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Novel Membrane Designed Polyether Sulfone Filter Reduces Filtration Membrane Obstruction Rate in Drop-Type With Adjustable Concentrator Cell-Free and Concentrated Ascites Reinfusion Therapy (DC-CART)（新規膜設計によるポリエーテルスルホン膜ろ過フィルターは濃縮調整が可能な落差式腹水濾過濃縮再静注療法におけるろ過膜閉塞率を低下させる）
Get PDF信州大学Shinshu University博士（医学）次の雑誌に発表。 /Artificial Organs 49(4) :592-599(2025); doi:10.1111/aor.14932 © 2024 The Author(s). Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License.doctoral thesi
Genetic analysis and genomic prediction of key fruit traits in chili pepper(Capsicum annuum L.)(トウガラシ（Capsicum annuum L.）における主要果実形質の遺伝解析およびゲノム予測)
No full text信州大学Shinshu University博士（農学）この博士論文は、次の学術雑誌論文を一部に使用しています。 || Molecular Breeding 45 :5(2024); doi:10.1007/s11032-024-01528-y © The Author(s), under exclusive licence to Springer Nature B.V. 2024|| Breeding Science 75(4) :303-314(2025); doi:10.1270/jsbbs.25011 © 2025 by JAPANESE SOCIETY OF BREEDING This is an open-access article distributed under the terms of the Creative Commons Attribution (BY) License.doctoral thesi
Synthetic short mRNA prevents metastasis via innate-adaptive immunity
No full textAlthough most cancer deaths are caused by metastasis, there are no effective therapeutic approaches. This study describes the efficacy of a short synthetic mRNA (s-mRNA) designed by the sequence of non-vesicular extracellular IL1β-mRNA found in the pre-metastatic lung of tumor-bearing mice. The administration of s-mRNA inhibits murine lung metastasis by inducing the innate and adaptive immune systems. s-mRNA binds to ZC3H12D, an RNA-binding protein on natural killer cells and cytotoxic T lymphocytes. The ZC3H12D-s-mRNA complex translocated to the nucleus without being involved in translation. This process induces cytolytic activity and cell death in cancer cells without inducing a cytokine storm, and immune cells retain their antitumor activity. Although the antitumor activity of cytotoxic lymphocytes declines as the disease progresses in cancer patients, s-mRNA induces sustained high killing capacities of natural killer cells and cytotoxic T lymphocytes from colon cancer patients. Therefore, s-mRNA could be a breakthrough solution to prevent metastasis.journal articl
Return-to-work support program outcomes for people on leave due to mood and stress-related disorders
No full textBackground: Mood disorders and stress-related disorders are the two leading causes of long-term employee absenteeism and cause significant social losses. Therefore, strengthening the support systems is essential to help employees return to work. Objective: This study aimed to investigate the outcomes of a return to work (RTW) rehabilitation program and to explore factors associated with RTW and continued employment. Methods: A five-times-a-week RTW intervention was implemented for three to four months for people on leave who had been diagnosed with a mood or stress-related disorder. RTW rates within one year of completing the program and RTW retention rates one year after returning to work were examined to explore factors associated with RTW and employment retention. Results: Of the 47 participants, 41 completed the RTW intervention, 35 returned to work (85.4%) within one year after the intervention, and 29 were still working one-year post their RTW (82.9%). The non-RTW group had a lower attendance rate for the program and showed an increase in anxious temperament. Additionally, compared to the RTW