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Theoretical study on the stability of insulin within poly-isobutyl cyanoacrylate (PIBCA) nanocapsule
No full textTo study the physical stability of insulin in drug delivery particles, we developed a coarse-grained (CG) model for insulin based on dissipative particle dynamics (DPD). Three insulin modelling schemes were considered: each amino acid as a bead (IM1), each amino acid being separated into one to three beads (IM2), and adding secondary structural information of insulin to IM2 (IM3). The best possible bead-bead interaction parameters were obtained from Hildebrand and Hansen solubility parameters by performing the constant-temperature DPD simulation with insulin models in 20% acetic acid solution. IM3 showed good results in terms of RMSF, RMSD and A1B30 distance compared to those of all-atom models from the literature. Then, the IM3 model was considered in an oil-filled poly (isobutyl cyanoacrylate) (PIBCA) nanocapsule. Two crucial factors were found that mainly influence the stability of insulin in oil: the PIBCA shell thickness and the amount of ethanol in the oil droplet. An appropriate PIBCA shell thickness is necessary to block the interaction between insulin and water outside, and ethanol could stabilise insulin with its good affinity for both insulin and oil
The role of a business model in market growth: The difference between the converted industry and the emerging industry
No full textThis paper investigates the role of business models: What differences exist between the roles of an already-existing market-based converted industry and a newly appearing market-based emerging industry? This study analyzed the status of the technologies and business models in the autonomous car and intelligent robot industries, as well as their recent two-year growth, using technology and business model patents. In addition, it investigated the current situation of the technologies, business models, and markets of the two industries based on literature reviews. This study then simulated the market growth of the autonomous car and intelligent robot industries using system dynamics. The simulations were established and verified by analyzing the references and citations of the technology patents and business model patents of the two industries. This study reached three conclusions. First, in the case of a converted industry such as autonomous cars, a strategy focused on a business model is useful in the early stage, whereas one focused on technology is efficient in the mature stage. Second, in the case of an emerging industry such as intelligent robots, a strategy focused on technology is somewhat more useful in the early stage than one focused on a business model; conversely, a strategy focused on technology is slightly more useful in the mature stage. Third, a business model is also important to supplement technology such as intelligent robots at a mature stage in Canada or autonomous cars at a mature stage in Japan. Highlights In the early stage of converted industry such as autonomous car, business model is more important than technology. In the early stage of emerging industry such as intelligent robot technology is more important than business model. In mature stage, technology and business model are simultaneously important in both industries
Topic Analysis of Scholarly Communication Research
Full text linkThis study aims to identify specific topics, trends, and structural characteristics of scholarly communication research, based on 1,435 articles published from 1970 to 2018 in the Scopus database through Latent Dirichlet Allocation topic modeling, serial analysis, and network analysis. Topic modeling, time series analysis, and network analysis were used to analyze specific topics, trends, and structures, respectively. The results were summarized into three sets as follows. First, the specific topics of scholarly communication research were nineteen in number, including research resource management and research data, and their research proportion is even. Second, as a result of the time series analysis, there are three upward trending topics: Topic 6: Open Access Publishing, Topic 7: Green Open Access, Topic 19: Informal Communication, and two downward trending topics: Topic 11: Researcher Network and Topic 12: Electronic Journal. Third, the network analysis results indicated that high mean profile association topics were related to the institution, and topics with high triangle betweenness centrality, such as Topic 14: Research Resource Management, shared the citation context. Also, through cluster analysis using parallel nearest neighbor clustering, six clusters connected with different concepts were identified
