating the concept of Aktionsart into the teaching of Russian verbal aspect
No full textThis paper evaluates a pedagogical intervention targeting verbal aspect selection in L2 Russian through explicit reflection on the role of Aktionsart. In some contexts, aspect in native use is mainly determined by this category, which, however, is hardly part of L2 Russian syllabi. In this study, 99 Italian learners of L2 Russian were divided into an experimental and
a control group. The control group followed the standard syllabus, while the experimental group participated in a metalinguistic discussion on the interaction between aspect and Aktionsart. All the participants were then asked to select the appropriate aspectual value in a set of 32 sentences manipulated with respect to Aktionsart and various types of aspectual
cues. To verify to what extent the pedagogical intervention shifted the respondents’ choices away from the default behaviour instantiated by the control group, associating the expression of completed events to the PF aspect, the experimental group completed the task again after a year. At the second test time, the participants were also asked to translate 12 Russian
sentences into Italian and justify their choice of aspectual forms. The experimental group demonstrated greater sensitivity to the role of Aktionsart in contexts that lacked aspectual cues, even though they failed to explicitly describe its role. Altogether, the pedagogical intervention seemed to exert a beneficial effect on the learners’ ability to select the most prototypical aspectual value but not on their ability to justify their choice
Syndromic and Non-Syndromic Primary Failure of Tooth Eruption: A Genetic Overview
Full text linkPrimary failure of tooth eruption (PFE) is a rare genetic disorder characterized by the failure of teeth to erupt in the absence of obvious physical obstructions, often resulting in a progressive open bite that is resistant to orthodontic treatment. While PFE can
be caused by genetic or systemic factors (such as cysts, tumors, and endocrine imbalances), the non-syndromic causes are primarily genetic, with an autosomal dominant inheritance pattern with variable expressivity. Several genes have been closely associated
with the non-syndromic PFE form. The PTH1R (parathyroid hormone 1 receptor) is the
most commonly PFE-associated gene. Additional genes associated with minor frequency
are Transmembrane protein 119 (TMEM119), which reduces the glycolytic efficiency of
bone cells, limiting their mineralization capacity and causing bone fragility; Periostin
(POSTN), which regulates the extracellular matrix and the bone’s response to mechanical
stress; and Lysine (K)-specific methyltransferase 2C (KMT2C), which establishes histone
methylation near the Wnt Family Member 5A (WNT5A) gene involved in dental development (odontogenesis). Syndromic forms of PFE are typically associated with complex multisystem disorders, where dental eruption failure is one of the clinical features of the
spectrum. These syndromes are often linked to genetic variants that affect ectodermal development, craniofacial patterning, and skeletal growth, leading to abnormal tooth development and eruption patterns. Notable syndromes include GAPO syndrome, ectodermal dysplasia, and cleidocranial dysplasia, each contributing to PFE through distinct molecular mechanisms, such as disruptions in dental structure development, cranial abnormalities, or systemic developmental delays. The main aim of this review is to provide a comprehensive overview of the genetic basis underlying both syndromic and non-syndromic
forms of PFE to facilitate precision diagnosis, foster the development of personalized therapeutic strategies, and offer new insights into managing this complex dental anomal
Medioevo della diversità. Per Roberto Greci, note biobibliografiche
No full textSi tratteggia il profilo biografico e scientifico del prof. Roberto Greci, docente di storia medievale all’Università di Parma, a cui viene dedicato il volume degli atti del convegno internazionale sul re longobardo Liutprando.The biographical and scientific profile of Prof. Roberto Greci, professor of medieval history at the University of Parma, to whom the volume of the proceedings of the international conference on the Lombard king Liutprando is dedicated, is outlined
Healthcare Poverty and Access to Healthcare Services in Italy: The Challenge of Public-Third sector Integration
No full textThe analysis proposed in the article falls within the studies on the relationship between health and inequalities, focusing specifically on the issue of healthcare poverty in high-income countries. This term refers to the consequences of resource scarcity on access to healthcare services, particularly those not covered by the public health system. The topic is addressed with specific reference to the Italian case, first demonstrating the existence of healthcare poverty even in a universalist context, and then analyzing the role played by third-sector organizations in mitigating the effects of this lack of public coverage for healthcare needs. In conclusion, the article highlights the need for a closer connection between the National Health Service and the services provided by non-profit organizations active in the area of social hardship
