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A comparative analysis of treatment-emergent cardiovascular events among patients with chronic lymphocytic leukemia treated with Bruton’s tyrosine kinase inhibitors –a single-centre real-world analysis
No full textJoint Hypermobility - Etiology, Classification, Clinical Presentation and Therapeutic Approach
No full textHipermobilnost zglobova (engl. joint hypermobility) prezentira se sposobnošću zgloba (ili skupine zglobova) da se pasivno ili aktivno pokreću izvan fizioloških granica oko osi kretanja. Hipermobilnost zglobova može biti asimptomatska i simptomatska; lokalizirana, periferna i generalizirana. Može biti dio nasljednog poremećaja vezivnog tkiva. Najčešći su oblici simptomatske hipermobilnosti zglobova poremećaji iz spektra hipermobilnosti (engl. hypermobility spectrum disorders) i hipermobilni tip Ehlers-Danlosova sindroma (engl. Ehlers-Danlos Syndrome - hypermobility type). Hipermobilnost zglobova često se kompenzira mišićnom napetošću u smislu grčeva, bolova i simptoma nalik fibromialgiji. Laksicitet i instabilitet zglobova pridonose lokaliziranom biomehaničkom opterećenju što dovodi do ozljede praćene nociceptivnom boli. U nekih prelazi u kronicitet i razvija se difuzna mišićno-koštana bol mehanizmom tzv. centralne senzitizacije. Generalizirana hiperalgezija posredovana je centralnom senzitizacijom i stoga bolesnici postaju intolerantni na tjelesnu aktivnost, ubrzavajući dekondicioniranje. Nadalje, neodgovarajuća propriocepcija može povećati rizik od ozljede. Sistemske manifestacije kod bolesnika sa simptomima hipermobilnosti heterogene su i različitog su intenziteta. Ocjenske ljestvice za procjenu hipermobilnosti zglobova imaju različite granične vrijednosti s obzirom na uzrast bolesnika, respektirajući činjenicu da je kod djece prisutan veći fiziološki raspon pokreta. Rano multidisciplinarno liječenje koje uključuje fizikalnu terapiju, opskrbu ortozama i kognitivno-bihevioralnu terapiju, može optimizirati ishode kod bolesnika. Anksioznost, simptomi depresivnosti, katastrofiziranje, kinezifobija i kognitivne smetnje također su sastavnice ovog sindroma zbog neprepoznavanja i nerazumijevanja ozbiljnosti svojega stanja. Poremećaji iz spektra hipermobilnosti i hipermobilni Ehlers-Danlosov sindrom s vrlo varijabilnom kliničkom prezentacijom i nepostojanjem specifičnog dijagnostičkog testa za potvrdu poremećaja, ponekad uslijed nedostatnog kliničkog znanja i iskustva, s ovakvom kazuistikom dovode do subdijagnosticiranja i izostanka adekvatnog terapijskog pristupa.Joint hypermobility refers to a joint's (or set of joints') ability to move passively or actively beyond the physiological limits around the axis of motion. Joint hypermobility is classified as asymptomatic or symptomatic; local, peripheral, or generalized. It can be part of a hereditary connective tissue disorder. Hypermobility Spectrum Disorders and Ehlers-Danlos Syndrome - Hypermobility Type are the most prevalent types of symptomatic joint hypermobility. It is frequently compensated by tense muscles that manifest as cramps, soreness, and fibromyalgia-like symptoms. Joint laxity and instability contribute to localized biomechanical load, resulting in injuries with nociception discomfort. Sometimes it becomes chronic, and diffuse musculoskeletal pain develops through the "central sensitization” mechanism. Central sensitization as a mediator of generalizing hyperalgesia makes patients intolerant of physical exertion and hastens deconditioning. Inadequate proprioception can exacerbate the risk of injury. Patients with joint hypermobility frequently lack sufficient proprioception. Systemic manifestations can be heterogeneous and of different intensities. Various rating scales assess joint hypermobility, each with a distinct cut-off based on age, considering that youngsters have a higher physiological range of motion. This syndrome also includes kinesiophobia, anxiety, depression symptoms, catastrophizing, and cognitive impairment since the affected are unable to acknowledge or comprehend the seriousness of their condition. Physical therapy, orthotic supplies, and cognitive behavioral therapy can optimize their outcomes. Hypermobility Spectrum Disorders and hypermobile Ehlers-Danlos Syndrome have inconsistent clinical presentation, and the absence of a specific diagnostic test, sometimes due to insufficient clinical expertise or previous experience leads to a further missed diagnosis and lack of appropriate therapeutic approach
Influence of Hot-Dip Galvanizing Cooling Process on Properties of 1000 MPa Multiphase Steel
