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Classical Studies in Secondary Education: Direction of the Courses of Study and Analysis of Teaching Materials
Get PDFArticle信州大学教育学部研究論集 18 : 41-54, (2024)departmental bulletin pape
コミュニティ・スクールにおける地域力の向上を目指した活動の実践 ―コミュニティ・ルームでの地域人材を活かした取り組みを通して―
Get PDFArticle令和5年度 信州大学大学院教育学研究科高度教職実践専攻（教職大学院）実践研究報告書抄録集 : 21-24, (2024)departmental bulletin pape
創作活動から始める「読むこと」の学習 －「創造性」と「批評性」の視点から物語の授業を問い直す－
Get PDFArticle令和5年度 信州大学大学院教育学研究科高度教職実践専攻（教職大学院）実践研究報告書抄録集 : 85-88, (2024)departmental bulletin pape
子どもの自律的な学びに求められること ―教師の子ども観に着目して―
Get PDFArticle令和5年度 信州大学大学院教育学研究科高度教職実践専攻（教職大学院）実践研究報告書抄録集 : 105-108, (2024)departmental bulletin pape
子どもの主体的探究を支える教師の学習指導
Get PDFArticle令和5年度 信州大学大学院教育学研究科高度教職実践専攻（教職大学院）実践研究報告書抄録集 : 113-116, (2024)departmental bulletin pape
Inter-strain Variation in Morphological Features of ʻKaida kabuʼ, a Local Turnip Variety of Nagano Prefecture, Japan
Get PDF長野県在来カブ品種‘開田蕪’の自家採種種子から開田高原全域を網羅するよう22系統を選出し栽培を行い，そのうち19系統について各系統最大10個体供試し，12項目について形態調査を行った．その結果，‘開田蕪’は幅広い系統間変異を有しており，高い遺伝的多様性を保持していることが示唆された．これは採種農家の多さと農家間の遺伝的交流に起因するものであると考えられた．また，かつて開田高原を２別する西野地区と末川地区それぞれに異なる在来カブ系統の存在が知られており，現在はまとめて‘開田蕪’と認識され差異はないとされるが，胚軸の形態データを用いた主成分分析の結果から農家の認識と近しい差異が認められた．また，同地域内で明確に分けて採種される‘ピンク蕪’は‘開田蕪’から突然変異として色素合成機能が欠損した個体を選抜して採種して生じた可能性が示唆された．‘開田蕪’の形態的，遺伝的多様性を維持していくためには採種母本数や採種農家数を損なわないだけでなく，地域内で希少性を認識し，維持するよう取り組むことが効果的であると考えられた．We selected 22 lines of ‘Kaida kabu’, a local turnip variety of Nagano Prefecture, from seed saving seeds and cultivated them throughout the ‘Kaida kougen’ and examined the morphological characteristics of up to 10 individuals of each strain. The results indicated that ‘Kaida kabu’ has a wide range of interstrain variation and retains a high level of genetic diversity. This may be due to the large number of seed saving farmers and genetic exchange among them. In the past, different strains of local turnips were known to exist in the Nishino and Suekawa districts, which divide the Kaida kougen, but now they are collectively known as ‘Kaida kabu’ and there is no difference between them. However, the results of a principal component analysis using morphological data of the roots showed that there were differences close to those recognized by farmers. It is also suggested that the ‘Pink kabu’, which is clearly separated within the same area, may have been produced by selecting individuals mutationally defective in pigment synthesis from the ‘Kaida kabu’. To maintain the morphological and genetic diversity of ‘Kaida kabu’, it would be effective not only to maintain the number of plants and farmers, but also to recognize and maintain the rarity of the species in the region.Article信州大学農学部AFC報告 22 : 37-44, (2024)departmental bulletin pape
Effect of Increased Telecommuting Days on Psychological Stress ―Mediated by Autonomy and Social Support―
Get PDFArticle信州大学経法論集 16 : 1-26, (2024)departmental bulletin pape
Development of the 12-Base Short Dimeric Myogenetic Oligodeoxynucleotide That Induces Myogenic Differentiation
Get PDFA myogenetic oligodeoxynucleotide (myoDN), iSN04 (5′-AGA TTA GGG TGA GGG TGA-3′), is a single-stranded 18-base telomeric DNA that serves as an anti-nucleolin aptamer and induces myogenic differentiation, which is expected to be a nucleic acid drug for the prevention of disease-associated muscle wasting. To improve the drug efficacy and synthesis cost of myoDN, shortening the sequence while maintaining its structure-based function is a major challenge. Here, we report the novel 12-base non-telomeric myoDN, iMyo01 (5′-TTG GGT GGG GAA-3′), which has comparable myogenic activity to iSN04. iMyo01 as well as iSN04 promoted myotube formation of primary-cultured human myoblasts with upregulation of myogenic gene expression. Both iMyo01 and iSN04 interacted with nucleolin, but iMyo01 did not bind to berberine, the isoquinoline alkaloid that stabilizes iSN04. Nuclear magnetic resonance revealed that iMyo01 forms a G-quadruplex structure despite its short sequence. Native polyacrylamide gel electrophoresis and a computational molecular dynamics simulation indicated that iMyo01 forms a homodimer to generate a G-quadruplex. These results provide new insights into the aptamer truncation technology that preserves aptamer conformation and bioactivity for the development of efficient nucleic acid drugs.ArticleBioTech 2024, 13(2), 11journal articl
Social psychological study of the way and walking(3): Rambling and psychological resilience
Get PDFArticle信州大学人文科学論集 11(2) : 53-70, (2024)departmental bulletin pape