Risk factors of dementia in a cohort of individuals with mild cognitive impairment in the Italian Interceptor project
No full textBackground: The Italian Interceptor project is aimed at identifying a prodromal dementia phase and developing a nationwide organizational model. This study compares the sociodemographic and neuropsychological characteristics of mild cognitive impairment non-converters (MCI-NC) and MCI-converters (MCI-C) to dementia, including Alzheimer's disease (AD), enrolled during the Interceptor project. Methods: Sociodemographic, clinical, and neuropsychological data of MCI individuals were collected at baseline (December 2018 to October 2020) and every six-month follow-up visit for 3 years. Logistic regression and Random Forest classifier were used to describe the study population. Results: From 356 participants, 104 were MCI-C, whereas 252 were MCI-NC. Compared to MCI-NC, MCI-C were predominantly female (p = 0.020), older (p < 0.001), and more cognitively impaired (p < 0.001). Higher physical activity was protective for progression (p < 0.001), but no difference was observed for smoking exposure (p = 0.312) between the two groups. Similar results were found for AD individuals compared to MCI-C/non-AD. The ROC curve based on a Random Forest classifier distinguishing MCI-C from MCI-NC showed an area under the curve (AUC) of 0.7347. Conclusions: Our findings confirm previous evidence in literature and may increase the insight on dementia pathology and help in defining intervention strategies to prevent or slow down disease progression
Treatment for ulnar neuropathy at the elbow
No full textUlnar neuropathy at the elbow (UNE) is the second most common entrapment neuropathy after carpal tunnel syndrome. Treatment may be conservative or surgical, but optimal management remains controversial. This is an update of a review first published in 2011 and previously updated in 2012 and 201
A network perspective on supply chain management in the structural reshaping of globalization
Full text linkThe research presents contributions on important topics such as the “reconfiguration” and “transformation” of supply chain structures. Reconfiguration involves processes such as the formation of the supply chain but also the development of new ways of exchanging information to improve communication flows between actors. The reconfiguration of the supply chain at an international level involves the theme of innovation. Some of the research proposes applications of models that can be traced back to the IMP approach
Impact of a Saccharomyces cerevisiae Fermentation Product Supplemented from 20 Days Before Dry-Off Through 60 Days of Lactation on the Metabolic Adaptation of Dairy Cows to the Peripartum Phase
No full textSixty Holstein cows were enrolled at -76 days from calving (DFC) and classified based on the daily SCC during the previous week from an automated milking system. The separation thresholds for low (L, n = 46) and high (H, n = 14) classifications were 100 K/mL for primiparous and 200 K/mL for multiparous cows. Cows were then assigned to two homogeneous groups to receive diets supplemented with 19 g/d of a Saccharomyces cerevisiae fermentation product (TRT; NutriTek, Diamond V, Cedar Rapids, IA, USA) or without supplementation (CTR) until 60 DFC. Cows were dried off at -56 DFC and monitored for disease incidence, milk yield and composition, plasma metabolic profile, and whole blood count from -76 to 60 DFC. Data were analyzed utilizing ANOVA and mixed models for repeated measures. During the dry period, TRT cows had greater plasma thiol and albumin compared to CTR. TRT-L cows had greater plasma protein and globulin than CTR-L. TRT-H cows had heightened hematocrit; reduced plasma globulin and haptoglobin; and higher albumin, albumin to globulin ratio, and thiol than CTR-H. TRT-H cows had greater concentrations of leukocytes and lymphocytes and lower plasma protein and ceruloplasmin at -54 DFC; lower reactive oxygen species to ferric ion-reducing antioxidant power ratios at -44 DFC; and greater concentrations of lymphocytes and plasma gamma glutamyl transferase at -7 DFC than CTR-H. After calving, TRT cows had a lower incidence of mastitis and higher butterfat, as well as greater plasma haptoglobin and aspartate amino transferase (AST) and reduced Mg compared to CTR. TRT cows had lower SCC between 1 and 7 DFC and a greater ECM between 41 and 60 DFC compared to CTR. TRT-H cows had lower SCC between 1 and 7 DFC and greater hemoglobin and plasma AST than CTR-H. Ameliorated immune system functions due to Saccharomyces cerevisiae fermentation product administration lowered the SCC in TRT-H cows and prevented the onset of new intramammary infections across both L and H SCC groups, supporting the improved productive performance of dairy cows