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The reporting quality of abstracts of randomized controlled trials on Curcuma longa L.: A cross-sectional study based on the MEDLINE database
No full textAim: To analyze the quality of abstracts of the randomized controlled clinical trials on Curcuma longa L.
Methods: We queried MEDLINE via PubMed for abstracts of randomized controlled trials on Curcuma longa L. and evaluated their reporting quality according to the criteria from the CONsolidated Standards Of Reporting Trials (CONSORT) statement. The collected data were analyzed using the χ2 statistical test to examine a correlation between the presence of CONSORT checklist items and the structure of the abstract.
Results: The search retrieved 170 scientific articles, of which 138 met our inclusion criteria. The median total score of the abstracts was 7, out of 17 checklist items, with most scores ranging between 6 and 9. We found significant differences regarding the presence of CONSORT items depending on the abstract structure: objective and primary outcomes appeared the most frequently, while source of funding and randomization process appeared the least frequently.
Conclusion: According to CONSORT criteria, abstracts of randomized controlled trials on Curcuma longa L. exhibit suboptimal quality. Most worryingly, there is a lack of information on funding sources and randomization processes in most of the abstracts, significantly impacting the transparency and trustworthiness of the clinical trials
Area and Power Optimized Architecture of Sample Rate Converter for IoT Gateway Applications
No full textNowadays, the Internet of things plays a major role in society for various applications such as medical diagnostics, telecommunications, agriculture, mobile computing, broadcasting, video surveillance etc. In Internet of Things (IoT) networks, several sensors with different data rates should be integrated to perform overall control or monitoring processes.High-speed data transmission technologies should be needed to communicate with IoT servers or storage. Generally, a gateway device is used to integrate low-data rate devices and IoT interfaces. Field Programmable Gate Array Logic (FPGA) can be utilized to implement high-speed and low-power gateway. The paper suggests a design of an FPGA-based IoT gateway architecture, which allows multi-protocol communications and an effective way of controlling sample rates. The design provides RF transceivers, protocol specific modules, and dynamic Sample Rate (SR) Selector to support smooth synchronization of data between diverse IoT devices. Clock generation and control blocks guarantee adaptive frequency assignment and upsampling and downsampling CIC filtering-based units ensure good signal conditioning. Experimental analysis shows that the presented method creates the low root mean square error (RMSE): 1.2 percent (downlink) and 1.4 percent (uplink), and high signal to noise ratios (SNR): 26.3 dB (downlink) and 24.8 dB (uplink) in 45 nm CMOS technology, resulting in better results than conventional 180 nm implementations. The Application-Specific Integrated Circuit (ASIC) implementation achieved a compact core area, reducing from 2.3 μm2 at 180 nm to 0.3 μm2 at 45 nm, demonstrating significant area efficiency with technology scaling. The results affirm that the architecture can provide reliable and high-quality data transfers of next-generation IoT gateways
Utjecaj grijanog duhana i električnih cigareta na količinu i sastav sline u usporedbi s klasičnim cigaretama
No full textSlina ima ključnu ulogu u održavanju oralnog zdravlja, a njezina količina i sastav mogu biti narušeni upora- bom duhanskih proizvoda. Ovaj pregledni rad analizira i uspoređuje učinke klasičnih cigareta, elektroničkih cigareta i proizvoda grijanog duhana na količinu i sastav sline, s naglaskom na brzinu protoka, pH vrijednost, viskoznost i imunološke sastavnice.
Slina predstavlja složen biološki sustav koji ima ključnu ulogu u održavanju oralne homeostaze. Promjene u njezinoj količini i sastavu mogu imati značajan utjecaj na oralno zdravlje. Pušenje je jedan od važnih čimbenika koji mogu utjecati na funkciju žlijezda slinovnica, ne samo kod klasičnih cigareta, već i kod novijih duhanskih proizvoda poput elektroničkih cigareta i proizvoda grijanog duhana.
Ovaj rad predstavlja narativni pregled literature. Pretraga literature provedena je do 1. srpnja 2025. godine u bazama PubMed, MEDLINE i Google Scholar. Korišteni su pojmovi povezani isključivo s utjecajem duhanskih proizvoda na slinu. Uključeni su radovi na engleskom, hrvatskom i srpskom jeziku, s naglaskom na primarna istraživanja provedena na ljudima. Podaci su sintetizirani narativno.