No full textFor 1000 MPa multiphase steel CP980+Z, simulation experiments were carried out under different slow-cooling and rapid-cooling temperatures, and the resulting me-chanical properties and microstructures were evaluated. The findings show that this work fills a gap in previous research on CP980+Z. Unlike earlier studies that focused on austenitization temperature or cold rolling reduction, this study systematically reveals the synergistic regulation mechanism of slow cooling in the intercritical re-gion and rapid cooling on the material’s overall performance. When the slow-cooling temperature ranges from 740 °C to 760 °C, the yield ratio meets the re-quired standards. When the final rapid-cooling outlet temperature is 350 °C, the strength–ductility balance and hole expansion capability reach optimal values. The underlying microstructural mechanism is governed by controlling ferrite nucleation and growth during slow cooling, and bainite–martensite transformation during rapid cooling. This combined control determines the content and distribution of martensite and martensite/austenite (M/A) islands
Community Resident and Sustainable Cultural Heritage Tourism Development: A Systematic Literature Review Using PRISMA
No full textResidents are key stakeholders in sustainable tourism development and play an essential role in tourism growth. While previous studies have explored residents' support for tourism from economic and environmental perspectives, the unique relationship between cultural heritage preservation and community empowerment has not been sufficiently explored. Cultural heritage tourism naturally generates conflicts between commodification and preservation, yet current frameworks often overlook residents' cultural identity and empowerment as crucial factors for sustainable outcomes. This omission is particularly significant in the post-pandemic recovery context, where heritage sites face increased risks of over-tourism and community marginalization. To address this gap, the study conducted a systematic literature review of 53 articles published through January 2025. Using the PRISMA methodology, it identified relevant theories and examined direct, mediating, and moderating factors. Additionally, this research developed a conceptual framework to support the sustainable development of cultural heritage tourism, offering new insights and guiding future studies. The findings provide valuable knowledge for tourism researchers, destination managers, and policymakers, while the framework serves as a practical tool for destinations seeking to balance tourism growth with heritage preservation and community well-being
A Novel Integrated Model of Train Rescheduling and Station Track Usage Planning Based on Harris Hawks Optimisation Algorithm
No full textCollaborative optimisation of train rescheduling plans and station track usage schemes has emerged as a popular research topic, which can avoid the risk of plan non-fulfilment due to conflicts between the two problems. This paper proposes an integrated model of train rescheduling and the station tracks usage planning, with the total delay time and changes in the station track usage plan as the optimisation objectives. The train tracking intervals, minimum running time in sections of the trains, minimum dwelling time and the track usage restriction, etc., are taken as the constraints of the model. Then, the Harris hawks optimisation algorithm is introduced and applied to find the solution of the model. The comparison of the computing results based on the classical particle swarm optimisation algorithm and the designed algorithm is carried out, and it is found that the total calculation time consumption decreases by 4.12%. The proposed method can provide decision support for daily train dispatching work
Dva velika matematičara 18. stoljeća: Bošković i Gelenbevî
No full textIn this paper, we describe and compare the lives and mathematical contributions of the greatest Croatian and the greatest Turkish mathematician of the 18th century: Ruđer Josip Bošković and Gelenbevî İsmail Efendi.U ovom članku opisujemo i uspoređujemo životopise i matematičke
doprinose najvećeg hrvatskog i najvećeg turskog matematičara 18. stoljeća, Ruđera Josipa Boškovića i Gelenbevî İsmail Efendije
Electrochemical oxidation of textile wastewater combined with 185 nm UV irradiation