Identifying Stakeholder Perspectives on Data Industry Regulation in South Korea
Full text linkData innovation is at the core of the Fourth Industrial Revolution. While the catastrophic COVID-19 pandemic has accelerated the societal shift toward a data-driven society, the direction of overall data regulation remains unclear and data policy experts have yet to reach a consensus. This study identifies and examines the ideal regulator models of data-policy experts and suggests an appropriate method for developing policy in the data economy. To identify different typologies of data regulation, this study used Q methodology with 42 data policy experts, including public officers, researchers, entrepreneurs, and professors, and additional focus group interviews (FGIs) with six data policy experts. Using a Q survey, this study discerns four types of data policy regulators: proactive activists, neutral conservatives, pro-protection idealists, and pro-protection pragmatists. Based on the results of the analysis and FGIs, this study suggests three practical policy implications for framing a nation's data policy. It also discusses possibilities for exploring diverse methods of data industry regulation, underscoring the value of identifying regulatory issues in the data industry from a social science perspective
Bridge to Future, 데이터로 만나는 미래유망기술
Full text link한국과학기술정보연구원(원장직무대행 조금원, 이하 KISTI)은 코로나19 팬데믹 이후 과학기술 미래 사회를 좌우할 핵심 유망기술을 발굴제시한 미래유망기술세미나 2020을 『KISTI 이슈브리프 제29호』에서 소개하였다
KISTI, 오픈액세스 가속화 위해 도서관협의체와 협력
Full text link한국과학기술정보연구원(원장 김재수, 이하 KISTI)은 한국대학도서관연합회(회장 오세훈, 이하 KUCLA) 및 한국전문도서관협의회(회장 오정훈, 이하 KSLA) 양 기관과 오픈액세스 협력 추진을 위한 협약을 22일 체결하였다. 이 협약은 협약기관이 주관하거나 운영하는 기존 구독기반 전자정보 컨소시엄을 오픈액세스 누구나 학술정보를 자유롭게 이용할 수 있도록 재정적, 법률적, 기술적 장벽을 제거한 학술정보 유통 모형
기반으로 전환하는데 상호 협력함으로써 우리나라의 고비용·독점적 학술정보 이용환경 해소에 그 목적이 있다
오픈액세스를 통한 디지털 포용의 실현
Full text link한국과학기술정보연구원(원장 김재수, 이하 KISTI)은 디지털 전환이 가속화되는 시대에 디지털 정보격차를 해소하는 디지털 포용의 방안으로 오픈액세스의 실천적 전략을 제시한 『KISTI 이슈브리프 제31호』를 발간하였다
KISTI, 교육 분야 연구데이터 관리 체계 구축·협력 업무협약
Full text link한국과학기술정보연구원(원장 김재수, 이하 KISTI)은 대구미래교육연구원(원장 이희갑)과 KISTI 대전본원에서 교육 및 연구 협력 사업 강화를 위한 업무협력 협약을 체결했다고 17일 밝혔다.
협약에 따라 양 기관은 ▲교육 분야 연구데이터 관리체계 수립에 관한 공동연구 및 상호교류 ▲국가연구데이터플랫폼(DataOn) 기반 연구데이터 관리 체계 협력 ▲데이터 리터러시 강화를 위한 공동교육과정 개발 및 운영 협력 ▲대구교육데이터에 대한 데이터저장소(IDR) 운영 및 기능개선 협력 ▲교육 빅데이터 지식 인프라의 공유 활용을 위한 연구 및 상호 교류에 적극 협력하게 된다
A Shift in Information Dissemination Methods in a Cultural Ritual amid the COVID-19 Pandemic
Full text linkThis study aims to unravel the shift in the customary method of disseminating information about the ritual of Perang Topat (literally translated as "rice-cake war") as carried out by the custom community of Kemaliq Lingsar in the West Lombok Regency of Indonesia during the COVID-19 pandemic. Grounded in the ethnography of communication research methodology, this study examines the process of the cultural ritual during the 2020 period of the pandemic and compares it to the ones held in 2018 and 2019 (before the current pandemic). Drawing on findings from observations, in-depth interviews, and documentation, it was revealed that the traditional or custom-oriented community of Kemaliq Lingsar abandoned all three prominently used methods of disseminating the information of the Perang Topat ritual that had been used prior to the pandemic, and that they were replaced by a strategy with solely face-to-face (FTF) interpersonal communication carried out by visiting the homes of the target participants of the cultural event. This method was relevant to the current viral crisis because it enabled the committee to minimize the number of spectators which might potentially violate COVID-19 health protocols. This finding also reinforces the hypothetical statement that interpersonal communication via FTF is effective in disseminating information in a limited manner and empowering the emotional bond between the individuals who share relationships and similar interests. The findings of the present study can be a reference for any events where physical distancing must be strictly imposed and require a limit to the number of participants during the pandemic
양자암호기반의 통신망 구축 및 성능시험 검증연구
No full text과학기술연구망(KREONET)에서는 기상기후 정보, 고에너지물리, 천문연구, 위성정보데이터, 유전체 연구데이터 등의 빅데이터 중심 첨단 연구 활동을 지원을 수행하고 있다. 기존의 네트워크 보안장비들이 있는 환경에서는 성능저하가 발생하기 때문에, 고성능 연구전용 네트워크 상에서 성능저하를 방지하고, 고속 연구협업을 위한 방안들이 연구되고 있다. 또한 최근 이슈가 되는 양자컴퓨터의 등장으로 기존 암호체계를 활용한 보안성에 위협이 되고 있다. 본 논문에서는 End-to-End의 고속 연구전용 네트워크상에서 양자암호기반의 통신망 구축을 통하여 물리적 보안성을 강화시키는 환경구축과 고성능 전송테스트를 통하여 양자암호기반 통신망을 구성한다. 물리적 암호화 수행 시에 망 성능에 미치는 영향을 분석하여, 고성능 연구협업 네트워크 구축을 위한 기초 자료로 활용하고자 한다