Značajan broj uključenih studija ne navodi precizne demografske podatke ispitanika niti trajanje izloženosti duhanskim proizvodima. Većina studija ima presječni dizajn, što ograničava procjenu dugoročnih učinaka. Heterogenost metodologije otežava izravnu usporedbu rezultata.
Dostupni dokazi upućuju na to da klasične cigarete, elektroničke cigarete i proizvodi grijanog duhana mogu negativno utjecati na količinu i sastav sline. Međutim, zbog ograničene kvalitete i heterogenosti dostupnih podataka, potrebna su daljnja longitudinalna istraživanja kako bi se donijeli čvršći zaključci
Impacts of country-specific aspects on tourists’ revisit intentions to cultural heritage sites: The mediating role of destination image
No full textPurpose – The current study seeks to appraise the key factors motivating foreign tourists to
revisit cultural heritage sites.
Methodology – Data were gathered through questionnaires distributed to foreign tourists
visiting Jordanian heritage sites, selected using purposive sampling. Of the 350 responses
gathered, 309 were deemed suitable for statistical analysis. Structural equation modeling was
conducted using SmartPLS.
Findings – Safety, security, and the destination image were revealed to be positively associated
with the intention to revisit cultural and heritage places. Contrarily, country knowledge,
accessibility, and price reasonableness were insignificant. The destination image significantly
mediated the relationship between country-specific aspects and revisit intention. Nonetheless,
the mediation effect was insignificant on the relationship between country knowledge,
accessibility, and price reasonableness.
Originality – The current study applied a novel approach by incorporating country-specific
factors, the destination image, and revisit intention to appraise cultural and heritage tourism.
Specifically, a positive destination image formed after visiting cultural and heritage sites
significantly influences revisit intention, fostering destination loyalty and contributing to the
economic sustainability of the tourism sector
Autonomic Nervous System Testing in Cardiovascular Patients: From Research to Clinical Application
No full textSAŽETAK
Autonomni živčani sustav (ANS) ima ključnu ulogu u kardiovaskularnoj (KV) regulaciji kroz dinamičku interakciju svojih simpatičkih i parasimpatičkih dijelova. Disregulacija autonomne ravnoteže sve se više prepoznaje kao važan patofiziološki doprinos širokom rasponu KV poremećaja. Različite neinvazivne metode, poput varijabilnosti srčanog ritma, oporavka srčanog ritma, osjetljivosti barorefleksa, praćenja arterijskoga tlaka i testiranja nagibnim stolom, pokazale su znatnu dijagnostičku i prognostičku vrijednost u procjeni autonomne funkcije, dok komplementarni postupci poput testa aktivnoga stajanja, Valsalvina manevra i testa dubokog disanja mogu ponuditi dodatan uvid u autonomnu kontrolu, ali su i dalje nedovoljno iskorišteni u rutinskoj praksi. Unatoč rastućim dokazima koji podržavaju njihovu kliničku relevantnost, šira klinička primjena testiranja ANS-a ostaje ograničena metodološkom heterogenošću, nedostatkom jedinstvenih standarda i nedovoljnim konsenzusom o interpretaciji i kliničkim putevima odlučivanja. Ovaj članak pruža integrirani pregled uobičajeno primjenjivanih modaliteta testiranja ANS-a, sažimajući njihovu fiziološku osnovu i procjenjujući njihovu kliničku primjenjivost u kardiologiji. Osim tehnološkog napretka, uspostavljanje jedinstvenih međunarodnih smjernica, standardiziranih protokola i okvira za interpretaciju temeljenih na konsenzusu bit će ključno za osiguranje dosljednosti, poboljšanje usporedivosti između istraživanja i olakšavanje integracije testiranja ANS-a u rutinsku kardiološku praksu. Zahvaljujući takvim zajedničkim naporima procjena ANS-a ima potencijal da se razvije od istraživačkog instrumenta do komponente personalizirane KV medicine.SUMMARY