No full textThe chemical oxygen demand (COD) results obtained after electrochemical oxidation and UV irradiation could hardly meet the strict discharge standard of COD for the textile wastewater after biological treatment. To further treat the textile wastewater after biological treatment, UV light at 185 nm was used in the centre of the commercial PbO2 mesh cylinder anode with the titanium cylinder cathode in a cylinder electrolyzer. Performances of electrochemical oxidation coupled with 185 nm UV irradiation were investigated at a pilot scale under different oxidation times, current density, initial pH, and electrolyte flow rate without addition of oxidant reagents. The experimental results show that the performance of electrochemical oxidation combined with 185 nm UV irradiation is better than that of either separately applied electrochemical oxidation or 185 nm UV irradiation. 2,4-di-tert-butylphenol, oleamide and octadecanamide could be effectively degraded by electrochemical oxidation combined with 185 nm UV irradiation. Under optimal operating conditions, the electrochemical oxidation with 185 nm UV irradiation could reduce the COD of textile wastewater from 74.0 to 31.0 mg L-1 with the electrical consumption of 252.86kWh per kg of degraded COD, cost of 5.78 CNY per m³ of textile wastewater, and carbon emissions of 141.10 kg CO2 per kg of degraded COD. Future research should investigate the interaction effects of variables, as well as the integration of renewable energy and broader contaminant removal capabilities
Corrosion Properties of Al2O3-TiO2 Ceramic Coatings Deposited by Plasma Spraying on AZ91 Magnesium Alloy in Different Environment
No full textMagnesium and its alloys are used in many industrial fields and are the lightest material group among green materials, but it limits the usage area due to its low corrosion resistance. Surface coating methods are used to improve the corrosion properties. In this study, it was aimed to determine the corrosion behavior of AZ91 magnesium alloy in different corrosive environments (0.3 M H2SO4 and 3.5% NaCl). For this purpose, different ratios of Al2O3 and TiO2 were coated on AZ91 Mg alloy using the Atmospheric Plasma Spray (APS) method. At the end of the study, the highest corrosion resistance was obtained in the 100% Al2O3 coated samples, and the corrosion rate in the 3.5% NaCl corrosive environment was higher than that of the 0.3 M H2SO4
Preparation of Recycled Paper Using Tea Stems and its Application in Product Design
No full text(1) Objective: This study aims to reduce waste and resource usage by utilizing discarded tea stems for producing recycled paper, and to explore its properties and potential in product design. (2) Methods: Tea stem recycled paper was fabricated via a conventional hand-sheet process using varying tea stem-to-pulp ratios, followed by physical property testing and Kansei-based visual-tactile evaluations. (3) Key Findings: Tea stem recycled paper showed comparable whiteness, moisture content, and opacity to commercial recycled papers, with the highest tensile strength at 10% tea stem content (12.3 ± 0.4% higher than Xuan paper). (4) Implications: Based on combined physical and sensory assessments, material-driven design models were proposed, highlighting functional uses for tea stem–pulp composites and aesthetic applications for tea stem-bark composites
Research on the Integration and Innovation Path of Artificial Intelligence and the Real Economy
No full textThis study aims to explore the impact of artificial intelligence (AI) integration on economic performance, focusing on the roles of frugal innovation and business model innovation as mediators. Utilizing a quantitative research design, data were collected from secondary sources, including industry reports and databases like the World Bank and OECD. The sample comprised 177 firms across various sectors, with a focus on small and medium-sized enterprises (SMEs). The findings reveal that AI-driven innovation significantly enhances economic performance, both directly and through its positive impact on real economy innovation. AI Integration Readiness (AIR) amplifies the AIDI→REI link yet shows a non-significant total moderation on EP (p = 0.15; BF10 = 1.8, anecdotal evidence for H0). Challenges such as the negative impacts of AI readiness on performance highlight the need for targeted support for SMEs. The study concludes that fostering AI capabilities and readiness is crucial for overcoming bottlenecks and achieving optimal economic outcomes, emphasizing the importance of supportive policies and infrastructure for broad-based AI adoption. These insights provide valuable implications for policymakers and business leaders aiming to leverage AI for sustainable economic growth and innovation