group, the non-RTW group showed significantly lower interpersonal relationship scores and decreased finger dexterity in the post-program evaluation, which may be associated with difficulties in returning to work. There was little improvement in cognitive function in the RTW non-continuation group, with a disrupted rhythm of life, depression, panic, and non-assertive self-expression. Conclusion: The RTW intervention demonstrated effectiveness for treating patients with mood and stress-related disorders. Future studies should investigate comparative trials with a control group while also increasing the sample size.journal articl
Image data and list of diagnoses for all cases
No full textData for an Article titled “Problems of magnetic resonance diagnosis for gastric-type mucin-positive cervical lesions of the uterus and its solutions using artificial intelligence”これらは本研究で使用した画像データです。画像データのファイル名に記載されている数字は症例番号を表しています。匿名化された各症例の診断名一覧はExcelファイルでご覧いただけます。These are image data used in this study. The numbers in the file names of the image data indicate the case numbers. You can view the list of diagnoses for each anonymized case in the Excel file.JSPS KAKENHI Grant number: 22K09593datase
Survey of large and medium-sized mammals using camera traps in the riverhead area of Uonogawa river : Result of the 2022 survey
Get PDFThe large and medium-sized mammalian fauna of Kiriake site within the riverhead area of Uonogawa river, in the northern part of Nagano Prefecture, Japan, were surveyed using camera traps from August to November 2022. Six camera traps were set up within the survey area, and recordings were obtained for a total of 330 days. Eight species of large and medium-sized mammals were recorded by the cameras : Macaca fuscata, Lepus brachyurus, Nyctereutes procyonoides, Ursus thibetanus, Martes melampus, Meles anakuma, Paguma larvata, and Sus scrofa.Article志賀自然教育研究施設研究業績 61 : 15-19, (2024)departmental bulletin pape
自尊感情が社交不安に及ぼす影響―他者からの否定的評価の恐れと肯定的評価の恐れに着目して―
Get PDF顕在的自尊感情(Explicit Self-Esteem : ESE) と潜在的自尊感情（Implicit Self-Esteem : ISE）の不一致は社交不安と関連がみられ，抑うつ的反芻など認知面にも影響を及ぼすことが明らかになっている。本研究では，社交不安の認知的要素である他者からの否定的評価に対する恐れ(Fear of Negative Evaluation : FNE)や肯定的評価に対する恐れ(Fear of PositiveEvaluation : FPE)と社交不安の関連に対するESEとISEの不一致の調整効果について検討することを目的とした。分析の結果，FNEやFPEと社交不安の関連に対するESEとISEの不一致の調整効果は認められなかった。その要因としては，ISEが文脈に依存する性質があることや，先行研究との実験条件の違いが考えられた。今後は，実験条件の設定や様々な年齢層に調査を行う必要があると考えられる。Article信州心理臨床紀要 23 : 77-91, (2024)departmental bulletin pape
視線注意手がかり効果―顔と物体の視覚処理の比較―
Get PDF本研究では，他者の視線を追従しようとする視線注意手がかり効果の検証を行った。併せて，顔と物体の判別がどのように処理されるのか検証した。実験Ⅰでは，左方向或いは右方向に視線を向けている顔画像，左右の何れかに正面が偏った家画像（物体）を提示して，ターゲットと手がかりの時間間隔が同効果の発現に及ぼす影響を検討した。実験Ⅱでは複数の時間間隔を設定し，視線注意手がかり効果，及び同様の実験パラダイムによる顔と家に対する視覚処理を検討した。結果，300msの時間間隔で視線注意手がかり効果が確認された。さらに，顔と家の視覚処理が類似していることを示唆する結果が得られた。Article信州心理臨床紀要 23 : 92-105, (2024)departmental bulletin pape
Recombinant γY278H Fibrinogen Showed Normal Secretion from CHO Cells, but a Corresponding Heterozygous Patient Showed Hypofibrinogenemia（患者の表現型とCHO細胞の産生能に乖離を認めた変異フィブリノゲンγY278Hの解析）
Get PDF信州大学(Shinshu university)博士（保健学）次の雑誌に発表。 /The American Journal of Pathology 193(6) :725-739(2023); doi:10.1016/j.ajpath.2023.03.002 © 2023 American Society for Investigative Pathology. Published by Elsevier Inc.上條 途夢. Recombinant γY278H Fibrinogen Showed Normal Secretion from CHO Cells, but a Corresponding Heterozygous Patient Showed Hypofibrinogenemia（患者の表現型とCHO細胞の産生能に乖離を認めた変異フィブリノゲンγY278Hの解析）. 信州大学, 2024, 博士論文. 博士（保健学）, 甲第54号, 令和06年03月20日授与.doctoral thesi