The autonomic nervous system (ANS) plays a pivotal role in cardiovascular (CV) regulation through the dynamic interplay of its sympathetic and parasympathetic divisions. Dysregulation of autonomic balance is increasingly recognized as an important pathophysiological contributor to a broad range of CV disorders. A variety of non-invasive methods, such as heart rate variability, heart rate recovery, baroreflex sensitivity, blood pressure monitoring, and tilt-table testing, have demonstrated substantial diagnostic and prognostic value in assessing autonomic function across CV disorders, while complementary procedures such as the active standing test, Valsalva maneuver, and deep-breathing test may offer additional insight on autonomic control but remain underutilized in routine cardiology. Despite growing evidence supporting their clinical relevance, the broader clinical adoption of ANS testing remains limited by methodological heterogeneity, absence of unified standards, and insufficient consensus on interpretation and clinical decision pathways. This article provides an integrated overview of commonly used ANS testing modalities, summarizing their physiological basis and evaluating their clinical applicability in cardiology. In addition to technological advances, establishing unified international guidelines, standardized protocols, and consensus-based interpretation frameworks will be crucial to ensure consistency, improve comparability between studies, and facilitate the integration of ANS testing into routine cardiological practice. Through such collaborative efforts, ANS assessment has the potential to evolve from a research instrument into a component of personalized CV medicine
Precision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions
No full textBackground and purpose: Non-scarring alopecia, principally androgenetic alopecia and alopecia areata is highly prevalent and psychologically burdensome; androgenetic alopecia is androgen-driven, whereas alopecia areata is autoimmune. This review synthesizes genetic architecture and pathway biology to outline a precision framework for targeted interventions. Experimental approach: We reviewed full-text studies from the past decade across PubMed, Web of Science and Google Scholar, applying explicit inclusion/exclusion criteria; emphasis was placed on Genome wide association studies and Next generation sequencing findings, immune and androgen-axis biology, environmental modifiers, and therapeutic evidence (conventional, targeted, and regenerative), alongside artificial Intelligence-enabled diagnostics. Key results: Androgenetic alopecia risk converges on androgen-receptor signalling and related loci, with perifollicular inflammation and oxidative stress as modifiers; finasteride remains a cornerstone therapy. Alopecia areata reflects polygenic immune dysregulation (e.g. Human leukocyte antigen/cytokine axes) with Janus Kinase-pathway inhibition yielding robust regrowth; across phenotypes, wingless-related integration sit/β-catenin and stem-cell programs are central targets. Regenerative options (Protein Rich Plasma, stem-cell/exosome approaches) and artificial Intelligence-assisted stratification are emerging adjuncts. Conclusion: A pathway-guided, genotype and phenotype-informed strategy, targeting the androgen axis for androgenetic alopecia, immune circuits for alopecia areata, and adding regenerative or microenvironmental therapies where indicated-promises earlier diagnosis and more durable, individualized outcomes, especially as genome-wide association study/next-generation sequencing and artificial Intelligence tools are integrated into care
Novosti: Sveučilište u Splitu nagrađuje znanstvenu izvrsnost: Priznanja najproduktivnijim istraživačima Kemijsko-tehnološkog fakulteta u Splitu
No full textUtjecaj sustava hranidbe na prinos, kemijski sastav i profil masnih kiselina sira proizvedenog od mlijeka lokalnih koza u sjevernom Meksiku
No full textThe objective of this research work was to determine the yield, texture, and quality of artisan goat cheese produced in a housed and extensive grazing production system in northern Mexico. Milk from ten adult local goats, at the beginning of lactation, with an average weight of 42±2.25 kg and 2.5 births, randomly distributed in two treatments (housed n=5 and grazing n=5), was used to make cheese. The goats had an adaptation period of 14 days and were milked manually for 28 days. Yield, texture, chemical composition (concentration of fat, protein, moisture, salt, and total solids), and fatty acid profile of the cheese were evaluated. Statistical analysis was performed as a repeated measures design with the MIXED procedure. The fatty acid profile was analyzed by one-factor ANOVA with the GLM procedure and the comparison of means was performed with Tukey’s test (pCilj ovoga istraživanja bio je utvrditi prinos, teksturalna svojstva i kvalitetu kozjeg sira proizvedenog u zatvorenom sustavu držanja i u sustavu ekstenzivne ispaše u sjevernom Meksiku. Za proizvodnju sira korišteno je mlijeko deset odraslih lokalnih koza na početku laktacije, prosječne tjelesne mase 42±2,25 kg i s prosječno 2,5 jarenja, koje su nasumično raspoređene u dva tretmana (zatvoreni sustav, n = 5; ispaša, n = 5). Nakon 14-dnevnog razdoblja prilagodbe, koze su tijekom 28 dana muzene ručno. Procijenjeni su prinos mlijeka i sira, teksturalna svojstva te kemijski sastav sira (udio masti, proteina, vlage, soli i ukupne suhe tvari), kao i profil masnih kiselina. Statistička analiza provedena je kao dizajn s ponovljenim mjerenjima primjenom MIXED postupka. Profil masnih kiselina analiziran je jednofaktorskom analizom varijance (ANOVA) u okviru GLM postupka, a usporedba srednjih vrijednosti provedena je Tukey testom (
Utjecaj miR-27a, miR-29B, miR-142 i miR-148a na kvalitetu mlijeka i zdravlje mliječne žlijezde kod krava s manjim i većim brojem somatskih stanica
No full textThis study investigated expressions of miR-27a-3p, miR-29B-2, miR-142-5p, miR-148a in Holstein with low (LSCC) and high somatic cell counts (HSCC). Relationships between miRNAs, SCC and key milk quality parameters were examined. Milk was aseptically collected from multiparous Holsteins in mid-lactation on a dairy farm, and cows were grouped by SCC (200,000 cells/mL). miRNAs expressions were quantified by RT-qPCR, and target genes, Protein-Protein Interaction, and pathway analysis were also conducted. In HSCC, all samples were CMT positive (1.91±0.17). The overall SCC was approximately 320,000 cells/mL, with values around 60,000 cells/mL in the LSCC and 540,000 cells/mL in HSCC. Milk composition parameters were similar between groups, while electrical conductivity (EC) was higher in HSCC. miR-27a-3p and miR-29B-2 were upregulated by approximately 3-fold in HSCC, whereas miR-148a showed more than 6-fold upregulation. miR-27a- 3p correlated positively with miR-29B-2, miR-148a, and EC. miR-29B-2 was positively correlated with miR-148a, SCC, fat, and EC. miR-142-5p showed negative correlation with protein, while miR-148a was positively correlated with SCC. A total of 1,020 target genes were identified, with PTEN being a common target of all four miRNAs, while SMAD3, TGFB2, OTUD4, and RPS6KA5 were regulated by three. Network analysis revealed 84 proteins engaged in 402 interactions. MCODE identified key genes related to host response, lipid metabolism, inflammation, and apoptosis. The results provide insights into the molecular mechanisms underlying mammary gland health and potential targets for improving milk quality.U ovom je istraživanju ispitivana ekspresija miR-27a-3p, miR-29B-2, miR-142-5p i miR-148a kod holstein krava s manjim (LSCC) i većim brojem somatskih stanica (HSCC). Analizirani su odnosi između miRNA, broja somatskih stanica (SCC) i ključnih parametara kvalitete mlijeka. Mlijeko je aseptički prikupljeno od višetelnih krava holstein pasmine u sredini laktacije na jednoj mliječnoj farmi, a krave su razvrstane prema SCC-u (200.000 stanica/mL). Ekspresija miRNA kvantificirana je metodom RT-qPCR, a provedene su i analize ciljnih gena, interakcija protein-protein te signalnih putova. U skupini HSCC svi su uzorci bili pozitivni na CMT (1,91±0,17). Ukupni SCC iznosio je približno 320.000 stanica/mL, s vrijednostima oko 60.000 stanica/mL u skupini LSCC i 540.000 stanica/mL u skupini HSCC. Parametri sastava mlijeka bili su slični između skupina, dok je električna vodljivost (EC) bila viša u HSCC skupini. miR-27a-3p i miR-29B-2 bili su pojačano izraženi približno trostruko u HSCC skupini, dok je miR-148a pokazao više od šestostrukog povećanja ekspresije. miR-27a-3p pozitivno je korelirao s miR- 29B-2, miR-148a i EC-om. miR-29B-2 bio je pozitivno koreliran s miR-148a, SCC-om, udjelom masti i EC-om. miR-142-5p je pokazao negativnu korelaciju s udjelom proteina, dok je miR-148a pozitivno korelirao sa SCC-om. Ukupno je identificirano 1020 ciljnih gena, pri čemu je PTEN bio zajednički cilj svih četiriju miRNA, dok su SMAD3, TGFB2, OTUD4 i RPS6KA5 bili regulirani s tri miRNA. Mrežna analiza otkrila je 84 proteina uključenih u 402 interakcije. MCODE je identificirao ključne gene povezane s odgovorom domaćina, metabolizmom lipida, upalom i apoptozom. Dobiveni rezultati pružaju uvid u molekularne mehanizme koji leže u osnovi zdravlja mliječne žlijezde te upućuju na potencijalne ciljeve za poboljšanje kvalitete mlijeka